1,483 Works

Development of Lactobacillus kimchicus DCY51T-mediated gold nanoparticles for delivery of ginsenoside compound K: in vitro photothermal effects and apoptosis detection in cancer cells

Yeon-Ju Kim, Haribalan Perumalsamy, Josua Markus, Sri Renukadevi Balusamy, Chao Wang, Seong Ho Kang, Seungah Lee, Sang Yong Park, Sung Kim, Verónica Castro-Aceituno, Seung Hyun Kim & Deok Chun Yang
We report a non-covalent loading of ginsenoside compound K (CK) onto our previously reported gold nanoparticles (DCY51T-AuCKNps) through one-pot biosynthesis using a probiotic Lactobacillus kimchicus DCY51T isolated from Korean kimchi. The ginsenoside-loaded gold nanoparticles were characterized by various analytical and spectroscopic techniques such as field emission transmission electron microscopy (FE-TEM), energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, X-ray powder diffraction (XRD), selected area electron diffraction (SAED), Fourier-transform infrared (FTIR) spectroscopy and dynamic light scattering (DLS). Furthermore,...

Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1

Wenliang Song, Tiening Zhang, Ni Yang, Tao Zhang, Ri Wen & Chunfeng Liu
Myocardial injury resulting from sepsis is the leading cause of death worldwide. Micro RNA miR-122-5p is involved in various physiological and pathological processes and is highly expressed in the heart of septic rats. However, its function in sepsis-caused myocardial injury remains elusive. Herein, a rat model of septic myocardial injury was established by intraperitoneal injection of lipopolysaccharide (LPS), and cardiomyocyte H9c2 was exposed to LPS to induce sepsis-related inflammatory injury in vitro. Inhibition of miR-122-5p...

Silenced lncRNA H19 and up-regulated microRNA-129 accelerates viability and restrains apoptosis of PC12 cells induced by Aβ25-35 in a cellular model of Alzheimer’s disease

Yan-Yun Zhang, Hai-Lan Bao, Li-Xia Dong, Yu Liu, Guo-Wei Zhang & Feng-Mao An
Accumulating data manifest that long non-coding RNA (lncRNAs) are involved in all kinds of neurodegenerative disorders, consisting of the onset and progression of Alzheimer’s disease (AD). The study was for the research of the mechanism of lncRNA H19 (H19) in viability and apoptosis of PC12 cells induced by Aβ25-35 in a cellular model of AD with the regulation of microRNA (miR)-129 and high mobility group box-1 protein (HMGB1). An AD cellular model of PC12 cells...

Increasing chitosanase production in Bacillus cereus by a novel mutagenesis and screen method

Chaozheng Zhang, Yi Li, Tianshuang Zhang & Hua Zhao
Chitosan hydrolysis by chitosanase is one of the most effective methods to produce chitosan oligosaccharides. One of the prerequisites of enzyme fermentation production is to select and breed enzyme-producing cells with good performance. So in the process of fermentation production, the low yield of chitosanase cannot meet the current requirement. In this paper, a strain producing chitosanase was screened and identified, and a novel mutagenesis system (Atmospheric and Room Temperature Plasma (ARTP)) was selected to...

Identification of hepatocellular carcinoma-related genes associated with macrophage differentiation based on bioinformatics analyses

Jun Cao, Chi Zhang, Guo-Qing Jiang, Sheng-Jie Jin, Qian Wang, Ao-Qing Wang & Dou-Sheng Bai
Macrophage differentiation is associated with tumorigenesis, including the tumorigenesis of hepatocellular carcinoma (HCC). Herein, we explored the value of macrophage differentiation-associated genes (MDGs) in the prognosis of HCC using data from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) databases. We performed multivariate Cox regression analyses to identify the hub genes affecting HCC patient prognoses. The correlations between hub genes and macrophage differentiation and immune checkpoint inhibitors (PD-1, PD-L1, and CTLA4)...

sj-tif-1-tag-10.1177_17562848231160630 – Supplemental material for Efficacy and safety of a triple combination of atezolizumab, bevacizumab plus GEMOX for advanced biliary tract cancer: a multicenter, single-arm, retrospective study

