639 Works

Sevoflurane suppresses migration and invasion of glioma cells by regulating miR-146b-5p and MMP16

Le Zhang, Jun Wang, Zhijie Fu, YanQiu Ai, Yanrong Li, Ying Wang & Yanping Wang
Glioma is the most common brain tumor with poor prognosis all over the world. Anesthetics have been demonstrated to have important impacts on cell migration and invasion in different cancers. However, the underlying mechanism that allows anesthetics-mediated progression of glioma cells remains elusive. Sevoflurane (Sev), a class of common anesthetics, was used to expose to U87-MG and U251 cells. The expressions of microRNA-146b-5p (miR-146b-5p) and matrix metallopeptidase 16 (MMP16)were measured by quantitative real-time polymerase chain...

Landscape of RNA editing reveals new insights into the dynamic gene regulation of spermatogenesis

Xiaodan Wang, Xiaolong Wu, Zhenshuo Zhu, Hao Li, Tongtong Li, Qun Li, Peng Zhang, Leijie Li, Dongxue Che, Xia Xiao, Tong Liu, Jinlian Hua & Mingzhi Liao
Spermatogenesis is an important physiological process associated with male infertility. As a kind of post-transcriptional regulation, RNA editings (REs) change the genetic information at the mRNA level. But whether there are REs and what’s the role of REs during the process are still unclear. In this study, we integrated published RNA-Seq datasets and established a landscape of RNA REs during the development of mouse spermatogenesis. Totally, 7530 editing sites occurred in 2012 genes among all...

Identification of Volatile Components in Tea Infusions by Headspace–Programmed Temperature Vaporization–Gas Chromatography–Mass Spectrometry (HS–PTV–GC–MS) with Chemometrics

Yan Zhou, Jie Yu, Liang Wang, Da Wu, Dawei Qi, Yunfei Sha & Baizhan Liu
In this work, the two-step headspace (HS) technique was applied to determine the actual volatile compositions of tea infusions. In order to eliminate the influence of water vapor to the gas chromatography-mass spectrometry (GC-MS) analysis and enable the capability to determine the volatile compounds in water base samples, a programed temperature vaporizer (PTV) was employed for the additional pre-concentration of thee analytes. While using the reported method, the volatile compounds were retained by the absorbent...

Epidemiology and clinical course of COVID-19 in Shanghai, China

Yinzhong Shen, Fang Zheng, Danfeng Sun, Yun Ling, Jun Chen, Feng Li, Tao Li, Zhiping Qian, Yuyi Zhang, Qingnian Xu, Li Liu, Qin Huang, Fei Shan, Lie Xu, Jun Wu, Zhaoqin Zhu, Zhigang Song, Shenyang Li, Yuxin Shi, Jianliang Zhang, Xueyun Wu, Joshua B. Mendelsohn, Tongyu Zhu & Hongzhou Lu
Background: Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in Shanghai. Methods: We retrospectively analysed 325 cases admitted at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020. Results: 47.4% (154/325) had visited Wuhan within 2 weeks of illness onset. 57.2% occurred in 67 clusters; 40% were situated within 53 family clusters. 83.7% developed fever during the disease course. Median times from...

Cement Catalyzed Valorization of Rice Straw into Upgraded Bio-Oil and Fuel Gases Using Pyrolysis Reactions

Ikram Uddin, Guijin Wang, Deyang Gao, Ning Li, Zahid Hussain & Baolin Hou
Rice straw is one of the major agricultural residues that is generated enormously in Asian countries. Thus, it is critical to develop an efficient process of converting this residue into valuable compounds in replacing fossil-based products. Herein, we developed an economically viable cement catalyst to pyrolyze the rice straw into bio-oil and fuel gas in a batch-type reactor. Under the optimized conditions, the maximum bio-oil yield of 41.07 wt.%, and gas yield of 30.53 wt.%...

Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target

Cun Li, Hin Chu, Xiaojuan Liu, Man Chun Chiu, Xiaoyu Zhao, Dong Wang, Yuxuan Wei, Yuxin Hou, Huiping Shuai, Jianpiao Cai, Jasper Fuk-Woo Chan, Jie Zhou & Kwok Yung Yuen
Rapid accumulation of viral proteins in host cells render viruses highly dependent on cellular chaperones including heat shock protein 90 (Hsp90). Three highly pathogenic human coronaviruses, including MERS-CoV, SARS-CoV and SARS-CoV-2, have emerged in the past 2 decades. However, there is no approved antiviral agent against these coronaviruses. We inspected the role of Hsp90 for coronavirus propagation. First, an Hsp90 inhibitor, 17-AAG, significantly suppressed MERS-CoV propagation in cell lines and physiological-relevant human intestinal organoids. Second,...

Antioxidant effects of diarylheptanoids from two Curcuma species

Chonglian Chen, Weifeng Dai, Lianli Zhang, Dong Wang, Xia Jiang & Mi Zhang
Five linear diarylheptanoids (1-5), including a new one (1), were isolated from the rhizomes of Curcuma kwangsiensis S. G. Lee et C. F. Liang, while four linear diarylheptanoids (6-9) and four cyclic diarylheptanoids (10-13) were isolated from the roots of Curcuma aromatica Salisb. Using the model of H2O2-induced PC12 cells, the antioxidant effects of these thirteen diarylheptanoids from these two traditional Chinese medicines from Curcuma genus of Zingiberaceae family were investigated. As result, they produced...

Antioxidant effects of diarylheptanoids from two Curcuma species

Chonglian Chen, Weifeng Dai, Lianli Zhang, Dong Wang, Xia Jiang & Mi Zhang
Five linear diarylheptanoids (1-5), including a new one (1), were isolated from the rhizomes of Curcuma kwangsiensis S. G. Lee et C. F. Liang, while four linear diarylheptanoids (6-9) and four cyclic diarylheptanoids (10-13) were isolated from the roots of Curcuma aromatica Salisb. Using the model of H2O2-induced PC12 cells, the antioxidant effects of these thirteen diarylheptanoids from these two traditional Chinese medicines from Curcuma genus of Zingiberaceae family were investigated. As result, they produced...

Trypanosoma evansi evades host innate immunity by releasing extracellular vesicles to activate TLR2-AKT signaling pathway

Ran Wei, Xin Li, Xiaocen Wang, Nan Zhang, Yuru Wang, Xichen Zhang, Pengtao Gong & Jianhua Li
Surra, one of the most important animal diseases with economic consequences in Asia and South America, is caused by Trypanosoma evansi. However, the mechanism of immune evasion by T. evansi has not been extensively studied. In the present study, T. evansi extracellular vesicles (TeEVs) were characterized and the role of TeEVs in T. evansi infection were examined. The results showed that T. evansi and TeEVs could activate TLR2-AKT pathway to inhibit the secretions of IL-12p40,...

Additional file 1 of Effect of preoperative CT angiography examination on the clinical outcome of patients with BMI ≥ 25.0 kg/m2 undergoing laparoscopic gastrectomy: study protocol for a multicentre randomized controlled trial

Cheng Meng, Shougen Cao, Xiaodong Liu, Leping Li, Qingsi He, Lijian Xia, Lixin Jiang, Xianqun Chu, Xinjian Wang, Hao Wang, Xizeng Hui, Zuocheng Sun, Shusheng Huang, Quanhong Duan, Daogui Yang, Huanhu Zhang, Yulong Tian, Zequn Li & Yanbing Zhou
Additional file 1. Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist.

