14,313 Works

Antiviral Activity of Bacterial Extracellular Ribonuclease Against Single-, Double-Stranded RNA and DNA Containing Viruses in Cell Cultures

Raihan Shah Mahmud
Antiviral Activity of Bacterial Extracellular Ribonuclease Against Single-, Double-Stranded RNA and DNA Containing Viruses in Cell Cultures (Article)
Raihan Shah Mahmud, Marina Efimova, Ahmed Mostafa, Vera Ulyanova & Olga Ilinskaya
BioNanoScience volume 6, pages561–563 (2016)DOI 10.1007/s12668-016-0279-9
https://link.springer.com/article/10.1007/s12668-016-0279-9

Deciding between the Covariance Analytical Approach and the Change-Score Approach in Two Wave Panel Data

Carmen Köhler, Johannes Hartig & Christine Schmid
The manuscript focuses on effects in nonrandomized studies with two outcome measurement occasions and one explanatory variable, and in which groups already differ at the pretest. Such study designs are often encountered in educational and instructional research. Two prominent approaches to estimate effects are (1) covariance analytical approaches and (2) latent change-score models. In current practice, both approaches are applied interchangeably, without a clear rationale for when to use which approach. The aim of this...

Hydration thermodynamics of cytosolic phospholipase A2 IVA predict its membrane-associated parts and its highly hydrated binding site

Sofia Vasilakaki, Johannes Kraml, Michael Schauperl, Klaus R. Liedl & George Kokotos
During biological events, the water molecules associated with the protein are re-oriented to adapt to the new conditions, inducing changes in the system’s free energy. The characterization of water structure and thermodynamics may facilitate the prediction of certain biological events, such as the binding of a ligand and the membrane-associated parts of a protein. In this computational study, we calculated the hydration thermodynamics of cytosolic phospholipase A2 group IV (GIVA cPLA2) to study the hydration...

Hydration thermodynamics of cytosolic phospholipase A2 IVA predict its membrane-associated parts and its highly hydrated binding site

Sofia Vasilakaki, Johannes Kraml, Michael Schauperl, Klaus R. Liedl & George Kokotos
During biological events, the water molecules associated with the protein are re-oriented to adapt to the new conditions, inducing changes in the system’s free energy. The characterization of water structure and thermodynamics may facilitate the prediction of certain biological events, such as the binding of a ligand and the membrane-associated parts of a protein. In this computational study, we calculated the hydration thermodynamics of cytosolic phospholipase A2 group IV (GIVA cPLA2) to study the hydration...

Protein binding and antioxidant studies of diimine based emissive surfactant–ruthenium(II) complexes

S. Nehru, S. Veeralakshmi, S. Kalaiselvam, S. P. Subin David, J. Sandhya & S. Arunachalam
Biophysical interaction of amphiphilic fluorescent surfactant–ruthenium(II) complexes and its precursor ruthenium(II) complexes with drug carrying proteins such as bovine and human serum albumins (BSA and HSA) have been studied through the UV-visible absorption, fluorescence and circular dichroism spectroscopic techniques to correlate the impact of head and tail groups of the metallosurfactants towards the designing of metallodrugs for the biomedical applications. The obtained results showed that both precursor– and surfactant–ruthenium(II) complexes interact with BSA/HSA via ground...

Protein binding and antioxidant studies of diimine based emissive surfactant–ruthenium(II) complexes

S. Nehru, S. Veeralakshmi, S. Kalaiselvam, S. P. Subin David, J. Sandhya & S. Arunachalam
Biophysical interaction of amphiphilic fluorescent surfactant–ruthenium(II) complexes and its precursor ruthenium(II) complexes with drug carrying proteins such as bovine and human serum albumins (BSA and HSA) have been studied through the UV-visible absorption, fluorescence and circular dichroism spectroscopic techniques to correlate the impact of head and tail groups of the metallosurfactants towards the designing of metallodrugs for the biomedical applications. The obtained results showed that both precursor– and surfactant–ruthenium(II) complexes interact with BSA/HSA via ground...

