19 Works

Clinical features of the first critical case of acute encephalitis caused by avian influenza A (H5N6) virus

Libing Zhang, Kaituo Liu, Qin Su, Xiao Chen, Xiaoquan Wang, Qingfeng Li, Wenlei Wang, Xuhua Mao, Jinmei Xu, Xin Zhou, Qin Xu, Le Zhou, Xiufan Liu & Pinghu Zhang
Highly pathogenic avian influenza virus (HPAIV) such as H5N1, H5N6, and H7N9 have been reported to frequently infect human, but acute encephalitis caused by HPAIV in human have been rarely reported. We report the first critical case of acute encephalitis with mild pneumonia caused by H5N6 virus. On January 25 of 2022, a 6-year-old girl with severe neurological symptoms was admitted to our hospital and rapidly developed to seizures and coma. Brain imaging showed abnormalities....

SWATH Proteomics analysis of placental tissue with intrahepatic cholestasis of pregnancy_part2

Yuxuan Jiang, Xiaoping Yin, Qian Xu, Xiaoxiao Tang, Huajie Zhang, Xueshan Cao, Jing Lin, Yi Wang, Fei Yang, NaseerUllah Khan, Liming Shen & Danqing Zhao
Introduction: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. Methods: The postpartum placental tissue of pregnant women with ICP were chosen as the...

SWATH Proteomics analysis of placental tissue with intrahepatic cholestasis of pregnancy_part2

Yuxuan Jiang, Xiaoping Yin, Qian Xu, Xiaoxiao Tang, Huajie Zhang, Xueshan Cao, Jing Lin, Yi Wang, Fei Yang, NaseerUllah Khan, Liming Shen & Danqing Zhao
Introduction: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. Methods: The postpartum placental tissue of pregnant women with ICP were chosen as the...

Molecular detection and identification of relapsing fever Borrelia in ticks and wild small mammals in China

Xiao-Ai Zhang, Feng Tian, Yue Li, Xiao-Long Zhang, Bao-Gui Jiang, Bao-Cheng Liu, Jing-Tao Zhang, Shen Tian, Heng Ding, Shuang Li, Hao Li, Li-Qun Fang & Wei Liu
We identified relapsing fever (RF) Borrelia in 1.45% (145/10426) of the ticks and 1.40% (40/2850) of the wild mammals in a field investigation in China. Three RF Borrelia species, including human-pathogenic Borrelia miyamotoi, Borrelia persica and unclassified Babesia sp. were determined. Main species determined from ticks was B. miyamotoi (44.14%), followed by the unclassified Borrelia sp. (42.76%), and Borrelia theileri (13.10%). In wild mammals, main species found was B. persica (57.50%), followed by the unclassified...

Handheld Devices for Control

Brad Myers, Jeffrey Nichols, Jacob Wobbrock, roni Rosenfeld, Kevin Litwack, Michael Higgins, Joe Hughes, Thomas Harris, Ronald Rosenfeld & Mathilde Pignol
With present and future wireless technologies, such as IEEE 802.11, BlueTooth, RF-Lite, and G3, handheld devices will frequently be in close, interactive communication. Many environments, including offices, meeting rooms, automobiles and classrooms already contain many computers and computerized appliances, and the smart homes of the future will have ubiquitous embedded computation. When the user enters one of these environments carrying a handheld device, how will that device interact with the environment? We are exploring, as...

Handheld Devices for Control

Brad Myers, Jeffrey Nichols, Jacob Wobbrock, roni Rosenfeld, Kevin Litwack, Michael Higgins, Joe Hughes, Thomas Harris, Ronald Rosenfeld & Mathilde Pignol
With present and future wireless technologies, such as IEEE 802.11, BlueTooth, RF-Lite, and G3, handheld devices will frequently be in close, interactive communication. Many environments, including offices, meeting rooms, automobiles and classrooms already contain many computers and computerized appliances, and the smart homes of the future will have ubiquitous embedded computation. When the user enters one of these environments carrying a handheld device, how will that device interact with the environment? We are exploring, as...

