Additional file 1: Figure S1. Schematic diagram of the synthesis of SLC-AN/SN@AQ NPs. Figure S2. BCA standard curve. Figure S3. Size stability of SLC-AN/SN@AQ NPs incubated in different biological media for 14 days. Figure S4. Cytotoxicity of SLC-AN NPs, SLC-AN/SN NPs, and SLC-AN/SN@AQ NPs to U87MG cells under normoxic or hypoxic conditions. Figure S5. NO production in U87MG cells after various treatments under normoxic conditions. Figure S6. TEER values of the bEnd.3 cell monolayer before...

Supplementary Material 3

Additional file 1: Table S1. List of RT-qPCR primers.

Additional file 1: Table S1. List of RT-qPCR primers.

Additional file 6: Table S3. Identification of LNM-specific DEGs.

Additional file 1. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.

Additional file 1: Additional Figures.

Additional file 7: Table S3. Attributed burden measures of CRDs to all risk factors for all ages number and ASR with percentage change by sex at national level, 1990 vs 2019. Data in parentheses are 95% Uncertainty Intervals (95% UIs); DALYs= Disability-Adjusted Life Years; YLLs= Years of Life Lost; YLDs= Years Lived with Disability

Additional file 1.

Additional file 1.

Additional file 1.

Additional file 34. Review history.

Additional file 2: Fig S2. Pathway analysis of the identified differential metabolites. (a) Pathway impact resulting from the differential metabolites using MetaboAnalyst 3.0 between WW and CC. Small p-value and big pathway impact factor indicate that the pathway is greatly influenced. (b) Pathway impact resulting from the differential metabolites using MetaboAnalyst 3.0 between OR and CC. Small p-value and big pathway impact factor indicate that the pathway is greatly influenced.

Additional file 3: Fig S3. The average monthly temperature and precipitation in the 2018, 2019, and 2020 growing seasons.

Additional file 1. Figure S1a. ‘Data’ page from the Breast Cancer Risk Estimator Decision Aid. Figure S1b. ‘Assessment’ page from the Breast Cancer Risk Estimator Decision Aid.Figure S1c. ‘Decision’ page from the Breast Cancer Risk Estimator Decision Ai. Table S3. Linear Mixed-effect Model of Linguistic Features and System Use on Patient’s Feeling Informed. Table S4. Linear Mixed-effect Model of Linguistic Features and System Use on Patient’s Benefit/Risk Clarity. Table S5. Linear Mixed-effect Model of Linguistic...

Additional file 2: Figure S1. Elimination of estrous cycle in female mice did not affect defensive behavior following exposure to looming stimuli.

Additional file 1. Explanation of Grouped Variables.

Additional file 1: Fig. S1. Differential transcriptomic and mutational profiles in PM gliomas with or without 1p19q co-deletion. Fig. S2. Declining expression of NFOL and MFOL signatures in PM gliomas from GSE4290. Fig. S3. Declining expression of NFOL and MFOL signatures in PM gliomas from the REMBRANDT dataset. Fig. S4. Genes upregulated in the PM gliomas were enriched in murine OPCs. Fig. S5. Genes concordantly enriched in both PM subtypes were differentially expressed between OPC...

Supplemental Material for Unicompartmental knee arthroplasty versus high tibial osteotomy for medial knee osteoarthritis: A systematic review and meta-analysis by Bin Zhang, Hanguang Qian, Hongfu Wu and Xiaofei Yang in Journal of Orthopaedic Surgery

Chemotherapy agents used in the standard treatments for many types of cancer are neurotoxic and can lead to lasting sensory and motor symptoms that compromise day-to-day movement functions in cancer survivors. To date, the details of movement disorders associated with chemotherapy are known largely through self-reported symptoms and functional limitations. There are few quantitative studies of specific movement deficits, limiting our understanding of dysfunction, as well as effective assessments and interventions. The aim of this...

Chemotherapy agents used in the standard treatments for many types of cancer are neurotoxic and can lead to lasting sensory and motor symptoms that compromise day-to-day movement functions in cancer survivors. To date, the details of movement disorders associated with chemotherapy are known largely through self-reported symptoms and functional limitations. There are few quantitative studies of specific movement deficits, limiting our understanding of dysfunction, as well as effective assessments and interventions. The aim of this...

Background: Control over automatic tendencies is often compromised in challenging situations when people fall back on automatic defensive reactions, such as freeze–fight–flight responses. Stress-induced lack of control over automatic defensive responses constitutes a problem endemic to high-risk professions, such as the police. Difficulties controlling automatic defensive responses may not only impair split-second decisions under threat, but also increase the risk for and persistence of posttraumatic stress disorder (PTSD) symptoms. However, the significance of these automatic...

Supplemental Material for MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway by Wei Zhang, Qiu Zhang, Qianbo Cui and Yu Xu in Human and Experimental Toxicology

Supplemental Material for MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway by Wei Zhang, Qiu Zhang, Qianbo Cui and Yu Xu in Human and Experimental Toxicology

There is no conclusive evidence comparing the efficacy of glucagon-like peptide 1 (GLP-1) receptor agonists to the other guidelines recommended pharmacotherapy for nonalcoholic fatty liver disease (NAFLD). Therefore, we aim to compare the effects of GLP-1 receptor agonists, pioglitazone and vitamin E in patients with NAFLD. We searched PubMed, Embase, Web of Science and Cochrane Library up to 11 April 2022. Randomized clinical trials (RCTs) comparing GLP-1 receptor agonists, pioglitazone and vitamin E against placebo...