553 Works

Primary graft failure following allogeneic hematopoietic stem cell transplantation: risk factors, treatment and outcomes

Juan Chen, Aiming Pang, Yuanqi Zhao, Li Liu, Runzhi Ma, Jialin Wei, Xin Chen, Yi He, Donglin Yang, Rongli Zhang, Weihua Zhai, Qiaoling Ma, Erlie Jiang, Mingzhe Han, Jiaxi Zhou & Sizhou Feng
Graft failure (GF) is an intractable complication of transplantation, which can severely affect the efficacy of the graft; however, the characteristics, incidence, and risk factors of primary GF have not been well described. This study aimed to analyze the risk factors and outcomes of primary GF to swiftly identify high-risk patients for GF. We performed a case-control study with a case-control ratio of 1:4 with 869 patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT)...

Long intergenic non-protein coding RNA 1273 confers sorafenib resistance in hepatocellular carcinoma via regulation of methyltransferase 3

Huifang Kong, Jie Sun, Wei Zhang, Huixin Zhang & Hong Li
Hepatocellular carcinoma (HCC) is often diagnosed in patients with advanced disease who are ineligible for curative surgical therapies. Sorafenib is a first-line agent approved for the treatment of advanced HCC. However, the frequent resistance of HCC cells to sorafenib greatly reduces its efficacy. Herein, we describe a novel long non-coding RNA (lncRNA) conferring sorafenib resistance. Long intergenic non-protein coding RNA 1273 (LINC01273) was significantly overexpressed in human HCC and sorafenib-resistant tissues, linking it to poor...

A transcriptomic analysis of neuropathic pain in the anterior cingulate cortex after nerve injury

Yu Zhang, Shiwei Jiang, Fei Liao, Zhifeng Huang, Xin Yang, Yu Zou, Xin He, Qulian Guo & Changsheng Huang
The anterior cingulate cortex (ACC) is a core brain region processing pain emotion. In this study, we performed RNA sequencing analysis to reveal transcriptomic profiles of the ACC in a rat chronic constriction injury (CCI) model. A total of 1628 differentially expressed genes (DEGs) were identified by comparing sham-operated rats with rats of 12 hours, 1, 3, 7, and 14 days after surgery, respectively. Although these inflammatory-related DEGs were generally increased after CCI, different kinetics...

Rare earth elements in the iron-oxide apatite (IOA) deposit: insights from apatite

Shengchao Yan & Wei Liu
Kiruna-type or IOA deposits are characterized by magnetite-apatite-actinolite associations and may contain considerable amounts of rare earth elements (REEs) that can be exploited as by-products. REEs in the Kiruna-type deposit, heterogeneously distributed, are mainly hosted in phosphates (e.g. apatite). Published data of apatite, together with other evidence, can be used to decipher the source, enrichment mechanism, and post-ore modification of REEs in the Kiruna-type deposits. Sr isotopes and melt inclusions compositions of apatite, together with...

Water-soluble chitosan and phytoremediation efficiency of two Brassica napus L. cultivars in cadmium-contaminated farmland soils

Jian-Lin Bian, Wei Cao, Jun-Mei Guo, Jun-Xing Yang, Xue-Dong Wang, Jie Wang, Jun Huang, Tian-Xiang Xia & Cun-Yan Xia
Pot and field trials were conducted to investigate Cd uptake and phytoremediation efficiency of two Brassica napus cultivars (QY-1 and SYH) with applied water-soluble chitosan (WSC, Pot: 0, 2% and 4%; Field: 0 and 10 g·m−2) grown in Cd-contaminated soils. The results from the pot and field trials generally showed that WSC treatments significantly increased Cd concentrations in shoot and root tissues by 33.77–159.71% (except for SYH/JY) and 7.42–168.71% of two B. napus cultivars compared...

TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss

Chen Yang, Huaqiang Tao, Haifeng Zhang, Yu Xia, Jiaxiang Bai, Gaoran Ge, Wenming Li, Wei Zhang, Long Xiao, Yaozeng Xu, Zhirong Wang, Ye Gu, Huilin Yang, Yu Liu & Dechun Geng
Increased bone resorption by osteoclasts after estrogen deficiency is the main cause of postmenopausal osteoporosis. TET2 (tet methylcytosine dioxygenase 2) is a DNA demethylase that regulates cellular function and differentiation potential. Macroautophagy/autophagy maintains cellular homeostasis by recycling unnecessary and damaged organelles. This study revealed that TET2 promoted bone loss in oophorectomized (OVX) mice and that TET2 promoted osteoclast differentiation by regulating autophagy. Tet2 knockdown inhibited autophagy and osteoclast differentiation in vitro. Mechanistically, Tet2 knockdown increased...

