36 Works

Additional file 4 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 4. miRNA sequences.

Additional file 5 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 5. Coding Sequence of Irak1 and Traf6 Genes.

Cocoa seeds and chocolate products interaction with gut microbiota; mining microbial and functional biomarkers from mechanistic studies, clinical trials and 16S rRNA amplicon sequencing

Mohamed A. Farag, Mohamad Louai M. Hariri, Aya Ehab, Masun Nabhan Homsi, Chao Zhao & Martin von Bergen
In recent years, gut microbiome has evolved as a focal point of interest with growing recognition that a well-balanced gut microbiota is highly relevant to an individual’s health status. The present review provides a mechanistic insight on the effects of cocoa chemicals on the gut microbiome and further reveals in silico biomarkers, taxonomic and functional features that distinguish gut microbiome of cocoa consumers and controls by using 16S rRNA gene sequencing data. The polyphenols in...

Additional file 1 of The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial

Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange, Kieran M. Tuohy, Camilla Diotallevi, Ilan Shelef, Frank B. Hu, Meir J. Stampfer & Iris Shai
Additional file 1: S1. Adherence to the intervention. S2. Sensitivity analysis. S3. Inclusion and Exclusion criteria. S4. Physical activity recommendations protocol. S5. Polyphenol-rich foods, provided at no cost to participants. S6. Magnetic resonance imaging. S7. Clinical parameters, laboratory methodology, and blood and urine polyphenols assessments. S8. Sample size and power calculations. Fig. S1. DIRECT PLUS flow chart. Fig. S2. Heatmap of abdominal adipose depots and metabolic and cardiovascular parameters at baseline. Fig. S3. The effect...

Shewanella oneidens microcosms laboratory data

Rico Leiser
Iron reduction by Shewanella oneidensis does not release microplastics from organo-metallic aggregates Abstract The presented study is a laboratory study elucidating the potential of the freshwater bacteria Shewanella oneidensis to reduce microplastic containing iron-organo aggegrates, and to release microplastics from the flocs through this reduction. The data were obtained by incubating 5 individual iron-organo flocs inside of microcosm (20 individual) with added S. oneidensis for 120 days and samplings conducted after 0, 20, 40, 60...

Checklist to Support the Helmholtz Centers in Implementing Policies on Sustainable Research Software

Reinhard Messerschmidt, Heinz Pampel, Felix Bach, Wolfgang zu Castell, Michael Denker, Ants Finke, Bernadette Fritzsch, Martin Hammitzsch, Uwe Konrad, Yvonne Leifels, Christoph Möhl, Marco Nolden, Markus Scheinert, Tobias Schlauch, Thomas Schnicke & Dirk Steglich
As the digitalization of research and teaching progresses, the number of software solutions developed at scientific institutions and used for the purpose of knowledge production is increasing. The accessibility and reuse of scientific results called for under the heading “open science” can be ensured in many fields only if, in addition to research data, program code is also made openly accessible. The present guide is addressed to decision-makers at the Helmholtz Centers who deal with...

GeoLaB - Geothermal Laboratory in the Crystalline Basement

Thomas Kohl , Eva Schill , Judith Bremer , Günter Zimmermann , Olaf Kolditz & Ingo Sass
In Central Europe, the largest geothermal potential resides in the crystalline basement rock with important hotspots in tectonically stressed areas. To better harvest this energy form under sustainable, predictable and efficient conditions, new focused, scientific driven strategies are needed. Similar to other geo-technologies, the complex processes in the subsurface need to be investigated in large-scale facilities to ensure environmental sustainability. The proposed new underground research laboratory GeoLaB (Geothermal Laboratory in the Crystalline Basement) will address...

Additional file 1 of Bio-nanocomplexes with autonomous O2 generation efficiently inhibit triple negative breast cancer through enhanced chemo-PDT

Zhihong Zeng, Zhou Wang, Simin Chen, Chang Xiao, Minzhuo Liu, Jie Zhang, Jialong Fan, Yanzhong Zhao & Bin Liu
Additional file 1: Figure S1. A. CS-1 loading capacity and encapsulation efficiency of CPCCM NPs. B. Ce6 loading capacity and encapsulation efficiency of CPCCM NPs. Figure S2. Cell viability assay. A. Viability of 4T1 cells treated with CS-1. B. Viability of MDA-MB-231 cells treated with CS-1. The concentrations of CS-1 are 0, 1, 2.5, 5, 10, 15, and 20 μM, respectively. Figure S3. Viability of MDA-MB-231 cells treated with CS-1, Ce6, CPCC, and CPCCM with/without...

