95 Works

Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicenter, proof-of-concept, observational study.

Yang Li, Xian Zhou, Tao Li, Shiji Chan, Yiqi Yu, Jing-Wen Ai, Haocheng Zhang, Feng Sun, Qiran Zhang, Lei Zhu, Lingyun Shao, Bin Xu & Wenhong Zhang
Background: Critically ill patients with COVID-19 are of grave concern. Those patients usually underwent a stage of excessive inflammation before developing acute respiratory distress syndrome. In this study, we test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit patients when used in the early phase of excessive inflammation namely, the therapeutic window. Methods: Among a Shanghai cohort and a validation cohort, we enrolled COVID-19 patients showing marked radiographic progression. Short-term, low-to-moderate-dose corticosteroids were considered for...

Synthesis of N-doped carbon dots for highly selective and sensitive detection of Metronidazole in real samples and its cytotoxicity studies

Xiaoxiang Wang, Tao Lin, Wei Wu, Haisuo Wu & Dongdong Yan
The current investigation reports the synthesis of N-CDs using glucosamine, ascorbic acid, and ethylenediamine precursors by a simple hydrothermal technique. The formation of N-CDs was proved by various characterization techniques such as X-ray Photoelectron Spectroscopy (XPS), X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Fourier-Transform Infrared Spectrophotometer (FT-IR). The optical properties were investigated by fluorescence and UV-vis spectrophotometer. Also, N-CDs showed high selectivity in detecting the MTZ compared to several other analytes. However, the metronidazole...

Apathy in amyotrophic lateral sclerosis: systematic review and meta-analysis of frequency, correlates, and outcomes

Mansur A. Kutlubaev, Jashelle Caga, Ying Xu, Daria K. Areprintseva, Ekaterina V. Pervushina & Matthew C. Kiernan
Objectives: To determine the frequency and correlates of apathy in amyotrophic lateral sclerosis (ALS) and its influence on the prognosis of the disease. Methods: Three databases were searched: MEDLINE, PubMed, and Google Scholar. Quantitative synthesis of the frequency of apathy in ALS was conducted using random effects in Stata (College Station, TX). Meta-regression and subgroup analyses were conducted to investigate the association between frequency of apathy in ALS and different covariates. Results: Fifty-two studies (51...

Phylogenetic analysis and virulence characteristics of Methicillin-Resistant Staphylococcus aureus ST764-SCCmec II: an Emerging hypervirulent Clone ST764-t1084 in China

Yanghua Xiao, Weihua Han, Bingjie Wang, Yanlei Xu, Huilin Zhao, Xinyi Wang, Lulin Rao, Jiao Zhang, Li Shen, Hui Zhou, Long Hu, Junhong Shi, Jingyi Yu, Yinjuan Guo, Han Xia & Fangyou Yu
Previous studies have shown that the increased prevalent ST764 clone in China, Japan, and other Asian areas. However, the knowledge of the genetic features and virulence characteristics of methicillin-resistant Staphylococcus aureus (MRSA) ST764 in China is still limited. In this study, we identified 52 ST764-SCCmec type II isolates collected from five cities in China between 2014 and 2021. Whole genome sequencing showed that the most common staphylococcal protein A (spa) types of ST764 in China...

Genetic, biological and epidemiological study on a cluster of H9N2 avian influenza virus infections among chickens, a pet cat, and humans at a backyard farm in Guangxi, China

Jing Yang, Jianhua Yan, Cheng Zhang, Shanqin Li, Manhua Yuan, Chunge Zhang, Chenguang Shen, Yang Yang, Lifeng Fu, Guanlong Xu, Weifeng Shi, Zhenghai Ma, Ting Rong Luo & Yuhai Bi
During an investigation in October 2018, two people with diarrhoea, mild abdominal pain, and mild arthralgia symptoms in Guangxi, China, were identified as infected by H9N2 avian influenza virus (AIV). Four H9N2 AIVs were isolated from one of two patients, a pet cat, and a dead chicken (two respective isolates from its lung and kidney tissues) bred by the patients at a backyard farm. Epidemiological investigation indicated that the newly bought chicken died first, and...

Humoral and Cellular Immunogenicity and Efficacy of a Coxsackievirus A10 Vaccine in Mice

Huan-Huan An, Meng Li, Rui-Lun Liu, Jie Wu, Sheng-Li Meng, Jing Guo, Ze-Jun Wang, Sha-Sha Qian & Shuo Shen
Coxsackievirus A10 (CV-A10) has become one of the major pathogens of hand, foot and mouth disease (HFMD), and studies on the vaccine and animal model of CV-A10 are still far from complete. Our study used a mouse adapted CV-A10 strain, which was lethal for 14-day-old mice, to develop an infected mouse model. Then this model was employed to establish an actively immunized-challenged mouse model to evaluate the efficacy of a formaldehyde-inactivated CV-A10 vaccine, which was...

