13,671 Works

The Aparnoi in Arsacid History

Marek Olbrycht
Marek Jan Olbrycht, The Aparnoi in Arsacid History, in: V. A. Alekshin, L.B. Kircho, Antiquities of Eastern Europe, Central Asia and Southern Siberia in the Context of Connections and Interactions in the Eurasian Cultural Space (new data and concepts): Proceedings of the International Conference, 18-22 November 2019, St. Petersburg. VOL. I. Ancient Central Asia in the context of Eurasian cultural space (new data and concepts). To the 90th anniversary of the birth of Vadim Mikhailovich...

The Aparnoi in Arsacid History

Marek Olbrycht
Marek Jan Olbrycht, The Aparnoi in Arsacid History, in: V. A. Alekshin, L.B. Kircho, Antiquities of Eastern Europe, Central Asia and Southern Siberia in the Context of Connections and Interactions in the Eurasian Cultural Space (new data and concepts): Proceedings of the International Conference, 18-22 November 2019, St. Petersburg. VOL. I. Ancient Central Asia in the context of Eurasian cultural space (new data and concepts). To the 90th anniversary of the birth of Vadim Mikhailovich...

MITHRADATES I OF PARTHIA AND INDIA

Marek Olbrycht
Marek Jan Olbrycht, MITHRADATES I OF PARTHIA AND INDIA, in: Luisa Prandi (ed.), EstOvest. Confini e conflitti fra Vicino Oriente e mondo Greco-Romano - Roma : «L’ERMA» di BRETSCHNEIDER, 2019 (Monografie / Centro ricerche e documentazione sull’antichità classica 46), 243-251.
https://www.torrossa.com/en/resources/an/4493910
http://digital.casalini.it/4493910

MITHRADATES I OF PARTHIA AND INDIA

Marek Olbrycht
Marek Jan Olbrycht, MITHRADATES I OF PARTHIA AND INDIA, in: Luisa Prandi (ed.), EstOvest. Confini e conflitti fra Vicino Oriente e mondo Greco-Romano - Roma : «L’ERMA» di BRETSCHNEIDER, 2019 (Monografie / Centro ricerche e documentazione sull’antichità classica 46), 243-251.
https://www.torrossa.com/en/resources/an/4493910
http://digital.casalini.it/4493910

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Minette Henriksson
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Minette Henriksson
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Niklas Brinkfeldt
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Niklas Brinkfeldt
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Molecular modeling studies of pyrrolo[2,3-d]pyrimidin-4-amine derivatives as JAK1 inhibitors based on 3D-QSAR, molecular docking, molecular dynamics (MD) and MM-PBSA calculations.

Seketoulie Keretsu, Swapnil P. Bhujbal & Seung Joo Cho
Rheumatoid Arthritis (RA) is an autoimmune disease caused by overproduction of pro-inflammatory cytokines. Janus Kinases (JAKs) mediate cytokines signaling through the Janus Kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways. Clinical studies have shown that Janus kinase 1 (JAK1) mediated signaling plays a key role in synovial response in rheumatoid arthritis. Hence, the inhibition JAK1 is considered as an important therapeutic route for treatment of rheumatoid arthritis. In this study, we have performed...

From normal to competo-allosteric regulation: Insights into the binding pattern dynamics of DSPI protein of Pseudomonas aeruginosa

Naila Zaman & Syed Sikander Azam
DSPI, a putative enoyl-coenzyme A (CoA) hydratase/isomerase, is anticipated to be involved in the synthesis of cis-2-decenoic acid (CDA), a quorum sensing (QS) signal molecule present in the superbug Pseudomonas aeruginosa. The current study not only adapts a broad-spectrum strategy for the lucid design of small molecule modulators but also provides novel allosteric inhibitors for DSPI, to investigate its function and potential as a therapeutic target. Docking analysis revealed that the compound 10252273, bound to...

In-silico profiling and structural insights into the impact of nSNPs in the P. falciparum acetyl-CoA transporter gene to understand the mechanism of drug resistance in malaria

Rahila Sardar, Nidhi Katyal, Shahzaib Ahamad, Dhananjay D. Jade, Shakir Ali & Dinesh Gupta
The continuous emergence of resistance to the available drugs poses major constraints in the development of effective therapeutics against Malaria. The Malaria drug resistance has been attributed to be the manifestation of numerous factors. For example, mutations in the parasite transporter protein acetyl-CoA transporter (Pfact) can remarkably affect its uptake affinity for a drug molecule against malaria, and hence enhance its susceptibility to resistance. To identify major contributors to its loss of functionality, we have...

The performance of the single-walled carbon nanotube covalently modified with polyethylene glycol to delivery of Gemcitabine anticancer drug in the aqueous environment

Heidar Moradnia, Heidar Raissi & Mahnaz Shahabi
A computational investigation of Gemcitabine drug adsorption on the single-walled carbon nanotube covalently modified with polyethylene glycol in a series of the configurations is studied using density functional theory calculations. It is observed that O…H hydrogen bonds are the dominating intermolecular interactions during the complex formation between anti-cancer drug and the nanotube. The studied hydrogen bonded complexes are treated theoretically to elucidate the nature of the intermolecular hydrogen bonds, geometrical structures, the binding energy and...

