Supplemental material, sj-pdf-1-pss-10.1177_09567976221097947 for Severe Developmental Dyscalculia Is Characterized by Core Deficits in Both Symbolic and Nonsymbolic Number Sense by Gisella Decarli, Francesco Sella, Silvia Lanfranchi, Giulia Gerotto, Silvia Gerola, Giuseppe Cossu and Marco Zorzi in Psychological Science

Introduzione critica al cuneiforme sumerico, risorse elettroniche e bibliografia.

Additional file 10: Figure S10. Inhibition of transforming growth factor beta (TGF-β) signaling blocks LAMC2-induced metastasis. (a) Enrichment plots for pancreatic cancer, focal adhesion, hypoxia, MAPK signaling, glycolysis and gluconeogenesis pathways in EGFP+ versus EGFP- cells isolated by FACS from subcutaneous tumors. (b) Western blot analysis for pSMAD2 and SMAD2 in EGFP- versus EGFP+ PANC-1 and #253 cells. Parallel GAPDH immunoblotting was performed. (c) Flow cytometry quantification of EGFP and ALK5-TGFβR1 in EGFP- and EGFP+...

Supplementary Material 1

This report provides a complete description of the general “Ciampate del diavolo” palaeontological site (Tora e Piccilli, Central-Southern Italy) and each of the human ichnites there found so far. This description is integrated and completed with the tables, graphs, and pictures given in Supplements 1, 2, and 3 of this volume [Panarello et al., 2022a;b;c]. We think that this huge amount of both numeric and visual data will be very useful for any other human...

The various on-field activities which have been carried out by researchers in the “Devil’s Trails” palaeontological site from 2005 to 2010 and the subsequent Ph.D. researches on the site that took place until 2016 have allowed us to identify - in addition to the various ichnological evidence of prehistoric times - also a series of anthropic cuts made in various historical times. These cuts sometimes overlap the prehistoric traces, or partially alter them, so creating...

This supplementary paper provides the complete visual atlas of some of the oldest human footprints (~350 ka) up to now known in the world which are known as “Ciampate del diavolo” or “Devil’s Trails” and are preserved on the Brown Leucitic Tuff created by the Roccamonfina volcano (Tora e Piccilli, Central-Southern Italy). High detailed planimetric maps (1 mm steps), depth maps, oblique quoted views, photographic and light controlled images created from photogrammetric 3D-models give a...

Additional file 4: Figure S4. Knockdown of LAMC2 does not affect cell growth. (a) Western blot analysis of LAMC2 in sh empty and LAMC2 knockdown cells. Parallel β-ACTIN immunoblotting was performed. (b) qPCR analysis for LAMC2 and CD44 gene expression in sh empty and LAMC2 knockdown cells. Data are normalized to GAPDH and are presented as fold change in gene expression relative to sh empty. (c) Representative images of sh empty and LAMC2 knockdown cells...

Additional file 6: Figure S6. Knockdown of LAMC2 affects tumorigenicity. (a) Representative images from a gelatin degradation assay of sh empty and LAMC2 knockdown cells. Nuclei were stained with Hoechst 33342 (blue), green represents actin (Alexa Fluor™ 488 Phalloidin) and red illustrates gelatin (Rodhamine). The white dashed line circles indicate the areas of degradation. (b) Degradation potential of sh empty and LAMC2 knockdown cells. (c) qPCR analysis for EMT genes in sh empty and LAMC2...

Supplemental material, sj-docx-1-dhj-10.1177_20552076221133696 for A topic trend analysis on COVID-19 literature by Sara Urru, Veronica Sciannameo, Corrado Lanera, Silvano Salaris, Dario Gregori and Paola Berchialla in Digital Health

Additional file 1. Appendix 1: The French version of Olfactory Disorder Questionnaire.

Additional file 1. Classification of treatment center countries of JIA patients into geographic regions.

Additional file 2. Classification of reported autoimmune diseases in parents of included JIA patients.

