496 Works

Additional file 2 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 2: Supplementary Figure S2. Correlation analysis of the 76 NRGs for CESC (A), OV (B), UCEC (C), and UCS D. Red indicates a positive correlation; blue indicates a negative correlation.

Additional file 6 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 6: Supplementary Figure S6. Expression values of NRGs in prognostic signature of OV. A-D Expression values of NRGs in TCGA for BACH2 (A), MLKL (B), MYC (C), MYCN (D), and SIRT2 (E). F-J Expression values of NRGs in our cohort for BACH2 (F), MLKL (I), MYC (G), MYCN (H), and SIRT2 (J).

Additional file 7 of A comprehensive pan-cancer analysis of necroptosis molecules in four gynecologic cancers

Jianfeng Zheng, Xintong Cai, Yu Zhang, Huihui Wang, Li Liu, Fengling Tang, Linying Liu & Yang Sun
Additional file 7: Supplementary Figure S7. Clinical value of risk score by independent prognostic analysis. A-H The Univariate Cox regression analysis and Multivariate Cox regression analysis for CESC (A-B), OV (C-D), UCEC (E-F), and UCS G-H.

Additional file 1 of SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis

Xiu Teng, Da-Chao Mou, Hui-Fang Li, Ling Jiao, Sha-Sha Wu, Jin-Kui Pi, Yan Wang, Meng-Li Zhu, Meng Tang & Yi Liu
Additional file 1: Figure S1. Feature plots for various genes that help to attribute identities. The intensity of blue is related to the relative expression of the gene in a particular cell.

Additional file 2 of SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis

Xiu Teng, Da-Chao Mou, Hui-Fang Li, Ling Jiao, Sha-Sha Wu, Jin-Kui Pi, Yan Wang, Meng-Li Zhu, Meng Tang & Yi Liu
Additional file 2: Figure S2. Frequency of SIGIRR in memory CD4 T cells in PBMCs of RA patients stratified by CCP expression.

Additional file 3 of SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis

Xiu Teng, Da-Chao Mou, Hui-Fang Li, Ling Jiao, Sha-Sha Wu, Jin-Kui Pi, Yan Wang, Meng-Li Zhu, Meng Tang & Yi Liu
Additional file 3: Figure S3. Cytokine production in SIGIRR-positive or SIGIRR-negative memory CD4 T cells of patients with RA and the healthy population. Related to Fig. 2. (A-B), Memory CD4 T cells were identified as CD4 + CD45RO + CD45RA − previously gated on single live (FVS780 −) lymphocytes (FSC low SSC low). Representative flow cytometry contour plots for intracellular cytokine production among SIGIRR+ memory CD4 T cells in healthy and RA cohorts (n =...

Additional file 4 of SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis

Xiu Teng, Da-Chao Mou, Hui-Fang Li, Ling Jiao, Sha-Sha Wu, Jin-Kui Pi, Yan Wang, Meng-Li Zhu, Meng Tang & Yi Liu
Additional file 4: Figure S4. Targeted disruption of the mouse gene encoding SIGIRR. (A), Schematic of Sigirr deletion in C57BL/6 mice and primers for genotyping. The offspring were born at the expected Mendelian ratios. (B), Sigirr genotyping using the F1, F2 and R1 primers listed in the Materials and Methods. The red arrow shows the knockout band (700 bp), and the blue arrow shows the wild-type band (500 bp). (C), Splenomegaly in naïve SIGIRR KO...

Additional file 3 of Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1

Jiang Zhou, Chengbin Wang, Yingliang Liu, Daming Cui, Zhenlin Wang, Yang Jiang & Liang Gao
Supplementary Figure 1. The validation of the patient-derived GSCs from fresh clinical GBM specimens. a: Immunofluorescence staining of the stem cell markers CD133+ and Nestin+ in the isolated neurospheres. b: The multi-lineage differentiation capacity and differentiated markers GFAP and ?IIItubulin were shown in the isolated neurospheres. c: The expression of circPTPRF in six GSCs and normal human astrocyte cells (NHA) was detected by qPCR. All data are shown as the mean ? SD (three independent...

Additional file 8 of RNA interference-mediated silencing of DNA methyltransferase 1 attenuates neuropathic pain by accelerating microglia M2 polarization

Ying Tan, Zongjiang Wang, Tao Liu, Peng Gao, Shitao Xu & Lei Tan
Additional file 8.

Additional file 9 of RNA interference-mediated silencing of DNA methyltransferase 1 attenuates neuropathic pain by accelerating microglia M2 polarization

Ying Tan, Zongjiang Wang, Tao Liu, Peng Gao, Shitao Xu & Lei Tan
Additional file 9.

