Additional file 1: Figure S1. Systematic review of NAC-related grade 3/4 adverse events and postoperative 30-day mortality. (A) The frequency of grade 3/4 adverse events and postoperative 30-day mortality in each regimen. (B) Forest plots of comparisons for grade 3/4 adverse events and postoperative 30-day mortality (S, surgery).

Additional file 1: Figure S1. Systematic review of NAC-related grade 3/4 adverse events and postoperative 30-day mortality. (A) The frequency of grade 3/4 adverse events and postoperative 30-day mortality in each regimen. (B) Forest plots of comparisons for grade 3/4 adverse events and postoperative 30-day mortality (S, surgery).

Additional file 4. Tucidinostat plus checkpoint blockade induces significant antitumor immunity. a Schema of the experiment. Mouse CT26 cells (5 × 105 cells) were engrafted into the flank of BALB/c mice. When established tumors were palpable 7 days after tumor cells inoculation, mice were treated with vehicle (DMSO, n=7), tucidinostat (25 mg/kg, gavage, daily, n=7), aPD-L1 (200 μg, i.p. injection, once every 3 days, n=7), or combination (n=7). The proportion of intratumoral CD8+ T cells...

Additional file 4. Tucidinostat plus checkpoint blockade induces significant antitumor immunity. a Schema of the experiment. Mouse CT26 cells (5 × 105 cells) were engrafted into the flank of BALB/c mice. When established tumors were palpable 7 days after tumor cells inoculation, mice were treated with vehicle (DMSO, n=7), tucidinostat (25 mg/kg, gavage, daily, n=7), aPD-L1 (200 μg, i.p. injection, once every 3 days, n=7), or combination (n=7). The proportion of intratumoral CD8+ T cells...

Additional file 5. Tucidinostat plus checkpoint blockade induces CCL5 secretion. a Mouse CT26 cells (5 × 105 cells) were engrafted into the flank of BALB/c mice. When established tumors were palpable 7 days after tumor cells inoculation, mice were treated with different doses (12.5, 25, 75 mg/kg, gavage, daily, n=5) of tucidinostat. The expression of CCL5 in peripheral blood serum from CT26 tumor-bearing mice on day 10 post treatment initiation. Mouse CT26 cells (5 ×...

Additional file 2. Figure S1: Boxplots of GSE84437 (a) and GSE62254 (b) expression profile data.

Additional file 2: Fig. S1. Rarefaction curves obtained from all samples.

Additional file 3: Fig. S2. The susceptibility of Sphingomonas to different antibiotics. (A) The inhibition zone of different antibiotics against Sphingomonas (a-f): sodium sulfate, gentamicin, chloramphenicol, tetracycline, amoxicillin, and ampicillin. (B) The line chart of different antibiotics to Sphingomonas.

Additional file 3: Fig. S2. The susceptibility of Sphingomonas to different antibiotics. (A) The inhibition zone of different antibiotics against Sphingomonas (a-f): sodium sulfate, gentamicin, chloramphenicol, tetracycline, amoxicillin, and ampicillin. (B) The line chart of different antibiotics to Sphingomonas.

Additional file 4: Fig. S3. Detection of Sphingomonas in nine field populations in 2019. Bars represent the mean ± SE (P < 0.05, Tukey’s test).

Additional file 6: Fig. S5. The stand curve of IMI (A), urea IMI (B) and 5-OH IMI (C).

Additional file 2: Fig. S2. The activation of IL-6/STAT3 pathway promotes the CSC-like phenotypes of TNBC cells.

Additional file 7. The effect of splenic denervation on vessels of EAM mice. A. HE staining for spleen histological signs of EAM mice and EAM+SDN mice. B. Representative images of whole spleen sections of EAM mice and EAM+SDN mice. Blue, nuclear staining. Green, CD31 is a sensitive and specific marker for vascular endothelial injury (especially white arrow). EAM: Experimental Autoimmune Myocarditis; SDN: Splenic Denervation; HE: hematoxylin and eosin.

Additional file 5: Supplementary Figure 2. Curve fitting of BMD distribution for postmenopausal women.

Additional file 6: Supplementary Figure 3. The residual-versus-fitted plot shows that fitted values do not have an obvious trend of failure.

Additional file 4: Supplementary Figure 1. Curve fitting of BMD distribution for older men.

Additional file 6: Supplementary Figure 3. The residual-versus-fitted plot shows that fitted values do not have an obvious trend of failure.

Figure S1. Some video-screenshot examples of egg ejection by green-backed tits in this study.

Additional file 4: Fig. S4. NLRP1-siRNA treatment reduces Aβ deposition in cortex of APP/PS1 mice (Thioflavin-S staining and Aβ1-42 by immunofluorescence, 100 × , bar = 100 μm).

Supplementary Material 3

Additional file 2. Unprocessed images of Western blot in Figure 1.

Supplemental material, sj-jpg-1-jcb-10.1177_0271678X221145090 for Progranulin released from microglial lysosomes reduces neuronal ferroptosis after cerebral ischemia in mice by Tingting Chen, Rubing Shi, Qian Suo, Shengju Wu, Chang Liu, Shuxian Huang, Khan Haroon, Ze Liu, Yuyan He, Heng-Li Tian, Yongting Wang, Yaohui Tang, Guo-Yuan Yang and Zhijun Zhang in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-jpg-2-jcb-10.1177_0271678X221145090 for Progranulin released from microglial lysosomes reduces neuronal ferroptosis after cerebral ischemia in mice by Tingting Chen, Rubing Shi, Qian Suo, Shengju Wu, Chang Liu, Shuxian Huang, Khan Haroon, Ze Liu, Yuyan He, Heng-Li Tian, Yongting Wang, Yaohui Tang, Guo-Yuan Yang and Zhijun Zhang in Journal of Cerebral Blood Flow & Metabolism

Additional file 5: Figure S2. Confocal fluorescence imaging showed the survival rate of BMSCs at the different sites of brain-VBM 2 days after cell seeding.Red box shown central site and carmine box shown peripheral site. The number at the bottow of images show dimension labels of Z-stack.

Additional file 6: Figure S3. Bioinformatic analysis of the proteins in brain-VBM and normal brain tissue showed the following: The enriched GO terms (B) showed that the protein functional characteristics were all associated with ECM, cell binding, and cell adhesion. KEGG pathway enrichment(C) showed the 20 cellular signaling pathways with the most differentially expressed proteins. A shows the cluster analysis of differentially expressed proteins.