142 Works

Experimental study on mechanical properties of S32001 duplex stainless steel at high temperatures

Ruixin Tang, Guobiao Lou & Wei Yang
This paper presents the mechanical properties data and constitutive model of S32001 stainless steel at elevated temperatures. S32001 stainless steel is a new type of duplex stainless steel, with good corrosion resistance and higher strength. Its yield strength at room temperature is about 1.9 times that of S304 and S316 series stainless steels, while the nickel element content is only 1 %~3 %. When used as structural steel, S32001 has good economy and significant advantages....

Bioinformatical and biochemical analyses on the protective role of traditional Chinese medicine against age-related macular degeneration

Yanqun Cao, Xiao-Ya Li, Gabriel Mbuta Tchivelekete, Xing Li, Xinzhi Zhou, Zhiming He, James Reilly, Zhoujin Tan & Xinhua Shu
Age-related macular degeneration (AMD) is the commonest cause of permanent vision loss in the elderly. Traditional Chinese medicine (TCM) has long been used to treat AMD, although the underlying functional mechanisms are not understood. This study aims to predict the active ingredients through screening the chemical ingredients of anti-AMD Decoction and to elucidate the underlying mechanisms. We collected the prescriptions for effective AMD treatment with traditional Chinese medicine and screened several Chinese medicines that were...

Referral criteria to palliative care for patients with Parkinson’s disease: a systematic review

Yiping Chen, Liyuan Hou, Wei Li, Qiaohong Wang, Wentao Zhou & Hui Yang
Objective: This systematic review aimed to identify the referral criteria for palliative care in patients with Parkinson’s disease. Methods: We conducted an electronic search for publications on referral criteria for palliative care in patients with Parkinson’s disease in six electronic databases. The articles were thoroughly reviewed by two independent reviewers for inclusion using a predefined data extraction list. The referral criteria were thematically classified using a coding methodology. Results: This systematic review included 36 publications....

Rg1 alleviates oxidative stress and spermatogonium apoptosis in D-gal-induced testicular toxicity by activating Akt

Ziling Wang, Kunhang Du, Jiying Hou, Hanxianzhi Xiao, Ling Hu, Xiongbin Chen, Lu Wang & Yaping Wang
Objectives: High reactive oxygen species (ROS) levels lead to cell death, and the testes are among the most vulnerable organs to oxidative damage. Rg1, an active ingredient extracted from the natural medicine ginseng, has potential anti-inflammatory, antioxidant and antiapoptotic properties. Our previous studies showed that Rg1 can effectively improve spermatogenic function in mice, but the specific mechanism remains unclear. The purpose of this study was to investigate the effect of Rg1 on oxidative stress and...

miR-199-3p Suppresses Cellular Migration and Viability, Promotes Progesterone Production in Goose Ovarian Follicles Before Selection Through Regulating ITGB8 and Other ECM-related Genes

Qin Li, Keshan Zhang, Xianzhi Zhao, Yushi Wang, Jing Li, Youhui Xie, Hang Zhong & Qigui Wang
1. The extracellular matrix (ECM) constitutes the basal lamina and the area between follicular cells. Remodelling the ECM is believed to be a key event in follicular development, especially during selection, and plays an important role in cell migration, survival, and steroidogenesis. miR-199-3p is differentially expressed in the goose granulosa layer during follicular selection and is reported to play a primary role in inhibiting cell migration and invasion. Nevertheless, the effect of miR-199-3p on ovarian...

Highly efficient removal of diclofenac sodium with polystyrene supported ionic liquid

Meng Cheng, Ruihua Li, Xin Du, Zihao Zhang & Hao Zhang
Diclofenac sodium (DS) is now recognized as an emerging pollutant, and is one of the most commonly discovered pharmaceuticals in water due to its extensive application in the clinic. This study examined the adsorption performance of a polystyrene supported ionic liquid material (PS-[Nim][Cl]) for the removal of diclofenac sodium (DS) from water. The data from this study showed that maximum removal of DS can be achieved even in conditions with significant pH and temperature fluctuations....

HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19

Ruihua Wang, Ying Sun, Bo-Hua Kuang, Xiao Yan, Jinju Lei, Yu-Xin Lin, Jinxiu Tian, Yating Li, Xiaoduo Xie, Tao Chen, Hui Zhang, Yi-Xin Zeng, Jincun Zhao & Lin Feng
Replicating SARS-CoV-2 has been shown to degrade HLA class I on target cells to evade the cytotoxic T-cell (CTL) response. HLA-I downregulation can be sensed by NK cells to unleash killer cell immunoglobulin-like receptor (KIR)-mediated self-inhibition by the cognate HLA-I ligands. Here, we investigated the impact of HLA and KIR genotypes and HLA-KIR combinations on COVID-19 outcome. We found that the peptide affinities of HLA alleles were not correlated with COVID-19 severity. The predicted poor...

