460 Works

Study on influencing factors of Pickering emulsion stabilized by modified montmorillonite and fatty alcohol polyoxyethylene ether

Qian Chen, Zeyu Yang, Xiumei Tai, Yanyun Bai & Guoyong Wang
Pickering emulsion is widely used in food, drug administration, and cosmetics. In practical applications, surfactants are often co-present with particles, so it is particularly critical to study particle-surfactant interactions. Pickering emulsions were prepared using stearyltrimethylammoniumchloride organic montmorillonite (STAC/MMT) and fatty alcohol polyoxyethylene ether (AEO-3) as stabilizers. Effects of AEO-3 content, STAC/MMT content, oil-water ratio, emulsification temperature, emulsification time on emulsion stability were systematically revealed by studying the particle size distribution and phase volume of the...

mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation

Youhua Liu, Yuanling Zhao, Ruifan Wu, Yushi Chen, Wei Chen, Yuxi Liu, Yaojun Luo, Chaoqun Huang, Botao Zeng, Xing Liao, Guanqun Guo, Yizhen Wang & Xinxia Wang
5-Methylcytosine (m5C) is a type of RNA modification that exists in tRNAs and rRNAs and was recently found in mRNA. Although mRNA m5C modification has been reported to regulate diverse biological process, its function in adipogenesis remains unknown. Here, we demonstrated that knockdown of NOL1/NOP2/Sun domain family member 2 (NSUN2), a m5C methyltransferase, increased lipid accumulation of 3T3-L1 preadipocytes through accelerating cell cycle progression during mitotic clonal expansion (MCE) at the early stage of adipogenesis....

Three new tyrosol derivatives from Huangjing wine

Yan-Bin Ren, Xing-Wen Wang, Jia-Xuan Bai, Chang Liu, Si-Lin Yu, Yue Zhou, Cong-Cong Lin, Da-Hong Yao, Jian Huang & Jin-Hui Wang
Phytochemical investigation on the concentrate of Huangjing wine, resulted in the isolation of three new tyrosol derivatives 4′′′-hydroxyphenethyl 2-(R)-hydroxy-3-phenylpropionate (1), 4′′′-hydroxyphenethyl(4′-hydroxy-3′-methoxyphenyl)propionate (2) and 4′′-hydroxyphenethyl ethyl succinate (3), together with 5 known compounds, ferulic acid (4), L-phenyllactic acid (5), hydroxytyrosol (6), dihydroferulic acid (7), cyclo(L-Pro-D-Tyr) (8). Their structures were elucidated using spectroscopic analysis and by comparison with the literature data. All compounds displayed antioxidant effect in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical. Among them, the new compound 2...

A transcriptomic analysis of neuropathic pain in the anterior cingulate cortex after nerve injury

Yu Zhang, Shiwei Jiang, Fei Liao, Zhifeng Huang, Xin Yang, Yu Zou, Xin He, Qulian Guo & Changsheng Huang
The anterior cingulate cortex (ACC) is a core brain region processing pain emotion. In this study, we performed RNA sequencing analysis to reveal transcriptomic profiles of the ACC in a rat chronic constriction injury (CCI) model. A total of 1628 differentially expressed genes (DEGs) were identified by comparing sham-operated rats with rats of 12 hours, 1, 3, 7, and 14 days after surgery, respectively. Although these inflammatory-related DEGs were generally increased after CCI, different kinetics...

Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway

Jiachen Duan, Mengyuan Jin, Dongjing Yang, Jihua Shi, Jie Gao, Danfeng Guo, Hongwei Tang, Shuijun Zhang & Baoping Qiao
Clear cell renal cell carcinoma, the most common type of renal cancer, is associated with poor survival. Ubiquitin-specific peptidase 2 regulates the molecular mechanisms of cancer cells. However, its mechanism in clear cell renal cell carcinoma remains unclear. Quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and immunohistochemistry were performed to assess ubiquitin-specific peptidase 2 expression in human clear cell renal cell carcinoma samples. Ubiquitin-specific peptidase 2 was weakly expressed in clear cell renal cell...

A plant nonenveloped double-stranded RNA virus activates and co-opts BNIP3-mediated mitophagy to promote persistent infection in its insect vector

Qifu Liang, Jiajia Wan, Huan Liu, Dongsheng Jia, Qian Chen, Aiming Wang & Taiyun Wei
Mitophagy that selectively eliminates damaged mitochondria is an essential mitochondrial quality control mechanism. Recently, mitophagy has been shown to be induced in host cells infected by a few animal viruses. Here, we report that southern rice black-streaked dwarf virus (SRBSDV), a plant nonenveloped double-stranded RNA virus, can also trigger mitophagy in its planthopper vector to prevent mitochondria-dependent apoptosis and promote persistent viral propagation. We find that the fibrillar structures constructed by the nonstructural protein P7-1...

