2,857 Works

Stachydrine is effective and selective against blast phase chronic myeloid leukaemia through inhibition of multiple receptor tyrosine kinases

Ruixin Gu, Wei Zhang & Dandan Xu
Resistance to BCR-ABL tyrosine kinase inhibitor (TKI) is the cause of treatment failure in blast phase chronic myeloid leukaemia (BP-CML). Agents that act synergistically with BCR-ABL TKI are required to improve response. This work investigated the effects of stachydrine in CML. CML cells were treated with control or stachydrine at 20, 40 and 80 µM. Proliferation and apoptosis were examined after 72 h treatment. Combination studies were performed in four groups: control, TKI, stachydrine and...

Probability of Study Success (PrSS) Evaluation Based on Multiple Endpoints in Late Phase Oncology Drug Development

Zhen Zhang, Yong Lin & Jingyi Liu
Phase 2 Oncology clinical trials are increasingly designed with multiple primary endpoints, such as progression-free survival (PFS) and overall survival (OS). While this gives a clearer picture of treatment benefit than trials with a single endpoint, it complicates the decision to begin a registration (phase 3) trial following a phase 2 trial. Methods for calculating the probability of study success (PrSS) assume the distribution of OS is well understood, but rarely consider the case of...

Fe3S2 cluster complexes containing aminodiphosphine ligand: synthesis, characterization, crystal structures and electrochemical properties

Jun Yang, Wen-Jing Tian, Shuang Lü, Jiao He, Kui Hu, Peng Yan, Hang Xu, Mao-Xin Zeng, Yu-Long Li & Qian-Li Li
In this article, six new Fe3S2 cluster complexes Fe3(µ3S)2(CO)7[(Ph2P)2NR] (1-6) (R = (CH2)2CH3, CH(CH3)2, (CH2)3CH3, CH2CH(CH3)2, p-C6H4CCH and m-C6H4CCH) were successfully synthesized by reactions of Fe3S2(CO)9 and the corresponding aminodiphosphines under refluxing toluene. Meanwhile, treatment of Fe3S2(CO)9 and (Ph2P)2NCH(CH3)Ph afforded two new Fe3S2 cluster complexes Fe3(µ3-S)2(CO)7[(Ph2P)2NCH(CH3)Ph] (7) and Fe3(µ3-S)2(CO)7[(κ2-Ph2P)2NCH(CH3)(Ph)] (8). Complexes 1–8 were characterized by elemental analysis, FT-IR, NMR spectroscopy, and especially X-ray crystallography. The elctrochemical properties were investigated by cyclic voltammetry, showing that they...

Hierarchical assembly and structural regulation of Ti8Ag2 oxo clusters via varying the length of the carbon chains in di-phosphine ligands

Chao Ma, Xiaofeng Yi, Jian Zhang & Lei Zhang
Atomically precise Ag-doped polyoxo-titanium oxo clusters (Ag-PTCs) are beneficial for the investigation on structure-property relationship of silver doped TiO2 materials. Although several Ag-PTC clusters have been reported, their hierarchical assembly into multidimensional structures remains unexplored. In this work, di-phosphine ligands with various carbon chain lengths were exploited to stabilize and induce the hierarchical assembly of Ti8Ag2 oxo clusters. Correspondingly, cis- and trans-isomers of {Ti8Ag2} are generated in the discrete cluster (PTC-337) and two 1D-chains (PTC-338...

Elevated D-Dimer levels correlate with the development of hepatorenal syndrome and a poor outcome in patients with cirrhosis

Baode Chen, Jing Liu, Yongtao Li, Xuelin He, Cheng Zhou, Yu Chen & Min Zheng
Whether hemostatic status was correlated with the diverse types of acute kidney injury in cirrhotic patients is unclear. The present study aimed to investigate the relationship between hemostatic markers and the diverse types of acute kidney injury (AKI) in liver cirrhosis. Cirrhotic patients with consecutive treatment at the First Affiliated Hospital of Medicine School, Zhejiang University, were pooled in a cohort. Their demographic and clinical data, biochemistry parameters and hemostatic markers were assessed to identify...

Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain

Shixin Tang, Hongyang Zhang, Yinyin Xia, Shiyue Luo, Yijun Liu, Xinhao Duan, Zhen Zou, Chengzhi Chen, Lixiao Zhou & Jingfu Qiu
Di (2-ethylhexyl) phthalate (DEHP) is one of the most prevalent xenoestrogen endocrine disruptor in daily life. A growing number of studies showed that DEHP could exhibit long-term adverse health effects on the human body, particularly in the liver, kidneys, heart and reproductive systems. However, the impact of oral intake of DEHP on the nervous system is extremely limited. In the present study, the adult C57BL/6J male mice were intragastrically administered with two dosages of DEHP...

