96 Works

Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-κB pathway

Shuai Mao, Lei Wang, Peipei Chen, Yong Lan, Rui Guo & Minzhou Zhang
Our previous works have shown that tanshinone IIA inhibited maladaptive extracellular matrix remodeling in cardiac fibroblasts implicating its potential role in treating of pathologic cardiac remodeling. However, the intrinsically poor solubility and bioavailability of tanshinone IIA hindered its clinical application. Here we develop monomethoxy-poly (ethylene glycol)-poly (lactic acid)-D-α-Tocopheryl polyethylene glycol 1000 succinate (mPEG-PLA-TPGS) nanoparticle incorporating tanshinone IIA (tanshinone IIA-NPs) and study its efficacy in post-infarction left ventricular (LV) remodeling. Male C57BL/6 mice underwent left coronary...

Aconiti lateralis Radix Praeparata inhibits Alzheimer’s disease by regulating the complex regulation network with the core of GRIN1 and MAPK1

Yutao Wang, Huixiang Zhang, Jing Wang, Ming Yu, Qianqian Zhang, Shan Yan, Dingyun You, Lanlan Shi, Lihuan Zhang, Limei Wang, Hongxiang Wu & Xue Cao
Current medicine for Alzheimer’s disease (AD) cannot effectively reverse or block nerve injury. Traditional Chinese Medicine practice and research imply Aconiti lateralis Radix Praeparata (Fuzi) may meet this goal. Analysing the anti-AD effect of Fuzi and its potential molecular mechanism. AD model cells were treated with Fuzi in 0-300 mg/mL for 24 h in 37 °C. The cell viability (CV) and length of cell projections (LCP) for each group were observed, analysed, and standardised using...

Complement receptor 3 mediates Aspergillus fumigatus internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK

Xuelin Han, Xueting Su, Zhiqian Li, Yanxi Liu, Shuo Wang, Miao Zhu, Changjian Zhang, Fan Yang, Jingya Zhao, Xianping Li, Fangyan Chen & Li Han
Complement receptor 3 (CD11b/CD18) is an important receptor that mediates adhesion, phagocytosis and chemotaxis in various immunocytes. The conidia of the medically-important pathogenic fungus, Aspergillus fumigatus can be internalized into alveolar epithelial cells to disseminate its infection in immunocompromised host; however, the role of CR3 in this process is poorly understood. In the present study, we investigated the potential role of CR3 on A. fumigatus internalization into type II alveolar epithelial cells and its effect...

Angiopoietin-like protein 8, molecular cloning and regulating lipid accumulation in goat intramuscular preadipocytes

Wei Huang, Yaqiu Lin, Hua Xiang, Jiangjiang Zhu & Yong Wang
This study aimed to clone the full-length open reading frame (ORF) of goat ANGPTL8 gene sequence, reveal its molecular and expression characteristics, and explore its effect on the differentiation of goat intramuscular preadipocytes. The full-length ORF sequence of goat ANGPTL8 gene was cloned by RT-PCR technology, and bioinformatics analysis was performed by related biological software. RT-qPCR was used to detect the expression of ANGPTL8 mRNA in goat tissues. Further use of RNA interference to study...

METTL21C mediates lysine trimethylation of IGF2BP1 to regulate chicken myoblast proliferation

Shanshan Wang, Jiarong Zhao, Ling Wang, Tao Zhang, Wenxian Zeng & Hongzhao Lu
1. Methyltransferase-like 21C (METTL21C) and insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) play important roles in the proliferation of chicken myoblasts. However, it remains unclear whether there is protein-protein interaction between METTL21C and IGF2BP1 to regulate proliferation of chicken myoblasts. 2. In this study, the Igf2bp1 gene was amplified from cDNA of liver tissue of Lueyang black-bone chicken to construct the overexpression vector HA-Igf2bp1. The HA-Igf2bp1 and Flag-Mettl21c vectors were individually transfected and co-transfected...