Kang Wang, Zong-Han Liu, Hong-Ming Yu, Yu-Qiang Cheng, Yan-Jun Xiang, Jing-Ya Zhong, Qian-Zhi Ni, Li-Ping Zhou, Chao Liang, Hong-Kun Zhou, Wei-Wei Pan, Wei-Xing Guo, Jie Shi & Shu-Qun Cheng
Supplemental material, sj-tif-1-tag-10.1177_17562848231160630 for Efficacy and safety of a triple combination of atezolizumab, bevacizumab plus GEMOX for advanced biliary tract cancer: a multicenter, single-arm, retrospective study by Kang Wang, Zong-Han Liu, Hong-Ming Yu, Yu-Qiang Cheng, Yan-Jun Xiang, Jing-Ya Zhong, Qian-Zhi Ni, Li-Ping Zhou, Chao Liang, Hong-Kun Zhou, Wei-Wei Pan, Wei-Xing Guo, Jie Shi and Shu-Qun Cheng in Therapeutic Advances in Gastroenterology

sj-tif-5-pie-10.1177_09544089221114253 - Supplemental material for Ultrasonic and phased-array inspection in titanium-based alloys: A review

Hongyuan Shi, Mahmoud Ebrahimi, Peng Zhou, Kangchen Shao & Jie Li
Supplemental material, sj-tif-5-pie-10.1177_09544089221114253 for Ultrasonic and phased-array inspection in titanium-based alloys: A review by Hongyuan Shi, Mahmoud Ebrahimi, Peng Zhou, Kangchen Shao and Jie Li in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering

sj-tif-6-pie-10.1177_09544089221114253 - Supplemental material for Ultrasonic and phased-array inspection in titanium-based alloys: A review

Hongyuan Shi, Mahmoud Ebrahimi, Peng Zhou, Kangchen Shao & Jie Li
Supplemental material, sj-tif-6-pie-10.1177_09544089221114253 for Ultrasonic and phased-array inspection in titanium-based alloys: A review by Hongyuan Shi, Mahmoud Ebrahimi, Peng Zhou, Kangchen Shao and Jie Li in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering

Long-term response to sintilimab, bevacizumab and chemotherapy in heavily pretreated microsatellite stable colon cancer. Supplementary Figure.

Quanli Han, Beifang Niu, Sheng Liu, Erhong Meng, Muhong Deng, Qi Wang & Zhi Cui
Supplmentary figure 1

Galectin-9 and PD-L1 antibody blockade combination therapy inhibits tumour progression in pancreatic cancer. Supplementary figures

Tingbo Liang, Xingyuan Xu, Xiaozhen Zhang, Qi Chen, Jian Xu & Enliang Li
Supplementary figures 1 and 2

sj-tif-2-tag-10.1177_17562848231155023 – Supplemental material for An explainable artificial intelligence system for diagnosing Helicobacter Pylori infection under endoscopy: a case–control study

Mengjiao Zhang, Jie Pan, Jiejun Lin, Ming Xu, Lihui Zhang, Renduo Shang, Liwen Yao, Yanxia Li, Wei Zhou, Yunchao Deng, Zehua Dong, Yijie Zhu, Xiao Tao, Lianlian Wu & Honggang Yu
Supplemental material, sj-tif-2-tag-10.1177_17562848231155023 for An explainable artificial intelligence system for diagnosing Helicobacter Pylori infection under endoscopy: a case–control study by Mengjiao Zhang, Jie Pan, Jiejun Lin, Ming Xu, Lihui Zhang, Renduo Shang, Liwen Yao, Yanxia Li, Wei Zhou, Yunchao Deng, Zehua Dong, Yijie Zhu, Xiao Tao, Lianlian Wu and Honggang Yu in Therapeutic Advances in Gastroenterology

Additional file 2 of Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation

Dongqin Wu, Nana Yu, Yang Gao, Rui Xiong, Luping Liu, Huiyang Lei, Sen Jin, Jiale Liu, Yingzhou Liu, Jiazhao Xie, Enjie Liu, Qiuzhi Zhou, Yanchao Liu, Shihong Li, Linyu Wei, Jingru Lv, Huilin Yu, Wenbo Zeng, Qiang Zhou, Fuqiang Xu, Min-Hua Luo, Yao Zhang, Ying Yang & Jian-Zhi Wang
Additional file 2: sFigure 2. Molecular characterization of cholinergic neurons in the MS. (A, D) Representative images show co-localization of ChAT with CaMKII or GABA by co-immunofluorescence staining. (B, C, E, F) Quantitative analyses showed that ~93% and ~28% of ChAT+ neurons were respectively co-stained with CaMKII and GABA, while ~13% CaMKII+ and ~7% GABA+ neurons were respectively ChAT. N = 6 mice per group. Scale bar, 50 μm.

