In this paper, we introduce a new first-order generalized Poisson integer-valued autoregressive process, for modeling integer-valued time series exhibiting a piecewise structure and overdispersion. Basic probabilistic and statistical properties of this model are discussed. Conditional least squares and conditional maximum likelihood estimators are derived. The asymptotic properties of the estimators are established. Moreover, two special cases of the process are discussed. Finally, some numerical results of the estimates and a real data example are presented.

Additional file 1: Table S1. Clinicopathological characteristics of patients with gastric cancer in this study. Table S2. Different microorganisms in Proximal T and Distal T compared to their respective non tumor samples. Table S3. Significant differences in metabolites between Distal T and Distal N. Table S4. Significant differences in metabolites between Proximal T and Proximal N. Table S5. Metabolic pathway enrichment of differential metabolites between Distal T and Distal N. Table S6. Metabolic pathway enrichment...

Additional file 2: Figure S2. The microbial relative abundance of proximal, distal tumor tissues and matched non-tumor tissues at the genus level. Proximal T,proximal GC tumor tissues; Proximal N,proximal GC non-tumor tissues; Distal T, distal GC tumor tissues; Distal N, distal GC non-tumor tissues.

Supplemental material, sj-pdf-2-imr-10.1177_03000605221139667 for Osteoperiosteal decortication and bone grafting combined with wave plating for femoral shaft aseptic atrophic nonunion after intramedullary nailing by Yao Lu, Liang Sun, Qian Wang, Cheng Ren, Yibo Xu, Haobo Ye, Ming Li, Hanzhong Xue, Qiang Huang, Zhong Li, Kun Zhang and Teng Ma in Journal of International Medical Research

Additional file 1: Figure S1. Stability of nanovesicles in PBS and PBS with 20% of fetal bovine serum (FBS). Nanovesicle sizes were measured using dynamic light scattering (n=3 per group). Results are presented as mean ± SD. Figure S2. The promotion of PLP-RvD1 treated macrophages to angiogenesis. (A) Capillary tube formation and (B) cell migration of HUVECs after cocultured with PBS, LP-RvD1 or PLP-RvD1 treated BMDMs. HUVECs cultured under normoxia were set as controls. Scalar...

Supplementary Material 1

Additional file 10. Figure S7: Prognostic value of presurgical ctDNA detection. A). The recurrence-free survival analysis of patients stratified by presurgical ctDNA detection. B). The multi-variant Cox regression for presurgical ctDNA detection. Abbreviations: RFS – recurrence-free survival, LNM – lymph node metastasis, LUAD – lung adenocarcinoma, LUSC - lung squamous-cell carcinoma.

Additional file 11. Methods.

Additional file 4. Figure S1: Availability of plasma samples. The availability of plasma samples for analysis at each schedule collection time point. Blue and red blocks denote samples collected before and after disease recurrence, respectively. Abbreviations: LUAD – lung adenocarcinoma, LUSC - lung squamous-cell carcinoma, RFS – recurrence-free survival, AT – adjuvant therapy, RT – radiotherapy, LNM – lymph node metastasis.

Romosozumab is a novel drug for the treatment of osteoporosis. The adverse reactions of romosozumab still need to be explored. The FDA Adverse Event Reporting System (FAERS) provides an enormous dataset for adverse events (AEs) analysis. AEs registered in FAERS between January 2019 and December 2020 were collected for this study. The reporting odds ratio (ROR) method was applied to analyze the AEs of romosozumab. The number of AEs ≥4 cases and ROR value 95%...

Additional file 8. Figure S5: Prognostic values of ctDNA detection based on clonal and subclonal mutations. A). The recurrence-free survival analysis of patients stratified by ctDNA detection based on only clonal mutation profiles. B). The recurrence-free survival analysis of patients stratified by ctDNA detection based on all clonal and subclonal mutations.

Additional file 2. Analysis of differential miRNA in chickens infected with Newcastle disease virus (NDV) or avian influenza virus (AIV). (A) The Vene Map different miRNAs of chicken infection NDV or AIV. (B) The Heat Map differential miRNAs of chicken infection with NDV. (C) The Volcano Map different miRNAs of chicken infection with AIV. The miRNA microarray using the R package “limma”. |logFC|> 2 and a p-value < 0.05 were set as the threshold to...

Supplementary Information

Supplemental material, sj-docx-1-jad-10.1177_10870547231153941 for Efficacy and Safety of PRC-063 for Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-analysis From Randomized Controlled Trials by Shixin Zhu, Tianyi Wang, Jiahe Wang, Siyuan Yang, Zhengquan Yu, Heng Gao and Gang Chen in Journal of Attention Disorders

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231153730 for In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease by Junfang Zhang, Jie Wang, Xiaomeng Xu, Zhiwen You, Qi Huang, Yiyun Huang, Qihao Guo, Yihui Guan, Jun Zhao, Jun Liu, Wei Xu, Yulei Deng, Fang Xie and Binyin Li in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231153730 for In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease by Junfang Zhang, Jie Wang, Xiaomeng Xu, Zhiwen You, Qi Huang, Yiyun Huang, Qihao Guo, Yihui Guan, Jun Zhao, Jun Liu, Wei Xu, Yulei Deng, Fang Xie and Binyin Li in Journal of Cerebral Blood Flow & Metabolism

In this study, the flax (Linum usitatissimum L.) genes associated with resistance to the disease pasmo (Septoria linicola (Speg.) Garassini) were mapped using genome resequencing and bulked segregant analysis (BSA) of genomic DNA of the pasmo-resistant parent y62–9, pasmo-susceptible parent y64–5, and F2 generation segregants. Pasmo resistance genes were identified using Gene Ontology (GO) functional prediction and gene annotation methods. A Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed the biological information and molecular...

Additional file 1: Table S1. Definition and classification of risk factors for cervical lymph node metastasis in PTMC.

Additional file 6: Figure S1. Subcellular location of ZNF71 protein (downloaded from HPA website).

Additional file 1. Supplementary materials for the prediction and prognosis of adverse maternal and foetal/neonatal outcomes in pulmonary hypertension.

High iron intake has been shown to be associated with poor cognition. We aimed to examine the association between iron-related dietary pattern (IDP) and cognitive function in Chinese adults. Longitudinal study data from the China Health and Nutrition Survey (CHNS) during 1991–2006 were used (N = 4852, ≥55 years old). Dietary intake was obtained from a 3-day food record during home visits. Reduced rank regression was used to construct IDP with iron intake as a...

Additional file6: Supplementary figure 1. The expression of immune checkpoint genes between FA metabolism-related lncRNA subgroups. (A, B) The boxplots display the dysregulation of immune checkpoint genes in the TCGA and GSE76427 cohorts.

Additional file7: Supplementary figure 2. Original gels for all western blots in Figure 9 Original gel image measuring immunopositivity against ferroptosis markers in HCC cells. ACTIN was used as loading control. Bands used in the manuscript have been boxed in red.

Additional file8: Supplementary figure 3. Original gels images for all western blots in Figure 9.

Additional file 5: Figure S4. Metabolite composition and difference between Proximal N and Distal N. A, B OPLS-DA showed that Proximal N and Distal N were not separated into two clusters. Test for OPLS-DA model showed that the OPLS-DA model for this study was valid.