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Additional file 3 of Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Adela Misove, Ales Vicha, Petr Broz, Katerina Vanova, David Sumerauer, Lucie Stolova, Lucie Sramkova, Miroslav Koblizek, Josef Zamecnik, Martin Kyncl, Zuzana Holubova, Petr Liby, Jakub Taborsky, Vladimir Benes, Ivana Pernikova, David T. W. Jones, Martin Sill, Terezia Stancokova, Lenka Krskova & Michal Zapotocky
Additional file 3: Fig. S1. A total number of pediatric intracranial LGG patients with known genetic alteration is dividedby anatomical location. Importantly, KIAA1549:BRAF ex9:ex10 variant fusion was detected solely in the upperspine.
Additional file 4 of Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Adela Misove, Ales Vicha, Petr Broz, Katerina Vanova, David Sumerauer, Lucie Stolova, Lucie Sramkova, Miroslav Koblizek, Josef Zamecnik, Martin Kyncl, Zuzana Holubova, Petr Liby, Jakub Taborsky, Vladimir Benes, Ivana Pernikova, David T. W. Jones, Martin Sill, Terezia Stancokova, Lenka Krskova & Michal Zapotocky
Additional file 4: Fig. S2. T-SNE analysis displaying Prague samples (large red dots) among reference cohort samples.
Additional file 1 of Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer
Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner & Peter Bronsert
Additional file 1: Figure S1. Expression of mRNA of ribosomal proteins in MDA-MB-231 cells. qPCR of the depicted genes in KLF7 transfected MDA-MB-231 cells reveal downregulation of RPL34 and RPL27 mRNA.
Additional file 1 of Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer
Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner & Peter Bronsert
Additional file 1: Figure S1. Expression of mRNA of ribosomal proteins in MDA-MB-231 cells. qPCR of the depicted genes in KLF7 transfected MDA-MB-231 cells reveal downregulation of RPL34 and RPL27 mRNA.
Additional file 2 of Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer
Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner & Peter Bronsert
Additional file 2: Figure S2. KLF7 expression in MCF7 cells. A. mRNA in KLF7 transfected MCF7 cells was strongly enhanced compared to control cells B. western blot of MCF7 protein lysate demonstrated increased protein level in KLF7OE cells. C. Densitometric quantification of western blots showed significantly higher KLF7 levels (n = 4). D. Nuclear localization of KLF7 in MCF7 cell spheres.
Additional file 2 of Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer
Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner & Peter Bronsert
Additional file 2: Figure S2. KLF7 expression in MCF7 cells. A. mRNA in KLF7 transfected MCF7 cells was strongly enhanced compared to control cells B. western blot of MCF7 protein lysate demonstrated increased protein level in KLF7OE cells. C. Densitometric quantification of western blots showed significantly higher KLF7 levels (n = 4). D. Nuclear localization of KLF7 in MCF7 cell spheres.
Additional file 3 of Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients
Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang & Fangmeng Fu
Supplementary Material 3
Additional file 2 of Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients
Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang & Fangmeng Fu
Supplementary Material 2
Additional file 3 of Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients
Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang & Fangmeng Fu
Supplementary Material 3
Additional file 3 of Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer
Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner & Peter Bronsert
Additional file 3: Figure S3. Analysis of processes involved in ribosomal biogenesis in MCF7 cells. A) KLF7OE does not lead to significant changes in mRNA expression of the indicated genes in export, pseudouridylation, rRNA cleavage. B) No changes in POP1 and RMRP mRNA level by KLF7OE in MCF7 cells.
Additional file 3 of Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer
Anne-Marie Lüchtenborg, Patrick Metzger, Miguel Cosenza Contreras, Victor Oria, Martin L. Biniossek, Franziska Lindner, Klemens Fröhlich, Ambrus Malyi, Thalia Erbes, Nicole Gensch, Jochen Maurer, Andreas Thomsen, Melanie Boerries, Oliver Schilling, Martin Werner & Peter Bronsert
Additional file 3: Figure S3. Analysis of processes involved in ribosomal biogenesis in MCF7 cells. A) KLF7OE does not lead to significant changes in mRNA expression of the indicated genes in export, pseudouridylation, rRNA cleavage. B) No changes in POP1 and RMRP mRNA level by KLF7OE in MCF7 cells.
Additional file 2 of Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients
Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang & Fangmeng Fu
Supplementary Material 2
Additional file 4 of Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Misove Adela, Vicha Ales, Broz Petr, Vanova Katerina, Sumerauer David, Stolova Lucie, Sramkova Lucie, Koblizek Miroslav, Zamecnik Josef, Kyncl Martin, Holubova Zuzana, Liby Petr, Taborsky Jakub, Benes Vladimir, Pernikova Ivana, Jones T. W. David, Sill Martin, Stancokova Terezia, Krskova Lenka & Zapotocky Michal
Additional file 4: Fig. S2. T-SNE analysis displaying Prague samples (large red dots) among reference cohort samples.
Additional file 3 of Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Misove Adela, Vicha Ales, Broz Petr, Vanova Katerina, Sumerauer David, Stolova Lucie, Sramkova Lucie, Koblizek Miroslav, Zamecnik Josef, Kyncl Martin, Holubova Zuzana, Liby Petr, Taborsky Jakub, Benes Vladimir, Pernikova Ivana, Jones T. W. David, Sill Martin, Stancokova Terezia, Krskova Lenka & Zapotocky Michal
Additional file 3: Fig. S1. A total number of pediatric intracranial LGG patients with known genetic alteration is dividedby anatomical location. Importantly, KIAA1549:BRAF ex9:ex10 variant fusion was detected solely in the upperspine.
Additional file 4 of Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Adela Misove, Ales Vicha, Petr Broz, Katerina Vanova, David Sumerauer, Lucie Stolova, Lucie Sramkova, Miroslav Koblizek, Josef Zamecnik, Martin Kyncl, Zuzana Holubova, Petr Liby, Jakub Taborsky, Vladimir Benes, Ivana Pernikova, David T. W. Jones, Martin Sill, Terezia Stancokova, Lenka Krskova & Michal Zapotocky
Additional file 4: Fig. S2. T-SNE analysis displaying Prague samples (large red dots) among reference cohort samples.
Additional file 3 of Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Adela Misove, Ales Vicha, Petr Broz, Katerina Vanova, David Sumerauer, Lucie Stolova, Lucie Sramkova, Miroslav Koblizek, Josef Zamecnik, Martin Kyncl, Zuzana Holubova, Petr Liby, Jakub Taborsky, Vladimir Benes, Ivana Pernikova, David T. W. Jones, Martin Sill, Terezia Stancokova, Lenka Krskova & Michal Zapotocky
Additional file 3: Fig. S1. A total number of pediatric intracranial LGG patients with known genetic alteration is dividedby anatomical location. Importantly, KIAA1549:BRAF ex9:ex10 variant fusion was detected solely in the upperspine.