A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner

Qiankun Yang, Jianguo Zhang, Feixue Liu, Huizhen Chen, Wei Zhang, Haitao Yang, Nana He, Jingquan Dong & Panpan Zhao
Aeromonas caviae, an important food-borne pathogen, induces serious invasive infections and inflammation. The pro-inflammatory IL-1β functions against pathogenic infections and is elevated in various Aeromonas infection cases. However, the molecular mechanism of A. caviae-mediated IL-1β secretion remains unknown. In this study, mouse macrophages (PMs) were used to establish A. caviae infection model and multiple strategies were utilized to explore the mechanism of IL-1β secretion. IL-1β was elevated in A. caviae infected murine serum, PMs lysates...

Hyperthermia promotes exosome secretion by regulating Rab7b while increasing drug sensitivity in adriamycin-resistant breast cancer

Di Xu, Wen-Juan Tang, Yi-Zhi Zhu, Zhen Liu, Kai Yang, Ming-Xing Liang, Xiu Chen, Yang Wu, Jin-Hai Tang & Wei Zhang
To investigate the mechanism through which hyperthermia promotes exosome secretion and drug sensitivity in adriamycin-resistant breast cancer. We first evaluated the effect of hyperthermia on adriamycin-resistant breast cancer viability and used transmission electron microscopy, nanoparticle tracking analysis, and a bicinchoninic acid kit to validate the effect of hyperthermia on exosome secretion. The effective targeting molecules and pathways changed by hyperthermia were explored by RNA microarray and verified in vitro. The adriamycin-resistant MCF-7/ADR cells co-incubated with...

Additional file 2 of Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co-expression network analysis

Xie Qiu, Wei Liu, Yifan Zheng, Kai Zeng, Hao Wang, Haijun Sun & Jianhua Dai
Additional file 2: Figure S1. Original blot and images. Figure S2. HMGB2 expression is not correlated with survival of patients with LUSC.

Additional file 2 of Evidence-based expert consensus on the management of primary central nervous system lymphoma in China

Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu, Yuqin Song, Xiaoguang Qiu, Wenbin Li, Song Lin, Xinghu Zhang, Dehong Lu, Junqiang Lei, Yaolong Chen & Ying Mao
Additional file 2. Search strategies in each database.

Additional file 4 of Evidence-based expert consensus on the management of primary central nervous system lymphoma in China

Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu, Yuqin Song, Xiaoguang Qiu, Wenbin Li, Song Lin, Xinghu Zhang, Dehong Lu, Junqiang Lei, Yaolong Chen & Ying Mao
Additional file 4. Delphi results.

Four organosulfur compounds from the seeds of Capsella bursa-pastoris and their anti-inflammatory activities

Zhen-Zhen Wei, Ti-Qiang Zhou, Zi-Ming Xia, Si-Fan Liu, Min Li, Guang-Jie Zhang, Ying Tian, Bin Li & Lin Wang
Phytochemical investigation of the seeds of Capsella bursa-pastoris led to the isolation of four organosulfur compounds. There were two new compounds, 10-methylsulfinyl-decanamide (1) and 11-methylsulfinyl-undecanamide (2), along with two known compounds (3 − 4), which all have a sulfoxide group and an amide or a nitrile group. Their chemical structures were elucidated by analysing UV, IR, ESI-MS and NMR spectroscopy. In addition, compounds 1 − 4 were evaluated for their anti-inflammatory activities by using LPS-induced...

In silico discovery of potential sodium–glucose cotransporter-2 inhibitors from natural products for treatment of heart failure via molecular docking and molecular dynamics simulation approach

Jiwu Kong, Ling Li, Huicheng Yuan, Feng Bai, Kai Yang, Liangcun Zhao & Shaohua Xu
Heart failure (HF) is the end stage of cardiovascular disease. Because of its complex condition and poor prognosis, HF has become an important public health problem in the world. Sodium–glucose cotransporter-2 (SGLT2) is a member of the glucose transporter family. Recently, SGLT2 inhibitors have been applied to treat HF. In this study, the main aim was to discover natural SGLT2 inhibitor from Chinese herbs through docking-based virtual screening. Totally 113 natural compounds of potential SGLT2...

Additional file 4 of Histological and molecular responses of Vigna angularis to Uromyces vignae infection

Xiwang Ke, Jie Wang, Xiaodan Xu, Yongxia Guo, Yuhu Zuo & Lihua Yin
Supplementary Material 4

Additional file 7 of Histological and molecular responses of Vigna angularis to Uromyces vignae infection

Xiwang Ke, Jie Wang, Xiaodan Xu, Yongxia Guo, Yuhu Zuo & Lihua Yin
Supplementary Material 7

Additional file 1 of The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial

Yihao Liu, Hui Zhang, Gang Yuan, Mi Yao, Bin Li, Jianying Chen, Yuling Fan, Ruohui Mo, Fenghua Lai, Xinwen Chen, Mengyuan Li, Binfeng Chen, Janet M. Lord, Sui Peng, KarKeung Cheng & Haipeng Xiao
Additional file 1.