Additional file 2 of Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation

Dongqin Wu, Nana Yu, Yang Gao, Rui Xiong, Luping Liu, Huiyang Lei, Sen Jin, Jiale Liu, Yingzhou Liu, Jiazhao Xie, Enjie Liu, Qiuzhi Zhou, Yanchao Liu, Shihong Li, Linyu Wei, Jingru Lv, Huilin Yu, Wenbo Zeng, Qiang Zhou, Fuqiang Xu, Min-Hua Luo, Yao Zhang, Ying Yang & Jian-Zhi Wang
Additional file 2: sFigure 2. Molecular characterization of cholinergic neurons in the MS. (A, D) Representative images show co-localization of ChAT with CaMKII or GABA by co-immunofluorescence staining. (B, C, E, F) Quantitative analyses showed that ~93% and ~28% of ChAT+ neurons were respectively co-stained with CaMKII and GABA, while ~13% CaMKII+ and ~7% GABA+ neurons were respectively ChAT. N = 6 mice per group. Scale bar, 50 μm.

Additional file 4 of Ten-year distant-recurrence risk prediction in breast cancer by CanAssist Breast (CAB) in Dutch sub-cohort of the randomized TEAM trial

Xi Zhang, Aparna Gunda, Elma Meershoek-Klein Kranenbarg, Gerrit-Jan Liefers, Badada Ananthamurthy Savitha, Payal Shrivastava, Chandra Prakash Vijay Kumar Serkad, Taranjot Kaur, Mallikarjuna Siraganahalli Eshwaraiah, Rob A. E. M. Tollenaar, Cornelis J. H. van de Velde, Caroline M. J. Seynaeve, Manjiri Bakre & Peter J. K. Kuppen
Additional file 4: Fig. S4. Hazard ratio estimates of overall survival (OS), invasive disease-free survival (iDFS), relapse-free survival (RFS), and distant recurrence-free interval (DRFi) between patients with or without chemotherapy or randomized arms receiving endocrine therapy alone in two CanAssist Breast (CAB) risk categories. (A) Low-risk group. (B) High-risk group.

Additional file 2 of Ten-year distant-recurrence risk prediction in breast cancer by CanAssist Breast (CAB) in Dutch sub-cohort of the randomized TEAM trial

Xi Zhang, Aparna Gunda, Elma Meershoek-Klein Kranenbarg, Gerrit-Jan Liefers, Badada Ananthamurthy Savitha, Payal Shrivastava, Chandra Prakash Vijay Kumar Serkad, Taranjot Kaur, Mallikarjuna Siraganahalli Eshwaraiah, Rob A. E. M. Tollenaar, Cornelis J. H. van de Velde, Caroline M. J. Seynaeve, Manjiri Bakre & Peter J. K. Kuppen
Additional file 2: Fig. S2. All-cause mortality, cumulative incidence of invasive breast cancer by CAB for the total cohort, and cumulative incidence of distant recurrence/death due to breast cancer (DM) by CAB for the subgroups. (A) All-cause mortality in the total cohort. (B) Cumulative incidence of invasive breast cancer for the entire cohort. (C) DM for patients who received adjuvant exemestane alone. (D) DM for patients who received sequential adjuvant regimen alone.

Obesity, metabolic dysfunction, and risk of kidney stone disease: a national cross-sectional study

Zhenyang Ye, Changjing Wu, Yang Xiong, Fuxun Zhang, Jinyang Luo, Lijing Xu, Jia Wang & Yunjin Bai
This study aimed to investigate the association between different metabolic syndrome-body mass index (MetS-BMI) phenotypes and the risk of kidney stones. Participants aged 20–80 years from six consecutive cycles of the NHANES 2007–2018 were included in this study. According to their MetS status and BMI, the included participants were allocated into six mutually exclusive groups: metabolically healthy normal weight (MHN)/overweight (MHOW)/obesity (MHO) and metabolically unhealthy normal weight (MUN)/overweight (MUOW)/obesity (MUO). To explore the association between...

Additional file 5 of The gut symbiont Sphingomonas mediates imidacloprid resistance in the important agricultural insect pest Aphis gossypii Glover

Nannan Lv, Ren Li, Shenhang Cheng, Lei Zhang, Pei Liang & Xiwu Gao
Additional file 5: Fig. S4. The abundance of Sphingomonas in the gut of the IMI-S and IMI-R strains and SXYC, SDBZ, XJSW and HBHS field populations. The bars with lowercase letters (a, b, c) are significantly different according to one-way ANOVA, followed by Tukey's multiple comparison test (P< 0.05).

