113 Works

A new diterpenoid alkaloid from Delphinium gyalanum C. Marquand & Airy Shaw

Xinyu Li, Meizhen Ye, Feng Gao, Xianli Zhou, Lin Chen & Shuai Huang
A new C19-diterpenoid alkaloid named gyalanutine A (1) and fourteen known compounds 2-15 were isolated from the plant of Delphinium gyalanum C. Marquand & Airy Shaw. Compound 1 displayed an unusual lycoctonine-type C19-diterpenoid alkaloid skeleton with the cleavage of N-C19 and C7-C17 bonds, and the construction of the N-C7 bond. Structures were identified by multiple spectroscopic analyses including 1 D, 2 D NMR, IR and HR-ESI-MS. Compounds were tested for acetylcholinesterase inhibitory and anti-inflammatory activity.

The Reinforcement of Sludge-Recycling Enhanced Flocculation by the Acid Activation of Settled Sludge

Wei Wei, Lin Sheng, Haoyang Gong, Dong Zhou, Xinli Cai & Shuguang Zhu
Sludge-recycling enhanced flocculation (SEF) is an effective method for enhancing flocculation. In the conventional SEF process, the settled sludge is recirculated into the flocculation process without any further treatment. However, studies have shown that the efficacy of the SEF process could be improved by pre-treating the sludge. In this work, the acid activation of sludge was performed using a range of pH values (1.0 – 6.0) and charge states, with and without long-chain bridging. The...

Complement receptor 3 mediates Aspergillus fumigatus internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK

Xuelin Han, Xueting Su, Zhiqian Li, Yanxi Liu, Shuo Wang, Miao Zhu, Changjian Zhang, Fan Yang, Jingya Zhao, Xianping Li, Fangyan Chen & Li Han
Complement receptor 3 (CD11b/CD18) is an important receptor that mediates adhesion, phagocytosis and chemotaxis in various immunocytes. The conidia of the medically-important pathogenic fungus, Aspergillus fumigatus can be internalized into alveolar epithelial cells to disseminate its infection in immunocompromised host; however, the role of CR3 in this process is poorly understood. In the present study, we investigated the potential role of CR3 on A. fumigatus internalization into type II alveolar epithelial cells and its effect...

Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis

Hajime Kato, Hiroyasu Sato, Michiaki Okuda, Jun Wu, Shingo Koyama, Yasuhiko Izumi, Tomonori Waku, Mitsuyoshi Iino, Masashi Aoki, Shigeki Arawaka, Yasuyuki Ohta, Kenichi Ishizawa, Kanan Kawasaki, Yasuomi Urano, Tomohiro Miyasaka, Noriko Noguchi, Toshiaki Kume, Akinori Akaike, Hachiro Sugimoto & Takeo Kato
The present study investigated the therapeutic effects of the curcumin derivative 3-[(1E)-2-(1H-indol-6-yl)ethenyl]-5-[(1E)-2-[2-methoxy-4-(2-pyridylmethoxy)phenyl]ethenyl]-1H-pyrazole (GT863) in amyotrophic lateral sclerosis (ALS). The inhibitory effect of GT863 on superoxide dismutase 1 (SOD1) aggregation was evaluated in cell-free assays. GT863 interfered with the conformational changes of the SOD1 protein and later, oligomeric aggregation. Furthermore, its antioxidant, anti-inflammatory, and neuroprotective effects were evaluated in cell-free and cultured cell assays. GT863 inhibited H2O2− and glutamate-induced cytotoxicity and activated an antioxidant responsive element...

Three new tyrosol derivatives from Huangjing wine

Yan-Bin Ren, Xing-Wen Wang, Jia-Xuan Bai, Chang Liu, Si-Lin Yu, Yue Zhou, Cong-Cong Lin, Da-Hong Yao, Jian Huang & Jin-Hui Wang
Phytochemical investigation on the concentrate of Huangjing wine, resulted in the isolation of three new tyrosol derivatives 4′′′-hydroxyphenethyl 2-(R)-hydroxy-3-phenylpropionate (1), 4′′′-hydroxyphenethyl(4′-hydroxy-3′-methoxyphenyl)propionate (2) and 4′′-hydroxyphenethyl ethyl succinate (3), together with 5 known compounds, ferulic acid (4), L-phenyllactic acid (5), hydroxytyrosol (6), dihydroferulic acid (7), cyclo(L-Pro-D-Tyr) (8). Their structures were elucidated using spectroscopic analysis and by comparison with the literature data. All compounds displayed antioxidant effect in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical. Among them, the new compound 2...

FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation

Xinyi Yang, Xiaying Zhao, Yuqi Zhu, Jingna Xun, Qin Wen, Hanyu Pan, Jinlong Yang, Jing Wang, Zhimin Liang, Xiaoting Shen, Yue Liang, Qinru Lin, Huitong Liang, Min Li, Jun Chen, Shibo Jiang, Jianqing Xu, Hongzhou Lu & Huanzhang Zhu
Acquired immunodeficiency syndrome (AIDS) cannot be completely cured, mainly due to the existence of a latent HIV-1 reservoir. However, our current understanding of the molecular mechanisms underlying the establishment and maintenance of HIV-1 latent reservoir is not comprehensive. Here, using a genome-wide CRISPR-Cas9 activation library screening, we identified E3 ubiquitin ligase F-box protein 34 (FBXO34) and the substrate of FBXO34, heterogeneous nuclear ribonucleoprotein U (hnRNP U) was identified by affinity purification mass spectrometry, as new...

Molecular detection and identification of relapsing fever Borrelia in ticks and wild small mammals in China

Xiao-Ai Zhang, Feng Tian, Yue Li, Xiao-Long Zhang, Bao-Gui Jiang, Bao-Cheng Liu, Jing-Tao Zhang, Shen Tian, Heng Ding, Shuang Li, Hao Li, Li-Qun Fang & Wei Liu
We identified relapsing fever (RF) Borrelia in 1.45% (145/10426) of the ticks and 1.40% (40/2850) of the wild mammals in a field investigation in China. Three RF Borrelia species, including human-pathogenic Borrelia miyamotoi, Borrelia persica and unclassified Babesia sp. were determined. Main species determined from ticks was B. miyamotoi (44.14%), followed by the unclassified Borrelia sp. (42.76%), and Borrelia theileri (13.10%). In wild mammals, main species found was B. persica (57.50%), followed by the unclassified...

Supplementary Table.doc

Bingyan Cao, Meijuan Liu, Yingxian Zhang, JiaJia Chen, Xiaoqiao Li, Chang Su, Wei Yang, Min Liu, Di Wu, Wenjing Li, Xuejun Liang, Qiao Wang, Haiyan Wei & Chunxiu Gong
Supplementary Table 1 Positive rate of different MODY screening criteria Supplementary Table 2 The clinical and genetic characteristics of MODY in two cohorts (gray lines represent the cohort 2)

Distribution, sources and health risk assessment of DDT and its metabolites in agricultural soils in Zhejiang Province, China

Ning Cui, Xiong Pan & Jing Liu
Dichlorodiphenyltrichloroethane (DDT) is well known for its harmful effects and has been officially banned as a pesticide around the world. However, DDT pollution still exists in natural environments in China because DDT degrade very slowly. In this study, 60 soil samples were collected from Cixi, Zhejiang Province, and 1) DDT and its metabolites were determined, 2) Health risk was estimated by using various indices. The results showed that the detection rate of DDT in soil...

Epidemiology, evolution, and biological characteristics of H6 avian influenza viruses in China

Xiaohao Xu, Qi Chen, Min Tan, Jia Liu, Xiyan Li, Lei Yang, Yuelong Shu, Dayan Wang & Wenfei Zhu
H6 avian influenza virus (AIV) is one of the most prevalent AIV subtypes in birds globally. To investigate the current situation and characteristics of H6 AIVs circulating in China, we analysed the epidemiology, genetic evolution and pathogenic features of this subtype. During 2000-2021, H6 subtype AIVs spread widely through Southern China and presented high host diversity. On analysing 171 H6 viruses isolated during 2009-2021, dynamic reassortments were observed among H6 and other co-circulating AIV subtypes,...

Isolation of Diaphorobacter sp. LW2 capable of degrading Phenanthrene and its migration mediated by Pythium ultimum

Jialu Li, Mei Hong, Rui Tang, Tingchen Cui, Yadong Yang, Jing Lv, Na Liu & Yutao Lei
Phenanthrene, one of polycyclic aromatic hydrocarbons, is stubborn and persistent which exists widely in petroleum contaminated soil. Filamentous fungi are good assistants to bacterial transport, by hyphae passing through soil pores and reaching further positions. An isolated bacterial strain, from the contaminated soil of coking plant, was identified as Diaphorobacter and named LW2, which could use phenanthrene as the only carbon source and energy for its growth. LW2 could degrade phenanthrene in a wide range...

Nonparametric adaptive CUSUM chart for detecting arbitrary distributional changes

Jun Li
Nonparametric control charts that can detect arbitrary distributional changes are highly desirable due to their flexibility to adapt to different distributional assumptions and changes. However, most of the nonparametric control charts in the literature either can only detect location changes, or involve intensive computation. In this article, we propose a new nonparametric adaptive CUSUM chart. The proposed control chart can detect arbitrary distributional changes and is computationally efficient. Its self-starting nature makes the proposed control...

