2,863 Works

The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity

Li Zhang, Fugui Zhang, Yifei Xiao, Jianhao Du, Xingwang Zhang, Min Chen & Baojian Wu
CYP2E1 plays an important role in drug metabolism and drug-induced hepatotoxicity. Here, we aimed to investigate a potential role for the nuclear receptor REV-ERBα in regulation of CYP2E1 expression and acetaminophen (APAP)-induced hepatotoxicity, and to determine the underlying mechanisms.Regulatory effects of REV-ERBα on CYP2E1 expression were assessed in vivo (using Rev-erbα-/- mice) and in vitro (using AML12 and HepG2 cells). In vitro microsomal CYP2E1 activity was probed using its specific substrate p-nitrophenol. Pharmacokinetic and acute...

The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity

Li Zhang, Fugui Zhang, Yifei Xiao, Jianhao Du, Xingwang Zhang, Min Chen & Baojian Wu
CYP2E1 plays an important role in drug metabolism and drug-induced hepatotoxicity. Here, we aimed to investigate a potential role for the nuclear receptor REV-ERBα in regulation of CYP2E1 expression and acetaminophen (APAP)-induced hepatotoxicity, and to determine the underlying mechanisms.Regulatory effects of REV-ERBα on CYP2E1 expression were assessed in vivo (using Rev-erbα-/- mice) and in vitro (using AML12 and HepG2 cells). In vitro microsomal CYP2E1 activity was probed using its specific substrate p-nitrophenol. Pharmacokinetic and acute...

Additional file 10 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 10. Figure S7: Prognostic value of presurgical ctDNA detection. A). The recurrence-free survival analysis of patients stratified by presurgical ctDNA detection. B). The multi-variant Cox regression for presurgical ctDNA detection. Abbreviations: RFS – recurrence-free survival, LNM – lymph node metastasis, LUAD – lung adenocarcinoma, LUSC - lung squamous-cell carcinoma.

Additional file 13 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 13. Supplementary results.

Additional file 6 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 6. Figure S3: Prognostic values of postsurgical ctDNA detection at 3 months and 6 months. A-B) The recurrence-free survival analysis (top panel) and multi-variant Cox regression (bottom panel) of postsurgical ctDNA detection at 3 months (A) and 6 months (B). For the analysis at 6 months after surgeries, only patients with plasma samples available at this scheduled point and followed-up for more than 6 months were included. Abbreviations: RFS – recurrence-free survival, LNM...

Additional file 1 of Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy

Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo & Guokun Wang
Additional file 1. Supplementary Tables and Figures.

Microstructure evolution and mechanical properties of CNT/Al composite joints via friction stir welding

Xiaopeng Li, Zeyu Zhang, Yong Wang, Yong Peng, Dejun Yan, Zhanqiu Tan, Qi Zhou & Kehong Wang
The traditional fusion welding of carbon nanotubes (CNTs) reinforcement aluminium matrix composites has serious welding defects due to the violent interfacial reaction and the brittle secondary phase. In this paper, friction stir welding (FSW), a solid-phase welding technique, was applied to join the CNT/Al matrix composites. The result shows that the tensile strength of the FSW joint fabricated at 800 rev min–1 and 100 mm min–1 is 511 MPa, reaching 92.1% of the CNT/Al composites....

Additional file 1 of Identification of pyroptosis-related genes and long non-coding RNAs signatures in osteosarcoma

Jian Zhang, Jianjian Deng, Rui Ding, Jinghong Yuan, Jiahao Liu, Xiaokun Zhao, Tianlong Wu, Jingyu Jia & Xigao Cheng
Additional file 1: Table S1. Risk coefficients of three PRGs. Table S2. Risk coefficients of six PRLs. Table S4. Primers used in this study.

