Patient-reported outcomes (PROs) are increasingly emphasized as endpoints in clinical trials of ulcerative colitis (UC). However, the prognostic value of early improvement in PROs for long-term outcomes remains unclear. This was a post-hoc analysis of 611 vedolizumab-treated or adalimumab-treated patients in the VARSITY trial (Clinicaltrial.gov: NCT02497469). Stool frequency (SF) and rectal bleeding score (RBS) as reported in the Mayo score at post-induction (week 6 and 14) was assessed for their association with one-year endoscopic improvement...

Patients with chronic obstructive pulmonary disease (COPD) suffer from persistent cough and breathlessness, which can be ameliorated by the Chinese herbal medicine glycyrrhiza. Furthermore, the SRC/MAPK pathway is activated in the process of oxidative stress and inflammation, which afflict COPD progression. Thus, this research aimed at dissecting the mechanism of compound glycyrrhiza oral solution (CGOS) relieving oxidative stress and inflammation in COPD via the SRC/MAPK pathway. After a COPD rat model was established using lipopolysaccharide...

Osteoarthritis (OA) is a progressive disease characterized by degeneration of cartilage and echinacoside (Ech) has anti-inflammatory and antioxidant effects in various human diseases. This study aimed to reveal the effect and potential mechanism of Ech on OA. The in vitro OA model was established by rat chondrocytes treated with IL-1β, and the in vivo OA model was established by anterior cruciate ligament transaction. The effect of Ech on the viability, inflammatory response, extracellular matrix (ECM)...

The critical roles of N6-methyladenosine (m6A) modification have been demonstrated by more and more evidence. However, the cross talk of m6A and long noncoding RNAs (lncRNAs) in non-small cell lung cancer (NSCLC) tumorigenesis is still unclear. Here, this work focused on the functions and molecular mechanism of m6A-modified lncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2) in NSCLC. Microarray analysis found that lncRNA DLGAP1-AS2 is upregulated in NSCLC cells. Clinical data showed that DLGAP1-AS2 high-expression was correlated...

Additional file 2: Fig S1. Generation of polyclonal antibodies against MBD5 and MBD6. Fig S2. The ASXL subunits link MBD5 and MBD6 to BAP1 complex via the C-terminal PHD fingers. Fig S3. MBD5 and MBD6 evolutionally contributes to stability of BAP1 complex. Fig S4. MBD6 but not MBD5 is critical for SCLC cell viability. Fig S5. Characterization of MBD6 occupancy in SCLC cells. Fig S6. MBD6 is essential for BAP1-dependent gene expression in SCLC. Fig...

To measure the effect of maternal family history of hypertension on preterm birth (PTB) and to identify factors that modified this association. A case-control study was nested in a prospective cohort of the entire pregnant population in Wuhan, China, from 2011 to 2013. Home-visit interviews were scheduled for all PTBs and their controls, to collect extensive information on maternal exposures to behavioral, environmental, and intergenerational risk factors of PTB. The effects of maternal family history...

Lists of differentially expressed genes (DEGs) found in symbiont-removed or symbiont-exchanged hydras.

Fitting methods and supplementary data

Additional file 4: SupplementaryTable 2. The top 10 co-cited references related to this field

Additional file 6: Supplementary Table 4. The top 10 institutions and cited institutions related to this field.

Additional file 1: Table S1. Clinical improvements in rituximab cohort and control cohort

Additional file 2: Supplemental Table 1. Resources used for our coronavirus disease-related data collection.

Additional file 2: Supplemental Table 1. Resources used for our coronavirus disease-related data collection.

Additional file 4: Supplemental Figure 4. Epidermal and Neural Lineages Diverge at St 10.5 (A) Number of enriched Neural GO Terms in genes significantly higher in the neural lineage (blue) and epidermal lineage (red) at each developmental stage. (B) Heatmap of the top 20 DE genes by Log2FC with a minimum expression of 10TPM between the epidermal and neural lineages at stage 10.5 (C) KEGG enrichment analysis of genes differentially expressed between epidermal and neural...

Additional file 6: Supplemental Figure 6. Mesendoderm Analysis. (A) Number of differentially expressed genes between the endoderm and ventral mesoderm lineages at each developmental stage (padj ≤ 0.05). (B) KEGG enrichment analysis of genes differentially expressed between ventral mesoderm and endoderm lineage at each developmental stage. Genes significantly increased in the endoderm lineage are enriched for TGF-beta genes, as defined by KEGG database from stages 10-10.5 and genes significantly higher in the ventral mesoderm lineage...

Additional file 9: Supplemental Figure 9. Raw Images of Supplemental Western Blots. (A) Supplemental Figure 5A Western blot analysis of lysates of developing mesoderm (20ng/uL BMP4/7) and endoderm (160ng/uL Activin) explants for pSmad2 and Smad2 with Actin loading control. Blot was cut prior to antibody hybridization to conserve antibody. Initial scan showing blot edges (top) and unedited high resolution scan of relevant size bands (bottom) both provided. (B) Supplemental Figure 7C Western Blot Analysis of...

Additional file 1. Supplementary tables and figures

Additional file 1. Supplementary tables and figures

Supplemental material, sj-docx-1-acr-10.1177_02841851211061438 for Patient exposure dose in interventional cardiology per clinical and technical complexity levels. Part 1: results of the VERIDIC project by Joelle Ann Feghali, Julie Delépierre, Olivera Ciraj Belac, Jérémie Dabin, Marine Deleu, Francesca De Monte, Milan Dobric, Aoife Gallagher, Lama Hadid-Beurrier, Patrick Henry, Hrvoje Hršak, Tom Kiernan, Rajesh Kumar, Željka Knežević, Carlo Maccia, Marija Majer, Françoise Malchair, Stéphane Noble, Davor Obrad, Marta Sans Merce, Georgios Sideris, George Simantirakis, Christian Spaulding, Giuseppe...

Aeromonas caviae, an important food-borne pathogen, induces serious invasive infections and inflammation. The pro-inflammatory IL-1β functions against pathogenic infections and is elevated in various Aeromonas infection cases. However, the molecular mechanism of A. caviae-mediated IL-1β secretion remains unknown. In this study, mouse macrophages (PMs) were used to establish A. caviae infection model and multiple strategies were utilized to explore the mechanism of IL-1β secretion. IL-1β was elevated in A. caviae infected murine serum, PMs lysates...

Supplementary Material for Service-Delivery Competencies in Home and Community-Based Services Needed to Achieve Person-Centered Planning and Practices: A Systematic Review by Jasin Wong, Jessica Pedersen, Niveda Tennety, Lindsay DuBois, Rudyard Chiu, Dhrumil Shah, Glenn Malecki, Q. Eileen Wafford, and Allen W. Heinemann in Journal of Applied Gerontology.

Additional file 1. Project Submission Form.

Additional file 1. Project Submission Form.

Supplemental Material for Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review by Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen, and Wei Zhang in International Journal of Immunopathology and Pharmacology

Additional file 3: This file contains a visual representation of BoostMEC’s second regression tree (tree_index = 1).