Additional file 1: Fig. S1. Flow-chart of the studied participants. Fig. S2. Cumulative incidence of cardiovascular and non-cardiovascular mortality in the whole population and according to glucose tolerance. Table S1. Cox-proportional hazard model evaluating the association between NT-ProBNP levels and all-cause mortality according to baseline HbA1c levels by excluding patients with chronic kidney disease.

Additional file 9: Supplementary Table 3. List of acronyms and their abbreviation used in this study.

Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated...

Supplemental material, sj-docx-3-tai-10.1177_20499361221141771 for The impact of Antimicrobial Stewardship Programmes in paediatric emergency department and primary care: a systematic review by Giulia Brigadoi, Sara Rossin, Davide Visentin, Elisa Barbieri, Carlo Giaquinto, Liviana Da Dalt and Daniele Donà in Therapeutic Advances in Infectious Disease

Supplemental material, sj-docx-3-tai-10.1177_20499361221141771 for The impact of Antimicrobial Stewardship Programmes in paediatric emergency department and primary care: a systematic review by Giulia Brigadoi, Sara Rossin, Davide Visentin, Elisa Barbieri, Carlo Giaquinto, Liviana Da Dalt and Daniele Donà in Therapeutic Advances in Infectious Disease

Supplemental material, sj-docx-5-tai-10.1177_20499361221141771 for The impact of Antimicrobial Stewardship Programmes in paediatric emergency department and primary care: a systematic review by Giulia Brigadoi, Sara Rossin, Davide Visentin, Elisa Barbieri, Carlo Giaquinto, Liviana Da Dalt and Daniele Donà in Therapeutic Advances in Infectious Disease

Grazing behaviour influences animal productivity and the conservation of grassland ecosystem services. We used GPS tracking and remote sensing (NDVI index) to monitor the grazing patterns of lactating cows on the ‘Malga Ombretta’ summer farm (1,957 m asl) in the Dolomites, eastern Italian Alps, from 5th July to 5th August 2018. The pasture area (35 ha) was grazed by a mixed herd of Simmental and Alpine grey cows (stocking density = 0.6 LU/ha) under traditional...

Endoplasmic reticulum stress is an emerging significant player in the molecular pathology of connective tissue disorders. In response to endoplasmic reticulum stress, cells can upregulate macroautophagy/autophagy, a fundamental cellular homeostatic process used by cells to degrade and recycle proteins or remove damaged organelles. In these scenarios, autophagy activation can support cell survival. Here we demonstrated by in vitro and in vivo approaches that megakaryocytes derived from col6a1−⁄− (collagen, type VI, alpha 1) null mice display...

Supplemental material, sj-docx-1-jbm-10.1177_03936155231154663 for Overordering of tumor marker for outpatients revealed by performance indicators and the impact of a health policy intervention: An observational study using administrative records by Massimo Gion, Roberto De Gobbi, Manuel Zorzi, Giovanni Carretta, Luca Leonardi, Stefano Guzzinati, Chiara Trevisiol, Maurizio Cancian, Giulia Cardinali, Federica Michieletto, Ruggero Dittadi, Aline S.C. Fabricio, Massimo Rugge and Francesca Russo in The International Journal of Biological Markers

Additional file 3: Figure S3. LAMC2 expression correlates with CSC content and function. (a) qPCR analysis of LAMC2 gene expression in adherent cells versus spheres. Data are normalized to GAPDH and are presented as fold change in gene expression relative to adherent cells (indicated as Adh). (b) Western blot analysis of LAMC2 in adherent cells versus spheres. Parallel β-ACTIN immunoblotting was performed. (c) qPCR analysis for CD44, CD133 and L1CAM genes in adherent cells versus...

Additional file 9: Figure S9. Global gene expression profiles of LAMC2-EGFP+ and EGFP--derived tumors. Heat map of differentially expressed genes in EGFP+ and EGFP- cells isolated from tumors.

Language is a technological tool, since it is the outcome of a process of exteriorisation of a set of intentional practices. This process of exteriorisation is semiotic in nature. Language as technology and technology as language are thus ways of socialize consciousness. On the basis of some recent results in applied linguistics, the paper suggests that language and technology have to be considered as “functioning” when they enable social relations, by collectivising consciousness and producing...

Initiation of protein-primed (-) strand DNA synthesis in hepatitis B virus (HBV) requires interaction of the viral polymerase with a cis-acting regulatory signal, designated epsilon (ε), located at the 5′-end of its pre-genomic RNA (pgRNA). Binding of polymerase to ε is also necessary for pgRNA encapsidation. While the mechanistic basis of this interaction remains elusive, mutagenesis studies suggest its internal 6-nt “priming loop” provides an important structural contribution. ε might therefore be considered a promising...