Additional file 1 of Modulation of gut microbiota, blood metabolites, and disease resistance by dietary β-glucan in rainbow trout (Oncorhynchus mykiss)

Simon Menanteau-Ledouble, Jakob Skov, Mie Bech Lukassen, Ulrike Rolle-Kampczyk, Sven-Bastiaan Haange, Inger Dalsgaard, Martin von Bergen & Jeppe Lund Nielsen
Additional file 1: Table S1. Allocation of the fish at the start of the experiment. Table S2. Analysis of the composition of the β-glucan used in this study. Figure S3. Principal component analysis showing the microbiota of the fish at week 6. Figure S4. Heatmap showing the 10 most abundant bacterial phyla in the intestine of the fish for the two control groups and the groups receiving the three different concentration of β-glucan. Table S5....

Parametric optimization and comparative study of an organic Rankine cycle power plant for two-phase geothermal sources

Chaofan Chen , Francesco Witte , Ilja Tuschy , Olaf Kolditz & Haibing Shao
For two-phase geothermal resource, Organic Rankine Cycle (ORC) based binary plant is often applied for power production. In this work, a network topology was built with the Thermal Engineering Systems in Python (TESPy) software to simulate the stationary operation of the ORC plant. With this topology, the performance of nine different working fluids are compared. From the thermodynamic perspective, the gross and net power output is optimized respectively. Results show that R600 has the highest...

Additional file 2 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 2. Supplementary methods and materials.

Cocoa seeds and chocolate products interaction with gut microbiota; mining microbial and functional biomarkers from mechanistic studies, clinical trials and 16S rRNA amplicon sequencing

Mohamed A. Farag, Mohamad Louai M. Hariri, Aya Ehab, Masun Nabhan Homsi, Chao Zhao & Martin von Bergen
In recent years, gut microbiome has evolved as a focal point of interest with growing recognition that a well-balanced gut microbiota is highly relevant to an individual’s health status. The present review provides a mechanistic insight on the effects of cocoa chemicals on the gut microbiome and further reveals in silico biomarkers, taxonomic and functional features that distinguish gut microbiome of cocoa consumers and controls by using 16S rRNA gene sequencing data. The polyphenols in...

Additional file 1 of The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial

Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange, Kieran M. Tuohy, Camilla Diotallevi, Ilan Shelef, Frank B. Hu, Meir J. Stampfer & Iris Shai
Additional file 1: S1. Adherence to the intervention. S2. Sensitivity analysis. S3. Inclusion and Exclusion criteria. S4. Physical activity recommendations protocol. S5. Polyphenol-rich foods, provided at no cost to participants. S6. Magnetic resonance imaging. S7. Clinical parameters, laboratory methodology, and blood and urine polyphenols assessments. S8. Sample size and power calculations. Fig. S1. DIRECT PLUS flow chart. Fig. S2. Heatmap of abdominal adipose depots and metabolic and cardiovascular parameters at baseline. Fig. S3. The effect...

Additional file 1 of De novo mutations within metabolism networks of amino acid/protein/energy in Chinese autistic children with intellectual disability

Wen-Xiong Chen, Bin Liu, Lijie Zhou, Xiaoli Xiong, Jie Fu, Zhi-Fang Huang, Ting Tan, Mingxi Tang, Jun Wang & Ya-Ping Tang
Additional file 1. Figure S1: Mendelian error rate of all families. Figure S2: The number of de novo mutations in probands and siblings followed Poisson distribution. Figure S3: Gene (protein synthesis) expression in different brain regions at various periods. Figure S4: Gene (energy) expression in different brain regions at various periods. Figure S5: Gene (pressure) expression in different brain regions at various periods. Figure S6: Gene (amino acid) expression in different brain regions at various...

Additional file 1 of MarineMetagenomeDB: a public repository for curated and standardized metadata for marine metagenomes

Muhammad Kabiru Nata’ala, Anderson P. Avila Santos, Jonas Coelho Kasmanas, Alexander Bartholomäus, João Pedro Saraiva, Sandra Godinho Silva, Tina Keller-Costa, Rodrigo Costa, Newton C. M. Gomes, André Carlos Ponce de Leon Ferreira de Carvalho, Peter F. Stadler, Danilo Sipoli Sanches & Ulisses Nunes da Rocha
Additional file 1. Table S1: Dictionary of terms used for filtering out non-marine samples.

