135 Works

Multi-locus identification of Psilocybe cubensis by high-resolution melting (HRM)

Xiaochun Zhang, Huan Yu, Ziwei Wang, Qi Yang, Ruocheng Xia, Yiling Qu, Ruiyang Tao, Yan Shi, Ping Xiang, Suhua Zhang & Chengtao Li
Hallucinogenic mushroom is a kind of toxic strain containing psychoactive tryptamine substances such as psilocybin, psilocin and ibotenic acid, etc. The mushrooms containing hallucinogenic components are various, widely distributed and lack of standard to define, which made a great challenge to identification. Traditional identification methods, such as morphology and toxicology analysis, showed shortcomings in old or processed samples, while the DNA-based identification of hallucinogenic mushrooms would allow to identify these samples due to the stability...

The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study

Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi & Xinling Liang
Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. We conducted a prospective, crossover, open-label study to investigate the effect of amiloride in patients with DKD. Safety and efficacy were assessed by monitoring urine protein creatinine ratio(uPCR), urinary albumin creatinine ratio (uACR),...

Increasing chitosanase production in Bacillus cereus by a novel mutagenesis and screen method

Chaozheng Zhang, Yi Li, Tianshuang Zhang & Hua Zhao
Chitosan hydrolysis by chitosanase is one of the most effective methods to produce chitosan oligosaccharides. One of the prerequisites of enzyme fermentation production is to select and breed enzyme-producing cells with good performance. So in the process of fermentation production, the low yield of chitosanase cannot meet the current requirement. In this paper, a strain producing chitosanase was screened and identified, and a novel mutagenesis system (Atmospheric and Room Temperature Plasma (ARTP)) was selected to...

Knockdown of lectin-like oxidized low-density lipoprotein-1 ameliorates alcoholic cardiomyopathy via inactivating the p38 mitogen-activated protein kinase pathway

Yifan Zhang, Ruiqi Zhang, Lan Lu, Na Zhou, Xiaoyan Lv, Xin Wang & Zhanbin Feng
LOX-1 triggers myocardial fibrosis, but its roles and mechanisms in alcoholic cardiomyopathy and the involvement of the downstream signaling pathways had not been fully reported. We planned to explore how LOX-1 facilitated myocardial fibrosis in alcoholic cardiomyopathy. The in vitro and in vivo alcoholic cardiomyopathy model was established by alcohol treatment to rats’ cardiac fibroblasts and rats, respectively. Masson staining was conducted to observe the collagen deposition and the IHC assay was executed to evaluate...

Additional file 6 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 6: Supplementary Figure S6. Expression values of NRGs in prognostic signature of OV. A-D Expression values of NRGs in TCGA for BACH2 (A), MLKL (B), MYC (C), MYCN (D), and SIRT2 (E). F-J Expression values of NRGs in our cohort for BACH2 (F), MLKL (I), MYC (G), MYCN (H), and SIRT2 (J).

Additional file 9 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 9: Supplementary Figure S9. The waterfall plot of somatic mutation features established with risk scores. A-B The waterfall plot of somatic mutation in CESC for high-risk group (A) and low-risk group B. C-D The waterfall plot of somatic mutation in OV for high-risk group (C) and low-risk group D. E-F The waterfall plot of somatic mutation in UCEC for high-risk g©p (E) and low-risk group F. G-H The waterfall plot of somatic mutation...

Additional file 4 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 4: Supplementary Figure S4. Statistical analysis of the number of differential NRGs and prognostic NRGs of the four GCs. Red bars show up-regulated NRGs in cancer tissue. The green bars show NRGs that are downregulated in cancer tissue. The blue bars show the sum of the differential NRGs. Yellow bars indicate prognostic NRGs.

Additional file 8 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 8: Supplementary Figure S8. The Nomogram model based on risk model and clinical features for GCs. A-B The Nomogram (A) and calibration curve (B) for CESC. C-D The Nomogram (C) and calibration curve (D) for OV. (E-F) The Nomo©m (E) and calibration curve (F) for UCEC. G-H The Nomogram (G) and calibration curve (H) for UCS.

Additional file 3 of Whole-cell tumor vaccines desialylated to uncover tumor antigenic Gal/GalNAc epitopes elicit anti-tumor immunity

Jianmei Huang, Meiying Li, Bingjie Mei, Junyang Li, Yi Zhu, Qiaoshan Guo, Jianming Huang & Guonan Zhang
Additional file 3: Fig. S3. Representative confocal immunofluorescence images of OC cells. (a) and (b) showed the images of unmodified, α2-3NA modified, and α2-6NA modified ID8 cells stained by α-2,3Sia (MAL II, green), α-2,6Sia (SNA, green), and Gal/GalNAc (PNA, pink). Scale bars: 100 μm.

Additional file 3 of Whole-cell tumor vaccines desialylated to uncover tumor antigenic Gal/GalNAc epitopes elicit anti-tumor immunity

Jianmei Huang, Meiying Li, Bingjie Mei, Junyang Li, Yi Zhu, Qiaoshan Guo, Jianming Huang & Guonan Zhang
Additional file 3: Fig. S3. Representative confocal immunofluorescence images of OC cells. (a) and (b) showed the images of unmodified, α2-3NA modified, and α2-6NA modified ID8 cells stained by α-2,3Sia (MAL II, green), α-2,6Sia (SNA, green), and Gal/GalNAc (PNA, pink). Scale bars: 100 μm.

Additional file 4 of Whole-cell tumor vaccines desialylated to uncover tumor antigenic Gal/GalNAc epitopes elicit anti-tumor immunity

Jianmei Huang, Meiying Li, Bingjie Mei, Junyang Li, Yi Zhu, Qiaoshan Guo, Jianming Huang & Guonan Zhang
Additional file 4: Fig. S4. DCs maturation/activation and subsequently lymphocyte activation. The PBMCs (a), immature DCs (b), co-incubation of DCs and tumor cells (c), and co-culture of mature DCs and lymphocytes (d) were observed under a phase-contrast microscope. Scale bars: 25 μm.