High-performance visible-light active Sr-doped porous LaFeO3 semiconductor prepared via sol–gel method

Xi-Tao Yin, Hua Huang, Jie-Li Xie, Davoud Dastan, Jing Li, Ying Liu, Xiao-Ming Tan, Xiao-Chun Gao, Wahab Ali Shah & Xiao-Guang Ma
In this work, we have successfully fabricated Sr-doped porous LaFeO3 samples via sol–gel method. The results reveal that Sr2+ cation is effectively doped into LaFeO3 crystal lattice substituting La3+ cation. The visible light catalytic performance of the materials was evaluated by the degradation of 2,4-dichlorophenol (2,4-DCP) and Rhodamine B (RhB). The amount-optimized Sr-doped porous LaFeO3 sample exhibited outstanding visible-light catalytic performance for the degradation of the model pollutants compared to the porous LaFeO3 alone. The...

Additional file 2 of Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co-expression network analysis

Xie Qiu, Wei Liu, Yifan Zheng, Kai Zeng, Hao Wang, Haijun Sun & Jianhua Dai
Additional file 2: Figure S1. Original blot and images. Figure S2. HMGB2 expression is not correlated with survival of patients with LUSC.

A magnetophoretic microdevice for multi-magnetic particles separation based on size: a numerical simulation study

Jia Ruan, Weiwei Zhang, Chi Zhang, Na Li, Jian Jiang & Huilan Su
Due to the outstanding properties, magnetic particles have been widely used as magnetic carriers and adsorbents in a diverse range of fields, such as biomedical diagnostics, food safety, and environmental monitoring, etc. Sorting different magnetic particles from each other based on size simultaneously can be very useful in multiple targets separation. To the best of our knowledge, this research firstly proposes the arc comb structure microfluidic (ACSM) chip for multi-magnetic particles separation based on size...

Additional file 1 of Interactions of CDKAL1 rs7747752 polymorphism and serum levels of L-carnitine and choline are related to increased risk of gestational diabetes mellitus

Hui Wang, Jing Li, Jinnan Liu, Junhong Leng, Weiqin Li, Zhijie Yu, Claudia H. T. Tam, Gang Hu, Ronald C. W. Ma, Zhongze Fang, Ying Wang & Xilin Yang
Additional file 1: Figure S1. Associations between L-carnitine and the risk of gestational diabetes mellitus (GDM) in Chinese women.

Additional file 3 of Using a mixed method to identify communication skills training priorities for Chinese general practitioners in diabetes care

Mi Yao, Gang Yuan, Kai Lin, Lijuan Liu, Hao Tang, Jieying Xie, Xinxin Ji, Rongxin Wang, Binkai Li, Jiajia Hao, Huichang Qiu, Dongying Zhang, Hai Li, Shamil Haroon, Dawn Jackson, Wei Chen, Kar Keung Cheng & Richard Lehman
Additional file 3:

Additional file 2 of Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis

Shengkui Qiu, Li Xie, Chen Lu, Chao Gu, Yiwen Xia, Jialun Lv, Zhe Xuan, Lang Fang, Jing Yang, Lu Zhang, Zheng Li, Weizhi Wang, Hao Xu, Bowen Li & Zekuan Xu
Additional file 2.

Additional file 1 of A genetic map of the chromatin regulators to drug response in cancer cells

Bo Chen, Pengfei Li, Mingyue Liu, Kaidong Liu, Min Zou, Yiding Geng, Shuping Zhuang, Huanhuan Xu, Linzhu Wang, Tingting Chen, Yawei Li, Zhangxiang Zhao, Lishuang Qi & Yunyan Gu
Additional file 1: Fig. S1. Lung cancer cell lines with RB1 mutations are resistant to CDK4/6 inhibitor, Fig. S2. Sensitive biomarkers interacted with CHEK1 in large intestine cancer cell lines, Fig. S3. Resistant biomarkers interacted with CHEK1 in lung cancer cell lines, Fig. S4. Functional analysis of the CRs genetic interaction, Fig. S5. Differential chromatin accessibility for CSL interactions, Fig. S6. Differential chromatin accessibility for CSV interactions, Fig. S7. TUBA1C subnetwork in drug related CSL...

Additional file 1 of Impact of the national hepatitis B immunization program in China: a modeling study

Zhixi Liu, Mengying Li, David W. Hutton, Abram L. Wagner, Ye Yao, Wenlong Zhu, Lingsheng Cao, Shenglan Tang, Jinhua Pan, Yesheng Wang, Qi Zhao, Hong Ren, Ying Wang & Weibing Wang
Additional file 1: Fig: S1. Transmission structure of the HBV mathematical model. Fig. S2. HBV infection and progression structure of Markov model. Fig. S3. Process of acute HBV infection. Fig. S4. Dynamic model fitting and prediction results. The blue points represent the observed incidence data, while the black cross represents the incidence data fitted by the model. Red triangles represent the predicted incidence data. Fig. S5. Exploration of feasible vaccination interventions on HBV. A: the...

