2 Works
Profile of clinical characteristics and serologic markers of sporadic hepatitis E in a community cohort study
Zi-Min Tang, Gui-Ping Wen, Dong Ying, Si-Ling Wang, Chang Liu, Wei-Kun Tian, Ying-Bin Wang, Mu-Jin Fang, Yu-Lin Zhou, Yun-Sheng Ge, Ting Wu, Jun Zhang, Shou-Jie Huang, Zi-Zheng Zheng & Ning-Shao Xia
Hepatitis E virus (HEV) is a pathogen of global significance, but the value of HEV-related markers in the diagnosis of hepatitis E remains controversial. Previous studies on hepatitis E profiles have been mainly cross-sectional and conducted among inpatients in large hospitals, and hepatitis E cases have been primarily defined by limited partial markers. In this community-based study, 4,110 active hepatitis cases from a population of nearly 600,000 were followed over 48 months and serial serum...
Induction of Significant Neutralizing Antibodies against SARS-CoV-2 by a Highly Attenuated Pangolin Coronavirus Variant with a 104nt Deletion at the 3'-UTR
Shanshan Lu, Shengdong Luo, Chang Liu, Muli Li, Xiaoping An, Mengzhe Li, Jun Hou, Huahao Fan, Panyong Mao, Yigang Tong & Lihua Song
SARS-CoV-2 related coronaviruses (SARS-CoV-2r) from Guangdong and Guangxi pangolins have been implicated in the emergence of SARS-CoV-2 and future pandemics. We previously reported the culture of a SARS-CoV-2r GX_P2V from Guangxi pangolins. Here we report the GX_P2V isolate rapidly adapted to Vero cells by acquiring two genomic mutations: an alanine to valine substitution in the nucleoprotein and a 104-nucleotide deletion in the hypervariable region (HVR) of the 3′-terminus untranslated region (3′-UTR). We further report the...