In this article, we study large-dimensional matrix factor models and estimate the factor loading matrices and factor score matrix by minimizing square loss function. Interestingly, the resultant estimators coincide with the Projected Estimators (PE) in Yu et al. which was proposed from the perspective of simultaneous reduction of the dimensionality and the magnitudes of the idiosyncratic error matrix. In other word, we provide a least-square interpretation of the PE for the matrix factor model, which...

Our goal in this work was to investigate the possible role and mechanism of regulated in development and DNA damage response 1 (REDD1) in mediating high glucose (HG)-induced podocyte injury in vitro. Mouse podocytes were stimulated with HG to establish HG injury model. Protein expression was examined by Western blotting. Cell viability was measured by cell counting kit-8 assay. Cell apoptosis was assessed by annexin V‐FITC/propidium iodide and TUNEL apoptotic assays. Levels of reactive oxygen...

Antibiotic resistance genes (ARGs) are widespread in aquaculture and pose a huge threat to aquaculture organisms and human health. In this study, occurrences and relative abundances of ARGs were analyzed in the guts of products cultured in freshwater ponds in the Yangtze River Delta region in China. A total of 29 ARGs were found in the gut samples, with detection frequencies ranging from 4.8% to 81%, and the relative abundances (ARGs/16S rRNA) ranging from 10−7...

High-strength bolts have been widely used in steel bolted connections, and fire-induced high temperatures will affect its basic mechanical properties and fracture behavior, leading to failure of the connection and even collapse of the overall structure. Tensile experiments are conducted on Grade 10.9 high-strength bolts to investigate the effect of stress triaxiality and heating history on their mechanical and fracture properties in the whole process of fire. The true stress-strain curves are obtained to determine...

Nonparametric control charts that can detect arbitrary distributional changes are highly desirable due to their flexibility to adapt to different distributional assumptions and changes. However, most of the nonparametric control charts in the literature either can only detect location changes, or involve intensive computation. In this article, we propose a new nonparametric adaptive CUSUM chart. The proposed control chart can detect arbitrary distributional changes and is computationally efficient. Its self-starting nature makes the proposed control...

The supplemental data of the manuscript: Treatment decision based on unilateral index from non-ACTH stimulated and ACTH stimulated adrenal vein sampling

A series of cerium-based high-entropy oxide catalysts (the ratio of CeO2 and HEO is 1:1) was prepared by a solid-state reaction method, which exploit their unique structural and performance advantages. The Ce-HEO-T samples can achieve 100% toluene conversion rate above 328 oC when they were used as catalysts directly. Subsequently, the Ce-HEO-500 exhibited the lowest temperature for toluene oxidation was used as a support to deposit different amounts of Au for a further performance improvement....

The effects of different soil properties on hydrology and nitrogen removal were studied in a simulated bioretention system. Soil capacity of permeability and water retention, changes in the soil environment, leachate concentrations at the surface and bottom layers, quantification of N removal from soil, microorganism and plant by 15N isotope tracer technique, and functional genes abundance at different depths were evaluated. The results showed that shallow root plants, soil compaction, and low organic matter content...

As an important component in steel connections, high-strength bolts have a high stress level and may experience creep deformation at high temperatures. This will lead to great deformation and even failure of steel connections, thus affecting progressive collapse resistance of steel structures. This paper experimentally and numerically investigates the creep behavior of 10.9 high-strength bolts under and after fire. The creep strain-time curves at different temperatures and stress levels were obtained using DIC measurement systems....

Epidemiological and interventional studies have been rarely conducted among those with positive interferon-γ release assay (IGRA) results and radiologically inactive tuberculosis (TB) lesions on chest radiograph. This study aimed to estimate the effectiveness and safety of a 6-week twice-weekly regimen (rifapentine plus isoniazid) among this key population in rural China. First, chest digital radiography was conducted to screen individuals with inactive TB lesions. Then, the identified participants were further evaluated and eligible participants with IGRA...

Nonparametric control charts that can detect arbitrary distributional changes are highly desirable due to their flexibility to adapt to different distributional assumptions and changes. However, most of the nonparametric control charts in the literature either can only detect location changes, or involve intensive computation. In this article, we propose a new nonparametric adaptive CUSUM chart. The proposed control chart can detect arbitrary distributional changes and is computationally efficient. Its self-starting nature makes the proposed control...

The role of thyroid hormones in tumors has been discussed in observational studies; however, the causal relationship between them remains controversial. Six different Mendelian randomization (MR) Methods, including Inverse variance weighted (IVW), MR-Egger, Simple mode, MR-Pleiotropy Residual Sum and Outlier methods (MR-PRESSO), Weighted mode and Weighted median were used to Two-Sample MR analysis. Our research shows that hypothyroidism genetically has a protective causal association with lung cancer.

