Silk fibroin hydrogel as mucosal vaccine carrier: induction of gastric CD4+TRM cells mediated by inflammatory response induces optimal immune protection against Helicobacter felis

Chupeng Hu, Wei Liu, Ningyin Xu, An Huang, Zhenxing Zhang, Menghui Fan, Guojing Ruan, Yue Wang, Tao Xi & Yingying Xing
Online Resource published via Taylor & Francis
Tissue-resident memory T (TRM) cells, located in the epithelium of most peripheral tissues, constitute the first-line defense against pathogen infections. Our previous study reported that gastric subserous layer (GSL) vaccination induced a “pool” of protective tissue-resident memory CD4+T (CD4+TRM) cells in the gastric epithelium. However, the mechanistic details how CD4+TRM cells form in the gastric epithelium are unknown. Here, our results suggested that the vaccine containing CCF in combination with Silk fibroin hydrogel (SF) broadened...
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https://doi.org/10.6084/m9.figshare.13034063.v1 Cite

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  • Beijing Tian Tan Hospital
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  • Hainan Medical University
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  • Sixth Affiliated Hospital of Sun Yat-sen University
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  • Shanghai University
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  • Guangzhou Center for Disease Control and Prevention
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  • Agricultural University of Hebei
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  • University of Washington
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  • Central South University
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  • Jilin University
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  • Xiamen University
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