STROBE checklist: Implication of use of 2014 Integrated Management of Childhood Illness Pneumonia Guidelines with and without pulse oximetry use in Malawi

Shubhada Hooli, Charles Makwenda, Norman Lufesi, Tim Colbourn, Tisungane Mvalo, Eric D. McCollum & Carina King
Background: Under-5 pneumonia mortality remains high in low-income countries. In 2014 WHO advised that children with chest indrawing pneumonia, but without danger signs or SpO2 < 90% be treated in the community, rather than hospitalized. In Malawi there is limited pulse oximetry availability. Methods: Secondary analysis of 13,413 under-5 pneumonia cases in Malawi. Pneumonia associated case fatality ratios (CFR) were calculated by disease severity under the assumptions of the 2005 and 2014 WHO Integrated Management...

2019 NSF Workshop on Connecting Large Facilities and Cyberinfrastructure

Ewa Deelman, Ilya Baldin, Brian Bockelman, Adam Bolton, Patrick Brady, Tom Cheatham, Laura Christopherson, Rafael Ferreira da Silva, Tom Gulbransen, Kate Keahey, Marina Kogan, Anirban Mandal, Angela Murillo, Jarek Nabrzyski, Valerio Pascucci, Steve Petruzza, Mats Rynge, Susan Sons, Dan Stanzione, Chaudhuri Surajit, Daryl Swensen, Alexander Szalay, Douglas Thain, John Towns, Charles Vardeman … & Jane Wyngaard

Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicenter, proof-of-concept, observational study.

Yang Li, Xian Zhou, Tao Li, Shiji Chan, Yiqi Yu, Jing-Wen Ai, Haocheng Zhang, Feng Sun, Qiran Zhang, Lei Zhu, Lingyun Shao, Bin Xu & Wenhong Zhang
Background: Critically ill patients with COVID-19 are of grave concern. Those patients usually underwent a stage of excessive inflammation before developing acute respiratory distress syndrome. In this study, we test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit patients when used in the early phase of excessive inflammation namely, the therapeutic window. Methods: Among a Shanghai cohort and a validation cohort, we enrolled COVID-19 patients showing marked radiographic progression. Short-term, low-to-moderate-dose corticosteroids were considered for...

Silk fibroin hydrogel as mucosal vaccine carrier: induction of gastric CD4+TRM cells mediated by inflammatory response induces optimal immune protection against Helicobacter felis

Chupeng Hu, Wei Liu, Ningyin Xu, An Huang, Zhenxing Zhang, Menghui Fan, Guojing Ruan, Yue Wang, Tao Xi & Yingying Xing
Tissue-resident memory T (TRM) cells, located in the epithelium of most peripheral tissues, constitute the first-line defense against pathogen infections. Our previous study reported that gastric subserous layer (GSL) vaccination induced a “pool” of protective tissue-resident memory CD4+T (CD4+TRM) cells in the gastric epithelium. However, the mechanistic details how CD4+TRM cells form in the gastric epithelium are unknown. Here, our results suggested that the vaccine containing CCF in combination with Silk fibroin hydrogel (SF) broadened...

Microcapillary LAMP for rapid and sensitive detection of pathogen in bovine semen

Syed Atif Ali, Nongthombam Boby, Prasanna Preena, Shiv Varan Singh, Gurpreet Kaur, Subrata Kumar Ghosh, Sukdeb Nandi & Pallab Chaudhuri
A microcapillary-based loop-mediated isothermal amplification (µcLAMP) has been described for specific detection of infectious reproductive pathogens in semen samples of cattle without sophisticated instrumentation. Brucella abortus, Leptospira interrogans serovar Pomona and bovine herpesvirus 1 (BoHV-1) cultures were mixed in bovine semen samples. The µcLAMP assay is portable, user-friendly, cost-effective, and suitable to be performed as a POC diagnostic test. We have demonstrated high sensitivity and specificity of µcLAMP for detection of Brucella, Leptospira, and BoHV-1...

Aggregation-induced emission tetraphenylethylene derivative as optical sensor for ammonia detection

Shoubin Zhang, Di Zhao, Liuyi Xiong, Yufeng Hu, Zhidong Lou, Yanbing Hou, Feng Teng & Qiuhong Cui
We propose a general approach for the achievement of optical sensors, where ammonia can be rapidly identified and detected through visible fluorescence changes. Here, a tetraphenylethylene derivative with carboxyl groups named TPE-2CA (4,4ʹ-(1,2-Diphenylethene-1,2-diyl) dibenzoyl acid) was applied in the sensor. The AIE (aggregation-induced emission) property of tetraphenylethylene structure provides the samples with excellent luminescent performance in aggregated state. The reaction between carboxyl groups and ammonia causes the shifts on luminescence spectra of the samples. Consequently,...