The performance of the single-walled carbon nanotube covalently modified with polyethylene glycol to delivery of Gemcitabine anticancer drug in the aqueous environment

Heidar Moradnia, Heidar Raissi & Mahnaz Shahabi
A computational investigation of Gemcitabine drug adsorption on the single-walled carbon nanotube covalently modified with polyethylene glycol in a series of the configurations is studied using density functional theory calculations. It is observed that O…H hydrogen bonds are the dominating intermolecular interactions during the complex formation between anti-cancer drug and the nanotube. The studied hydrogen bonded complexes are treated theoretically to elucidate the nature of the intermolecular hydrogen bonds, geometrical structures, the binding energy and...

Correlation of structure, function and protein dynamics in myoglobins from Eurasian woodcock, chicken and ostrich.

Sara Ragucci, Alessio Ruggiero, Rosita Russo, Nicola Landi, Mariangela Valletta, Angela Chambery, Luigi Russo & Antimo Di Maro
Myoglobin (Mb), oxygen-binding heme-protein retrieved primarily in muscles, is a local oxygen reservoir providing to oxygen when oxygen delivery is insufficient during catabolism. Furthermore, Mb structure is studied as example of molecular evolution for its ability to respond to environmental pressures and adapt to it through few amino acid substitutions. Here, in order to explore the structure-function-dynamics relationships of Eurasian woodcock chicken and ostrich Mbs we have applied an integrated approach in which spectroscopic and...

Correlation of structure, function and protein dynamics in myoglobins from Eurasian woodcock, chicken and ostrich.

Sara Ragucci, Alessio Ruggiero, Rosita Russo, Nicola Landi, Mariangela Valletta, Angela Chambery, Luigi Russo & Antimo Di Maro
Myoglobin (Mb), oxygen-binding heme-protein retrieved primarily in muscles, is a local oxygen reservoir providing to oxygen when oxygen delivery is insufficient during catabolism. Furthermore, Mb structure is studied as example of molecular evolution for its ability to respond to environmental pressures and adapt to it through few amino acid substitutions. Here, in order to explore the structure-function-dynamics relationships of Eurasian woodcock chicken and ostrich Mbs we have applied an integrated approach in which spectroscopic and...

In Silico Identification and Evaluation of Bacillus subtilis Cold Shock Protein B (cspB)-like Plant RNA Chaperones

Suman , Meenakshi Chaudhary & Vikrant Nain
Cold shock domain (CSD) proteins with nucleic acid binding properties are well conserved from bacteria to higher organisms. In bacteria, the cold shock proteins (CSPs) are single domain RNA chaperones, whereas in animals and plants, CSDs are accompanied by additional domains with roles in transcription regulation. Bacterial CSPs (Escherischia coli-cspA and Bacilus subtilis-cspB) have successfully imparted drought tolerance in transgenic plants; however, these cannot be deployed in food crops due to their low public acceptance...

In Silico Identification and Evaluation of Bacillus subtilis Cold Shock Protein B (cspB)-like Plant RNA Chaperones

Suman , Meenakshi Chaudhary & Vikrant Nain
Cold shock domain (CSD) proteins with nucleic acid binding properties are well conserved from bacteria to higher organisms. In bacteria, the cold shock proteins (CSPs) are single domain RNA chaperones, whereas in animals and plants, CSDs are accompanied by additional domains with roles in transcription regulation. Bacterial CSPs (Escherischia coli-cspA and Bacilus subtilis-cspB) have successfully imparted drought tolerance in transgenic plants; however, these cannot be deployed in food crops due to their low public acceptance...

Supplementary File.docx

Neyanzhou Neyanzhou
1. Huamin Zhou, Huan Li, Jingjing Cao, Binyan Wang, Huiyuan Guo, Yun Song, Lishun Liu, Chengzhang Liu, Di Xie, Jing Nie, Ming Liang, Xiaobin Wang, Yong Huo, Hao Zhang, Xiping Xu, and Xianhui Qin. Data from: Plasma 25-hydroxyvitamin D3 concentrations and risk of new-onset proteinuria in hypertensive patients. Figshare. Deposited 21 January 2020

Supplementary File.docx

Neyanzhou Neyanzhou
1. Huamin Zhou, Huan Li, Jingjing Cao, Binyan Wang, Huiyuan Guo, Yun Song, Lishun Liu, Chengzhang Liu, Di Xie, Jing Nie, Ming Liang, Xiaobin Wang, Yong Huo, Hao Zhang, Xiping Xu, and Xianhui Qin. Data from: Plasma 25-hydroxyvitamin D3 concentrations and risk of new-onset proteinuria in hypertensive patients. Figshare. Deposited 21 January 2020

Material Suplementari 7.xlsx

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Material Suplementari 7.xlsx

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Material Suplementari 10.xlsx

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Material Suplementari 10.xlsx

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