Physico-chemical assessment of on-farm bioconversion of organic waste in dairy farms in context to sustainability and circular bioeconomy

Pramod K. Pandey, Brahmaver D. Shetty, Patrick Wickam, Peiman Aminabadi, Zhao Chen, Kelly Mai, Jeffery W. Stackhouse & Michele T. Jay-Russell
On a milk-producing dairy farm, milk production is correlated with manure production and number of cattle, and manure is widely used as soil fertilizer. However, excessive dairy manure production is linked with greenhouse gas emissions and water quality issues. On-farm planning of manure storage and application to enhance soil nutrients are essential in a circular economy to reduce environmental impact, where manure is not landfilled and incinerated. Instead, it creates a nutrient resource for crops,...

Elective single versus double blastocyst-stage embryo transfer in women aged 36 years or older: a retrospective cohort study

He Cai, Ben Mol, Stephan Gordts, Hui Wang & Juanzi Shi
We evaluated if elective single-blastocyst transfer (eSBT) could be adopted in women aged 36 or older. In this retrospective cohort, women aged ≥36 years received IVF ovarian stimulation cycles and had ≥ two blastocysts. A total of 240 women underwent eSBT and 189 double-blastocyst transfer (DBT) in the first transfer cycle. The subsequent frozen-thawed embryo transfer cycles were a combination of single- and double- blastocyst transfers. Analysis was stratified for patients in age groups 36–37,...

Charge-reversal nanomedicine based on black phosphorus for the development of A Novel photothermal therapy of oral cancer

Zimu Li, Qingyun Liu, Yi Zhang, Yao Yang, Xiaomin Zhou, Wei Peng, Zhigang Liang, Xiaowei Zeng, Qiuxu Wang & Nansha Gao
Driven by the lifestyle habits of modern people, such as excessive smoking, drinking, and chewing betel nut and other cancer-causing foods, the incidence of oral cancer has increased sharply and has a trend of becoming younger. Given the current mainstream treatment means of surgical resection will cause serious damage to many oral organs, so that patients lose the ability to chew, speak, and so on, it is urgent to develop new oral cancer treatment methods....

mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern

Haomeng Wang, Zhao Chen, Zhenghua Wang, Jin Li, Zhihong Yan, Jinbo Yuan, Airu Zhu, Lan Chen, Ye Liu, Chenlong Hu, Ali Zhu, Guowei Li, Yuehu Li, Jie Deng, Liqiao Ma, Xiuwen Sui, Wei Miao, Junqiang Li, Xiuyu Zheng, Jinhua Piao, Yanfeng Yao, Juhong Rao, Chao Shan, Zhiming Yuan, Jincun Zhao … & Tao Zhu
In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high level cross-reactive neutralization for Beta, original, Delta and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use...

Transcriptomic analysis of the innate immune signatures of SARS-CoV-2 protein subunit vaccine ZF2001 and a mRNA vaccine RRV

Qian Wang, Ziyang Song, Jinghuan Yang, Qian He, Qunying Mao, Yu Bai, Jianyang Liu, Chaoqiang An, Xujia Yan, Bopei Cui, Lifang Song, Dong Liu, Miao Xu & Zhenglun Liang
Analysis of large-scale gene expression post vaccination can provide an overview of immune responses. We used transcriptional approaches to comprehensively analyze the innate immune response signatures elicited by protein subunit (PS) vaccine ZF2001 and a mRNA vaccine named RRV. A fine-grained time-dependent dissection of large-scale gene expression post immunization revealed that ZF001 induced MHC class II-related genes, including cd74 and H2-Aa, more expeditiously than RRV. Notably, RRV induced MHC class I-related genes like Tap1/2, B2m...

Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by 3 doses of BNT162b2 vaccine or BA.1 infection

Chaitanya Kurhade, Jing Zou, Hongjie Xia, Mingru Liu, Qi Yang, Mark Cutler, David Cooper, Alexander Muik, Ugur Sahin, Kathrin U. Jansen, Ping Ren, Xuping Xie, Kena A. Swanson & Pei–Yong Shi
Distinct SARS-CoV-2 Omicron sublineages have evolved showing increased fitness and immune evasion than the original Omicron variant BA.1. Here we report the neutralization activity of sera from BNT162b2 vaccinated individuals or unimmunized Omicron BA.1-infected individuals against Omicron sublineages and “Deltacron” variant (XD). BNT162b2 post-dose 3 immune sera neutralized USA-WA1/2020, Omicron BA.1-, BA.2-, BA.2.12.1-, BA.3-, BA.4/5-, and XD-spike SARS-CoV-2s with geometric mean titers (GMTs) of 1335, 393, 298, 315, 216, 103, and 301, respectively; thus, BA.4/5...