Effect of wounding and wound age on infection of canola cotyledons by Leptosphaeria maculans, interacting with leaf wetness

Shuanglong Huang, Chun Zhai, Zhongwei Zou, Fei Liu, Paula Parks, Linda Mcgregor, W. G. Dilantha Fernando & Gary Peng
Blackleg, caused by the fungus Leptosphaeria maculans, is an important disease of canola. Both ascospores and pycnidiospores of the fungus can infect intact leaves under conditions of extended leaf wetness, with infection then progressing further into the stem. In western Canada, spring is typically cool and dry and additional factors may be involved for successful infection. This study was designed to assess the effect of wounding and wound age on cotyledon infection, to evaluate the...

Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques

Pingchao Li, Qian Wang, Yizi He, Chenchen Yang, Zhengyuan Zhang, Zijian Liu, Bo Liu, Li Yin, Yilan Cui, Peiyu Hu, Yichu Liu, Pingqian Zheng, Wei Wang, Linbing Qu, Caijun Sun, Suhua Guan, Liqiang Feng & Ling Chen
Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but...

Different cellular mechanisms from low- and high-dose zinc oxide nanoparticles-induced heart tube malformation during embryogenesis

Mengwei Wang, Ping Zhang, Zeyu Li, Yu Yan, Xin Cheng, Guang Wang & Xuesong Yang
With the wide application of nanometer materials in daily life, people pay more attention to the potential toxicity of nanoparticles to human fetal development once the nanoparticles are absorbed into the human body during pregnancy. However, there was no directly solid evidence for ZnO NPs-caused congenital heart defects. Hence, we investigated the effect of ZnO NPs exposure on early cardiogenesis using the chicken/mouse embryo models. First, we showed ZnO NPs reduced H9c2 cell viability in...

Spectral correlation between wheat genotype replications over the visible and near-infrared spectrum

Xuebin Yang, Xu Wang, Byron Evers, Yaokui Cui & Jesse Poland
The growth stage best suitable for wheat yield phenotyping has been a hot topic. This study provides a fresh insight into it, from the perspective of spectral correlation between wheat genotype replications. A number of 340 wheat genotypes and their replication were distributed in separate parts (west and east) of an experiment field (2019–2020) in Ashland, Kansas, USA. Unmanned aerial vehicle based hyperspectral images (400–100 nm) of the experiment field were taken over the late...

A Time-Varying Network for Cryptocurrencies

Li Guo, Wolfgang Karl Härdle & Yubo Tao
Cryptocurrencies return cross-predictability and technological similarity yield information on risk propagation and market segmentation. To investigate these effects, we build a time-varying network for cryptocurrencies, based on the evolution of return cross-predictability and technological similarities. We develop a dynamic covariate-assisted spectral clustering method to consistently estimate the latent community structure of cryptocurrencies network that accounts for both sets of information. We demonstrate that investors can achieve better risk diversification by investing in cryptocurrencies from different...

Bimetallic Mn-Ce loaded on different zeolite carriers applied in the toluene abatement in air by non–thermal plasma DDBD Reactor

Su Liu, Jiabin Zhou, Dan Liu, Xianjie Liu & Wenbo Liu
A sequence of zeolite carriers (Carrier = ZSM-5, Small crystal ZSM-5, MCM-41, SBA-15) were used to support active metals Mn-Ce, which have presented an enormous potential for plasma oxidation of toluene in air. The prepared samples were detected by means of N2 adsorption-desorption, SEM, XPS, H2-TPR, etc. Through the activity evaluation in the Non-thermal Plasma Reactor, we found that the catalysts with different carriers showed distinct degradation activities. The performance of mesoporous supported catalysts was...

ZKSQL code

Xiling Li, Chenkai Weng, Yongxin Xu, Xiao Wang & Jennie Rogers
This is code for VLDB 2023 of "ZKSQL: Verifiable and Efficient Query Evaluation with Zero-Knowledge Proofs" (Initial Paper ID: 771; Shepherding Paper ID: 967)

ZKSQL code

Xiling Li, Chenkai Weng, Yongxin Xu, Xiao Wang & Jennie Rogers
This is code for VLDB 2023 of "ZKSQL: Verifiable and Efficient Query Evaluation with Zero-Knowledge Proofs" (Initial Paper ID: 771; Shepherding Paper ID: 967)