Removal Characteristics of Heavy Metal ions in Rainwater Runoff by Bioretention Cell Modified with Biochar

Jiaqing Xiong, Guohao Li, Junguo Zhu, Jianqiang Li, Yuan Yang, Shengxia An & Chengkui Liu
As a form of pollution source control and a low-impact development measure, bioretention is a convenient, economical and effective method for the removal of heavy metals from stormwater runoff, which can adapt to the randomness and uncontrollability of non-point source pollution. However, few studies have assessed the performance of bioretention in the simultaneous removal multiple heavy metals and the impact of heavy metal migration on the bioretention life cycle. In this study, the removal rates...

Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry

Huan Sun, Yan Li, Peipei Liu, Chengpeng Qiao, Xiaomin Wang, Lianao Wu, Kefang Liu, Yu Hu, Chao Su, Shuguang Tan, Shumei Zou, Guizhen Wu, Jinghua Yan, George Fu Gao, Jianxun Qi & Qihui Wang
Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry

Personalized Policy Learning using Longitudinal Mobile Health Data

Xinyu Hu, Min Qian, Bin Cheng & Ying Kuen Cheung
Personalized policy represents a paradigm shift from one-decision-rule-for-all users to an individualized decision rule for each user. Developing personalized policy in mobile health applications imposes challenges. First, for lack of adherence, data from each user are limited. Second, unmeasured contextual factors can potentially impact on decision making. Aiming to optimize immediate rewards, we propose using a generalized linear mixed modeling framework where population features and individual features are modeled as fixed and random effects, respectively,...

Chemical composition characteristics and source analysis of PM2.5 in Jiaxing, China: Insights into the effect of COVID-19 outbreak

Chuanfang Xiong, Yinglong Zhang, Jing Yan, Xiaoxia Yang, Qiongzhen Wang, Rui Tu & Yi He
Jiaxing is a medium-sized city in the Yangtze River Delta (YRD), which showed complex local and surrounding pollution sources. To study the COVID-19 impact on the ambient PM2.5 in Jiaxing, we collected the PM2.5 samples from January 2 to April 25, 2020 and analyzed their chemical compositions (including carbon components, water-soluble ions (WSIs), and inorganic elements). The concentration of PM2.5 was 83.13 ± 30.93 μg/m3 before COVID-19 pandemic, and then remarkably decreased with COVID-19 outbreak...

Mapping active paddy rice area over monsoon Asia using time-series Sentinel – 2 images in Google Earth Engine; A case study over Lower Gangetic Plain

Arabinda Maiti, Prasenjit Acharya, Srikanta Sannigrahi, Qi Zhang, Somnath Bar, Suman Chakraborti, Bijoy K Gayen, Gunadhar Barik, Surajit Ghosh & Milap Punia
We proposed a modification of the existing approach for mapping active paddy rice fields in monsoon-dominated areas. In the existing PPPM approach, LSWI higher than EVI at the transplantation stage enables the identification of rice fields. However, it fails to recognize the fields submerged later due to monsoon floods. In the proposed approach (IPPPM), the submerged fields, at the maximum greenness time, were excluded for better estimation. Sentinel–2A/2B time-series images were used for the year...

Nickel (ii) effects on Anammox reaction: reactor performance, dehydrogenase, sludge morphology and microbial community changes

Jian Cheng, Liang Qiao, Wen Xu, Yulan Qian, Yiyang Ge, Ting Xia & Yan Li
Nickel (ii) (Ni2+) is considered as one of the necessary trace elements in the process of Anammox culture, but it may have toxic effects at high concentration. This study explored the long-term influence of Ni2+ on the denitrification efficiency of Anammox bioreactors. The results showed that when the concentration of Ni2+ was 0.5 mg/L, the bioreactor had the highest denitrification efficiency, while the removal efficiency of ammonia nitrogen and nitrite nitrogen gradually decreased at concentrations...