Comparisons on fluid-solid heat transfer simulation for localized fire resistance

Xuanyi Zhou, Jinggang Zhou, Beihua Cong & Wei Wang
A research idea of multi-physics field coupling can be used to solve the structural fire resistance problem. Most of the previous CFD-FEM numerical simulations in structural fire resistance studies apply adiabatic surface temperature (AST) to accurately describe the complex fire analysis boundary conditions, and this methodology belongs to the use of iterative coupling methods to achieve fluid-solid heat transfer coupling. However, there is less application for another direct two-way coupling method. In this paper, a...

Convective heat transfer coefficient of steel member in localized fire condition

Jinggang Zhou, Xuanyi Zhou, Beihua Cong & Wei Wang
At present, values adopted from specifications are mostly used to define the convective heat transfer coefficient ch in localized fire researches. In this paper, the specific scenario of the steel column surrounded by fire plume is selected as a typical case to explore the surface ch change rules of the steel column. This paper conducts a two-way coupling simulation analysis of the fire and the thermal models by means of CFD codes. First, the validity...

Post-fire tensile behavior of Hole-anchored Bolts Bolted T-stub connection

Peijun Wang, Yang You, Mei Liu, Fangzhou Liu & Wenchao Zhang
A test was designed and conducted to investigate the post-fire tensile behavior of the novel Hole-anchored Bolt (HB) bolted T-stub connection. The HB was anchored by the bolt hole with internal threads, for which the HB could be installed from one-side and is very suitable for the installation of the closed-section steel component. The full-period test method was used to consider the influence of load level and the fire temperature on the residual mechanical behavior...

Cadomian crust of Eastern Iran: evidence from the Tapeh Tagh granitic gneisses

Habib Mollai, Rahim Dabiri, Habib Allah Torshizian, Georgia Pe-Piper & Wei Wang
Late Neoproterozoic to Early Cambrian (Cadomian) magmatic rocks are abundant in Iran, but their occurrence in east-central Iran is voluminous. This paper reports, for the first time, on the Cadomian rocks of the eastern Iranian region known as Tapeh Tagh and deals with their geochemistry and uranium-lead (U-Pb) zircon ages. The Tapeh Tagh region contains masses of Cadomian meta-igneous rocks (including various types of granitic gneiss) and overlying meta-sedimentary rocks. The granitic gneisses show tectonic...

Degradation of 1,4-dioxane by heterogeneous photocatalysis and a photo-Fenton-like process under fluorescent light

Linkon Bhattacharjee, Chunjie Xia, Ethan Krouse, Haoran Yang & Jia Liu
The overall objective of this study was to develop cost-effective treatment processes for 1,4-dioxane removal that were safe and easy to scale up. Degradation of 1,4-dioxane was conducted and compared for the first time by heterogeneous photocatalysis and a photo-Fenton-like process under cool white fluorescent light in mild conditions, using two types of commercial nanoparticles―titanium dioxide (TiO2) and nanoscale zero-valent iron (nZVI), respectively. Both types of nanoparticles removed >99.9% of 1,4-dioxane in a short period...

Recovery of Vanadium with Melamine in Acidic Medium

Hao Peng, Jing Guo, Qian Gong, Qiao Zhou, Xingxing Wang, Huaping Liu, Yao He, Bing Li & Wenbing Shi
Many hydro-metallurgical methods are developed to recover vanadium, while the ammonium salts precipitation possesses the final step and it has threatened to the environment. The key point is to find a new compound to replace ammonium salts without reducing the vanadium recovery efficiency. Some compounds with -NH2 function group have attracted our attention as they have similar function group with ammonium salts. In this paper, the adsorption of vanadium with melamine is conducted. The results...

Block-wise Variable Selection for Clustering via Latent States of Mixture Models

Beomseok Seo, Lin Lin & Jia Li
Mixture modeling is a major paradigm for clustering in statistics. In this paper, we develop a new block-wise variable selection method for clustering by exploiting the latent states of the hidden Markov model on variable blocks or the Gaussian mixture model. The variable blocks are formed by depth-first-search on a dendrogram created based on the mutual information between any pair of variables. It is demonstrated that the latent states of the variable blocks together with...