Elective single versus double blastocyst-stage embryo transfer in women aged 36 years or older: a retrospective cohort study

He Cai, Ben Mol, Stephan Gordts, Hui Wang & Juanzi Shi
We evaluated if elective single-blastocyst transfer (eSBT) could be adopted in women aged 36 or older. In this retrospective cohort, women aged ≥36 years received IVF ovarian stimulation cycles and had ≥ two blastocysts. A total of 240 women underwent eSBT and 189 double-blastocyst transfer (DBT) in the first transfer cycle. The subsequent frozen-thawed embryo transfer cycles were a combination of single- and double- blastocyst transfers. Analysis was stratified for patients in age groups 36–37,...

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

Yating Ning, Meng Xiao, David S. Perlin, Yanan Zhao, Minya Lu, Yi Li, Zhengyu Luo, Rongchen Dai, Shengjie Li, Jiajun Xu, Lingli Liu, Hong He, Yun Liu, Fushun Li, Yuguang Guo, Zhongju Chen, Yingchun Xu, Tianshu Sun & Li Zhang
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C. parapsilosis has emerged in several countries, but little is known about the susceptibility profile in China or about mechanisms of resistance. Here, we investigated the echinocandin susceptibilities of 2523 C. parapsilosis isolates collected from China and further explored the resistance mechanism among echinocandin-resistant isolates. Anidulafungin exhibited the highest...

Cervical HPV infection in Guangzhou, China: an epidemiological study of 198,111 women from 2015 to 2021

Xiaohan Yang, Yuanyuan Li, Yuan Tang, Zhiyu Li, Sanfeng Wang, Xiping Luo, Tianwen He, Aihua Yin & Mingyong Luo
Persistent high-risk human papillomavirus (HPV) infection is the pivotal cause of cervical carcinogenesis. HPV types distribution varies greatly by region, and its long-term changes of prevalence remain to be fully characterized in China. Here, the largest population of 198,111 consecutive women who underwent routine cervical screening were investigated from 2015 to 2021 in Guangzhou, south China. The results showed that the overall HPV prevalence was 21.66% (42,911/198,111), and the annual prevalence increased significantly from 2015...

Clinical prognostic risk analysis and progression factor exploration of primary breast lymphoma

Jili Deng, Lan Mi, Xiaopei Wang, Jun Zhu, Chen Zhang & Yuqin Song
: A primary breast lymphomais a rare form of extranodal lymphoma type. We aimed to analyze prognosticriskfactors and explore relapse factors in primary breast diffuse large B cell lymphoma (PB-DLBCL). : From November 2003 to September 2020, sixty-three patients from two medical centers newly diagnosed with PB-DLBCL patients were analyzed retrospectively. : The median age was 52, and >50% of patients were post-menopausal. The international prognostics index (IPI) (0–1) was mainlyin the low-risk group (84%),...

Intraday Periodic Volatility Curves

Torben G. Andersen, Tao Su, Viktor Todorov & Zhiyuan Zhang
The volatility of financial asset returns displays pronounced variation over the trading day. Our goal is nonparametric inference for the average intraday volatility pattern, viewed as a function of time-of-day. The functional inference is based on a long span of high-frequency return data. Our setup allows for general forms of volatility dynamics, including time-variation in the intraday pattern. The estimation is based on forming local volatility estimates from the high-frequency returns over overlapping blocks of...

Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry

Huan Sun, Yan Li, Peipei Liu, Chengpeng Qiao, Xiaomin Wang, Lianao Wu, Kefang Liu, Yu Hu, Chao Su, Shuguang Tan, Shumei Zou, Guizhen Wu, Jinghua Yan, George Fu Gao, Jianxun Qi & Qihui Wang
Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry

Nickel (ii) effects on Anammox reaction: reactor performance, dehydrogenase, sludge morphology and microbial community changes

Jian Cheng, Liang Qiao, Wen Xu, Yulan Qian, Yiyang Ge, Ting Xia & Yan Li
Nickel (ii) (Ni2+) is considered as one of the necessary trace elements in the process of Anammox culture, but it may have toxic effects at high concentration. This study explored the long-term influence of Ni2+ on the denitrification efficiency of Anammox bioreactors. The results showed that when the concentration of Ni2+ was 0.5 mg/L, the bioreactor had the highest denitrification efficiency, while the removal efficiency of ammonia nitrogen and nitrite nitrogen gradually decreased at concentrations...