National Socialist Black Metal and the Justification for Hate: The Example of Polish band Graveland

Ryan Buesnel
Paper presented at Adelaide University Department of History 'Western Civilisation in the Twenty-First Century' Conference, 21st February 2020.
Abstract: 'National Socialist Black Metal' (NSBM) emerged as a heavy metal subculture in the early 1990s and continues to flourish as an outlet for racist and extremist ideologies. This paper will examine the history of the NSBM movement and will trace its thematic content as it relates to issues of race, cultural separateness and historical revisionism. Particular...

National Socialist Black Metal and the Justification for Hate: The Example of Polish band Graveland

Ryan Buesnel
Paper presented at Adelaide University Department of History 'Western Civilisation in the Twenty-First Century' Conference, 21st February 2020.
Abstract: 'National Socialist Black Metal' (NSBM) emerged as a heavy metal subculture in the early 1990s and continues to flourish as an outlet for racist and extremist ideologies. This paper will examine the history of the NSBM movement and will trace its thematic content as it relates to issues of race, cultural separateness and historical revisionism. Particular...

editorialia.com.jpg

Juan Antonio Lloret Egea
Es: | Publicación científico – técnica internacional sobre los estados de la Inteligencia Artificial | Eng: International scientific and technical publication on the states of Artificial Intelligence |

Service Dog Impact Evaluation

Tom COLEMAN
Service Dog Impact Evaluation. An independent, third-party evaluator examine the impact that Pawsitivity service dogs have on the people they serve, and using a rigorous qualitative evaluation method, describe the results. Conducted by Aurora Consulting, contracted by Pawsitivity Service Dogs (Executive Director Tom Coleman).

Service Dog Impact Evaluation

Tom COLEMAN
Service Dog Impact Evaluation. An independent, third-party evaluator examine the impact that Pawsitivity service dogs have on the people they serve, and using a rigorous qualitative evaluation method, describe the results. Conducted by Aurora Consulting, contracted by Pawsitivity Service Dogs (Executive Director Tom Coleman).

KDomdouzis SQL Booklet.pdf

Konstantinos Domdouzis
SQL University Lecture Material

KDomdouzis SQL Booklet.pdf

Konstantinos Domdouzis
SQL University Lecture Material

Varying–Coefficient Panel Data Models with Nonstationarity and Partially Observed Factor Structure

Chaohua Dong, Jiti Gao & Bin Peng
In this paper, we study a varying–coefficient panel data model with both nonstationarity and partially observed factor structure. Two approaches are proposed in this paper. The first approach proposed in the main text considers a sieve based method to estimate the unknown coefficients as well as the factors and loading functions simultaneously, while the second approach proposed in the online supplementary document involving the principal component analysis provides an alternative estimation method. We establish asymptotic...

Supplemental data_Hodzic et al.

Amir Hodzic, Francois Tournoux, Patrick Gendron, Odile Bonnefous, Eric Saloux, Paul Milliez & Hervé Normand
Supplemental methods and figure S1

Supplemental data_Hodzic et al.

Amir Hodzic, Francois Tournoux, Patrick Gendron, Odile Bonnefous, Eric Saloux, Paul Milliez & Hervé Normand
Supplemental methods and figure S1

editorialia.com.jpg

Juan Antonio Lloret Egea
Es: | Publicación científico – técnica internacional sobre los estados de la Inteligencia Artificial | Eng: International scientific and technical publication on the states of Artificial Intelligence |

RAP test report 210220.pdf

Karen Hytteballe Ibanez, Christina Steensboe, Nikoline Dohm Lauridsen & Mogens Sandfær
This report provides an overview of the two tests of DTU RAP that have been completed in the OPERA project. The report first summarizes the approach used for the tests and then presents the feedback from the test participants as well as the resulting changes to DTU RAP following each of the two tests.