This book gives a detailed report of twenty years of scientific research, investigations and studies on the site with Middle Pleistocene fossil footprints, known as “Devil's Trails" paleontological site, which is located on the north-eastern slopes of the Roccamonfina volcano, in the locality of Foresta (municipality of Tora e Piccilli, Central-Southern Italy). The fossilised human and animal footprints, radiometrically dated to 349 3 ka years ago, are described here in detail and contextualised in the worldwide...

Here we report about a fossil handprint located in the "Ciampate del diavolo" palaeontological site (Tora e Piccilli, central-southern Italy). Radiometrically dated at ~350 ka, it is the only fossilized Middle-Pleistocene human handprint up to know known in the world and the oldest so far. This handprint, called TP_M1, cannot be compared with anything similar at present, either in hypogeal or subaerial environments and is completely unrelated to any cultural purpose. Since it can only...

Fossil human footprints are among the rarest and most precious finds for the study of antiquity. Their value lies in their power to describe body structures, actions, and behaviours. Their rarity is because - almost always - they are preserved on deposits that have turned into soft rocks which are easily eroded by natural agents and damaged by human wrong actions and management. Considering human ichnites as any other archaeological find to be preserved is...

This supplementary paper provides graphical schemes of all the geometric constructions carried out to apply the selected mensural conventions to the fossil human footprints widely known as “Ciampate del diavolo” or “Devil’s Trails” (Tora e Piccilli, Roccamonfina volcano, Central-Southern Italy). These graphical schemes help to complete the final dimensional dataset and provide further data very useful in any other morphometric and human gait-analysis comparations. Moreover, the dimensional values obtained through these geometric elaborations, if compared...

Introduzione critica all'elamita, risorse elettroniche e bibliografia.

Structure from Motion (SfM) photogrammetry is based on the use of algorithms allowing the automatically identification of a large amount of homologous points (or pixels) between images overlapping areas. The coordinates of the homologous points (provided in different reference systems for each acquisition), allow the images alignment meaning the internal and external camera calibration. The number and the distribution of homologous points drives the entire procedure of photogrammetric restitution. In some cases, due to a...

Der Beitrag versucht greifbar zu machen, inwiefern die von der Corona- Pandemie verstärkte existenzielle Langeweile in einem Verhältnis zu Narrativen steht, die über Medien in Form von technischen Bildern an das Individuum herangetragen werden. In weiterer Folge ist von Bedeutung, welche Auswirkungen die vermittelten Narrative auf ein solches Individuum haben und ob durch sie ein Ausweg aus der existenziellen Langeweile/Leere geschaffen werden kann, respektive inwiefern sie durch diesen Prozess sogar noch verstärkt wird.

Introduzione critica al proto-elamita, risorse elettroniche e bibliografia.

Supplemental material, sj-docx-1-tah-10.1177_20406207221127550 for Coexisting conditions and concomitant medications do not affect venetoclax management and survival in chronic lymphocytic leukemia by Anna Maria Frustaci, Giovanni Del Poeta, Andrea Visentin, Paolo Sportoletti, Alberto Fresa, Candida Vitale, Roberta Murru, Annalisa Chiarenza, Alessandro Sanna, Francesca Romana Mauro, Gianluigi Reda, Massimo Gentile, Marzia Varettoni, Claudia Baratè, Chiara Borella, Antonino Greco, Marina Deodato, Giulia Zamprogna, Roberta Laureana, Alessandra Cipiciani, Andrea Galitzia, Angelo Curto Pelle, Francesca Morelli, Lucio Malvisi, Marta Coscia,...

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the...

Supplemental material, sj-docx-1-qjp-10.1177_17470218221146540 for Verbal deception in picture naming by Eduardo Navarrete, Marta De Pedis and Anna Lorenzoni in Quarterly Journal of Experimental Psychology

This study aimed to assess the consequences of reducing the concentrates supply level (CSL) in the lactating cows’ diet on Alpine dairy system’s GHG emissions. Consequential-based Life Cycle Assessment (cLCA) was adopted to assess the consequences within the ‘dairy_system’ (farm plus milk processing) and outside (‘expanded_system’). The functional unit was 1 kg of protein and fat (ProtFat). Data (1-year average) originated from 40 dairy farms in the Alps, collected through farm questionnaires during farm visits....