Adaptive parameter of standard deviation enhances the power of noninvasive prenatal screens

Li Qu, Qixi Wu, Xiaoke Yang, Weiwei Wang, Bing Xu, Guangyu Shan, Lin Liang, Shaowei Wang & Jingbo Zhang
Traditional Z-test methods during noninvasive prenatal screens (NIPS) use the fixed parameter of standard deviation (SD), which ignores the influence of actual sequencing read counts of a sample on the results. The aim of this study is to eliminate the influence of the sequencing depth of individual samples on the results and enhance the power of NIPS. In this study, we propose an improved NIPS method, which calculates the SD in the Z-score process adaptively...

A new diterpenoid alkaloid from Delphinium gyalanum C. Marquand & Airy Shaw

Xinyu Li, Meizhen Ye, Feng Gao, Xianli Zhou, Lin Chen & Shuai Huang
A new C19-diterpenoid alkaloid named gyalanutine A (1) and fourteen known compounds 2-15 were isolated from the plant of Delphinium gyalanum C. Marquand & Airy Shaw. Compound 1 displayed an unusual lycoctonine-type C19-diterpenoid alkaloid skeleton with the cleavage of N-C19 and C7-C17 bonds, and the construction of the N-C7 bond. Structures were identified by multiple spectroscopic analyses including 1 D, 2 D NMR, IR and HR-ESI-MS. Compounds were tested for acetylcholinesterase inhibitory and anti-inflammatory activity.

Removal Characteristics of Heavy Metal ions in Rainwater Runoff by Bioretention Cell Modified with Biochar

Jiaqing Xiong, Guohao Li, Junguo Zhu, Jianqiang Li, Yuan Yang, Shengxia An & Chengkui Liu
As a form of pollution source control and a low-impact development measure, bioretention is a convenient, economical and effective method for the removal of heavy metals from stormwater runoff, which can adapt to the randomness and uncontrollability of non-point source pollution. However, few studies have assessed the performance of bioretention in the simultaneous removal multiple heavy metals and the impact of heavy metal migration on the bioretention life cycle. In this study, the removal rates...

Comparison of the accelerating effect of graphene oxide and graphene on anaerobic transformation of bisphenol F by Pseudomonas sp. LS

Hong Lu, Jingyi Li, Ze Fu, Xiaolei Wang, Jiti Zhou & Jing Wang
It was found that bisphenol F (BPF) could be anaerobically transformed to 4,4-dihydroxybenzophenone using nitrate as an electron acceptor by Pseudomonas sp. LS. However, BPF removal was a slow process under anaerobic conditions. In the present study, effects of graphene oxide (GO) and graphene on the anaerobic transformation of BPF were studied in detail. Results showed that GO (2-10 mg/L) and graphene (2-20 mg/L) could increase anaerobic biotransformation rate of BPF. For GO-mediated system, GO...

Temporal and Spatial Characteristics of Flocculated Suspended Solids in a Deep Reservoir: an in situ Observation in the Biliuhe Reservoir

Yuyu Liu, Yuqing Feng, Xin Jiang, Shiguo Xu, Lin Zhu & Guoqing Sang
The amount of total suspended solids (TSS) is the most visible indicator for evaluating water quality in reservoirs. Previous investigations paid more attention to TSS of the surface layer in reservoirs, while suspended particles are prone to settle, resuspend, and aggregate at the bottom of reservoir. There may be different patterns of the TSS in different depths. Hence, it is significant to explore the temporal and spatial characteristics of suspended solids in different depths of...

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  • Sichuan University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Shanghai Jiao Tong University
  • Fudan University
  • Zhejiang University
  • Sun Yat-sen University
  • Capital Medical University
  • West China Hospital of Sichuan University
  • Shandong University
  • Huazhong University of Science and Technology