Additional file 4: Table S4. Threshold cycle (Ct) values from qRT-PCR of HNSCC cell lines and human normal nasopharyngeal cell line.

Additional file 1. Supplementary figures.

Supplemental Material for Relationship Between Atherogenic Index of Plasma and Serum Uric Acid in Patients With Untreated Essential Hypertension in China: A Cross-Sectional Study by Xiaoxiang Ma, MD, PhD, Xin Zhang, MD, PhD, Yanhua Yang, MSc, Li Jiang, BSc, and Zhaoyi Huang, BSc in Angiology

Music therapy, like red-pink (soothing) music, is an important treatment for neurological disorders associated with learning and memory. Magnetic fields have been proved to have a similar regulating effect. However, the effect of magnetic fields with musical rhythm generated by the combination of the two has not been confirmed. This study aimed to investigate the regulation of magnetic stimulation with music rhythm on LTP (long-term potentiation) of Schaffer-CA1. This article selected three sorts of music...

The present study aimed to assess the effects of epileptic treatment of the aerial part of Bupleurum chinense DC. in kainic acid (KA)-induced epilepsy rats and LPS-induced BV2 cells, as well as to identify the active chemical constituents. The in vivo and vitro results showed that 20% ethanol elution fractions of the aerial part of B. chinense DC. (BCE-20) and 70% ethanol elution fractions of the aerial part of B. chinense DC. (BCE-70) could improve...

Controlled-release urea (CRU) and normal urea have been shown to improve yield and nitrogen use efficiency (NUE) in rice. However, the effects of combined fertilizers (CRU and normal urea, at different N ratios) on rice yield, temperature and solar radiation utilization efficiency (TSRUE) and NUEs remain unclear. In this study, CRU with release periods of 60 days and 100 days were mixed with urea at N ratios of 7:3, 6:4, 5:5, 4:6 and 3:7 and...

The present work aims to prove the concept of tumor-targeted drug delivery mediated by platelets. Doxorubicin (DOX) attached to nanodiamonds (ND-DOX) was investigated as the model payload drug of platelets. In vitro experiments first showed that ND-DOX could be loaded in mouse platelets in a dose-dependent manner with a markedly higher efficiency and capacity than free DOX. ND-DOX-loaded platelets (Plt@ND-DOX) maintained viability and ND-DOX could be stably held in the platelets for at least 4...

The litchi semen are traditional medications for treating liver fibrosis (LF) in China. The mechanism remains unclear. This study investigates the anti-liver fibrotic mechanism of the total flavonoids of litchi semen (TFL). Sprague-Dawley rats with carbon tetrachloride-induced LF were treated with TFL (50 and 100 mg/kg) for 4 weeks. The anti-liver fibrotic effects of TFL were evaluated and the underlying mechanisms were investigated via histopathological analysis, proteomic analysis and molecular biology technology. Significant anti-LF effects...

TFEB (transcription factor EB) regulates multiple genes involved in the process of macroautophagy/autophagy and plays a critical role in lifespan determination. However, the detailed mechanisms that regulate TFEB activity are not fully clear. In this study, we identified a role for HSP90AA1 in modulating TFEB. HSP90AA1 was phosphorylated by CDK5 at Ser 595 under basal condition. This phosphorylation inhibited HSP90AA1, disrupted its binding to TFEB, and impeded TFEB’s nuclear localization and subsequent autophagy induction. Pro-autophagy...

Additional file 12. Volcano plots for the differential expression analysis. These plots depict the log2 fold-change (x-axis) against the -log10 of the uncorrected p-value (y-axis) for each gene in each pairwise comparison in the medial preoptic area (MPOA, A), nucleus accumbens (NAc, B), and lateral septum (LS, C). Differentially expressed genes are depicted in red.

Additional file 13. Functional enrichment of genes differentially expressed in the medial preoptic area (MPOA). For each pairwise comparison, the functional enrichments in gene ontologies of the biological processes (A), cellular components (B), and molecular functions (C) categories were tested for the differentially expressed genes up- or down-regulated (UP, and DOWN, respectively). The labels of pairwise comparisons were coded in two letters: the first one represents the phenotype (M: mothers, F: fathers, P: paternal males,...

Additional file 1. Time spent in each behavior during the parental behavior test. The total duration across the entire test session is depicted for each animal for the autogrooming, carry, huddling, licking & grooming, locomotion, nest building, and sniffing behaviors; each data point thus represents a distinct animal. The horizontal line in the shaded violin represents the 50% quantile of the density estimate.

Additional file 20. Analysis of variance (ANOVA) results for the estimated proportions of the “Neurons” cell type in the genes differentially expressed in the medial preoptic area (MPOA), nucleus accumbens (NAc), and lateral septum (LS).)

Additional file 25. Functional enrichment of gene ontologies of the cellular components category in gene co-expression modules derived from the weighted gene coexpression network analysis (WGCNA).

Additional file 25. Functional enrichment of gene ontologies of the cellular components category in gene co-expression modules derived from the weighted gene coexpression network analysis (WGCNA).

Additional file 27. Functional enrichment of pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) in gene co-expression modules derived from the weighted gene coexpression network analysis (WGCNA).

Additional file 2. Analysis of variance (ANOVA) results for all behaviors scored during the parental behavior test.

Additional file 1. Other details of this study.

Supplementary Material 1: Figure S1. Sensitivity analysis of the effect of Qigong interventions on depression

Additional file 1: Table S1: Gene ontology (GO) enrichment analysis of the STEAP3-related genes.

Additional file 2: Table S2: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis of the STEAP3-related genes.

Additional file 1: Table S1: Gene ontology (GO) enrichment analysis of the STEAP3-related genes.

Supplement 1

Additional file 1. Methods. Figure S1. WGCNA of the lipid species profile. Figure S2. Boruta analysis result. Figure S3. Violin Plot of the Targeted Lipidomics. Figure S4. Correlation among identified lipid species.

The ocellated angelshark (Squatina tergocellatoides Chen, 1963) is a threatened shark within the family Squatinidae. In the present study, we reported the mitochondrial genome sequence of the ocellated angelshark. The complete mitochondrial genome is 16,683 bp in length and contains 37 mitochondrial genes and a control region as similar to most fishes. In addition, we constructed a maximum-likelihood phylogenetic tree of S. tergocellatoides and its relative species. This work will provide molecular data for further...