1,213 Works

REDUCED GLUTAREDOXIN 1 SIMULATION TRAJECTORY, MODELS 281- 325.

L.NILSSON N.FOLOPPE

CYP21A2Bruque2016

A model of the human CYP21A2 protein based on the structure of the bovine CYP21A2 (PDB ID: 3QZ1) was generated using MODELLER version 9.11 including heme cofactor explicitly. Amino acid sequence was taken from UniProt (NP_000491.4) while alignments were performed with MEGA 4 software. A significant improvement of the model was obtained by manually displacing L129 in the automatic alignment and iterative loop refinement. The use of multiple templates of other proteins of the CYP...

KSHV glycoprotein B

Formyl peptide receptor 1 (FPR1)

Formyl peptide receptor 1 (FPR1) is a cell surface receptor protein, belonging to G protein-coupled receptor (GPCR) super-family, that binds and is activated by oligopeptides containing the N-Formylmethionine which are released by microorganisms and injured tissues. Hence, FPR1 is an important component of the immune system operating on host defense and inflammation. It is known that its high expression in several cancers although its function in tumor invasion and metastasis is poorly known. In this...

NS3 MutantM (JFH-1)

To gain an insight into mutation flexibility across sequence space of hepatitis C virus (HCV) genome, we created mutant libraries, differing from the parent sequence as well as each other by using a random mutagenesis approach; the proportion of mutations increased across these libraries with declining template amount or dATP concentration. Replication efficiency of full-genome mutant libraries ranged between 71 and 329 foci forming unit (FFU) per 105 Huh7.5 cells. Mutant libraries with low proportions...

Multidrug transporter AcrD of E. coli

Resistance-Nodulation-cell Division (RND) transporters AcrB and AcrD of Escherichia coli expel a wide range of substrates out of the cell in conjunction with AcrA and TolC, contributing to the onset of bacterial multidrug resistance. AcrB is the best characterized RND transporter, and its structure has been solved by several labs both without and with bound substrates and inhibitors. AcrD, a close homolog of AcrB, shares an overall sequence identity of nearly 66% (similarity ~80%) but...

Bacillus subtilis YqjX protein

The YolD family (that includes both Bacillus subtilis YolD and YqjX (this model)) is part of the WYL-like superfamily, predicted to have an SH3 β-barrel fold related to Sm domains. In our analysis, among the closest detected structural matches were E. coli YaeO, a Rho-specific inhibitor of transcription termination, and a cyanobacterial Hfq homolog. Model assessment showed that YqjX and YolD sequences are indeed compatible with the SH3 β-barrel structure. Interestingly, UmuD' has an all...

Mouse Eugenol Odorant Receptor

Molecular interactions of odorants with their olfactory receptors (ORs) are of central importance for the ability of the mammalian olfactory system to detect and discriminate a vast variety of odors with a limited set of receptors. How a particular OR binds and distinguishes different odorant molecules remains largely unknown on a structural basis. Here we investigated this question for the mouse eugenol receptor (mOR-EG). By screening a large odorant library, we discovered a wide range...

Herbaspirillum seropedicae Recombinase A, active form, wild type

In this work we have performed in vitro, in vivo and in silico studies of Recombinase A from Herbaspirillum seropedicae (HsRecA) - Uniprot AC Q9F672 -, both the wild type and the L53Q mutant. This mutation is located at the Make ATP Work motif (MAW) and impairs the ATPase and DNA-strand exchange activities, however, it does not affect the binding of ADP, ATP and ssDNA. At complementation studies of E. coli recA1 with the HsRecA...

Homology model of ANR from Pseudomonas aeruginosa

Pseudomonas aeruginosa is a deadly opportunistic human pathogen. The organism codes for different virulence factors and among them is HCN synthesized by HCN synthase enzyme. the enzyme is encoded by the hcnABC operon. It is to be noted that the expression of the genes of the hcnABC operon are regulated by LasR, ANR and RhlR proteins. ANR protein belongs to the FNR family. It works in anaerobic condition. It binds to the promoter DNA as...

REDUCED GLUTAREDOXIN 1 SIMULATION TRAJECTORY, MODELS 71-140.

L.NILSSON N.FOLOPPE

REDUCED GLUTAREDOXIN 1 SIMULATION TRAJECTORY, MODELS 71-141

L.NILSSON N.FOLOPPE

SOXW- A PERIPLASMIC THIOREDOXIN

T.C.GHOSH A.BAGCHI

PISUM SATIVUM DEFENSIN 1(PSD1)MUTANT A18E

E.KURTENBACH P.C SATHLER

S2 SUBUNIT MODEL OF SARS CORONAVIRUS S PROTEIN

A.BERNINI O.SPIGA

PISUM SATIVUM DEFENSIN 1(PSD1)MUTANT G12R

E.KURTENBACH P.C SATHLER

MOLECULAR MODELLING OF SEABASS IL-10

A.M.FACCHIANO S.COSTANTINI

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