14,192 Works

Study of means to reduce the effects of methane-air dust explosions in underground coal mine drifts

Yurii Skob
Study of means to reduce the effects of methane-air dust explosions in underground coal mine drifts

Study of means to reduce the effects of methane-air dust explosions in underground coal mine drifts

Yurii Skob
Study of means to reduce the effects of methane-air dust explosions in underground coal mine drifts

Empowering of Women in the World Economy

Gia Mosashvili
Abkhazia is a breakaway region of Georgia with 240, 000 population (Freedom House. 2018). Ethnic Abkhazians firstly expanded over western Georgia in the ninth century and soon integrated in Sakartvelo with ethnic Georgians. There were no any interstate disputes between Abkhazians and Georgians during long-term history. But bilateral relations changed after the Soviet Union’s national building policy, when Soviet authorities started creating of a national identity and wrote down languages for people, with none-written languages....

Apremilast: A Review in Oral Ulcers of Behçet’s Disease

Emma D Deeks
Compliance with Ethical Standards Disclosure: The preparation of this review was not supported by any external funding.Conflicts of interest: Emma Deeks is a salaried employees of Adis International Ltd/Springer Nature, is responsible for the article content and declares no relevant conflicts of interest. Additional information about this Adis Drug Review can be found here AbstractThe oral phosphodiesterase 4 inhibitor apremilast (Otezla®) is indicated for the treatment of oral ulcers associated with Behçet’s disease in some...

Apremilast: A Review in Oral Ulcers of Behçet’s Disease

Emma D Deeks
Compliance with Ethical Standards Disclosure: The preparation of this review was not supported by any external funding.Conflicts of interest: Emma Deeks is a salaried employees of Adis International Ltd/Springer Nature, is responsible for the article content and declares no relevant conflicts of interest. Additional information about this Adis Drug Review can be found here AbstractThe oral phosphodiesterase 4 inhibitor apremilast (Otezla®) is indicated for the treatment of oral ulcers associated with Behçet’s disease in some...

Spanish Language Influence on English Language and Vice Versa

Gia Mosashvili
In Linguistics, mutual influence of languages is the most actual issue. In this way, influence of Spanish language on English and vice versa is an obvious example. Both languages have huge numbers of native speakers. They are both spoken as native or official languages over the vast geographical areas which cover a large number of countries. They are both official languages of the United Nations and many other international organizations. Subsequently, features of these languages...

Crizanlizumab: First Approval

Hannah A. Blair
Compliance with Ethical StandardsFunding The preparation of this review was not supported by any external funding.Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Hannah A. Blair is a salaried employee of Adis International Ltd/Springer Nature, is responsible for the article...

Crizanlizumab: First Approval

Hannah A. Blair
Compliance with Ethical StandardsFunding The preparation of this review was not supported by any external funding.Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Hannah A. Blair is a salaried employee of Adis International Ltd/Springer Nature, is responsible for the article...

Calculation and measurement of the three-dimensional flow in axial compressor cascades, with and without end-bends

Yurii Skob, Mykhaylo Ugryumov, Vasiliy Menshikov & V.I. Pismenniy
Calculation and measurement of the three-dimensional flow in axial compressor cascades with and without end-bends

Calculation and measurement of the three-dimensional flow in axial compressor cascades, with and without end-bends

Yurii Skob, Mykhaylo Ugryumov, Vasiliy Menshikov & V.I. Pismenniy
Calculation and measurement of the three-dimensional flow in axial compressor cascades with and without end-bends

Méthodologie pour la validation du simulateur de voilier par des essais en mer, une première tentative

Kostia RONCIN, Jean-Michel Kobus, Paul Iachkine & Sophie Barré
La réalisation du simulateur a été motivée par la perspective de son utilisation à des fins sportives. L'objectif est de disposer d'un outil d'analyse tactique et stratégique afin d'apporter des réponses quantifiées aux questions des coureurs. La dernière partie de cet article présente un exemple du type de réponse que peut apporter le simulateur pour l'évaluation de scenarii tactiques. Pour que ces réponses soient pertinentes, il faut que le simulateur soit validé par des essais...