Data from: Pathogen spillover driven by rapid changes in bat ecology. Data Index: Overview of study datasets, structure, sources, availability, associated analyses

Peggy Eby, Alison Peel, Andrew Hoegh, Wyatt Madden, John Giles, Peter Hudson & Raina Plowright

STROBE checklist: Implication of use of 2014 Integrated Management of Childhood Illness Pneumonia Guidelines with and without pulse oximetry use in Malawi

Shubhada Hooli, Charles Makwenda, Norman Lufesi, Tim Colbourn, Tisungane Mvalo, Eric D. McCollum & Carina King
Background: Under-5 pneumonia mortality remains high in low-income countries. In 2014 WHO advised that children with chest indrawing pneumonia, but without danger signs or SpO2 < 90% be treated in the community, rather than hospitalized. In Malawi there is limited pulse oximetry availability. Methods: Secondary analysis of 13,413 under-5 pneumonia cases in Malawi. Pneumonia associated case fatality ratios (CFR) were calculated by disease severity under the assumptions of the 2005 and 2014 WHO Integrated Management...

Semaphorin 3A Inhibits Endoplasmic Reticulum Stress Induced by High Glucose in Müller Cells

Mengyang Li, Enzhong Jin, Li Zhu, Chi Ren, Zhiqiao Liang, Mingwei Zhao & Jinfeng Qu
This study aimed to explore the effect of the Semaphorin3A (Sema3A)/Neuropilin-1 (Nrp-1) pathway on Müller cell activities and endoplasmic reticulum (ER) stress induced by high glucose (HG) in vitro. The primary Müller cells of C57BL/6J mice were isolated and cultured in normal or high glucose medium. The expression of endogenous Sema3A and its coreceptor Nrp-1 was measured by Western blot. Müller cells were incubated with exogenous recombinant Sema3A protein or transfected with lentiviral vectors expressing...

SWATH Proteomics analysis of placental tissue with intrahepatic cholestasis of pregnancy_part1

Yuxuan Jiang, Xiaoping Yin, Qian Xu, Xiaoxiao Tang, Huajie Zhang, Jing Lin, Yi Wang, Fei Yang, NaseerUllah Khan, Liming Shen & Danqing Zhao
Introduction: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. Methods: The postpartum placental tissue of pregnant women with ICP were chosen as the...

BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) Promotes Lung Adenocarcinoma by Interacting with Zinc Finger Protein ZNF143 and Regulating Glycolysis

Xiaolei Zhou, Yanli Yuan, Hongping Kuang, Bingxiang Tang, Hui Zhang & Manlin Zhang
Lung adenocarcinoma (LUAD) is one of the most common causes of cancer death in men. BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) has been reported to contribute to the initiation and development of several cancers. Here, we aimed to explore the potential role of BUB1B in LUAD. We found BUB1B was upregulated in LUAD, suggesting its potential role as a biomarker for LUAD diagnosis. Significantly, LUAD patients with high BUB1B expression had a shorter survival...

Adverse Outcome Pathways and Linkages to Transcriptomic Effects Relevant to Ionizing Radiation Injury

Jihang Yu, Wangshu Tu, Andrea Payne, Chris Rudyk, Sarita Cuadros Sanchez, Saadia Khilji, Premkumari Kumarathasan, Sanjeena Subedi, Brittany Haley, Alicia Wong, Catalina Anghel, Yi Wang & Vinita Chauhan
In the past three decades, a large body of data on the effects of exposure to ionizing radiation and the ensuing changes in gene expression has been generated. These data have allowed for an understanding of molecular-level events and shown a level of consistency in response despite the vast formats and experimental procedures being used across institutions. However, clarity on how this information may inform strategies for health risk assessment needs to be explored. An...

SWATH Proteomics analysis of placental tissue with intrahepatic cholestasis of pregnancy_part1

Yuxuan Jiang, Xiaoping Yin, Qian Xu, Xiaoxiao Tang, Huajie Zhang, Jing Lin, Yi Wang, Fei Yang, NaseerUllah Khan, Liming Shen & Danqing Zhao
Introduction: Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second and third trimesters. The disease's etiology and diagnostic criteria are currently unknown. Based on a sequence window to obtain all theoretical fragment ions (SWATH) proteomic approach, this study sought to identify potential proteins in placental tissue that may be involved in the pathogenesis of ICP and adverse fetal pregnancy outcomes. Methods: The postpartum placental tissue of pregnant women with ICP were chosen as the...

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