Characteristics and driving factors of antibiotic resistance genes in aquaculture products from freshwater ponds in China Yangtze River Delta

Yiqin Chen, Bin Jia, Juan-Ying Li, Dan Li & Wenhui He
Antibiotic resistance genes (ARGs) are widespread in aquaculture and pose a huge threat to aquaculture organisms and human health. In this study, occurrences and relative abundances of ARGs were analyzed in the guts of products cultured in freshwater ponds in the Yangtze River Delta region in China. A total of 29 ARGs were found in the gut samples, with detection frequencies ranging from 4.8% to 81%, and the relative abundances (ARGs/16S rRNA) ranging from 10−7...

Treatment decision based on unilateral index from non-ACTH stimulated and ACTH stimulated adrenal vein sampling-Supplemental materials

Xizi Zhang, Xiaoyu Shu, Jun Yang, Qingfeng Cheng, Zhipeng Du, Ying Song, Yi Yang, Jinbo Hu, Jian Long, Feifei Wu, Qifu Li & Shumin Yang
The supplemental data of the manuscript: Treatment decision based on unilateral index from non-ACTH stimulated and ACTH stimulated adrenal vein sampling

Novel H5N6 reassortants bearing the clade HA gene of H5N8 virus have been detected in poultry and caused multiple human infections in China

Wenli Gu, Jianzhong Shi, Pengfei Cui, Cheng Yan, Yaping Zhang, Congcong Wang, Yuancheng Zhang, Xin Xing, Xianying Zeng, Liling Liu, Guobin Tian, Yasuo Suzuki, Chengjun Li, Guohua Deng & Hualan Chen
The globally circulating H5N8 avian influenza viruses bearing the clade hemagglutinin (HA) gene are responsible for the loss of more than 33 million domestic poultry since January 2020. Moreover, the H5N8 viruses have reassorted with other avian influenza viruses and formed H5N1, H5N2, H5N3, H5N4, and H5N5 viruses in Europe, Africa, and North America. In this study, we analyzed 15 H5N6 viruses isolated from poultry and seven H5N6 viruses isolated from humans, and found...

Aconiti lateralis Radix Praeparata inhibits Alzheimer’s disease by regulating the complex regulation network with the core of GRIN1 and MAPK1

Yutao Wang, Huixiang Zhang, Jing Wang, Ming Yu, Qianqian Zhang, Shan Yan, Dingyun You, Lanlan Shi, Lihuan Zhang, Limei Wang, Hongxiang Wu & Xue Cao
Current medicine for Alzheimer’s disease (AD) cannot effectively reverse or block nerve injury. Traditional Chinese Medicine practice and research imply Aconiti lateralis Radix Praeparata (Fuzi) may meet this goal. Analysing the anti-AD effect of Fuzi and its potential molecular mechanism. AD model cells were treated with Fuzi in 0-300 mg/mL for 24 h in 37 °C. The cell viability (CV) and length of cell projections (LCP) for each group were observed, analysed, and standardised using...

Fracture behavior of high-strength bolts and connections in the whole process of fire

Qiao Chen, Jian Jiang, Wei Chen & Jihong Ye
High-strength bolts have been widely used in steel bolted connections, and fire-induced high temperatures will affect its basic mechanical properties and fracture behavior, leading to failure of the connection and even collapse of the overall structure. Tensile experiments are conducted on Grade 10.9 high-strength bolts to investigate the effect of stress triaxiality and heating history on their mechanical and fracture properties in the whole process of fire. The true stress-strain curves are obtained to determine...

Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway

Xiaojing Wang, Jing Yang, Wenxing Wang, Yun Li & Yue Yang
Our goal in this work was to investigate the possible role and mechanism of regulated in development and DNA damage response 1 (REDD1) in mediating high glucose (HG)-induced podocyte injury in vitro. Mouse podocytes were stimulated with HG to establish HG injury model. Protein expression was examined by Western blotting. Cell viability was measured by cell counting kit-8 assay. Cell apoptosis was assessed by annexin V‐FITC/propidium iodide and TUNEL apoptotic assays. Levels of reactive oxygen...

