285 Works

Emerging English Transitives over the Last Two Centuries

Liwen Hou & David Smith

Developing a predictive model for perinatal morbidity among small for gestational age infants

Nathan R. Blue, Amanda A. Allshouse, William A. Grobman, Robert C. Day, David M. Haas, Hyagriv N. Simhan, Samuel Parry, George R. Saade & Robert M. Silver
While neonates with birth weight <10th percentile are at increased risk of morbidity and mortality, most of these are constitutionally small and not at increased risk. There are no current strategies that reliably distinguish constitutionally small neonates from small neonates at the highest risk of morbidity, so additional tools for risk stratification are needed. Our objectives were to identify factors that are independently associated with perinatal morbidity among neonates with birth weight <10th percentile (small...

Stachydrine is effective and selective against blast phase chronic myeloid leukaemia through inhibition of multiple receptor tyrosine kinases

Ruixin Gu, Wei Zhang & Dandan Xu
Resistance to BCR-ABL tyrosine kinase inhibitor (TKI) is the cause of treatment failure in blast phase chronic myeloid leukaemia (BP-CML). Agents that act synergistically with BCR-ABL TKI are required to improve response. This work investigated the effects of stachydrine in CML. CML cells were treated with control or stachydrine at 20, 40 and 80 µM. Proliferation and apoptosis were examined after 72 h treatment. Combination studies were performed in four groups: control, TKI, stachydrine and...

End of induction patient reported outcomes predict clinical remission and endoscopic improvement with vedolizumab and adalimumab in ulcerative colitis

Emily Chu Lee Wong, Badar Hasan, Parambir S. Dulai, John K. Marshall, Walter Reinisch & Neeraj Narula
Patient-reported outcomes (PROs) are increasingly emphasized as endpoints in clinical trials of ulcerative colitis (UC). However, the prognostic value of early improvement in PROs for long-term outcomes remains unclear. This was a post-hoc analysis of 611 vedolizumab-treated or adalimumab-treated patients in the VARSITY trial (Clinicaltrial.gov: NCT02497469). Stool frequency (SF) and rectal bleeding score (RBS) as reported in the Mayo score at post-induction (week 6 and 14) was assessed for their association with one-year endoscopic improvement...

Compound glycyrrhiza oral solution alleviates oxidative stress and inflammation by regulating SRC/MAPK pathway in chronic obstructive pulmonary disease

Xiaolin Xu, Mulan Huang, Xiaofeng Duan, Hongyu Liu, Wei Zhang & Dan Li
Patients with chronic obstructive pulmonary disease (COPD) suffer from persistent cough and breathlessness, which can be ameliorated by the Chinese herbal medicine glycyrrhiza. Furthermore, the SRC/MAPK pathway is activated in the process of oxidative stress and inflammation, which afflict COPD progression. Thus, this research aimed at dissecting the mechanism of compound glycyrrhiza oral solution (CGOS) relieving oxidative stress and inflammation in COPD via the SRC/MAPK pathway. After a COPD rat model was established using lipopolysaccharide...

A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner

Qiankun Yang, Jianguo Zhang, Feixue Liu, Huizhen Chen, Wei Zhang, Haitao Yang, Nana He, Jingquan Dong & Panpan Zhao
Aeromonas caviae, an important food-borne pathogen, induces serious invasive infections and inflammation. The pro-inflammatory IL-1β functions against pathogenic infections and is elevated in various Aeromonas infection cases. However, the molecular mechanism of A. caviae-mediated IL-1β secretion remains unknown. In this study, mouse macrophages (PMs) were used to establish A. caviae infection model and multiple strategies were utilized to explore the mechanism of IL-1β secretion. IL-1β was elevated in A. caviae infected murine serum, PMs lysates...