While some evidence of an effect of radiation exposure on respiratory disease at low dose levels has now emerged, there is heterogeneity in the risks between different studies and countries. In this paper, we aim to show the effect of radiation on three different sub-types of respiratory disease mortality through the analysis of the NRRW cohort in UK. The NRRW cohort consisted of 174,541 radiation workers. Doses to the surface of the body were monitored...

This paper presents the mechanical properties data and constitutive model of S32001 stainless steel at elevated temperatures. S32001 stainless steel is a new type of duplex stainless steel, with good corrosion resistance and higher strength. Its yield strength at room temperature is about 1.9 times that of S304 and S316 series stainless steels, while the nickel element content is only 1 %~3 %. When used as structural steel, S32001 has good economy and significant advantages....

Introduction: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. Methods: The postpartum placental tissue of pregnant women with ICP were chosen as the...

1. The extracellular matrix (ECM) constitutes the basal lamina and the area between follicular cells. Remodelling the ECM is believed to be a key event in follicular development, especially during selection, and plays an important role in cell migration, survival, and steroidogenesis. miR-199-3p is differentially expressed in the goose granulosa layer during follicular selection and is reported to play a primary role in inhibiting cell migration and invasion. Nevertheless, the effect of miR-199-3p on ovarian...

Replicating SARS-CoV-2 has been shown to degrade HLA class I on target cells to evade the cytotoxic T-cell (CTL) response. HLA-I downregulation can be sensed by NK cells to unleash killer cell immunoglobulin-like receptor (KIR)-mediated self-inhibition by the cognate HLA-I ligands. Here, we investigated the impact of HLA and KIR genotypes and HLA-KIR combinations on COVID-19 outcome. We found that the peptide affinities of HLA alleles were not correlated with COVID-19 severity. The predicted poor...

The effects of different soil properties on hydrology and nitrogen removal were studied in a simulated bioretention system. Soil capacity of permeability and water retention, changes in the soil environment, leachate concentrations at the surface and bottom layers, quantification of N removal from soil, microorganism and plant by 15N isotope tracer technique, and functional genes abundance at different depths were evaluated. The results showed that shallow root plants, soil compaction, and low organic matter content...

A heteronuclear Tb-Al complex (1) was obtained by pyridine-2,6-dicarboxylic acid (H2PDA), AlCl3 and Tb4O7 under hydrothermal condition. Single-crystal X-ray diffraction analysis reveals that 1 is an ion-pair and consists of [Al(H2O)6]3+ cation and [Tb(PDA)3]3- anion; the [Al(H2O)6]3+ cations and [Tb(PDA)3]3- anions are further connected by hydrogen bonds to construct a 3D NaCl-like topology. Lattice water molecules in 1 fabricate a cubic (H2O)8-octamer by hydrogen bonds, which is located in the void of 1. Luminescent property...

Cyclopentanol (CPL) was an eco-friendly solvent as well as important platform chemical which could be generated from biomass-derived furfural (FFA). In this paper, A series of Ni, Cu, Mo, Co bimetallic catalysts with different metals loadings supported on Carbon nanotubes (CNT) were synthesized by an impregnation method for aqueous-phase hydrogenation of FFA to obtain CPL. Various effects of reaction parameters such as, reaction solvent, reaction temperature, reaction time, and different loading amount of Ni over...

The role of thyroid hormones in tumors has been discussed in observational studies; however, the causal relationship between them remains controversial. Six different Mendelian randomization (MR) Methods, including Inverse variance weighted (IVW), MR-Egger, Simple mode, MR-Pleiotropy Residual Sum and Outlier methods (MR-PRESSO), Weighted mode and Weighted median were used to Two-Sample MR analysis. Our research shows that hypothyroidism genetically has a protective causal association with lung cancer.

Introduction: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. Methods: The postpartum placental tissue of pregnant women with ICP were chosen as the...

Introduction: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. Methods: The postpartum placental tissue of pregnant women with ICP were chosen as the...

As RIPK2 (receptor interacting serine/threonine kinase 2) has been shown to to alleviate excessive inflammatory responses, the following study conducted a systematic and in-depth analysis of the mRNA-seq and miRNA-seq data from chicken macrophages with/without over-expression of RIPK2 (oeRIPK2) combined with/without avian pathogenic E. coli (APEC) infection to identify the miRNA-mRNA interaction network and potential signalling pathways involved. A total of 9,201 differentially expressed (DE) mRNAs and 300 DE miRNA were identified in both oeRIPK2+APEC...

As an important component in steel connections, high-strength bolts have a high stress level and may experience creep deformation at high temperatures. This will lead to great deformation and even failure of steel connections, thus affecting progressive collapse resistance of steel structures. This paper experimentally and numerically investigates the creep behavior of 10.9 high-strength bolts under and after fire. The creep strain-time curves at different temperatures and stress levels were obtained using DIC measurement systems....