Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway

Chengjian Zhou, Ping Li, Meihong Han & Xuejun Gao
Fat deposition in skeletal muscle is an important aspect of improving meat quality. Isoflavones can promote animal anabolism, but whether and how they regulate muscle fat deposition remain largely unclear. In this study, we explored the role and corresponding molecular mechanism of one of the major isoflavones, daidzein, in fat deposition in C2C12 myoblast cells. In the absence of fatty acids (FAs), daidzein did not promote triglyceride synthesis and lipid droplet formation in cells but...

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Affiliations

  • The First Affiliated Hospital of Jinzhou Medical University
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  • Capital Medical University
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  • Xi'an Jiaotong University
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  • Guangdong Provincial Hospital of Traditional Chinese Medicine
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  • Zhongda Hospital Southeast University
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  • Nanjing University
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  • China Pharmaceutical University
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  • Beijing Institute of Technology
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  • Shanghai Jiao Tong University
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  • Wuhan Business University
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