Supplementary document for Mid-infrared Nb₄N₃-based superconducting nanowire single photon detectors for wavelengths up to 10 μm - 6047159.pdf

Yiming Pan, Hui Zhou, XINGYU ZHANG, Huiqin Yu, Lu Zhang, Mengting Si, Hao Li, Lixing YOU & Zhen Wang
more details about the experiment

Supplementary document for Mid-infrared Nb₄N₃-based superconducting nanowire single photon detectors for wavelengths up to 10 μm - 5989819.pdf

Yiming Pan, Hui Zhou, XINGYU ZHANG, Huiqin Yu, Lu Zhang, Mengting Si, Hao Li, Lixing YOU & Zhen Wang
detailed description of some measurements

Supplementary document for Mid-infrared Nb₄N₃-based superconducting nanowire single photon detectors for wavelengths up to 10 μm - 5989819.pdf

Yiming Pan, Hui Zhou, XINGYU ZHANG, Huiqin Yu, Lu Zhang, Mengting Si, Hao Li, Lixing YOU & Zhen Wang
detailed description of some measurements

Additional file 5 of Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes

Weicheng Chen, Feifei Wang, Weijia Zeng, Xinyan Zhang, Libing Shen, Yuan Zhang & Xiangyu Zhou
Additional file 5: Supplementary Methods

Additional file 1 of Chicken miR-126-5p negatively regulates antiviral innate immunity by targeting TRAF3

Jie Wang, Yuqiang Cheng, Longlong Wang, Aixi Sun, Zhenyu Lin, Wenxian Zhu, Zhaofei Wang, Jingjiao Ma, Henan Wang, Yaxian Yan & Jianhe Sun
Additional file 1. Primers used to detect relative gene mRNA expression levels with quantitative RT-PCR.

Supplementary Information from Rheology of marine sponges reveals anisotropic mechanics and tuned dynamics

Emile A. Kraus, Lauren E. Mellenthin, Sara A. Siwiecki, Dawei Song, Jing Yan, Paul A. Janmey & Alison M. Sweeney
Sponges are animals that inhabit many aquatic environments while filtering small particles and ejecting metabolic wastes. They are composed of cells in a bulk extracellular matrix, often with an embedded scaffolding of stiff, siliceous spicules. We hypothesize that the mechanical response of this heterogeneous tissue to hydrodynamic flow influences cell proliferation in a manner that generates the body of a sponge. Towards a more complete picture of the emergence of sponge morphology, we dissected a...

Elevated D-Dimer levels correlate with the development of hepatorenal syndrome and a poor outcome in patients with cirrhosis

Baode Chen, Jing Liu, Yongtao Li, Xuelin He, Cheng Zhou, Yu Chen & Min Zheng
Whether hemostatic status was correlated with the diverse types of acute kidney injury in cirrhotic patients is unclear. The present study aimed to investigate the relationship between hemostatic markers and the diverse types of acute kidney injury (AKI) in liver cirrhosis. Cirrhotic patients with consecutive treatment at the First Affiliated Hospital of Medicine School, Zhejiang University, were pooled in a cohort. Their demographic and clinical data, biochemistry parameters and hemostatic markers were assessed to identify...

Study on Physicochemical Properties and Potential Applications of Chemically Treated Luffa Sponge Fibers

Beibei Weng, Dao Cheng, Fangcheng Yuan, Xinzhou Wang, Fuli Wang, Hao Wang, Qingyang Zhang, Kaiting Zhang, Shanshan Wu, Yuhong Gao, Jiachen Wang, Yan Lv, Zicheng Wu, Yingquan Tan, Yong Guo & Yuxia Chen
To explore and expand the application of luffa sponge (LS) fiber, three methods were used to chemically modify the LS fibers. The nanoindentation (NI) results show that the LS fibers exhibit a high elastic modulus (12.4 GPa) and hardness (0.7 GPa). Upon treating the fibers with 5%NaOH-5%H2O2, the NI hardness of the fibers increases by 14.3%. However, when 10%NaOH-20%CH3COOH (method B) is used, the hardness of the cell walls decreases by 28.6%. In this case,...

A plant nonenveloped double-stranded RNA virus activates and co-opts BNIP3-mediated mitophagy to promote persistent infection in its insect vector

Qifu Liang, Jiajia Wan, Huan Liu, Dongsheng Jia, Qian Chen, Aiming Wang & Taiyun Wei
Mitophagy that selectively eliminates damaged mitochondria is an essential mitochondrial quality control mechanism. Recently, mitophagy has been shown to be induced in host cells infected by a few animal viruses. Here, we report that southern rice black-streaked dwarf virus (SRBSDV), a plant nonenveloped double-stranded RNA virus, can also trigger mitophagy in its planthopper vector to prevent mitochondria-dependent apoptosis and promote persistent viral propagation. We find that the fibrillar structures constructed by the nonstructural protein P7-1...

Registration Year

  • 2022
    553

Resource Types

  • Text
    553

Affiliations

  • Beijing Tian Tan Hospital
    553
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    435
  • Capital Medical University
    433
  • Fudan University
    388
  • Shanghai Jiao Tong University
    361
  • Sichuan University
    330
  • Nanjing Medical University
    316
  • Peking University
    314
  • Sun Yat-sen University
    312
  • Huazhong University of Science and Technology
    311