Immune checkpoint inhibitors (ICIs) -induced adverse events (AEs) have been reported affecting almost all human organs. However, studies about ocular AEs are few. A meta-analysis was performed to evaluate the risks of ICI-related ophthalmic AEs compare to chemotherapy. Methods: Eligible studies were selected from phase II/III randomized controlled trials investigating ICIs. The data were analyzed by R software and Stata. Odds ratio of treatment-related AE (trAEs) and nonspecific ophthalmic trAEs (NS-trAEs) were lower for PD-1/PD-L1...

The Meso- to Neoproterozoic Eras were characterized by environmental, evolutionary, and lithospheric stability in the North China Craton (NCC). It is controversial that huge uplift(s) occurred in the North China Craton during this period. The southern NCC developed early terrestrial deposition in the late-Paleoproterozoic and glacial sequence in the late Neoproterozoic record integrated geological history of the NCC in the intervening interval. Geochemistry compositions of mid-Mesoproterozoic carbonaceous slates (ca. 1330 Ma) show similar provenances to...

Supplemental material, sj-pdf-1-prf-10.1177_02676591211031468 for Establishment of a venovenous extracorporeal membrane oxygenation in a rat model of acute respiratory distress syndrome by Yongnan Li, Jian Huang, Rongzhi Zhang, Shixiong Wang, Xingdong Cheng, Pengbin Zhang, Kerong Zhai, Wei Wang, Debin Liu and Bingren Gao in Perfusion

Supplemental material, sj-pdf-1-prf-10.1177_02676591211031468 for Establishment of a venovenous extracorporeal membrane oxygenation in a rat model of acute respiratory distress syndrome by Yongnan Li, Jian Huang, Rongzhi Zhang, Shixiong Wang, Xingdong Cheng, Pengbin Zhang, Kerong Zhai, Wei Wang, Debin Liu and Bingren Gao in Perfusion

Fig. S1. Myelopoiesis in Tg(drl:hoxa9;hsp70:meis1) embryos receiving one time of HS induction or daily HS induction. Embryos were assayed by WISH for mpx at 5 dpf. HS, heat-shock; NS, no statistical significance. ;Fig. S2. A subgroup of Tg(drl:hoxa9;hsp70:meis1) adult fish develops AML-like phenotypes after one time HS in the embryos. Tg(drl:hoxa9;hsp70:meis1) embryos were HS induced at 24 hpf once and grown to adulthood. (A) May-Grünwald/Giemsa staining of the whole kidney marrow blood cells and peripheral...

Additional file 2. Supplementary Figures.

Additional file 1. Section S1: The specific process of Focal liver lesion puncture biopsy procedure. Section S2: Image archiving and scanning parameters of CT and MRI. Table S1: FLLs with TIV images characteristics. Except where indicated, data are numbers of nodules or TIV cases and numbers in parentheses are percentages. * datas are Mean ± SD. / means NA. AP: Arterial phase; APHE: Arterial phase hyperenhancement; CEUS: Contrast-enhanced ultrasound; FLLs: Focal liver lesions; HCC: Hepatocellular...

Supplemental Document (revised)

Supplementary Material 1

Supplementary Material 2

Additional file 2: Fig. S1. Evolutionary inference of nutrition types for Neottieae. Numbers in bold near branches indicate the node number, as referred to Fig. 3. Large pie charts show the relative probabilities of alternative ancestral states obtained by BayesTraits. Fig. S2. Ancestral range reconstruction for Neottieae using BioGeoBEARS under the statistical DEC model. Numbers in bold near branches indicate the node number, as referred to Fig. 3. Large pie charts show the relative probabilities...

Additional file 1.

Supplemental Document (revised)

Additional file 1: Supplemental file 1. Study information sheet for patients.

Phosphorus (P) as an essential nutrient for life sustains the productivity of food systems; yet misdirected P often accumulates in wastewater and triggers water eutrophication if not properly treated. Although technologies have been developed to remove P, little attention has been paid to the recovery of P from wastewater. This work provides a comprehensive review of the state-of-the-art P removal technologies in the science of wastewater treatment. Our analyses focus on the mechanisms, removal efficiencies,...

Additional file 1: Supplementary Fig. S1. PGA with highly complex structure under SEM. Supplementary Fig. S2. Two other crosslinking methods. Supplementary Fig. S3. The detailed process of fabricating DCDS suture with standardization. Supplementary Fig. S4. The tensile strength of double-layers swim bladder with and without crosslinking.

Supplementary Material 1

Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated...

Asini Corii Colla (ACC) and Taurus Corii Colla (TCC) are well-known for their high nutritional value, especially for medicinal purposes. However, the aforementioned are also potential candidates for adulteration because of their low yield and high price. A UPLC-MS/MS approach based on the specific peptide was proposed to detect adulterated gelatin with possible mixed animal species. To explore the antioxidant activity, the peptides were separated to evaluate their effect on ·OH radical and DPPH· scavenging...

Supplemental material, sj-docx-3-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch,...

Supplemental material, sj-docx-6-taj-10.1177_20406223221143245 for Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis by Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang and Yunshan Cao in Therapeutic Advances in Chronic Disease

In this work, the influence of sand impingements on cathodic protection (CP) of marine carbon steel in natural sea water was studied in comparison with the CP performances in static and flowing sea water without sand particles. Results show that the propagation of local active anodic dissolution at the steel inclusions could be totally inhibited by providing sufficient cathodic current in the sea water free of sand particles. However, the local ‘CP shielding’, potential fluctuation...

Space-filling designs are a convenient and effective approach for exploring the input space for experiments. However, standard choices for these designs strive to provide uniform density of points throughout the region of interest. There are numerous situations where flexibility to adapt the density of points to match specific design objectives would be advantageous to maximize the efficiency of the design. In this paper, we propose non-uniform space-filling (NUSF) designs to achieve a user-specified desired density...

Space-filling designs are a convenient and effective approach for exploring the input space for experiments. However, standard choices for these designs strive to provide uniform density of points throughout the region of interest. There are numerous situations where flexibility to adapt the density of points to match specific design objectives would be advantageous to maximize the efficiency of the design. In this paper, we propose non-uniform space-filling (NUSF) designs to achieve a user-specified desired density...

The systemic review and meta-analysis aimed to identify the predictors for short-term successful weaning from CRRT in severe AKI patients. PubMed, Embase, the Cochrane Library, and grey literature were searched for relevant studies investigating variables for short-term successful weaning from CRRT to August 2022. Our criteria included patients with AKI who required CRRT but excluded patients with kidney failure. The pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using fixed-effect (I2≤50% and...