Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis

Christopher Morgan
In most organisms, the number and distribution of crossovers that occur during meiosis are tightly controlled. All chromosomes must receive at least one “obligatory crossover” and crossovers are prevented from occurring near one another by “crossover interference”. However, the mechanistic basis of this phenomenon of crossover interference has remained mostly mysterious. Using quantitative super-resolution cytogenetics and mathematical modelling, we investigated crossover positioning in the Arabidopsis thaliana wild-type, an over-expressor of the conserved E3 ligase HEI10,...

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  • European Molecular Biology Laboratory
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  • John Innes Centre
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  • ETH Zurich
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