3,843 Works

Epidemiologisches Bulletin 06 / 2005

Robert Koch-Institut

Measuring adolescents' HRQoL via self reports and parent proxy reports: an evaluation of the psychometric properties of both versions of the KINDL-R instrument

Michael Erhart, Ute Ellert, Bärbel-Maria Kurth & Ulrike Ravens-Sieberer
Background: Several instruments are available to assess children's health-related quality of life (HRQoL) based on self reports as well as proxy reports from parents. Previous studies have found only low-to-moderate agreement between self and proxy reports, but few studies have explicitly compared the psychometric qualities of both. This study compares the reliability, factorial validity and convergent and known group validity of the self-report and parent-report versions of the HRQoL KINDL-R questionnaire for children and adolescents....

Tick-borne encephalitis in Europe, 2007 to 2009

Oliver Donoso Mantke, Camille Escadafal, Matthias Niedrig & M. Pfeffer
As a follow-up of a retrospective survey on tick borneencephalitis (TBE) in 2008, the European Network for Diagnostics of “Imported” Viral Diseases launched a new survey in 2010, to collect broader information on TBE prevalence between 2007 and 2009 and to observe possible changes compared to the previous data. A two-part questionnaire was mailed to contact points in all European Union (EU) Member States and four non-EU countries (Bosnia and Herzegovina, Norway, Russia, and Switzerland)....

Male-mediated gene flow in patrilocal primates.

Grit Schubert, Colin J. Stoneking, Mimi Arandjelovic, Christophe Boesch, Nadin Eckhardt, Gottfried Hohmann, Kevin Langergraber, Dieter Lukas & Linda Vigilant
Background: Many group–living species display strong sex biases in dispersal tendencies. However, gene flow mediated by apparently philopatric sex may still occur and potentially alters population structure. In our closest living evolutionary relatives, dispersal of adult males seems to be precluded by high levels of territoriality between males of different groups in chimpanzees, and has only been observed once in bonobos. Still, male–mediated gene flow might occur through rare events such as extra–group matings leading...

A novel human polyomavirus closely related to the African green monkey-derived lymphotropic polyomavirus (LPV)

Nelly Scuda, Jörg Hofmann, Sébastien Calvignac, Klemens Ruprecht, Peter Liman, Joachim Kühn, Hartmut Hengel & Bernhard Ehlers
A novel human polyomavirus was identified with generic PCR in a kidney transplant patient under immunosuppressive treatment. Its genome was completely amplified and sequenced. In phylogenetic analyses it appeared as the closest relative to the African green monkey-derived lymphotropic polyomavirus (LPV). Further investigation of clinical samples from immunocompromised patients with specific nested PCR revealed additional positive samples indicating that the virus naturally infects humans. The virus was tentatively named Human Polyomavirus 9 (HPyV9). The previously...

Interspecies transmission of simian foamy virus in a natural predator-prey system

Fabian Leendertz, Florian Zirkel, Emmanuel Couacy-Hymann, Heinz Ellerbrok, Vladimir Morozov, Georg Pauli, Claudia Hedemann, Pierre Formenty, Siv Aina Jensen, Christophe Boesch & Sandra Junglen
Simian foamy viruses (SFV) are ancient retroviruses of primates and have coevolved with their host species for as many as 30 million years. Although humans are not naturally infected with foamy virus, infection is occasionally acquired through interspecies transmission from nonhuman primates. We show that interspecies transmissions occur in a natural hunter-prey system, i.e., between wild chimpanzees and colobus monkeys, both of which harbor their own species-specific strains of SFV. Chimpanzees infected with chimpanzee SFV...

Kinder und Jugendliche mit besonderem Versorgungsbedarf im Follow-up: Ergebnisse der KiGGS-Studie 2003 – 2012

Elvira Mauz, Roma Schmitz & Christina Poethko-Müller
Weltweit ist die Häufigkeit chronischer Erkrankungen bei Kindern stark angestiegen. Chronisch kranke Kinder und ihre Familien haben diagnoseübergreifend besondere Herausforderungen zu meistern. Dazu gehört ein erschwerter Übergang in das Erwachsenenalter mit veränderten Versorgungsbedingungen und Zuständigkeiten. An einer Untergruppe der KiGGS-Kohorte wird untersucht, welche Chance chronisch kranke Kinder und Jugendliche haben, im jungen Erwachsenenalter ein Leben zu führen, ohne sich chronisch krank oder gesundheitsbedingt eingeschränkt zu fühlen und zum anderen, welche Faktoren mit einem ungünstigen Verlauf...

Epidemiologisches Bulletin 19 / 2001

Robert Koch-Institut

Participation in health behaviour change programmes

Susanne Jordan & Elena Von Der Lippe
Health behaviour change programmes to promote healthy behaviours are aimed at, among other things, counteracting the emergence of widespread non-communicable diseases. Which population groups use these programmes? This analysis is based on data from DEGS1, which was conducted from 2008–2011. People aged 18–79 years were asked about their participation in programmes in the last 12 months in the fields of nutrition, physical activity and relaxation (n=7,807). The analysis was stratified by sex, age, socioeconomic status...

