Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-κB pathway

Shuai Mao, Lei Wang, Peipei Chen, Yong Lan, Rui Guo & Minzhou Zhang
Online Resource published via Taylor & Francis
Our previous works have shown that tanshinone IIA inhibited maladaptive extracellular matrix remodeling in cardiac fibroblasts implicating its potential role in treating of pathologic cardiac remodeling. However, the intrinsically poor solubility and bioavailability of tanshinone IIA hindered its clinical application. Here we develop monomethoxy-poly (ethylene glycol)-poly (lactic acid)-D-α-Tocopheryl polyethylene glycol 1000 succinate (mPEG-PLA-TPGS) nanoparticle incorporating tanshinone IIA (tanshinone IIA-NPs) and study its efficacy in post-infarction left ventricular (LV) remodeling. Male C57BL/6 mice underwent left coronary...
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https://doi.org/10.6084/m9.figshare.7165432.v1 Cite

Registration Year

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  • Charité - University Medicine Berlin
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  • Yunnan University
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  • Sun Yat-sen University
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  • Zhejiang University
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  • University of Washington
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  • Guangdong University of Foreign Studies
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  • Air Force Medical University
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  • Fudan University Shanghai Cancer Center
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  • The Ohio State University
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  • Henan Normal University
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