3 Works

EVALUATION OF THE EFFECTS OF GLYCOSAMINOGLYCANS ON THE ACTIVITY OF CYSTEINE PROTEASE CATHEPSIN INHIBITORS

WAGNER ALVES DE SOUZA JÚDICE
Cathepsins B and L, cysteine ​​lysosomal proteases, are important targets in the development of a variety of therapeutic agents due to the involvement of these proteases in various disease conditions. They are associated with cancer progression due to the degradation capacity of the extracellular matrix, facilitating invasion, angiogenesis and metastasis, in addition to favoring viral replication in human cells. Studies suggest that GAGs play a key role in cell signaling, which serves to modulate a...

Effect of diet on the bacterial diversity of termite guts

Alberto Arab
A evolução da relação simbiótica com microrganismos permitiu aos cupins decompor a lignocelulose ingerida de substratos derivados de plantas, incluindo fezes de herbívoros e húmus. Entretanto, alguns aspectos da digestão da lignocelulose nos cupins que perderam evolutivamente a associação com protozoários (aqueles da família Termitidae) ainda são pouco conhecidos e constituem uma boa oportunidade para avaliar questões relacionadas à ecologia alimentar no contexto da evolução e adaptação desse grupo. O objetivo geral desta proposta é...

Spatial analysis of the vulnerability of water wells and aquifers in the Alto Tietê basin

Rodrigo Nehara
Groundwater is defined as waters located below ground level, which is considered an adequate source for supply, in addition to having advantages such as being a safe source in times of drought, excellent natural quality and great storage capacity in aquifers. However, contaminating activities of an anthropic nature directly affect their quality. One way to protect groundwater is to study, assess and know the vulnerability of the respective aquifers and water bodies, which guide the...

Registration Year

  • 2021
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Resource Types

  • Output Management Plan
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Affiliations

  • Universidade Federal do ABC
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  • Federal University of Sao Paulo
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  • Universidade de Mogi das Cruzes
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