Additional file 6: Fig. S5. Anti-CSF1 antibody abolished the effects of LARRPM on M2 macrophage infiltration. A THP-1 cells were subjected to transwell migration assays towards A549 cells with LARRPM overexpression or A549 control cells treated with anti-CSF1. Scale bar: 100 µm. B THP-1 cells were subjected to transwell migration assays towards HCC827 cells with LARRPM depletion or HCC827 control treated with anti-CSF1. Scale bar: 100 µm. C M1 and M2 polarization markers expression in...

Additional file 3. Collection Proof of Strain GDFS1009.

Additional file 5. Collection Proof of Strain RW10569.

Additional file 2: Figure S2. A–B and E–F. H460 and H520 cells were treated with 4 μM celastrol, and the levels of intracellular ROS were determined by flow cytometry and fluorescence microscope. C–D and G–H. H460 and H520 cells were treated with different concentrations of celastrol (0, 1, 2, and 4 μM) for 2 h. NAC was used at a dose of 5 μM, either alone or as a1h pretreatment, and the levels of intracellular...

Additional file 1: Fig. S1. (A) Kaplan-Meier survival analysis of ten hub genes (KNG1, CYP11A1, SMPD1, DAND5, NKPD1, RP11-59D5_B.2, CTD-2184C24.2, RP11-680F8.3, RP11-51F16.9, CTD-2012K14.8) in L_cancer patients between high-expression and low-expression groups. (B) Kaplan-Meier survival analysis of ten hub genes (MOCS1, PTGS2, PLEKHA8P1, ZC3H12C, LPO, METTL11B, RP11-278A23.1, RP11-452K12.7, RP11-742B18.1, RP11-626H12.2) in R_cancer patients between high-expression and low-expression groups.

The pollution of heavy metals in the soil around the tailings pond was evaluated. The content of heavy metals in the aboveground and underground parts of plants around the tailings pond was determined. The remediation potential of plants for heavy metals was evaluated.

Additional file 5: Figure S4. Effect of IRAK-M on activation of JNK and p38 MAPK pathways in A549 cells. Protein expression of p-JNK, JNK, p-p38, p38 after (a) IL-1β (1 ng/ml), (b) TNF-α (10 ng/ml), (c) IL-33 (100 ng/ml) and (d) HDM (10 μg/ml) stimulation for 10, 30 and 60 min. P-JNK was normalized to total JNK, while p-p38 was normalized to total p38. Values are expressed as mean ± SEM (n = 3). *P...

Additional file 1: Supplementary figure 1.

Additional file 2. Figure S1: Boxplots of GSE84437 (a) and GSE62254 (b) expression profile data.

Additional file 2: Fig. S1. Ahi1 KO mice showed depression-like behaviors.

Additional file 3: Fig. S2. Total GR expression was reduced in the hypothalamus of Ahi1 KO mice.

Additional file 5: Fig. S4. Ahi1 knockdown did not alter cell viability.

Additional file 7: Fig. S6. Citrate synthase activity, isocitrate dehydrogenase activity, and ATP5A content were unchanged in Ahi1 KO mice.

Additional file 9: Fig. S8. ATP stability was evaluated by an ATP kit.

Additional file 1: Figure S1. Plasmid mapping for overexpression of ZBTB4.

Additional file 1: Figure S1. Higher-order aberrations (HOAs) and modulation transfer functions after implantation of the trifocal intraocular lens. Ocular and intraocular HOAs for 6 mm (a, b) and 4 mm (c, d) pupil diameters. Ocular and intraocular modulation transfer functions (MTF) at different spatial frequencies for 6 mm (e, f) and 4 mm (g, h) pupil diameters. RMS, root mean square; cpd, cycles per degree. Error bars represent standard error of the mean. *P...

Additional file 1: Figure S1. ROC curves of the probability of MLR and CRP in predicting all-cause mortality.

Additional file 1. S-plots in the negative and positive ion modes. A: S-plot of Control and Model group; B: S-plot of Model and Sch group; C: S-plot of Control and Model group; D: S-plot of Model and Sch group. (A and Bin positive ion mode, C and D in positive ion mode).

Additional file 1: Fig. S1. Relative quantitative statistics of protein expression in Western Blot. (A) Relative quantitative statistics of protein expression of KPNA2, KPNA1, KPNA3, KPNA4, and KPNB1 levels in the gastrocnemius muscle of the ischemic hindlimb of model mice at 1 d, 3 d, 7 d, and 14 d. (B) Relative quantitative statistics of protein expression of KPNA2, KPNA1, KPNA3, KPNA4 and KPNB1 in HUVEC at 0 h, 6 h, 12 h, 24 h...

Additional file 2: Figure S2. RNA-seq results of CTPS2 knockdown. A Volcano plots showing differentially expressed genes. B The expression level of Bax and Bcl-2 was validated through qPCR assays. C KEGG enrichment analysis of differentially expressed transcripts.

Additional file 1: Figure S1. Confirmation of the silencing or overexpression efficiency. (A) RT-qPCR analysis of the expression of GAS5 in pericytes after transfection with shGAS5-1–4#. (B) RT-qPCR analysis of the level of GAS5 in pericytes after transfection with pcDNA3.0-GAS5. (C and D) Western blotting analysis of the levels of PDGFRα/β in pericytes transfected with shPDGFRα/β-1-4#. (E and F) The protein levels of PDGFRα/β in pericytes after transfection with pcDNA3.0-PDGFR α/β were evaluated via Western...

Additional file 1. The comparison of platelet counts between platelets transfused and untransfused.

Additional file 1: Fig. S1. The regulatory network between miRNAs and shared genes of SLE and IPF. Green triangles represent the common miRNAs. Rectangles represent the shared gene between SLE and IPF, in which the shared gene, included in the HALLMARK_HYPOXIA gene set, marked yellow.

Additional file 3: Fig S3. The prognostic role of IKZF1 mutation in the specific genetic AML subtype. (A-B) The influence of IKZF1 mutation on the OS (A) and PFS (B) of CSF3R-mutated AML. (C-D) The influence of IKZF1 mutation on the prognosis of the CEBPA-mutated AML was studied, and the OS (A) as well as RFS (B) of CEBPAWT plus non-CEBPAbZIP-inf-MUT and CEBPAbZIP-inf-MUT groups with or without IKZF1 mutation were showed.

Additional file 1: Figure S1. ROC curves of the probability of MLR and CRP in predicting all-cause mortality.