Chemical composition characteristics and source analysis of PM2.5 in Jiaxing, China: Insights into the effect of COVID-19 outbreak

Chuanfang Xiong, Yinglong Zhang, Jing Yan, Xiaoxia Yang, Qiongzhen Wang, Rui Tu & Yi He
Jiaxing is a medium-sized city in the Yangtze River Delta (YRD), which showed complex local and surrounding pollution sources. To study the COVID-19 impact on the ambient PM2.5 in Jiaxing, we collected the PM2.5 samples from January 2 to April 25, 2020 and analyzed their chemical compositions (including carbon components, water-soluble ions (WSIs), and inorganic elements). The concentration of PM2.5 was 83.13 ± 30.93 μg/m3 before COVID-19 pandemic, and then remarkably decreased with COVID-19 outbreak...

Comparison of the accelerating effect of graphene oxide and graphene on anaerobic transformation of bisphenol F by Pseudomonas sp. LS

Hong Lu, Jingyi Li, Ze Fu, Xiaolei Wang, Jiti Zhou & Jing Wang
It was found that bisphenol F (BPF) could be anaerobically transformed to 4,4-dihydroxybenzophenone using nitrate as an electron acceptor by Pseudomonas sp. LS. However, BPF removal was a slow process under anaerobic conditions. In the present study, effects of graphene oxide (GO) and graphene on the anaerobic transformation of BPF were studied in detail. Results showed that GO (2-10 mg/L) and graphene (2-20 mg/L) could increase anaerobic biotransformation rate of BPF. For GO-mediated system, GO...

Antibody persistence and safety after heterologous boosting with orally aerosolised Ad5-nCoV in individuals primed with two-dose CoronaVac previously: twelve-month analyses of a randomized controlled trial

Lairun Jin, Rong Tang, Shipo Wu, Xiling Guo, Haitao Huang, Lihua Hou, Xiaoqin Chen, Tao Zhu, Jinbo Gou, Jin Zhong, Hongxing Pan, Lunbiao Cui, Yin Chen, Xin Xia, Jialu Feng, Xue Wang, Qi Zhao, XiaoYu Xu, Zhuopei Li, Xiaoyin Zhang, Wei Chen, Jingxin Li & Fengcai Zhu
Antibody persistence and safety up to 12 months of heterologous orally administered adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in individuals who were primed with two-dose inactivated SARS-CoV-2 vaccine (CoronaVac) previously, has not been reported yet. This randomized, open label, single-center trial included Chinese adults who have received two-dose CoronaVac randomized to low-dose or high-dose aerosolised Ad5-nCoV group, or CoronaVac group. In this report, we mainly evaluated the geometric mean titres (GMTs) of neutralising antibodies (NAbs)...

Differential and mechanism analysis of sulfate influence on the degradation of 1,1,2- trichloroethane by nano- and micron-size zero-valent iron

Yi Li, Naijin Wu, Jiuhao Song, Zhenxia Wang, Peizhong Li & Yun Song
The in-situ reduction of zero-valent iron (ZVI) is an effective method for removing chlorinated aliphatic hydrocarbons (CAHs) from groundwater. The heterogeneity of environmental conditions is also crucial in affecting dechlorination efficiency. Until now, the effect of Sulfate (SO42−) on ZVI activity has been debated, and the related mechanism research on SO42− behavior during the abiotic reduction process of chlorinated alkanes is still lacking. In this study, the impacts of SO42− concentrations (0, 2, 4, 8,...

SWATH Proteomics analysis of placental tissue with intrahepatic cholestasis of pregnancy_part2

Yuxuan Jiang, Xiaoping Yin, Qian Xu, Xiaoxiao Tang, Huajie Zhang, Xueshan Cao, Jing Lin, Yi Wang, Fei Yang, NaseerUllah Khan, Liming Shen & Danqing Zhao
Introduction: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. Methods: The postpartum placental tissue of pregnant women with ICP were chosen as the...

SWATH Proteomics analysis of placental tissue with intrahepatic cholestasis of pregnancy_part2

Yuxuan Jiang, Xiaoping Yin, Qian Xu, Xiaoxiao Tang, Huajie Zhang, Xueshan Cao, Jing Lin, Yi Wang, Fei Yang, NaseerUllah Khan, Liming Shen & Danqing Zhao
Introduction: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. Methods: The postpartum placental tissue of pregnant women with ICP were chosen as the...

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  • Central South University
  • Zhejiang University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Shanghai Jiao Tong University
  • Huazhong University of Science and Technology
  • Sun Yat-sen University
  • Capital Medical University
  • Shandong University
  • Fudan University
  • Chinese Academy of Sciences