Echinacoside alleviates osteoarthritis in rats by activating the Nrf2-HO-1 signaling pathway

Zhijun Tan & Bin Zhang
Osteoarthritis (OA) is a progressive disease characterized by degeneration of cartilage and echinacoside (Ech) has anti-inflammatory and antioxidant effects in various human diseases. This study aimed to reveal the effect and potential mechanism of Ech on OA. The in vitro OA model was established by rat chondrocytes treated with IL-1β, and the in vivo OA model was established by anterior cruciate ligament transaction. The effect of Ech on the viability, inflammatory response, extracellular matrix (ECM)...

METTL3-induced DLGAP1-AS2 promotes non-small cell lung cancer tumorigenesis through m6A/c-Myc-dependent aerobic glycolysis

Qiang Zhang, Yu Zhang, Hui Chen, Lei-Na Sun, Bin Zhang, Dong-Sheng Yue, Chang-Li Wang & Zhen-Fa Zhang
The critical roles of N6-methyladenosine (m6A) modification have been demonstrated by more and more evidence. However, the cross talk of m6A and long noncoding RNAs (lncRNAs) in non-small cell lung cancer (NSCLC) tumorigenesis is still unclear. Here, this work focused on the functions and molecular mechanism of m6A-modified lncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2) in NSCLC. Microarray analysis found that lncRNA DLGAP1-AS2 is upregulated in NSCLC cells. Clinical data showed that DLGAP1-AS2 high-expression was correlated...

Additional file 1 of Using human factors principles to redesign a 3D lab workflow during the COVID-19 pandemic

Ethan P. Larsen, Elizabeth Silvestro, Daria F. Ferro, Asif Chinwalla, Natalie Oppenheimer, Sarah Rogers, Raymond W. Sze & Flaura K. Winston
Additional file 1. Project Submission Form.

Additional file 1 of Using human factors principles to redesign a 3D lab workflow during the COVID-19 pandemic

Ethan P. Larsen, Elizabeth Silvestro, Daria F. Ferro, Asif Chinwalla, Natalie Oppenheimer, Sarah Rogers, Raymond W. Sze & Flaura K. Winston
Additional file 1. Project Submission Form.

Supplemental Material - Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review

Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen & Wei Zhang
Supplemental Material for Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review by Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen, and Wei Zhang in International Journal of Immunopathology and Pharmacology

Additional file 3 of BoostMEC: predicting CRISPR-Cas9 cleavage efficiency through boosting models

Oscar A. Zarate, Yiben Yang, Xiaozhong Wang & Ji-Ping Wang
Additional file 3: This file contains a visual representation of BoostMEC’s second regression tree (tree_index = 1).

Additional file 1 of Adaptation and study protocol of the evidence-based Make Better Choices (MBC2) multiple diet and activity change intervention for a rural Appalachian population

Nancy E. Schoenberg, Deanna Sherman, Angela Fidler Pfammatter, Michelle K. Roberts, Ming-Yuan Chih, Sarah C. Vos & Bonnie Spring
Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents*.

Additional file 4 of Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma

Guisheng Zhao, Patrick Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin S. Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri, Javad Nazarian, Michael E. Pacold, Daniel J. Brat, Theodore Nicolaides, Bin Chen & Rintaro Hashizume
Additional file 4: Supplementary Figures S1. Enriched target class of TOP (top) and HDAC (bottom) in the predictions. Supplementary Figures S2. Cell viability assay valuation of MMF. Supplementary Figures S3. RNAseq analysis of MMF-treated SF8628 (A) and SU-DIPG- IV (B) cells. Supplementary Figures S4. Expression of IMPDH2 in pediatric high-grade glioma cells. Supplementary Figures S5. In vivo anti-tumor activity of MMF by CED in orthotopic patient-derived DIPG xenografts.

Additional file 1 of Marijuana use and DNA methylation-based biological age in young adults

Drew R. Nannini, Yinan Zheng, Brian T. Joyce, Tao Gao, Lei Liu, David R. Jacobs, Pamela Schreiner, Chunyu Liu, Steve Horvath, Ake T. Lu, Kristine Yaffe, Stephen Sidney, Philip Greenland, Donald M. Lloyd-Jones & Lifang Hou
Additional file 1: Supplemental Table 1. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years 15 and 20 by tobacco smoking status. Supplemental Table 2. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years 15 and 20 by race. Supplemental Table 3. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years...