Zum Zusammenhang zwischen körperlicher Aktivität und Gesundheit bei Kindern und Jugendlichen

Susanne Krug, Darko Jekauc, Christina Poethko-Müller, Alexander Woll & Martin Schlaud
Aufgrund des zunehmend diskutierten Gesundheitszustandes von Kindern und Jugendlichen sowie der veränderten Bewegungswelt ist die Frage nach der Wirkung körperlicher Aktivität auf Gesundheitsaspekte von großer Bedeutung. Der Kinder- und Jugendgesundheitssurvey (KiGGS) des Robert Koch-Instituts liefert erstmals bundesweit repräsentative Querschnittdaten zum Zusammenhang zwischen Gesundheit und körperlicher Aktivität. Unter Berücksichtigung soziodemografischer Faktoren legen die Ergebnisse einen positiven Zusammenhang zwischen allgemeinem Gesundheitszustand und verschiedenen Arten der körperlichen Aktivität nahe. Die Ergebnisse variieren dabei hinsichtlich Geschlecht und Art der...

Molecular characterization of blaNDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007

Yvonne Pfeifer, Gottfried Wilharm, Esther Zander, Thomas A. Wichelhaus, Stefan Göttig, Klaus-Peter Hunfeld, Harald Seifert, Wolfgang Witte & Paul G. Higgins
Objectives: To investigate the genetic environment of the metallo-β-lactamase gene blaNDM-1 in an Acinetobacter baumannii isolated in 2007 in a German hospital. Methods: Antimicrobial susceptibility testing was performed and resistance genes were characterized by PCR amplification and sequencing. Transferability of β-lactam resistance was tested by broth mating assays and transformation of plasmids. The genetic background of blaNDM-1 was analysed by primer walking. Typing of the A. baumannii strain was performed by repetitive extragenic palindromic sequence-based...

Epidemiologisches Bulletin 13 / 2000

Robert Koch-Institut

Epidemiologisches Bulletin 22 / 2005

Robert Koch-Institut

Epidemiologisches Bulletin 19 / 2012

Robert Koch-Institut

Frequency and impact of confounding by indication and healthy vaccinee bias in observational studies assessing influenza vaccine effectiveness: a systematic review

Cornelius Remschmidt, Ole Wichmann & Thomas Harder
Background: Evidence on influenza vaccine effectiveness (VE) is commonly derived from observational studies. However, these studies are prone to confounding by indication and healthy vaccinee bias. We aimed to systematically investigate these two forms of confounding/bias. Methods: Systematic review of observational studies reporting influenza VE and indicators for bias and confounding. We assessed risk of confounding by indication and healthy vaccinee bias for each study and calculated ratios of odds ratios (crude/adjusted) to quantify the...

Immunisation with foamy virus Bet fusion proteins as novel strategy for HIV-1 epitope delivery

Michael Mühle, Kerstin Hoffmann, Martin Löchelt & Joachim Denner
The induction of 2F5- and 4E10-like antibodies broadly neutralising HIV-1 and targeting the membrane external proximal region (MPER) of the transmembrane envelope protein gp41 would be a major advancement for the development of a preventive HIV-1 vaccine, but successful attempts remain rare. Recent studies demonstrated that broadly reactive antibodies develop relatively late during infection and after intensive affinity maturation. Therefore, a prolonged antigen delivery might be beneficial to induce them. Replicating foamy viruses which are...

Predominance of influenza A(H1N1)pdm09 virus genetic subclade 6B.1 and influenza B/Victoria lineage viruses at the start of the 2015/16 influenza season in Europe

E. Broberg, A. Melidou, Katarina Prosenc, K. Bragstad, Olav Hungnes, Brunhilde Schweiger, Marianne Wedde, Barbara Biere & Silke Buda
Influenza A(H1N1)pdm09 viruses predominated in the European influenza 2015/16 season. Most analysed viruses clustered in a new genetic subclade 6B.1, antigenically similar to the northern hemisphere vaccine component A/California/7/2009. The predominant influenza B lineage was Victoria compared with Yamagata in the previous season. It remains to be evaluated at the end of the season if these changes affected the effectiveness of the vaccine for the 2015/16 season.

Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus

Gudrun Leidig-Bruckner, Sonja Grobholz, Thomas Bruckner, Christa Scheidt-Nave, Peter Nawroth & Jochen G. Schneider
Background: Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type 1 and 2 diabetes. Methods: Three hundred and ninety-eight consecutive diabetic patients from a single outpatient clinic received a standardized questionnaire on osteoporosis risk factors, and were evaluated for diabetes-related complications, HbA1c levels, and lumbar spine (LS) and femoral neck (FN) BMD. Of these, 139...

Epidemiologisches Bulletin 25 / 2014

Robert Koch-Institut

RAMBO-K: Rapid and Sensitive Removal of Background Sequences from Next Generation Sequencing Data

Simon H. Tausch, Bernhard Y. Renard, Andreas Nitsche & Piotr Wojciech Dabrowski
Background: The assembly of viral or endosymbiont genomes from Next Generation Sequencing (NGS) data is often hampered by the predominant abundance of reads originating from the host organism. These reads increase the memory and CPU time usage of the assembler and can lead to misassemblies. Results: We developed RAMBO-K (Read Assignment Method Based On K-mers), a tool which allows rapid and sensitive removal of unwanted host sequences from NGS datasets. Reaching a speed of 10...

A novel Coltivirus-related virus isolated from free-tailed bats from Côte d’Ivoire is able to infect human cells in vitro

Sabrina Weiss, Piotr Wojtek Dabrowski, Andreas Kurth, Siv Aina J. Leendertz & Fabian H. Leendertz
Background: Zoonotic transmission events play a major role in the emergence of novel diseases. While such events are virtually impossible to predict, wildlife screening for potential emerging pathogens can be a first step. Driven by recent disease epidemics like severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and Ebola, bats have gained special interest as reservoirs of emerging viruses. Methods: As part of a bigger study investigating pathogens in African bats we screened...

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  • HU Berlin - Robert-Koch-Institut (RKI)