Additional file 1 of Comparison of intestinal flora between patients with chronic and advanced Schistosoma japonicum infection

Chen Zhou, Junhui Li, Chen Guo, Zhaoqin Zhou, Zhen Yang, Yu Zhang, Jie Jiang, Yu Cai, Jie Zhou & Yingzi Ming
Additional file 1: Fig. S1. Shannon curve showed that all samples were saturated.

Additional file 1 of Comparison of intestinal flora between patients with chronic and advanced Schistosoma japonicum infection

Chen Zhou, Junhui Li, Chen Guo, Zhaoqin Zhou, Zhen Yang, Yu Zhang, Jie Jiang, Yu Cai, Jie Zhou & Yingzi Ming
Additional file 1: Fig. S1. Shannon curve showed that all samples were saturated.

Additional file 2 of Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development

Xueqian Jiang, Xijiang Yang, Fan Zhang, Tianhui Yang, Changfu Yang, Fei He, Ting Gao, Chuan Wang, Qingchuan Yang, Zhen Wang & Junmei Kang
Additional file 2: Fig. S2 Leaf- related QTLs on 32 linkage groups from a genetic linkage map of maternal parent (P2).

Additional file 16 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop

Yongzhen Mo, Yumin Wang, Yian Wang, Xiangying Deng, Qijia Yan, Chunmei Fan, Shuai Zhang, Shanshan Zhang, Zhaojian Gong, Lei Shi, Qianjin Liao, Can Guo, Yong Li, Guiyuan Li, Zhaoyang Zeng, Weihong Jiang, Wei Xiong & Bo Xiang
Additional file 16: Figure S7. c-Myc promotes circPVT1 generation by recruiting SRSF1 to couple transcription to splicing. A. The luciferase reporter gene activity of the PVT1 promoter was analyzed in NPC cells after overexpression of c-Myc. Data were represented as mean ± SD. ***, p < 0.001. B. The binding of transcription factor c-Myc to the PVT1 promoter detected by ChIP assay. Three sites on the PVT1 promoter were identified as potential c-Myc binding sites...

Additional file 1 of Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses

Qian Wang, Han-yang Li, Zhuo-min Ling, Gang Chen & Zhong-Ya Wei
Additional file 1: Figure S1. Panx 2 and Panx 3 mRNA expression after CCI. A-B. A qPCR assay was used to detect Panx 2 (A) and Panx 3 (B) mRNA levels at 4 and 14 days post-CCI. The data are mean ± SEM. n = 3 mice/group. **p < 0.01, ***p < 0.001, vs. sham injury. The data were analyzed by one-way ANOVA followed by Dunnett’s test.

Additional file 2 of JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway

Qin Lin, Zheng Chen, Wei Shi, Zeheng Lv, Xiaoping Wan & Kun Gao
Additional file 2: Fig. S1. JAK1 overexpression suppresses EC cell growth and migration.

Additional file 3 of JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway

Qin Lin, Zheng Chen, Wei Shi, Zeheng Lv, Xiaoping Wan & Kun Gao
Additional file 3: Fig. S2. JAK1 knockdown elevates the expression of HIF downstream genes in SPEC-2 cells.

Additional file 4 of JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway

Qin Lin, Zheng Chen, Wei Shi, Zeheng Lv, Xiaoping Wan & Kun Gao
Additional file 4: Fig. S3. JAK1 overexpression downregulates the expression of HIF downstream genes in Ishikawa cells.

Additional file 11 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 11: Supplementary Figure S11. Expression of immune checkpoints in the low and high-risk groups for CESC (A), OV (B), UCEC (C), and UCS D. ∗P<0.05; ∗∗P<0.01; ∗∗∗P<0.001; ns: not significant. The blue bars represent the low-risk group and the red bars represent the high-risk group.

Additional file 1 of CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma

Jungang Zhao, Rizhao Li, Jiacheng Li, Ziyan Chen, Zixia Lin, Baofu Zhang, Liming Deng, Gang Chen & Yi Wang
Supplementary Material 1

Additional file 2 of CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma

Jungang Zhao, Rizhao Li, Jiacheng Li, Ziyan Chen, Zixia Lin, Baofu Zhang, Liming Deng, Gang Chen & Yi Wang
Supplementary Material 2

Additional file 1 of M7G-Related lncRNAs predict prognosis and regulate the immune microenvironment in lung squamous cell carcinoma

Junfan Pan, Zhidong Huang, Hancui Lin, Wenfang Cheng, Jinhuo Lai & Jiancheng Li
Additional file 1: Supplementary Fig. 1. Co-expression intensity of prognostic m7G-related IncRNAs and their associated mRNAs.

Additional file 2 of M7G-Related lncRNAs predict prognosis and regulate the immune microenvironment in lung squamous cell carcinoma

Junfan Pan, Zhidong Huang, Hancui Lin, Wenfang Cheng, Jinhuo Lai & Jiancheng Li
Additional file 2: Supplementary Fig. 2. RT-qPCR was used to detect the expression of m7G-related IncRNAs. *p<0.05, **p<0.01, and ***p<0.001.

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  • Guangdong Academy of Medical Sciences
    135
  • Nanjing Medical University
    119
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    87
  • Jiangsu Province Hospital
    86
  • Huazhong University of Science and Technology
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  • West China Hospital of Sichuan University
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  • Zhejiang University
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  • Shanghai Jiao Tong University
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  • Chinese PLA General Hospital
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