270 Works

A PERFORMER’S GUIDE TO NORMAN BOLTER’S MORNING WALK FOR TROMBONE AND PIANO

Justin Croushore
For the past 45 years, Norman Bolter has been one of the most prolific and important composers, performers, and educators for the trombone. Born in Minnesota in 1955, Bolter held the position of Second Trombone of the Boston Symphony Orchestra and Principal Trombone of the Boston Pops from 1975 until 2009. He has taught at leading conservatories, universities, and festivals around the world and continues to teach as trombone faculty at the New England Conservatory...

Measuring Congestion for Strategic Highway Investment for Tomorrow (SHIFT) Implementation (PL-32)

Mei Chen, Xu Zhang, Fahmida Rahman, Jacob Brashear & Reginald R. Souleyrette
The Kentucky Transportation Cabinet (KYTC) has moved toward a data-driven decision-making process, the Strategic Highway Investment Formula for Tomorrow (SHIFT), to allocate funds for highway improvement projects. SHIFT requires that candidate projects be scored on five critical metrics: safety, asset management, congestion, economic growth, and benefit/cost analysis. The measure of congestion used in SHIFT 2018 was a combination of volume-to-service flow ratio (VSF) and design hourly volume (DHV). VSF is a traditional performance measure developed...

THE ROLE OF NEURAL PRECURSOR CELL EXPRESSED DEVELOPMENTALLY DOWN-REGULATED PROTEIN 9 IN ENHANCED AGGRESSIVENESS OF HEXAVALENT CHROMIUM TRANSFORMED BRONCHIAL EPITHELIAL CELLS

Peter Van Wie
Hexavalent chromium (Cr(VI)) is classified as a confirmed human carcinogen by the International Agency for Research and Cancer (IARC) and by the U.S. Environmental Protection Agency (EPA). Chronic exposure to (Cr(VI)) causes malignant cell transformation in human bronchial epithelial BEAS-2B cells. These Cr(VI)-transformed cells exhibit a highly aggressive phenotype including increased migration, invasion, and angiogenesis. The Cas family protein neuronal precursor developmentally down regulated protein 9 (NEDD9/Cas-L/HEF1) was dramatically overexpressed in Cr(VI)-transformed cells compared to...

Outsiders to Whom?

Kyle Eveleth
The study of young adult literature has become widespread within Children’s and Young Adult Literature specifically and literary studies as a whole. However, the term “young adult” which defines and focalizes both the literature itself and the ostensible readers for whom it is produced remains a poorly-examined area. The present study examines the creation of one branch of what we now call “young adult literature” from its roots in the United States in the early...

BARRIERS AND FACILITORS OF HEALTHCARE USE AMONG PEOPLE WHO INJECT DRUGS

Candice Kuns-Adkins
Hepatitis C Virus (HCV) is an infection that can have grave consequences when left untreated. Hepatitis C can be easily eradicated with direct acting antiviral therapy. People who inject drugs (PWID) and inmates are among those with the highest incidence of HCV. However, cure rates among this population remains low. This is, in part, related to an interruption in the HCV care cascade such that only 30% of PWID are linked to care and only...

GAY MEN AND SATISFACTION WITH HEALTH CARE INTERACTIONS

Michael Huggins
The purpose of this research was to determine relationships among depression, anxiety, self-rated physical and mental health, self-advocacy, internalized homophobia, and quality of patient-provider communication to satisfaction with health care interactions. These were measured while controlling for select demographic variables: age; ethnicity; urban or rural domicile; relationship status; household income; highest educational attainment; health insurance; disclosure to health care provider as a gay man; reason for last healthcare visit; and, general health self-rating. The specific...

NEUROPSYCHOLOGICAL CORRELATES OF STRIATAL DOPAMINERGIC DYSFUNCTION IN PARKINSON’S DISEASE

Brittany Walls
Parkinson’s disease (PD) is a common neurodegenerative disorder associated with dysfunction of the basal ganglia, which contributes to a range of motor, cognitive, and affective symptoms. Striatal dopaminergic deficits are one of the core pathological mechanisms thought to contribute to the extra-motor (i.e., cognitive and affective) symptoms in early PD. The present study investigated the relationship between striatal dopaminergic integrity and cognition in 21 patients with PD and 21 age and education matched controls. Each...

LOST & FOUND AN ELECTRO-ACOUSTIC MUSICAL COMPOSITION REFERENCING A DAY IN AN AFRICAN VILLAGE

George Essilfie
Electro-acoustic music composition makes it possible for composers to manipulate sounds with the computer with either alone or both live and prerecorded sounds. From the end of the 19th century when the first electronic devices for performing music were developed up till today, transformations in music technology keep surfacing and the possibilities with working with sounds have become endless. Electro-acoustic music has the ability to conjure mental images using vast sound manipulation techniques using the...