Additional file 1 of Effect of COVID-19 on the implementation of a multifaceted intervention to improve teamwork and quality for hospitalized patients: a qualitative interview study

Iva A. Terwilliger, Milisa Manojlovich, Julie K. Johnson, Mark V. Williams & Kevin J. O’Leary
Additional file 1 .

Additional file 1 of SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal

Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang & Wenzhi Tian
Additional file 1. Supplement figures (Figs. S1–S15), materials and methods.

Additional file 3 of Emergency versus delayed hepatectomy following transarterial embolization in spontaneously ruptured hepatocellular carcinoma survivors: a systematic review and meta-analysis

Wei Zhang, Zhangkan Huang & Xu Che
Additional file 3: Supplemental file 3. Begg’s test and Egger's test for each outcome.

Additional file 1 of A genetic map of the chromatin regulators to drug response in cancer cells

Bo Chen, Pengfei Li, Mingyue Liu, Kaidong Liu, Min Zou, Yiding Geng, Shuping Zhuang, Huanhuan Xu, Linzhu Wang, Tingting Chen, Yawei Li, Zhangxiang Zhao, Lishuang Qi & Yunyan Gu
Additional file 1: Fig. S1. Lung cancer cell lines with RB1 mutations are resistant to CDK4/6 inhibitor, Fig. S2. Sensitive biomarkers interacted with CHEK1 in large intestine cancer cell lines, Fig. S3. Resistant biomarkers interacted with CHEK1 in lung cancer cell lines, Fig. S4. Functional analysis of the CRs genetic interaction, Fig. S5. Differential chromatin accessibility for CSL interactions, Fig. S6. Differential chromatin accessibility for CSV interactions, Fig. S7. TUBA1C subnetwork in drug related CSL...

Additional file 1 of A novel semiautomatic Chinese keywords instrument screening delirium based on electronic medical records

Ling Chen, Nan Li, Yuxia Zheng, Langli Gao, Ning Ge, Dongmei Xie & Jirong Yue
Additional file 1.

Additional file 2 of Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease

Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He, Hanping Li, Mingliang Zhang, Hui Zheng, Jiyan Chen, Min Huang & Shilong Zhong
Additional file 2. Additional Methods. Fig. S1. The Kaplan–Meier curves of LVEF (A-B) and LVMI (C-D) for risks of death and MACE in the discovery cohort. Fig. S2. Correlation network of metabolic signatures for MACE risk and clinical factors. Fig. S3. Representative total ion flow diagrams between different QC samples under positive ion mode (A) and negative ion mode (B). Fig. S4. The visualization image analysis of the quality improvement procedures for typical features (Kynurenine)...

Additional file 1 of Examining relationships between perceived neighborhood social cohesion and ideal cardiovascular health and whether psychosocial stressors modify observed relationships among JHS, MESA, and MASALA participants

Akilah J. Dulin, Jee Won Park, Matthew M. Scarpaci, Laura A. Dionne, Mario Sims, Belinda L. Needham, Joseph L. Fava, Charles B. Eaton, Alka M. Kanaya, Namratha R. Kandula, Eric B. Loucks & Chanelle J. Howe
Supplementary Material 1

Additional file 1 of Interventions to mitigate vaping misinformation: protocol for a scoping review

Navin Kumar, Sam Hampsher, Nathan Walter, Kate Nyhan & Munmun De Choudhury
Additional file 1. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.

Registration Year

  • 2023
    22
  • 2022
    238
  • 2021
    11
  • 2020
    11
  • 2019
    3

Resource Types

  • Text
    285

Affiliations

  • Northwestern University
    285
  • Sun Yat-sen University
    146
  • Zhejiang University
    143
  • Sichuan University
    141
  • First Affiliated Hospital of Soochow University
    140
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    137
  • Wuhan University
    134
  • West China Hospital of Sichuan University
    133
  • Shanghai Jiao Tong University
    133
  • Southern Medical University
    129