Comparison of the accelerating effect of graphene oxide and graphene on anaerobic transformation of bisphenol F by Pseudomonas sp. LS

Hong Lu, Jingyi Li, Ze Fu, Xiaolei Wang, Jiti Zhou & Jing Wang
It was found that bisphenol F (BPF) could be anaerobically transformed to 4,4-dihydroxybenzophenone using nitrate as an electron acceptor by Pseudomonas sp. LS. However, BPF removal was a slow process under anaerobic conditions. In the present study, effects of graphene oxide (GO) and graphene on the anaerobic transformation of BPF were studied in detail. Results showed that GO (2-10 mg/L) and graphene (2-20 mg/L) could increase anaerobic biotransformation rate of BPF. For GO-mediated system, GO...

Block-wise Variable Selection for Clustering via Latent States of Mixture Models

Beomseok Seo, Lin Lin & Jia Li
Mixture modeling is a major paradigm for clustering in statistics. In this paper, we develop a new block-wise variable selection method for clustering by exploiting the latent states of the hidden Markov model on variable blocks or the Gaussian mixture model. The variable blocks are formed by depth-first-search on a dendrogram created based on the mutual information between any pair of variables. It is demonstrated that the latent states of the variable blocks together with...

Potent Immunogenicity and Broad-Spectrum Protection Potential of Microneedle Array Patch-Based COVID-19 DNA Vaccine Candidates Encoding Dimeric RBD Chimera of SARS-CoV and SARS-CoV-2 Variants

Feng Fan, Xin Zhang, Zhiyu Zhang, Yuan Ding, Limei Wang, Xin Xu, Yaying Pan, Fang-Yuan Gong, Lin Jiang, Lingyu Kang, Zhuo Ha, Huijun Lu, Jiawang Hou, Zhihua Kou, Gan Zhao, Bin Wang & Xiao-Ming Gao
Breakthrough infections by SARS-CoV-2 variants pose a global challenge to COVID-19 pandemic control, and the development of more effective vaccines of broad-spectrum protection is needed. In this study, we constructed pVAX1-based plasmids encoding receptor-binding domain (RBD) chimera of SARS-CoV-1 and SARS-CoV-2 variants, including pAD1002 (encoding RBDSARS/BA1), pAD1003 (encoding RBDSARS/Beta) and pAD131 (encoding RBDBA1/Beta). Plasmids pAD1002 and pAD131 were far more immunogenic than pAD1003 in terms of eliciting RBD-specific IgG when intramuscularly administered without electroporation. Furthermore,...

Preparation and evaluation of a nanoemulsion containing cordycepin and its protective effect on skin

Hucheng Zhang, Lina Deng, Jun Yang, Guowei Yang, Haitao Fan, Yiqi Yin, Shuai Luo, Shuangshi Li, Linying Liu & Ming Yang
The purpose of this work was to analyze and evaluate the functional properties of a new nanoemulsion that contained cordycepin. Droplet size and distribution were measured, and the stability of the nanoemulsion in different storage conditions was evaluated. We also tested skin irritation caused by the nanoemulsion, cordycepin stability in the nanoemulsion, anti-aging effect, and microbial challenge. The nanoemulsion was homogeneous with proper dispersion stability, and cordycepin was stable for eight months within the cosmetic...

Selective aqueous-phase hydrogenation of furfural to cyclopentanol over Ni-based CNT catalysts

Haihong Xia, Jing Li, Jun Zhao, Minghao Zhou & Jianchun Jiang
Cyclopentanol (CPL) was an eco-friendly solvent as well as important platform chemical which could be generated from biomass-derived furfural (FFA). In this paper, A series of Ni, Cu, Mo, Co bimetallic catalysts with different metals loadings supported on Carbon nanotubes (CNT) were synthesized by an impregnation method for aqueous-phase hydrogenation of FFA to obtain CPL. Various effects of reaction parameters such as, reaction solvent, reaction temperature, reaction time, and different loading amount of Ni over...

Human parainfluenza 3 and respiratory syncytial viruses detected in pangolins

Tengcheng Que, Jing Li, Yugan He, Panyu Chen, Wei Lin, Meihong He, Lei Yu, Aiqiong Wu, Luohao Tan, Yingjiao Li, Yanling Hu & Yigang Tong
Pangolins have gained increasing global attention owing to their public health significance as potential zoonotic hosts since the identification of SARS-CoV-2-related viruses in them. Moreover, these animals could carry other respiratory viruses. In this study, we investigated the virome composition of 16 pangolins that died in 2018 with symptoms of pneumonia using metagenomic approaches. A total of eight whole virus sequences belonging to the Paramyxoviridae or Pneumoviridae families were identified, including one human parainfluenza virus...