Méthodologie pour la validation du simulateur de voilier par des essais en mer, une première tentative

Kostia RONCIN, Jean-Michel Kobus, Paul Iachkine & Sophie Barré
La réalisation du simulateur a été motivée par la perspective de son utilisation à des fins sportives. L'objectif est de disposer d'un outil d'analyse tactique et stratégique afin d'apporter des réponses quantifiées aux questions des coureurs. La dernière partie de cet article présente un exemple du type de réponse que peut apporter le simulateur pour l'évaluation de scenarii tactiques. Pour que ces réponses soient pertinentes, il faut que le simulateur soit validé par des essais...

Metformin-related lactic acidosis with acute kidney injury: results of a French observational multicenter study

Anthony Corchia, Alain Wynckel, Julien Journet, Julie Moussi Frances, Nihel Skandrani, Alexandre Lautrette, Lara Zafrani, Elisabeth Lewandowski, Pascal Reboul, Laurence Vrigneaud, Zoubir Djerada & Philippe Rieu
Background: Metformin-associated lactic acidosis (MALA) and metformin-induced lactic acidosis (MILA) remain controversial entities. Metformin toxic effect depends on accumulation to lead to lactic acidosis (LA), particularly during an episode of acute kidney injury (AKI). In MILA, no other condition contributing to LA is found. The aims of this study were to describe the characteristics and prognosis of AKI associated with LA in metformin users and to clarify the role of this drug in the different...

Mathematical Models, Methods and Improvement Technology of the Turbomachinery Rows

Mykhaylo Ugryumov, Yurii Skob, V.V. Constantinov, V.I. Pismenniy & A.V. Menyajlov
The authors develop an information model for three-dimensional viscous gas flow in axial turbomachine rows. This model provides a system solution to the problem of turbomachine row improvement. The improvement methodology, comprising a combination of matched methods, satisfies the basic principles of the system problem solution architecture. Calculation results are presented from an integrated computational study of the aerodynamic efficiency of prospective air engine compressor blade rows. The use of simplified mathematical models, effective numerical...

Mathematical Models, Methods and Improvement Technology of the Turbomachinery Rows

Mykhaylo Ugryumov, Yurii Skob, V.V. Constantinov, V.I. Pismenniy & A.V. Menyajlov
The authors develop an information model for three-dimensional viscous gas flow in axial turbomachine rows. This model provides a system solution to the problem of turbomachine row improvement. The improvement methodology, comprising a combination of matched methods, satisfies the basic principles of the system problem solution architecture. Calculation results are presented from an integrated computational study of the aerodynamic efficiency of prospective air engine compressor blade rows. The use of simplified mathematical models, effective numerical...

The gradient test and its finite sample size properties in a conditional maximum likelihood and psychometric modeling context

Clemens Draxler, Andreas Kurz & Artur J. Lemonte
In asymptotic theory, the gradient test proposed by Terrell is a recent likelihood-based hypothesis testing approach which can be considered as an alternative to the well-established trinity of likelihood ratio, Rao score, and Wald tests. The gradient test has not yet entered into the mainstream of applied statistics. This is particularly true for the psychometric context. This research discusses a novel application of the gradient test within the conditional maximum likelihood and the Rasch modeling...

The gradient test and its finite sample size properties in a conditional maximum likelihood and psychometric modeling context

Clemens Draxler, Andreas Kurz & Artur J. Lemonte
In asymptotic theory, the gradient test proposed by Terrell is a recent likelihood-based hypothesis testing approach which can be considered as an alternative to the well-established trinity of likelihood ratio, Rao score, and Wald tests. The gradient test has not yet entered into the mainstream of applied statistics. This is particularly true for the psychometric context. This research discusses a novel application of the gradient test within the conditional maximum likelihood and the Rasch modeling...

Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment

Guofei Li & Limei Zhao
Tumor microenvironment is closely related to the occurrence and development of liver cancer. Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment promoting tumor deterioration and metastasis by inhibiting immune cells. Previous studies showed that PI3Kγ inhibitor could reverse the phenotype of TAMs, relieve immunosuppression and sensitize chemotherapy drugs, suggesting that the combination of PI3Kγ inhibitor and chemotherapeutics is likely to bring new breakthroughs in the treatment of liver cancer. Based on it, this...