The Effect of the Acidic Gas Pollutant on Wool Keratin Fiber Structure

Zhe Jiang, Rubing Bai, Jinfang Zhang, Ende Li, Yifan Cui, Ning Zhang, Nan Zhang & Qiang Wang
Increase in air pollution caused by acidic gases, such as nitrogen dioxide, call for the need to study potential effects on the structure of textile materials. Wool is a natural protein fiber which is easily damaged due to rich reaction positions and cross-linked bonds in the fiber. This study reports, for the first time, effect of nitrogen dioxide, as a model acid gas pollutant, on the structure of wool. On the macro level, wool fabric...

Functional redundancy changes along a drought stress gradient for the shift of selection effect to complementarity effect in experimental plant communities

Song Gao, Xiaoyan Wang, Tong Chen, Qiaodi Yan, Mengchun Shen, Jiang Wang & Feihai Yu
Species interactions alter with environmental change, which influences the relationship between biodiversity and ecosystem functioning (BEF). How BEF relationships change with environments requires knowledge of the changes of functional attributes in individual species in response to environmental change. Here, we assembled experimental plant communities with different species richness (1, 2, 4, 8, and 16) and exposed them to a drought stress gradient (control, moderate and intensive drought stress). Functional redundancy decreased with increasing drought stress...

A theoretical study on the electronically excited-state spectroscopic properties of phosphorus nitride

Hui Liu, Huihua Zhang, Deheng Shi & Zunlue Zhu
The potential energy curves of 103 Ω states generated from the 39 Λ–S states of PN have been calculated using the internally contracted multireference configuration interaction method with the Davidson modification. Core-valence correlation and scalar relativistic corrections, as well as the basis-set extrapolation to the complete basis set limit are considered. The spin–orbit coupling is computed using the state interaction approach with the Breit-Pauli Hamiltonian. The spectroscopic parameters and molecular constants of bound and quasibound...

A theoretical study on the electronically excited-state spectroscopic properties of phosphorus nitride

Hui Liu, Huihua Zhang, Deheng Shi & Zunlue Zhu
The potential energy curves of 103 Ω states generated from the 39 Λ–S states of PN have been calculated using the internally contracted multireference configuration interaction method with the Davidson modification. Core-valence correlation and scalar relativistic corrections, as well as the basis-set extrapolation to the complete basis set limit are considered. The spin–orbit coupling is computed using the state interaction approach with the Breit-Pauli Hamiltonian. The spectroscopic parameters and molecular constants of bound and quasibound...

Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder

Yuan Feng, Wan Dai, Junyu Ke, Yong Cui, Shuang Li, Jingjing Ma, Wenfeng Guo, Gang Chen, Ning Li & Yanwu Li
Valerian extract capsule (VEC) is an effective Chinese patent medicine used for gastrointestinal (GI) diseases. To investigate the detailed pharmacological activity for VEC clinical effects in GI diseases. Sprague-Dawley rats were divided into six groups: control, model, and drug-treated (VEC-L, VEC-M, VEC-H, and teprenone). Rats were orally administered VEC (124, 248, 496 mg/kg) and teprenone (21.43 mg/kg) for 3 consecutive days. After 1 h, the five groups (except the control group) were orally given ethanol...

Application progress of intelligent flavor sensing system in the production process of fermented foods based on the flavor properties

Siying Li, Dongdong Du, Jun Wang & Zhenbo Wei
Fermented foods are sensitive to the production conditions because of microbial and enzymatic activities, which requires intelligent flavor sensing system (IFSS) to monitor and optimize the production process based on the flavor properties. As the simulation system of human olfaction and gustation, IFSS has been widely used in the field of food with the characteristics of nondestructive, pollution-free, and real-time detection. This paper reviews the application of IFSS in the control of fermentation, ripening, and...

sj-pdf-1-tah-10.1177_20406207221132346 – Supplemental material for Serum proteomics screening intercellular adhesion molecule-2 improves intermediate-risk stratification in acute myeloid leukemia

