Additional file 6: Figure S6. Single-cell sequencing analysis of adult mice intestine. a Dotplot for highest specificity gene markers of cell clusters. Dot size represents the percentage of cells expressing the denoted gene, and the color represents average normalized expression level within the denoted cluster. b The expression of GFAP in different cell clusters by analysis of the Uniform Manifold Approximation and Projection (UMAP). c Different cell subpopulation of the GSE156905 dataset derived from the...

Additional file 1: Fig. S1. Projection of totaL AF/AFL incidence and death and their age-standardized rates from, 1990 TO 2034.

Additional file 2: Fig. S2. The number and rough ratio of incidence, prevalence, death and dalys in men and women worlwide from 1990 TO 2019.

Additional file 3: Fig. S3. Trends in age standardized incidence, prevalence, death and Dalys rate in 5 SDI regions, From 1990 TO 2019.

Additional file 5: Fig. S5. Trends in the 5 risk factors attributed to AF/AFL in each of the 5 SDI regions, from 1990 to 2019.

Additional file 2: Fig. S2. KEGG enrichment of differential expressed genes in septic patients compared with healthy person. a The volcano plot was constructed using the fold change values and P-adjust. Red dots indicate upregulated genes; blue dots indicate downregulated genes. b The heatmap of the differential gene expression, where different colors represent trends of gene expression in different tissues. c, d The enriched KEGG signaling pathways were selected to demonstrate the primary biological actions...

Additional file 4: Fig. S4. Effects of cilostazol treatment on complete blood counts after CLP. a, b The level of platelets (a), WBC (b), NEUT (c), MONO (d) and LYMPH (e) (n = 5). WBC, white blood cells; NEUT, neutrophil; MONO, monocyte; LYMPH, lymphocyte. The data are presented as the mean ± SEM, *P < 0.05, ***P < 0.001, and ns indicates no significant difference.

Additional file 7: Fig. S7. Effect of LPS and CD40L on TRAFs proteins in EGCs. a Representative western blot images of TRAFs proteins expression in EGCs. b-g Western blot analysis of TRAF1 (b), TRAF2 (c), TRAF3 (d), TRAF4 (e), TRAF5 (f) and TRAF6 (g) expression in different groups of EGCs (n = 6). The data are presented as the mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

Supplementary Figure 1. Principal component analysis of the plaque bacteriome from HC, OPL, and OSCC individuals. Supplementary Figure 2. Principal component analysis of the saliva bacteriome from HC, OPL, and OSCC individuals. Supplementary Figure 3. Principal component analysis of the plaque mycobiome from HC, OPL, and OSCC individuals. Supplementary Figure 4. Principal component analysis of the saliva mycobiome from HC, OPL, and OSCC individuals. Supplementary Figure 5. Bubble plot of the plaque bacteriome and mycobiome...

Head and neck squamous cell carcinoma (HNSCC) remains a dreadful malignancy bearing poor clinical efficacy, with emerging evidences indicating RNA-binding proteins’ (RBPs’) relevance to the evolution of the disease. Categorized as RBPs, the K-homology domain-containing 1 (KHDC1) family is proved to be closely related to cell survival and death. As a novel KHDC1 member, only one study is currently available in osteoarthritis synovial cells to unveil KHDC1L’s function of promoting proliferation. Nevertheless, to the best...

Supplemental material, sj-jpg-1-tej-10.1177_20417314221147113 for Construction of a pancreatic cancer nerve invasion system using brain and pancreatic cancer organoids by Chenyun Song, Xinyu Chen, Jixin Ma, Hada Buhe, Yang Liu, Hexige Saiyin and Lixiang Ma in Journal of Tissue Engineering

Supplemental material, sj-tif-2-acr-10.1177_02841851221080521 for Diagnostic values of MRI indexes for polycystic ovary syndrome by Shaojuan Wang, Meimei Zhang, Xuyu Hu, Na Duan, Xiao Chen, Yanyun Yin and Zhongqiu Wang in Acta Radiologica

Supplemental material, sj-tif-3-acr-10.1177_02841851221080521 for Diagnostic values of MRI indexes for polycystic ovary syndrome by Shaojuan Wang, Meimei Zhang, Xuyu Hu, Na Duan, Xiao Chen, Yanyun Yin and Zhongqiu Wang in Acta Radiologica

Supplemental material, sj-png-2-taj-10.1177_20406223221143245 for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis by Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang and Yunshan Cao in Therapeutic Advances in Chronic Disease

Supplemental material, sj-tif-2-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

Supplemental material, sj-tif-4-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

Supplemental material, sj-tif-5-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

Supplemental material, sj-tif-6-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

Supplemental material, sj-tif-7-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

Supplemental material, sj-tif-12-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

Supplemental material, sj-tif-3-onc-10.1177_11795549221127161 for Effect of Number of Retrieved Lymph Nodes on Prognosis in FIGO Stage IA1-IIA2 Cervical Cancer Patients Treated With Primary Radical Surgery by Shan Jiang, Peng Jiang, Tingting Jiang, Yuan Tu, Jingni Zhang, Ning Li, Wei Kong, Yuzhen Huang and Rui Yuan in Clinical Medicine Insights: Oncology

Previously, we reported that the mediation of Newcastle disease virus (NDV) pathogenicity by the 524YLMY527 motif depends mainly on the regulation of F protein transport to the cell surface. The virus and host determinants that govern this intracellular trafficking remain unknown. Here, we confirmed that host adaptor protein (AP) complexes are involved in NDV infection using small interfering RNA. The transport of viral F protein to the cell surface depends on host transport proteins. We...

Additional file 1: Supplementary Figure 1. MMP-13 levels in the medium of IL-1β-induced C28/I2 cells detected by ELISA.

Additional file 5. Fig. S1: Characterization of sEV by TEM, Western blot analysis and NTA. A Representative images under transmission electron microscopy. B Particle size and distribution detected by nanoparticle tracking analysis. C Western blotting analysis for sEV marker CD63 and CD9.

Additional file 6. Fig. S2: LNM-GC-sEV increases FAO activity in BM-MSCs. A CPT1A expression in BM-MSCs treated with sEV derived from GC cells with different LNM capacity was measured by Western Blot. B–D The effect of GC-sEV on the FAO activity in BM-MSCs was evaluated, including activity of CPT1, β-oxidation rate and ATP level. E–Z Relative levels of protein. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.