Extension of a Quaternary-Active Shear Zone across the Reelfoot Fault Stepover Arm

Brooks Rosandich
Many seismic hazard source parameters such as slip rate, total displacement, strain accommodation, geographic fault location, etc. are poorly constrained in the New Madrid seismic zone (NMSZ). This is in large part due to the masking effect of the thick Mississippi embayment sediment package on seismogenic structures and features. Consequently, much of the subsurface geologic characterization needed for understanding seismic hazard sources requires geophysical imaging. Recent seismic reflection surveys 12 km NE of the Reelfoot...

Safety Analysis for SHIFT Implementation

Reginald R. Souleyrette, Riana Tanzen, William Nicholas Staats, Eric R. Green & Mei Chen
The Strategic Highway Investment Formula for Tomorrow (SHIFT) program research team evaluated the program’s 2018 safety component and developed a new methodology to rank the safety needs of 2020 projects. For the current year, the research team suggests replacing the SHIFT 2018 formulas (based on three naive crash measures) with a new metric, Excess Expected Crashes, formulated from the most current safety analysis guidelines available in the Highway Safety Manual. In addition, the research team...

THE LINKS BETWEEN GULF OF MEXICO SEAFLOOR CHARACTERISTICS AND PETROLEUM HYDROCARBONS FOLLOWING THE DEEPWATER HORIZON OIL SPILL

Kimberly Schindler
The Gulf of Mexico (GoMx) is among the most productive regions for offshore oil and natural gas recovery. In 2010, the Deepwater Horizon (DWH) drilling rig exploded, burned for three days, sank, and released over 4 million barrels of oil in the subsequent 84 days before it was capped. Some oil was buoyant enough to float to the ocean surface, where some was removed via a myriad techniques. Importantly, a plume of oil remained suspended...

MODELING THE CONDENSED-PHASE BEHAVIOR OF Π-CONJUGATED POLYMERS

Walker Mask
It is well established that the morphology and physical properties of an organic semiconducting (OSC) material regulate its electronic properties. However, structure-function relationships remain difficult to describe in polymer-based OSC, which are of particular interest due to their robust mechanical properties. If relationships among the molecular and bulk levels of structure can be found, they can aid in the design of improved materials. To explore and detail important structure-function relationships in polymer-based OSC, this work...

Investigation of Thiol-Containing Biomarkers and Their Role in the Exposome

Tracy Gastineau-Stevens
Exposomics is an emerging area of study that looks at how the environment around a person or persons affects their overall health. Biomarkers have emerged as useful tools to better understand how the exposome affects a person. In this work, we investigate two potential endogenous biomarkers, homocysteine and glutathione that have been previously implicated in a number of diseases that have been linked to environmental causes. We also investigated an environmental exposure, the fungicide Ziram,...

Open Secrets, Congressional Oversight, and the Geopolitics of the CIA Drone Program

Marita C. Murphy
Analyzing four congressional hearings that publicly discuss the CIA’s ‘secret’ drone program, this thesis considers the interaction between publicity and secrecy in facilitating practices of later-modern warfare. Specifically, I examine the content of these drone hearings within the broader context of leaks, Obama administration speeches, and public interest in CIA drones to better understand how open secrecy engages with public oversight. I argue these hearings are deceptively productive. While they largely fail as oversight events,...

THE IMPACT OF MATERNAL NUTRITION DURING PREGNANCY ON INFLAMMATION AND BIRTH OUTCOMES

Lori Ogden
More than 85% of American adults do not consume recommended amounts of fruits or vegetables. Preterm birth and hypertensive disorders of pregnancy are common adverse conditions affecting pregnancy and are leading causes of maternal and fetal morbidity and mortality. Preterm birth affects nearly 10% of all births in the United States and is on the rise, as are hypertensive disorders, which have increased by 25% over the last two decades. Pregnancy is a state of...

But What Has Helga Crane to Do with the West Indies?

Rachel Carr
“But What Has Helga Crane to Do with the West Indies? Plantation Afterlives in the Black Atlantic” situates the emergence of the southern gothic in modernist American and Caribbean works as a response to the shifting cultural narrative of the plantation in the twentieth century. In this project, I argue that the plantation seeps out of its place and time to haunt landscapes it may never have touched and times in which slavery is long...