Nan Zhang, Xiaoyan Liu, Jinxian Wu, Xinqi Li, Qian Wang, Guopeng Chen, Linlu Ma, Sanyun Wu & Fuling Zhou
Supplemental material, sj-pdf-1-tah-10.1177_20406207221132346 for Serum proteomics screening intercellular adhesion molecule-2 improves intermediate-risk stratification in acute myeloid leukemia by Nan Zhang, Xiaoyan Liu, Jinxian Wu, Xinqi Li, Qian Wang, Guopeng Chen, Linlu Ma, Sanyun Wu and Fuling Zhou in Therapeutic Advances in Hematology

Additional file 3 of Targeting Bruton’s tyrosine kinase in vitreoretinal lymphoma: an open-label, prospective, single-center, phase 2 study

Wenxue Guan, Liang Wang & Xiaoyan Peng
Additional file 3. Additional methods.

A novel strategy for orthogonal genetic regulation on different RNA targeted loci simultaneously

Yongjian Guo, Liang Wang, Zhen Qi, Yu Liu, Kun Tian, Huanran Qiang, Pei Wang, Guohua Zhou, Xiaobo Zhang & Shu Xu
No current RNA-targeted interference tools have been reported to simultaneously up and down-regulate different gene expressions. Here we characterized an RNA-targeted genetic regulatory strategy composed of a flap endonuclease 1 (FEN1) and specific mis-hairpin DNA probes (mis-hpDNA), to realize the orthogonal genetic regulation. By targeting mRNA, the strategy hindered the translation and silenced genes in human cells with efficiencies of ~60%. By targeting miRNA, the strategy prevented the combination of miRNA to its specific mRNA...

Additional file 1 of Psychometric validation of a chinese version of COVID-19 vaccine hesitancy scale: a cross-sectional study

Yiman Huang, Yijin Wu, Zhenwei Dai, Weijun Xiao, Hao Wang, Mingyu Si, Wenjun Wang, Xiaofen Gu, Li Ma, Li Li, Shaokai Zhang, Chunxia Yang, Yanqin Yu, Youlin Qiao & Xiaoyou Su
Additional file 1: COVID-19 Vaccine Hesitancy Scale Item Description.

Additional file 1 of Risk factors and outcomes of postoperative stroke in surgical treatment for giant intracranial aneurysms

Hao Wang, Junlin Lu, Xin Chen & Qiang Hao
Additional file 1: Table Supplementary. Logistic regression analysis for postoperative strokes in clipping sub-group.

sj-pdf-3-imr-10.1177_03000605221126874 - Supplemental material for Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade

Jiameng Huang, Qiang Huang, Jiyao Xue, Huiqin Liu, Yang Guo, Hui Chen & Liang Zhou
Supplemental material, sj-pdf-3-imr-10.1177_03000605221126874 for Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade by Jiameng Huang, Qiang Huang, Jiyao Xue, Huiqin Liu, Yang Guo, Hui Chen and Liang Zhou in Journal of International Medical Research

Additional file 1 of Molecular characteristics of a coxsackievirus A12 strain in Zhejiang of China, 2019

Linjie Hu, Lu Zhou, Pingping Wang, Hairenguli Maimaiti & Yihan Lu
Additional file 1. Supplementary tables showing the information of sequences analyzed.

Additional file 5 of Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses

Nadeem Shaikh, Alice Mazzagatti, Simone De Angelis, Sarah C. Johnson, Bjorn Bakker, Diana C. J. Spierings, René Wardenaar, Eleni Maniati, Jun Wang, Michael A. Boemo, Floris Foijer & Sarah E. McClelland
Additional file 5. Review history.

Supplemental Material - Theoretical, numerical, and experimental studies on controlled synchronization strategy of four-axis variable trajectory equal-thickness screen

Sai Li, Chusheng Liu, Gao Chen, Hao Wang, Hongxi Li & Deyi He
Supplemental Material for Theoretical, numerical, and experimental studies on controlled synchronization strategy of four-axis variable trajectory equal-thickness screen by Sai Li, Chusheng Liu, Gao Chen, Hao Wang, Hongxi Li and Deyi He in Journal of Vibration and Control.

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