Facile in situ fabrication of a direct Z-scheme BiOCl/bismuth niobate heterojunction and its effective photodegradation of RhB

Huining Zhang, Yankui Xiao, Zhongyu Shi, Lihong Tian, Yuling Tang, Xingmao Liu, Yangyi Tian & Yan Lin
Bismuth-based photocatalytic technology has been a promising way to degrade contaminants in the aqueous system. In this work, a direct Z-scheme BiOCl/Bi3NbO7 heterojunction with a different molar ratio of Bi and Nb elements was fabricated through a facile in situ growth method. The structural and photoelectric characteristics of these as-prepared samples were investigated by SEM, XPS, TEM, XRD, BET, UV-vis DRS, PL, EIS and TPC. The photocatalytic activity was evaluated by the degradation of RhB,...

First identification of human infection with Erysipelothrix Piscisicarius by metagenomic next-generation sequencing

Weifeng Huang, Dan Han, Qingqing Cai, Xiaoli Yi, Jin Tang, Yuan Fang & Yihan Lu
First identification of human infection with Erysipelothrix Piscisicarius by metagenomic next-generation sequencing

Clinical features of the first critical case of acute encephalitis caused by avian influenza A (H5N6) virus

Libing Zhang, Kaituo Liu, Qin Su, Xiao Chen, Xiaoquan Wang, Qingfeng Li, Wenlei Wang, Xuhua Mao, Jinmei Xu, Xin Zhou, Qin Xu, Le Zhou, Xiufan Liu & Pinghu Zhang
Highly pathogenic avian influenza virus (HPAIV) such as H5N1, H5N6, and H7N9 have been reported to frequently infect human, but acute encephalitis caused by HPAIV in human have been rarely reported. We report the first critical case of acute encephalitis with mild pneumonia caused by H5N6 virus. On January 25 of 2022, a 6-year-old girl with severe neurological symptoms was admitted to our hospital and rapidly developed to seizures and coma. Brain imaging showed abnormalities....

Pediatric and adult asthma clinical phenotypes: a real world, big data study based on acute exacerbations

Jie Xu, Jiang Bian & Jennifer N Fishe
Asthma is a heterogeneous disease with a range of observable phenotypes. To date, the characterization of asthma phenotypes is mostly limited to allergic versus non-allergic disease. Therefore, the aim of this big data study was to computationally derive asthma subtypes from the OneFlorida Clinical Research Consortium We obtained data from 2012-2020 from the OneFlorida Clinical Research Consortium. Longitudinal data for patients greater than two years of age who met inclusion criteria for an asthma exacerbation...

Artifact for \"Coverage Guided Fault Injection for Cloud Systems\", accepted at ICSE 2023

Yu Gao, Wensheng Dou, Dong Wang, Wenhan Feng, Jun Wei, Hua Zhong & Tao Huang
This artifact bundles all evaluation resources related to the paper: Yu Gao, Wensheng Dou, Dong Wang, Wenhan Feng, Jun Wei, Hua Zhong, Tao Huang. 2023. Coverage Guided Fault Injection for Cloud Systems. In 45th International Conference on Software Engineering (ICSE '23).
The full package contains: source code of our tool, tool used to run the experiments, scripts used in our experiments. Moreover, we provide .md files with guides on how to set up and...

The causal relationship between Thyroid function and Lung cancer: A mendelian randomization study

Xinhui Wang, Xue Liu, Jie Yuan, Huizhi Zhou, Yuyao Wang, Guoyu Tian, Xueying Liu, Mulin Tang, Xue Meng, Yuchen Li, Yuwei Chai, Chunjia Kou, Qingqing Yang, Juyi Li, Li Zhang & Haiqing Zhang
The role of thyroid hormones in tumors has been discussed in observational studies; however, the causal relationship between them remains controversial. Six different Mendelian randomization (MR) Methods, including Inverse variance weighted (IVW), MR-Egger, Simple mode, MR-Pleiotropy Residual Sum and Outlier methods (MR-PRESSO), Weighted mode and Weighted median were used to Two-Sample MR analysis. Our research shows that hypothyroidism genetically has a protective causal association with lung cancer.

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  • Capital Medical University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Shanghai Jiao Tong University
  • Zhejiang University
  • Sichuan University
  • Huazhong University of Science and Technology
  • University of Chinese Academy of Sciences
  • Fudan University
  • Shandong University
  • Sun Yat-sen University