Precursor-mediated colloidal synthesis of compositionally tunable Cu−Sb−M−S (M = Zn, Co, and Ni) nanocrystals and their transport properties

Maria Zubair, VASILY LEBEDEV, Mohini Mishra, Temilade Esther Adegoke, Ibrahim Saana Aminu, Yu Zhang, Andreu Cabot & KEVIN T. RYAN
The solution-based colloidal synthesis of multinary semi-conductor compositions has allowed the design of new inorganic materials impacting a large variety of applications. Yet there are certain compositions that have remained elusive--particularly quaternary structures of transition metal-based (e.g., Co, Zn, Ni, Fe, Mn, and Cr) copper antimony chalcogenides. These are widely sought for tuning the electrical and thermal conductivity as a function of the size, composition, and crystal phase. In this work, a facile hot injection...

Exploration of the potential neuroprotective compounds targeting GluN1-GluN2B NMDA receptors

Meixi He, Yi Wang, Xiaozhe Zhang & Lihua Zhang
The N-methyl-d-aspartic acid (NMDA) receptors belongs to the family of ionotropic glutamate receptors, which could mediate most excitatory synaptic transmission in the brain. It is interesting to know if some available drugs have regulatory effects on the NMDARs. Herein, the present study reports the discovery of drugs targeting NMDAR using virtual screening. In this study, talniflumate with the EC50 value at 61.49 nM was successfully screened. The interaction analysis of this compound was further explored...

Additional file 1 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Additional file 1: Fig. S1: The ABCDE model and the quartet model of floral organ development in Arabidopsis thaliana.

Additional file 4 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Additional file 4: Table S1: The primers used for qRT-PCR verification.

Additional file 5 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Additional file 5: Table S2: ESI-MS/MS parameters for determination of eight phytohormones.

Additional file 7 of Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Additional file 7: Table S4: Summary of RNA-Seq data and mapping metrics.

Supplementary document for High-performance All-inorganic CsPbBr₃ Quantum Dots with a Low-Threshold Amplified Spontaneous Emission and Lasing - 6173938.pdf

Shuya Ning, Fan Duan, naming zhang, Kang Dai, Jiajia He, Zhihui Liu, Shuo Wang & Fanghui Zhang
Figure S1(PLQY),Figure S2 (emission spectra)

Cytotoxic flavonoids from the leaves of Callicarpa nudiflora hook

Jin-Lin Zhang, Yin Xiao, Lu Zhou, Shao-Yang Yin, Jia-Yin Long, Hong-Lin Xiang, Xi-Feng Sheng & Hui Zou
A new flavonoid glycoside, luteolin-3′-O-β-D-6″-acetyl glucopyranoside (1), along with six known flavonoids, were isolated from the leaves of Callicarpa nudiflora Hook. The structures of the isolated compounds were established on the basis of extensive spectroscopic analyses. Compound 6 exhibited potent cytotoxicity and compounds 1 and 7 exhibited moderate cytotoxicity against human hepatocellular carcinoma SMMC-7721 cells.

Supplemental Material - Predicting housing construction period based on a cox proportional hazard model––an empirical study of housing completions in the greater Toronto and Hamilton area

Yu Zhang & Eric J Miller
Supplemental Material for Predicting housing construction period based on a cox proportional hazard model––an empirical study of housing completions in the greater Toronto and Hamilton area by Yu Zhang and Eric J Miller in Environment and Planning B: Urban Analytics and City Science

Additional file 2 of Obesity promotes lipid accumulation in lymph node metastasis of gastric cancer: a retrospective case‒control study

Jian Xiao, Kuan Shen, Kanghui Liu, Yuanhang Wang, Hao Fan, Quan Cheng, Xinyi Zhou, Li Hu, Gang Wang, Zekuan Xu & Li Yang
Additional file 2: Supplementary Table 1. Subgroup analysis for the association between categorized BMI and lymph node metastasis.

Plant growth and heavy meal accumulation characteristics of Spathiphyllum kochii cultured in three soil extractions with and without silicate supplementation

Kehui Liu, Chenglong Dai, Chunming Li, Jie Hu, Zhiwei Wang, Yi Li, Fangming Yu & Guangluan Li
A hydroponic method was conducted to test whether Spathiphyllum kochii is tolerant to multiple HMs as well as to evaluate whether sodium silicate promotes plant growth and alleviates HM stress mainly by assessing biomass, HM accumulation characteristics and antioxidant enzyme activities (AEAs). Three soil extractions from an uncontaminated soil, a comparable lightly HM-contaminated soil (EnSE), and a comparable heavily HM-contaminated soil (ExSE) with or without 1 mM sodium silicate supplementation were used. S. kochii showed...

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  • Affiliated Hospital of Nantong University
  • Zhejiang University
  • Fudan University
  • Huazhong University of Science and Technology
  • Shanghai Jiao Tong University
  • Chinese Academy of Sciences
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Central South University
  • Tongji University
  • Nanjing Medical University