Social dysfunction is transdiagnostically associated with default mode network dysconnectivity in schizophrenia and Alzheimer’s disease

Ilja M. J. Saris, Moji Aghajani, Lianne M. Reus, Pieter-Jelle Visser, Yolande Pijnenburg, Nic J. A. van der Wee, Amy C. Bilderbeck, Andreea Raslescu, Asad Malik, Maarten Mennes, Sanne Koops, Celso Arrango, Jose Luis Ayuso-Mateos, Gerard R. Dawson, Hugh Marston, Martien J. Kas & Brenda W. J. H. Penninx
Social dysfunction is one of the most common signs of major neuropsychiatric disorders. The Default Mode Network (DMN) is crucially implicated in both psychopathology and social dysfunction, although the transdiagnostic properties of social dysfunction remains unknown. As part of the pan-European PRISM (Psychiatric Ratings using Intermediate Stratified Markers) project, we explored cross-disorder impact of social dysfunction on DMN connectivity. We studied DMN intrinsic functional connectivity in relation to social dysfunction by applying Independent Component Analysis...

Registration Year

  • 2021
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Resource Types

  • Other
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Affiliations

  • Vrije Universiteit Amsterdam
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  • Amsterdam UMC Location VUmc
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  • University of Groningen
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  • Amsterdam Neuroscience
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  • Leiden University
    1
  • GGZ inGeest
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  • Amsterdam University Medical Centers
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  • Leiden University Medical Center
    1