RAP test report 210220.pdf

Karen Hytteballe Ibanez, Christina Steensboe, Nikoline Dohm Lauridsen & Mogens Sandfær
This report provides an overview of the two tests of DTU RAP that have been completed in the OPERA project. The report first summarizes the approach used for the tests and then presents the feedback from the test participants as well as the resulting changes to DTU RAP following each of the two tests.

Cultural influences on perception of disability and disabled people: a comparison of opinions from students in the United Kingdom (UK) Pakistan (PAK) about a generic wheelchair using a semantic differential scale

Salman Asghar, George Edward Torrens & Robert Harland
Assistive Technology (AT) product use occurs within a socio-cultural setting. The growth internationally in the AT product market suggests that designers need to be aware of the influences that diverse cultures may have on the societal perception of an AT product through its semantic attributes. The study aimed to evaluate the visual interaction with an AT product by young adults from Pakistan, a collectivist society, and the United Kingdom (UK), an individualist society. A paper-based...

A review of gait disorders in the elderly and neurological patients for robot-assisted training

Asim Ghaffar, Abbas A. Dehghani-Sanij & Sheng Quan Xie
Purpose: Ambulation is an important objective for people with pathological gaits. Exoskeleton robots can assist these people to complete their activities of daily living. There are exoskeletons that have been presented in literature to assist the elderly and other pathological gait users. This article presents a review of the degree of support required in the elderly and neurological gait disorders found in the human population. This will help to advance the design of robot-assisted devices...

Molecular docking, 3D-QSAR, and molecular dynamics simulations of thieno[3,2‑b]pyrrole derivatives against anticancer targets of KDM1A/LSD1

Xiangyu Zhang, Jiangkun Yan, Hanxun Wang, Ying Wang, Jian Wang & Dongmei Zhao
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme, which has been proposed as a promising target for anticancer drug development. Extensive research on LSD1 inhibitors has been performed since its discovery. In order to get more information for lead identification and optimization, we carried out a molecular modeling study on a set of 43 thieno[3,2‑b]pyrrole competitive inhibitors of LSD1 using three-dimensional quantitative structure-activity relationship (3D-QSAR), molecular docking and molecular dynamics (MD) simulations. Based...

Carbon fullerene act as potential lead molecule against prospective molecular targets of biofilm-producing multi-drug resistant Acinetobacter baumanni and Pseudomonas aerugenosa: Computational modeling and MD simulation studies

Sinosh Skariyachan, Dharshini Gopal, Sanjana Pratab Kadam, Aditi G Muddebihalkar, Akshay Uttarkar & Vidya Niranjan
This study aimed to screen putative drug targets associated with biofilm formation of multidrug-resistant Acinetobacter baumannii and Pseudomonas areugenosa and prioritize carbon nano-fullerene as potential lead molecule by structure-based virtual screening. Based on the functional role, 36 and 83 genes that are involved in biofilm formation of A. baumannii and P. areugenosa respectively were selected and metabolic network was computationally constructed. The genes that lack three-dimensional structures were predicted and validated. Carbon nano-fullerene selected as...

Structural Facets of POU2F1 in Light of the Functional Annotations and Sequence-Structure Patterns

Ashmita Dey, Sagnik Sen, Vladimir N. Uversky & Ujjwal Maulik
POU domain class 2 homebox 1 or POU2F1 is broadly known as an important transcription factor. Due to its association with different types of malignancies, POU2F1 became one of the key factors in pancancer analysis. However, in spite of considering this protein as a potential drug target, none of the drug targeting POU2F1 has been designed as of yet due to the extreme structural flexibility of this protein. In this article, we have proposed a...

Structural Facets of POU2F1 in Light of the Functional Annotations and Sequence-Structure Patterns

Ashmita Dey, Sagnik Sen, Vladimir N. Uversky & Ujjwal Maulik
POU domain class 2 homebox 1 or POU2F1 is broadly known as an important transcription factor. Due to its association with different types of malignancies, POU2F1 became one of the key factors in pancancer analysis. However, in spite of considering this protein as a potential drug target, none of the drug targeting POU2F1 has been designed as of yet due to the extreme structural flexibility of this protein. In this article, we have proposed a...

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