Development of a naringenin microemulsion as a prospective ophthalmic delivery system for the treatment of corneal neovascularization: in vitro and in vivo evaluation

Yu Ma, Jingjing Yang, Yali Zhang, Chunyan Zheng, Zhen Liang, Ping Lu, Fei Song, Yuwei Wang & Junjie Zhang
Naringenin, a flavonoid, possesses antiangiogenic potential and inhibits corneal neovascularization (CNV); however, its therapeutic use is restricted due to poor solubility and limited bioavailability. In this study, we developed a naringenin microemulsion (NAR-ME) for inhibiting CNV. NAR-ME formulation was composed of triacetin (oil phase), Cremophor RH40 (CRH40), PEG400, and water, its droplet size was 13.22 ± 0.13 nm with a narrow size distribution (0.112 ± 0.0014). The results demonstrated that NAR-ME released higher and permeated...

Cadomian crust of Eastern Iran: evidence from the Tapeh Tagh granitic gneisses

Habib Mollai, Rahim Dabiri, Habib Allah Torshizian, Georgia Pe-Piper & Wei Wang
Late Neoproterozoic to Early Cambrian (Cadomian) magmatic rocks are abundant in Iran, but their occurrence in east-central Iran is voluminous. This paper reports, for the first time, on the Cadomian rocks of the eastern Iranian region known as Tapeh Tagh and deals with their geochemistry and uranium-lead (U-Pb) zircon ages. The Tapeh Tagh region contains masses of Cadomian meta-igneous rocks (including various types of granitic gneiss) and overlying meta-sedimentary rocks. The granitic gneisses show tectonic...

The demulsification of oily wastewater by a hyperbranched polymer grafted SiO2

Yu Zhang, Jiazhe Kuang, Bin Li, Yuanzhu Mi, Ying Yang & Xuening Feng
In this work, a PAMAM@SiO2 demulsifier was synthesized by the reaction of a hyperbranched poly (amido amine) (PAMAM) and KH570 modified SiO2. The structure, morphology and composition of PAMAM@SiO2 were characterized by FT-IR, SEM and EDS. The effect of the concentration of PAMAM@SiO2, salinity and temperature on the demulsification performance was systematically studied. The results showed that the transmittance of aqueous phase after demulsification could reach as high as 92.1% at optimal conditions, and corresponding...

Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry

Huan Sun, Yan Li, Peipei Liu, Chengpeng Qiao, Xiaomin Wang, Lianao Wu, Kefang Liu, Yu Hu, Chao Su, Shuguang Tan, Shumei Zou, Guizhen Wu, Jinghua Yan, George Fu Gao, Jianxun Qi & Qihui Wang
Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry

Personalized Policy Learning using Longitudinal Mobile Health Data

Xinyu Hu, Min Qian, Bin Cheng & Ying Kuen Cheung
Personalized policy represents a paradigm shift from one-decision-rule-for-all users to an individualized decision rule for each user. Developing personalized policy in mobile health applications imposes challenges. First, for lack of adherence, data from each user are limited. Second, unmeasured contextual factors can potentially impact on decision making. Aiming to optimize immediate rewards, we propose using a generalized linear mixed modeling framework where population features and individual features are modeled as fixed and random effects, respectively,...

A new diterpenoid alkaloid from Delphinium gyalanum C. Marquand & Airy Shaw

Xinyu Li, Meizhen Ye, Feng Gao, Xianli Zhou, Lin Chen & Shuai Huang
A new C19-diterpenoid alkaloid named gyalanutine A (1) and fourteen known compounds 2-15 were isolated from the plant of Delphinium gyalanum C. Marquand & Airy Shaw. Compound 1 displayed an unusual lycoctonine-type C19-diterpenoid alkaloid skeleton with the cleavage of N-C19 and C7-C17 bonds, and the construction of the N-C7 bond. Structures were identified by multiple spectroscopic analyses including 1 D, 2 D NMR, IR and HR-ESI-MS. Compounds were tested for acetylcholinesterase inhibitory and anti-inflammatory activity.

Chemical composition characteristics and source analysis of PM2.5 in Jiaxing, China: Insights into the effect of COVID-19 outbreak

Chuanfang Xiong, Yinglong Zhang, Jing Yan, Xiaoxia Yang, Qiongzhen Wang, Rui Tu & Yi He
Jiaxing is a medium-sized city in the Yangtze River Delta (YRD), which showed complex local and surrounding pollution sources. To study the COVID-19 impact on the ambient PM2.5 in Jiaxing, we collected the PM2.5 samples from January 2 to April 25, 2020 and analyzed their chemical compositions (including carbon components, water-soluble ions (WSIs), and inorganic elements). The concentration of PM2.5 was 83.13 ± 30.93 μg/m3 before COVID-19 pandemic, and then remarkably decreased with COVID-19 outbreak...

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  • Sun Yat-sen University
  • Zhejiang University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Fudan University
  • Shanghai Jiao Tong University
  • Sichuan University
  • Huazhong University of Science and Technology
  • Capital Medical University
  • University of Chinese Academy of Sciences
  • Shandong University