Echinacoside alleviates osteoarthritis in rats by activating the Nrf2-HO-1 signaling pathway

Zhijun Tan & Bin Zhang
Osteoarthritis (OA) is a progressive disease characterized by degeneration of cartilage and echinacoside (Ech) has anti-inflammatory and antioxidant effects in various human diseases. This study aimed to reveal the effect and potential mechanism of Ech on OA. The in vitro OA model was established by rat chondrocytes treated with IL-1β, and the in vivo OA model was established by anterior cruciate ligament transaction. The effect of Ech on the viability, inflammatory response, extracellular matrix (ECM)...

Prevention of ulcerative colitis by Huangqin decoction: reducing the intestinal epithelial cell apoptosis rate through the IFN-γ/JAK/ETS signalling pathway

Xiaowei Mo, Kairui Tang, Lijing Deng, Xingyi Zhou, Xiaojuan Li, Yupei Zhang & Jing Wang
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease that is closely related to inflammation and apoptosis. The traditional Chinese medicine compound preparation Huangqin decoction (HQD) has been widely used in the clinical treatment of UC, but the specific mechanism of its function is still inconclusive. To explore the pathogenesis of UC based on the IFN-γ/JAK/ETS signalling pathway, and to clarify the biological mechanism of HQD. Forty 8-week-old male C57BL/6 mice were randomly divided...

E74 Like ETS Transcription Factor 3 is a Negative Regulator of Pathogenic Lamina Propria T Helper 17.1 Cells in Murine Colitis

Bo Hu, Hao Wang & Fei Xiao
Interleukin-17A (IL-17A)-expressing T cells, including T helper 17 (Th17) and T helper 17.1 (Th17.1) cells, play a significant role in inflammatory bowel diseases (IBDs). Identifying the mechanisms underlying the heterogeneity and plasticity of IL-17A-expressing T cells is crucial for understanding and controlling their pathogenicity. The role of E74 like ETS transcription factor 3 (ELF3) in regulating the pathogenicity of IL-17A-expressing T cells has not been studied before. Dextran sulfate sodium was used to induce acute...

Diverse early diagenetic processes of ferromanganese nodules from the eastern Pacific Ocean: evidence from mineralogy and in-situ geochemistry

Rong Su, Fengyue Sun, Xiaohu Li, Fengyou Chu, Guosheng Sun, Jie Li, Hao Wang, Zhenggang Li, Cong Zhang, Weiyan Zhang, Xiaohan Gong & Yanhui Dong
Ferromanganese nodules are a potential energy resource because of their high contents of economically interesting elements (i.e. Mn, Ni, Cu, and Zn). These are higher in diagenetic layers than in hydrogenetic layers. The study of the causes of elemental accumulation in the diagenetic layer is useful for the exploration metal-rich nodules. A diagenetic-dominant ferromanganese nodule, from the central Clarion–Clipperton Fracture Zone of the eastern Pacific Ocean was studied from core to rim. It was divided...

Comparative transcriptome analysis on drought stress-induced floral formation of Curcuma kwangsiensis

Xin Feng, Liying Zhou, Aiwu Sheng, Ling Lin & Huicheng Liu
The rhizomes and tubers of Curcuma kwangsiensis have extensive medicinal value in China. However, the inflorescences of C. kwangsiensis are rarely known in horticulture, because of its low field flowering rate. In order to improve the flowering rate of C. kwangsiensis, we conducted drought stress treatment on the rhizome of C. kwangsiensis. The flowering rate of rhizome was the highest after 4d of drought stress treatment, and the buds on the rhizome could be obviously...

Comparative transcriptome analysis on drought stress-induced floral formation of Curcuma kwangsiensis

Xin Feng, Liying Zhou, Aiwu Sheng, Ling Lin & Huicheng Liu
The rhizomes and tubers of Curcuma kwangsiensis have extensive medicinal value in China. However, the inflorescences of C. kwangsiensis are rarely known in horticulture, because of its low field flowering rate. In order to improve the flowering rate of C. kwangsiensis, we conducted drought stress treatment on the rhizome of C. kwangsiensis. The flowering rate of rhizome was the highest after 4d of drought stress treatment, and the buds on the rhizome could be obviously...

Additional file 1 of Evaluation and analysis of anxiety and depression symptoms for college students during COVID-19 pandemic

Dingwei Gao, Qingzhi Xiang, Ganghua Lu, Junyu Tong, Wen Jiang, Xiaqing Yu, Ru Wang, Zhongwei Lv & Dan Li
Additional file 1. Description of sample size.