Additional file 2 of Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling

Heshu Liu, Rui Yan, Zeru Xiao, Xuying Huang, Jiannan Yao, Jian Liu, Guangyu An & Yang Ge
Additional file 2: Fig. S2. The activation of IL-6/STAT3 pathway promotes the CSC-like phenotypes of TNBC cells.

Additional file 1 of Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling

Heshu Liu, Rui Yan, Zeru Xiao, Xuying Huang, Jiannan Yao, Jian Liu, Guangyu An & Yang Ge
Additional file 1: Fig. S1. The proportion of CD8+ T cells was unchanged in thymus after anti-CD8α treatment..

Additional file 3 of Menstrual blood-derived endometrial stem cells alleviate neuroinflammation by modulating M1/M2 polarization in cell and rat Parkinson’s disease models

Han Li, Jinghui Wei, Zhigang Zhang, Junyao Li, Yaokai Ma, Ping Zhang & Juntang Lin
Additional file 3: Fig. S2. Uncropped WB images of Arg1, iNOS, TH and β-actin. A: WB result of Arg1 (36 kDa). B: WB result of iNOS (110-130 kDa, 65-70 kDa). C: WB result of β-actin (43 kDa). D: WB result of TH (57 kDa). E: WB result of β-actin (43 kDa). Dashed lines indicated where they were cropped to make Fig.6C and Fig.4J.

sj-tiff-2-jhc-10.1369_00221554231161693 – Supplemental material for Multiplex Immunofluorescence Image Quality Checking Using DAPI Channel–referenced Evaluation

Jun Jiang, Raymond Moore, Clarissa E. Jordan, Ruifeng Guo, Rachel L. Maus, Hongfang Liu, Ellen Goode, Svetomir N. Markovic & Chen Wang
Supplemental material, sj-tiff-2-jhc-10.1369_00221554231161693 for Multiplex Immunofluorescence Image Quality Checking Using DAPI Channel–referenced Evaluation by Jun Jiang, Raymond Moore, Clarissa E. Jordan, Ruifeng Guo, Rachel L. Maus, Hongfang Liu, Ellen Goode, Svetomir N. Markovic and Chen Wang in Journal of Histochemistry & Cytochemistry

Additional file 1 of Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation

Qi Cheng, Jing Wu, Yingqian Xia, Qing Cheng, Yinjuan Zhao, Peixiang Zhu, Wangling Zhang, Shihu Zhang, Lei Zhang, Yushan Yuan, Chaojun Li, Guiquan Chen & Bin Xue
Additional file 1: Figure S1. Expression patterns for different types of cells in hGfap-Cre-mediated knockout of Ggps1. A Representative fluorescence images for co-staining of Pax6/Ggpps in the cerebellum. Brain sections at P4 and P7 were used. Whereas there were abundant Pax6+/Ggpps+ cells in control mice, there were little Pax6+/Ggpps+ cells in Ggps1 cKO mice. B Enlarged images for the boxed areas in A. C Representative fluorescence images for co-staining of NeuN/Ggpps in the cerebellum. Whereas...

Additional file 2 of Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation

Qi Cheng, Jing Wu, Yingqian Xia, Qing Cheng, Yinjuan Zhao, Peixiang Zhu, Wangling Zhang, Shihu Zhang, Lei Zhang, Yushan Yuan, Chaojun Li, Guiquan Chen & Bin Xue
Additional file 2. Unprocessed images of Western blot in Figure 1.

Additional file 2 of Clinical and radiographic outcomes of stand-alone oblique lateral interbody fusion in the treatment of adult degenerative scoliosis: a retrospective observational study

Yu Zhang, Chen Liu & Xin Ge
Additional file 2: Figure S2. The Cobb angle, sagittal parameters and LL before (A,C and E) and after (B,D and F) operation of case 23.

Additional file 5 of Iris lactea var. chinensis plant drought tolerance depends on the response of proline metabolism, transcription factors, transporters and the ROS-scavenging system

Yue Zhang, Ruihai Zhang, Zhen Song, Weidong Fu, Lingling Yun, Jinhui Gao, Guang Hu, Zhonghui Wang, Hanwen Wu, Guoliang Zhang & Jiahe Wu
Additional file 5.

Registration Year

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Affiliations

  • Peking University
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  • Chinese Academy of Medical Sciences & Peking Union Medical College
    1,009
  • Fudan University
    982
  • Shanghai Jiao Tong University
    972
  • Sichuan University
    940
  • Zhejiang University
    909
  • Huazhong University of Science and Technology
    886
  • Chinese Academy of Sciences
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  • Sun Yat-sen University
    809
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    798