Plasma miRNA profile at COVID-19 onset predicts severity status and mortality
Asier Fernández-Pato, Ana Virseda-Berdices, Salvador Resino, Pablo Ryan, Oscar Martínez-González, Felipe Peréz-García, María Martin-Vicente, Daniel Valle-Millares, Oscar Brochado-Kith, Rafael Blancas, Amalia Martínez, Francisco C. Ceballos, Sofía Bartolome-Sánchez, Erick Joan Vidal-Alcántara, David Alonso, Natalia Blanca-López, Ignacio Ramirez Martinez-Acitores, Laura Martin-Pedraza, María Ángeles Jiménez-Sousa & Amanda Fernández-Rodríguez
MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic biomarkers of severity and survival. Plasma miRNome of 96 COVID-19 patients that developed asymptomatic/mild, moderate and severe disease was sequenced together with a group of healthy controls. Plasma immune-related biomarkers were...