Photodynamic therapy – hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity

Nikola Plenagl, Lili Duse, Benjamin Sebastian Seitz, Nathalie Goergen, Shashank Reddy Pinnapireddy, Jarmila Jedelska, Jana Brüßler & Udo Bakowsky
Photodynamic therapy (PDT) is an established noninvasive tumor treatment. The hydrophobic natural occurring pigment hypericin shows a lot of attractive properties for the application in PDT. Hence, the administration to biological systems or patients requires the formulation in drug carriers enabling sufficient bioavailability. Therefore, free hypericin was encapsulated by the thin film hydration method or a hypericin-hydroxypropyl-β-cyclodextrin inclusion complex (Hyp-HPβCD) was incorporated by dehydration-rehydration vesicle method in either conventional or ultra-stable tetraether lipid (TEL) liposomes....

Transient blood–brain barrier disruption is induced by low pulsed electrical fields in vitro: an analysis of permeability and trans-endothelial electric resistivity

Shirley Sharabi, Yael Bresler, Orly Ravid, Chen Shemesh, Dana Atrakchi, Michal Schnaider-Beeri, Fabien Gosselet, Lucie Dehouck, David Last, David Guez, Dianne Daniels, Yael Mardor & Itzik Cooper
The blood–brain barrier (BBB) is limiting transcellular and paracellular movement of molecules and cells, controls molecular traffic, and keeps out toxins. However, this protective function is the major hurdle for treating brain diseases such as brain tumors, Parkinson’s disease, Alzheimer’s disease, etc. It was previously demonstrated that high pulsed electrical fields (PEFs) can disrupt the BBB by inducing electroporation (EP) which increases the permeability of the transcellular route. Our goal was to study the effects...

Surface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers

Livia P. Mendes, Can Sarisozen, Ed Luther, Jiayi Pan & Vladimir P. Torchilin
Modification of nanoparticle surfaces with PEG has been widely considered the gold standard for many years. However, PEGylation presents controversial and serious challenges including lack of functionality, hindered cellular interaction, allergic reactions, and stimulation of IgM production after repetitive dosing that accelerates blood clearance of the nanoparticles. We report the development of novel liposomal formulations surface-modified with a low molecular weight, branched polyethyleneimine (bPEI)–lipid conjugate for use as an alternative to PEG. The formulations had...

Identifying the key residues instrumental in imparting stability to amyloid beta protofibrils – a comparative study using MD simulations of 17-42 residues

Madhu Sudan Dutta & Soumalee Basu
Extracellular plaques, the hallmark of Alzheimer’s disease brains, consist of insoluble amyloid fibrils that result from the aggregation of amyloid beta peptides. None of the few therapeutic options currently adopted, address the cause of the disease. Instead, they reduce symptom of the disease. Inhibition of aggregation or destabilization of aggregates therefore, emerges as a preferable therapeutic approach. Designing inhibitors or destabilizers demands comprehensive knowledge of the residues of amyloid beta responsible for the phenomenal structural...

Combined adjustment of injection timing and compression ratio for an agricultural diesel engine fuelled with Nahar methyl ester

Santosh Kumar Dash, Pradip Lingfa & Debabrata Barik
This study investigates the effect of compression ratio (CR: 16, 17, standard 17.5, 18) and injection timing (IT: 21°CA, standard 23, 25°CA) of a single cylinder direct injection diesel engine having power output 3.5 kW at rated speed 1500 rpm fuelled by an optimal Nahar methyl ester blend (NME40). For NME40/CR18, the BTE is improved by 1.09% and EGT is lowered by 2.98% compared to NME40 at standard engine settings, at full load. The HC,...

Combined adjustment of injection timing and compression ratio for an agricultural diesel engine fuelled with Nahar methyl ester

Santosh Kumar Dash, Pradip Lingfa & Debabrata Barik
This study investigates the effect of compression ratio (CR: 16, 17, standard 17.5, 18) and injection timing (IT: 21°CA, standard 23, 25°CA) of a single cylinder direct injection diesel engine having power output 3.5 kW at rated speed 1500 rpm fuelled by an optimal Nahar methyl ester blend (NME40). For NME40/CR18, the BTE is improved by 1.09% and EGT is lowered by 2.98% compared to NME40 at standard engine settings, at full load. The HC,...

Dug-well vs. Tube-well.pdf

Avash Pandey
Understanding the technicalities of water quality in Bihar

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