Additional file 1 of Modulation of gut microbiota, blood metabolites, and disease resistance by dietary β-glucan in rainbow trout (Oncorhynchus mykiss)

Simon Menanteau-Ledouble, Jakob Skov, Mie Bech Lukassen, Ulrike Rolle-Kampczyk, Sven-Bastiaan Haange, Inger Dalsgaard, Martin von Bergen & Jeppe Lund Nielsen
Additional file 1: Table S1. Allocation of the fish at the start of the experiment. Table S2. Analysis of the composition of the β-glucan used in this study. Figure S3. Principal component analysis showing the microbiota of the fish at week 6. Figure S4. Heatmap showing the 10 most abundant bacterial phyla in the intestine of the fish for the two control groups and the groups receiving the three different concentration of β-glucan. Table S5....

Additional file 1 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 1. Animal protocol.

Additional file 5 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 5. Coding Sequence of Irak1 and Traf6 Genes.

Measurement of Diffuse Submarine Groundwater Discharge at intertidal puddles at the Königshafen - Sylt

Sebastian Janßen , Alexandra Nozik , Ulf Mallast & Nils Moosdorf
Coastal regions represent a transition between land and sea. From the hydro(geo)logical point of view freshwater and saltwater are coming together here. The groundwater discharge which discharges directly into the sea is called submarine groundwater discharge (SGD). At the regional scale, SGD is often measured indirectly based on tracers. At the local scale, SGD flux over time can be measured directly, e.g. using seepage meters. However, this method only represents the punctual source of discharge....

Pore-scale modeling of acid etching in a carbonate fracture

Renchao Lu , Xing-yuan Miao , Olaf Kolditz & Haibing Shao
Acid fracturing technique has been widely used in the oil and gas industry for improving the carbonate reservoir permeability. In recent years this chemical stimulation technique is borrowed from the oil and gas industry, employed in the enhanced geothermal systems at Groß Schönebeck, Germany (Zimmermann et al., 2010), and at Soultz-sous-Forêts, France (Portier et. al., 2009). In principle, acid fracturing technique utilizes strong acids that react with acid-soluble rock matrix to non-uniformly etch the fracture...

Stormwater harvesting in ephemeral streams: how to effectively bypass clogging layers and thick vadose zones

Jose David Henao Casas , Fritz Kalwa , Marc Walther & Randolf Rausch
In drylands, stormwater is often collected in surface basins and subsequently stored in shallow aquifers via infiltration to cope with water scarcity. These groundwater recharge schemes are often accompanied by high evaporation rates and hygiene problems due to low infiltration rates, which are a consequence of clogging layers on the topsoil and the presence of a thick vadose zone. The present study aims to develop a conceptual solution to increase groundwater recharge rates in stormwater...

Additional file 1 of Controlling blooms of Planktothrix rubescens by optimized metalimnetic water withdrawal: a modelling study on adaptive reservoir operation

Chenxi Mi, David P. Hamilton, Marieke A. Frassl, Tom Shatwell, Xiangzhen Kong, Bertram Boehrer, Yiping Li, Jan Donner & Karsten Rinke
Additional file 1: Fig. S1. Cumulative frequency for the occurrence time of the maximum P. rubescens concentration, based on the simulation results from the sensitivity test scenarios. The vertical dashed line shows the time under the reference simulation (i.e., day of 214). Fig. S2. Comparison of net specific growth rates of P. rubescens in the reference scenario (scenario R), averaged over the depth layer from 10 to 12 m, with the specific water withdrawal rates...

Additional file 2 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 2. Supplementary methods and materials.

Additional file 3 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 3. Primers of target genes.

Additional file 3 of miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu & Limin Rong
Additional file 3. Primers of target genes.

Registration Year

  • 2022
    36

Resource Types

  • Text
    36

Affiliations

  • Helmholtz Centre for Environmental Research
    36
  • Beijing Tian Tan Hospital
    14
  • North West Agriculture and Forestry University
    14
  • Central South University
    14
  • Jilin University
    14
  • Key Laboratory of Guangdong Province
    14
  • Guangdong Academy of Agricultural Sciences
    14
  • Beijing Institute of Technology
    14
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    14
  • Jinan University
    14