Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry

Objectives To estimate the attack rates, and identify the risk factors of COVID-19 infection. Methods Based on a retrospective cohort study, we investigated 11,580 contacts of COVID-19 cases in Guangdong Province from January 10 to March 15, 2020. All contacts were tested by RT-PCR to detect their infection of SARS-COV-2. Attack rates by characteristics were calculated, and logistic regression was used to estimate the risk factors of infection for COVID-19. Results A total of 515...

Background: Critically ill patients with COVID-19 are of grave concern. Those patients usually underwent a stage of excessive inflammation before developing acute respiratory distress syndrome. In this study, we test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit patients when used in the early phase of excessive inflammation namely, the therapeutic window. Methods: Among a Shanghai cohort and a validation cohort, we enrolled COVID-19 patients showing marked radiographic progression. Short-term, low-to-moderate-dose corticosteroids were considered for...