Additional file 1 of LAG3 blockade coordinates with microwave ablation to promote CD8+ T cell-mediated anti-tumor immunity

Dong Shao, Yaping Chen, Hao Huang, Yingting Liu, Junjun Chen, Dawei Zhu, Xiao Zheng, Lujun Chen & Jingting Jiang
Additional file 1: Figure S1. Flow cytometry analysis was used to confirm the differences of sub-populations in MWA and MWA combined with the LAG3 blockade groups. A. Gating strategy of tumor infiltrating Foxp3+Tregs. B. The percentage of Tregs was not significantly changed in MWA and MWA combined with the LAG3 blockade groups (n=5 for each group). C. Gating strategy of sub-sets of tumor infiltrating DCs and macrophages. D. There were not significant changes of DCs,...

Additional file 1 of Assessment of life support skills of resident dentists using OSCE: cross-sectional survey

Fan Yang, Chen Zheng, Tianer Zhu & Denghui Zhang
Additional file 1: Table S1. OSCE criteria scores of CPR for stage assessment in standardized training.

Additional file 5 of Assessment of life support skills of resident dentists using OSCE: cross-sectional survey

Fan Yang, Chen Zheng, Tianer Zhu & Denghui Zhang
Additional file 5: Table S5. Questionnaire on perception on training of first-aid skills during standardized training.

Additional file 6 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 6. Relationships between parental behavior test behaviors. For each pair of behavior, a linear model was fit. Each individual point represents a distinct animal, and the shaded area depicts the 95% confidence interval.

Supplementary document for High-precision distributed detection of rail defect by tracking the acoustic propagation waves - 5907594.pdf

Cunzheng Fan, Hao Li, Baoqiang Yan, Yixiang Sun, Tao He, Tianye Huang, Zhijun Yan & Qizhen Sun
The model of defect location error and principle of the DAS system

Additional file 1 of AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang & Jinhong Chen
Additional file 1.

Additional file 1 of Human umbilical cord mesenchymal stem cells combined with pirfenidone upregulates the expression of RGS2 in the pulmonary fibrosis in mice

Xian Wu, Hao Gou, Ou Zhou, Huijun Qiu, Hanmin Liu, Zhou Fu & Lina Chen
Additional file 1: Table S1. Basic data of the number of dead mice treated with different doses of PFD. Table S2. Basic data of the number of dead mice treated with PFD and hUC-MSCs. Figure S1. Flow cytometry detection of surface mesenchymal stem cell markers of hUC-MSCs. Figure S2. The primitive view of the differentiation of hUC-MSCs. A: hUC-MSCs differentiated into chondrogenic cells. B: hUC-MSCs differentiated into osteogenic cells. C: hUC-MSCs differentiated into adipogenic cells....

Additional file 2 of Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis

Wang-Yu Cai, Xi Luo, Wei Wu, Jianyuan Song, Ning-Ning Xie, Cuicui Duan, Xiao-Ke Wu & Jian Xu
Additional file 2: Supplementary table 1. PRISMA 2022 checklist.

Additional file 3 of Mucosal-associated invariant T cells predict increased acute graft-versus-host-disease incidence in patients receiving allogeneic hematopoietic stem cell transplantation

Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han & Sizhou Feng
Additional file 3: Hub genes of each enriched gene set.

Additional file 3 of Mucosal-associated invariant T cells predict increased acute graft-versus-host-disease incidence in patients receiving allogeneic hematopoietic stem cell transplantation

Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han & Sizhou Feng
Additional file 3: Hub genes of each enriched gene set.

Additional file 4 of Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis

Wang-Yu Cai, Xi Luo, Wei Wu, Jianyuan Song, Ning-Ning Xie, Cuicui Duan, Xiao-Ke Wu & Jian Xu
Additional file 4: Supplementary table 3. Meta-regression results.

sj-docx-1-tct-10.1177_15330338221132035 - Supplemental material for Construction and Validation of Prognosis Nomogram for Metastatic Lung Squamous Cell Carcinoma: A Population-Based Study

Yuting Liu, Min Sun, Ying Xiong, Xinyue Gu, Kai Zhang & Li Liu
Supplemental material, sj-docx-1-tct-10.1177_15330338221132035 for Construction and Validation of Prognosis Nomogram for Metastatic Lung Squamous Cell Carcinoma: A Population-Based Study by Yuting Liu, Min Sun, Ying Xiong, Xinyue Gu, Kai Zhang and Li Liu in Technology in Cancer Research & Treatment

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  • Sun Yat-sen University
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  • Chinese Academy of Medical Sciences & Peking Union Medical College
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  • Chinese Academy of Sciences
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  • Huazhong University of Science and Technology
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