Multi-Scale Computational Studies of Calcium (Ca2+) Signaling

Bin Sun
Ca2+ is an important messenger that affects almost all cellular processes. Ca2+ signaling involves events that happen at various time-scales such as Ca2+ diffusion, trans-membrane Ca2+ transport and Ca2+-mediated protein-protein interactions. In this work, we utilized multi-scale computational methods to quantitatively characterize Ca2+ diffusion efficiency, Ca2+ binding thermodynamics and molecular bases of Ca2+-dependent protein-protein interaction. Specifically, we studied 1) the electrokinetic transport of Ca2+ in confined sub-µm geometry with complicated surfacial properties. We characterized the...

Modern Charity

Matthew Bryant Cheney
Scholars over the past two decades (Denning, Szalay, Edmunds, Robbins) have theorized the different ways literature of the Mid-Twentieth Century reflects the dawn of the liberal US welfare state. While these studies elaborate on the effect rapidly expanding public aid had on literary production of the period, many have tended to undervalue the lingering influence on midcentury storytelling of private charity and philanthropy, those traditional aid institutions fundamentally challenged by the Great Depression and historically...

Making Experts

Vaughn M. Krebs
“Makers” around the world cohere in a digital and physical network of technology hobbyists. “Makers" are open-source hardware enthusiasts who use machines like 3D printers and laser cutters - manufacturing tools that have only recently become accessible to laypeople - to make things. “Makers" share a vision for a world where everyone would be able to make almost anything, supplanting top-down economic systems and channels of production. This ethnographic research examines a subset of the...

Synthesis and Characterization of Carbonaceous Particles from Xylose and Soybean Residuals

Shanshan Wang
Carbonaceous materials, especially in micro and nanoscale, are useful in optical, energy storage, electronic, and biomedical devices or technologies. Techniques have been developed for preparation and modification of the carbonaceous materials, while it is still challenging to tailor the properties of carbonaceous materials effectively and economically. Laser is a powerful tool in academic and industrial laboratories, which also plays important roles in the preparation and modification of high-performance carbonaceous nanomaterials. In this study low-cost hydrothermal...

STUDIES OF OXIDATIVE DAMAGE, BRAIN PROTEOME, AND NEUROCHEMICAL METABOLITES IN COGNITIVE AND NEURODEGENERATIVE DISORDERS

Xiaojia Ren
The rate of cancer patients is increasing as the development of science and technology. Twenty million cancer survivors are estimated living in the United States by 2025. However, many cancer survivors show cognitive dysfunction, negatively affecting the quality of life. These cognitive impairments are recognized as chemotherapy-induced cognitive impairment (CICI), also called "chemo brain" by cancer survivors, including the diminished ability of memory and learning, hard to concentrate and focus, as well as diminution of...

GROWING OLD AS A ROCK STAR

JoAnna Sloggy
This dissertation focuses on the aging voice - specifically the aging elite vocal athlete. It is comprised of four components; a series of research studies and a viewpoint piece designed to explore the awareness, struggles, and vocal compensations of aging singers dealing with age related vocal and performance problems. The overarching goal of these studies is to inform the development of a voice care protocol for the aging rock star to guide customized intervention for...

IMPROVING BICYCLE INFRASTRUCTURE WITH THE USE OF BICYCLE SHARE TRAVEL DATA

Jennifer Mintao Weast
Bicycling as a mode of transportation has been increasing in recent years due to its environmental and health benefits. The availability of bicycles through bicycle share programs has made bicycling a more viable option. With this increase, there is a need for complementary improvements of bicycle infrastructure. Many local and regional transportation agencies are recognizing this need and developing a master plan or safety action plan to improve the city’s bicycle and walking facilities. This...

CONNECTING THE PIECES

Alexa Johnson
Low back pain in collegiate athletes has been reported at a rate of 37% from a wide array of sports including soccer, volleyball, football, swimming, and baseball. Whereas, in a military population the prevalence of low back pain is 70% higher than the general population. Compensatory movement strategies are often used as an attempt to reduce pain. Though compensatory movement strategies may effectively reduce pain, they are often associated with altered lower extremity loading patterns....

A Performance Guide to Arthur Bliss's Sonata for Viola and Piano

Andrew Braddock
Arthur Bliss’s Sonata for Viola and Piano stands as a significant achievement in early twentieth-century chamber music for viola and is the result of a fruitful collaboration between composer and virtuoso performer. Multiple scholars recognize the sonata as one of Bliss’s finest works. Despite these accolades, the work has failed to attract sustained scholarly investigation. This document provides performers with the necessary tools for a thorough and contextualized presentation of the work. The main body...

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    270
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