Additional file 4 of LARRPM restricts lung adenocarcinoma progression and M2 macrophage polarization through epigenetically regulating LINC00240 and CSF1

Yue Li, Chen Chen, Hai-lin Liu, Zhen-fa Zhang & Chang-li Wang
Additional file 4: Figure S3. LINC00240 repressed proliferation, induced apoptosis and inhibited migration and invasion of LUAD cells. A LINC00240 expression in A549 cells with LINC00240 stable overexpression or control was detected by qRT-PCR. B Cell proliferation of A549 cells with LINC00240 stable overexpression or control was detected using CCK-8 assays. C Cell proliferation of A549 cells with LINC00240 stable overexpression or control was detected using EdU incorporation assays. Scale bar: 100 µm. Red color...

Additional file 7 of LARRPM restricts lung adenocarcinoma progression and M2 macrophage polarization through epigenetically regulating LINC00240 and CSF1

Yue Li, Chen Chen, Hai-lin Liu, Zhen-fa Zhang & Chang-li Wang
Additional file 7: Fig. S6. Depletion of LARRPM in LUAD cells enhanced the oncogenic roles of infiltrated M2 macrophages. A–F Conditioned medium (CM) was collected from co-culture of macrophages with HCC827 cells with LARRPM depletion or control HCC827 cells, or collected from only HCC827 cells with LARRPM depletion or control HCC827 cells. A Cell proliferation of HCC827 cells treated with the CM was detected using CCK-8 assays. B Cell proliferation of HCC827 cells treated with...

Additional file 1 of Autism-like behaviors regulated by the serotonin receptor 5-HT2B in the dorsal fan-shaped body neurons of Drosophila melanogaster

Haowei Cao, Junbo Tang, Qisha Liu, Juan Huang & Rui Xu
Additional file 1: Fig. S1. Repetitive behavior is regulated by serotonin in females. Grooming numbers of Trh01 mutant (A) or Trh knockdown (B) female flies during a 5-min observation period. (C) Feeding 2 mg/mL 5-HTP for 3 days rescued excessive grooming behavior of Trh01 mutant male flies during a 5-min observation period (n= 10-15 flies for each genotype). Error bars are shown as the mean ± SEM. For all data, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.

Additional file 1 of Autism-like behaviors regulated by the serotonin receptor 5-HT2B in the dorsal fan-shaped body neurons of Drosophila melanogaster

Haowei Cao, Junbo Tang, Qisha Liu, Juan Huang & Rui Xu
Additional file 1: Fig. S1. Repetitive behavior is regulated by serotonin in females. Grooming numbers of Trh01 mutant (A) or Trh knockdown (B) female flies during a 5-min observation period. (C) Feeding 2 mg/mL 5-HTP for 3 days rescued excessive grooming behavior of Trh01 mutant male flies during a 5-min observation period (n= 10-15 flies for each genotype). Error bars are shown as the mean ± SEM. For all data, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.

Additional file 2 of Autism-like behaviors regulated by the serotonin receptor 5-HT2B in the dorsal fan-shaped body neurons of Drosophila melanogaster

Haowei Cao, Junbo Tang, Qisha Liu, Juan Huang & Rui Xu
Additional file 2: Fig. S2. Ubiquitous knockdown of serotonin receptors has no effect on the climbing ability of flies. (A) qRT-PCR analysis of the mRNA expression of all five serotonin receptor knockdown lines. (B) Climbing ability of serotonin receptor knockdown flies detected by a negative geotaxis assay. Error bars are shown as the mean ± SEM. For all data, *p<0.05, **p<0.01, ***p<0.001.

sj-tif-5-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-tif-5-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-tif-6-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-tif-6-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-tif-8-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-tif-8-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-tif-9-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-tif-9-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-tif-11-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-tif-11-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-jpg-13-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-jpg-13-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

Additional file 12 of Combination of oral STING agonist MSA-2 and anti-TGF-β/PD-L1 bispecific antibody YM101: a novel immune cocktail therapy for non-inflamed tumors

Ming Yi, Mengke Niu, Yuze Wu, Hong Ge, Dechao Jiao, Shuangli Zhu, Jing Zhang, Yongxiang Yan, Pengfei Zhou, Qian Chu & Kongming Wu
Additional file 12. Figure S12. Histogram representing the proportion of clusters in each group.

Additional file 4 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Rong Li, Jing Zhang, Qiong Wang, Meng Cheng & Bin Lin
Additional file 4: Figure S4. TPM1 knockdown exacerbates inflammation in the TREM2−/− mouse retina. A, B Western blot analysis (A) and quantification of TPM1 (B) in the retina of C57BL/6J (WT) and TREM2−/− mice. Data are presented as mean ± SEM and analyzed by unpaired two-tailed Student’s t test (WT vs. TREM2−/−, **p < 0.01). C, D Western blot analysis (C) and quantification of TREM2 (D) in WT mice following LPS and siCTR or siTPM1-1...

Additional file 6 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Rong Li, Jing Zhang, Qiong Wang, Meng Cheng & Bin Lin
Additional file 6: Figure S6. TPM1 knockdown elicits inflammation-related transcriptomic alterations in the WT retina. A, B DEGs associated with the phagosome formation pathway (A) and neuroinflammation signaling pathway (B) in WT mice after treatments with LPS and siTPM1-1 or siCTR.

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