Additional file 3. Prevalence rates of diseases from the “other autoimmune disease” category in parents of included JIA patients (n = 17,346).

Additional file 1: Fig. S1. Flow-chart of the studied participants. Fig. S2. Cumulative incidence of cardiovascular and non-cardiovascular mortality in the whole population and according to glucose tolerance. Table S1. Cox-proportional hazard model evaluating the association between NT-ProBNP levels and all-cause mortality according to baseline HbA1c levels by excluding patients with chronic kidney disease.

Additional file 9: Supplementary Table 3. List of acronyms and their abbreviation used in this study.

Grazing behaviour influences animal productivity and the conservation of grassland ecosystem services. We used GPS tracking and remote sensing (NDVI index) to monitor the grazing patterns of lactating cows on the ‘Malga Ombretta’ summer farm (1,957 m asl) in the Dolomites, eastern Italian Alps, from 5th July to 5th August 2018. The pasture area (35 ha) was grazed by a mixed herd of Simmental and Alpine grey cows (stocking density = 0.6 LU/ha) under traditional...

Endoplasmic reticulum stress is an emerging significant player in the molecular pathology of connective tissue disorders. In response to endoplasmic reticulum stress, cells can upregulate macroautophagy/autophagy, a fundamental cellular homeostatic process used by cells to degrade and recycle proteins or remove damaged organelles. In these scenarios, autophagy activation can support cell survival. Here we demonstrated by in vitro and in vivo approaches that megakaryocytes derived from col6a1−⁄− (collagen, type VI, alpha 1) null mice display...

Additional file 3: Figure S3. LAMC2 expression correlates with CSC content and function. (a) qPCR analysis of LAMC2 gene expression in adherent cells versus spheres. Data are normalized to GAPDH and are presented as fold change in gene expression relative to adherent cells (indicated as Adh). (b) Western blot analysis of LAMC2 in adherent cells versus spheres. Parallel β-ACTIN immunoblotting was performed. (c) qPCR analysis for CD44, CD133 and L1CAM genes in adherent cells versus...

Additional file 9: Figure S9. Global gene expression profiles of LAMC2-EGFP+ and EGFP--derived tumors. Heat map of differentially expressed genes in EGFP+ and EGFP- cells isolated from tumors.

This book gives a detailed report of twenty years of scientific research, investigations and studies on the site with Middle Pleistocene fossil footprints, known as “Devil's Trails" paleontological site, which is located on the north-eastern slopes of the Roccamonfina volcano, in the locality of Foresta (municipality of Tora e Piccilli, Central-Southern Italy). The fossilised human and animal footprints, radiometrically dated to 349 3 ka years ago, are described here in detail and contextualised in the worldwide...

Here we report about a fossil handprint located in the "Ciampate del diavolo" palaeontological site (Tora e Piccilli, central-southern Italy). Radiometrically dated at ~350 ka, it is the only fossilized Middle-Pleistocene human handprint up to know known in the world and the oldest so far. This handprint, called TP_M1, cannot be compared with anything similar at present, either in hypogeal or subaerial environments and is completely unrelated to any cultural purpose. Since it can only...

Fossil human footprints are among the rarest and most precious finds for the study of antiquity. Their value lies in their power to describe body structures, actions, and behaviours. Their rarity is because - almost always - they are preserved on deposits that have turned into soft rocks which are easily eroded by natural agents and damaged by human wrong actions and management. Considering human ichnites as any other archaeological find to be preserved is...

This supplementary paper provides graphical schemes of all the geometric constructions carried out to apply the selected mensural conventions to the fossil human footprints widely known as “Ciampate del diavolo” or “Devil’s Trails” (Tora e Piccilli, Roccamonfina volcano, Central-Southern Italy). These graphical schemes help to complete the final dimensional dataset and provide further data very useful in any other morphometric and human gait-analysis comparations. Moreover, the dimensional values obtained through these geometric elaborations, if compared...

Introduzione critica all'elamita, risorse elettroniche e bibliografia.