Additional file 1 of Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

Jonathan Higham, Lyndsay Kerr, Qian Zhang, Rosie M. Walker, Sarah E. Harris, David M. Howard, Emma L. Hawkins, Anca-Larisa Sandu, J. Douglas Steele, Gordon D. Waiter, Alison D. Murray, Kathryn L. Evans, Andrew M. McIntosh, Peter M. Visscher, Ian J. Deary, Simon R. Cox & Duncan Sproul
Additional file 1: Supplementary figures Fig. S1-5 and legends.

Fig. S1. Myelopoiesis in Tg(drl:hoxa9;hsp70:meis1) embryos receiving one time of HS induction or daily HS induction. Embryos were assayed by WISH for mpx at 5 dpf. ;Fig. S2. A subgroup of Tg(drl:hoxa9;hsp70:meis1) adult fish develops AML-like phenotypes after one time HS in the embryos.;Fig. S3. Flow cytometry assay of the whole kidney marrow cells in WT, Tg(drl:hoxa9) and Tg(drl:hoxa9;hsp70:meis1) adult fish.;Fig. S4. Genome-wide transcriptional analysis of the kidney marrow cell of WT and Tg(drl:hoxa9;hsp70:meis1) adult fish.;Fig. S5. May-Grünwald and Giemsa staining of the peripheral blood cells from 7-dpf Tg(drl:hoxa9;hsp70:meis1) embryos with or without Lef treatment.

Wei Wang, Hongji Li, Mengling Huang, Xue Wang, Wei Li, Xiaoqing Qian & Lili Jing
Fig. S1. Myelopoiesis in Tg(drl:hoxa9;hsp70:meis1) embryos receiving one time of HS induction or daily HS induction. Embryos were assayed by WISH for mpx at 5 dpf. HS, heat-shock; NS, no statistical significance. ;Fig. S2. A subgroup of Tg(drl:hoxa9;hsp70:meis1) adult fish develops AML-like phenotypes after one time HS in the embryos. Tg(drl:hoxa9;hsp70:meis1) embryos were HS induced at 24 hpf once and grown to adulthood. (A) May-Grünwald/Giemsa staining of the whole kidney marrow blood cells and peripheral...

Additional file 1 of Identification of a flavonoid C-glycosyltransferase from fern species Stenoloma chusanum and the application in synthesizing flavonoid C-glycosides in Escherichia coli

Rong Ni, Xin-Yan Liu, Jiao-Zhen Zhang, Jie Fu, Hui Tan, Ting-Ting Zhu, Jing Zhang, Hai-Long Wang, Hong-Xiang Lou & Ai-Xia Cheng
Additional file 1: Fig. S1. The possible biosynthetic pathways for C-glycosylflavones. F2H: flavanone 2-hydroxylase; FNS: flavone synthase; CGT: C-glycosyltransferase. Fig. S2. SDS-PAGE analysis of recombinant proteins. M: Weight marker, Lane 1: pET32a, Lane 2: ScGT1, Lane 3: ScGT2, Lane 4: ScGT3, Lane 5: ScGT4, Lane 6: ScCGT1-H26A, Lane 7: ScCGT1-L143T, Lane 8: ScCGT1-P164T, Lane 9: ScCGT1-L301G, Lane 10: ScCGT1-D141I/P142D, Lane 11: ScCGT1-4T (S108D/H109P/V110F/L111F). Fig. S3. Sugar donor selectivity of ScCGT1. A. HPLC chromatograms of the...

sj-docx-3-npx-10.1177_1934578X221125089 - Supplemental material for Network Pharmacology and Molecular Docking of Shiwei Qingwen Decoction Reveal TNF as a Potential Target for Alleviating Mild COVID-19 Symptoms

Chen-xiong Yang, Shang-zhi Ma, Qian Zhang, Shu-yun Guo, Xiao-di Hu, Yan-ju Liu, Li Wen & Zhong-shi Zhou
Supplemental material, sj-docx-3-npx-10.1177_1934578X221125089 for Network Pharmacology and Molecular Docking of Shiwei Qingwen Decoction Reveal TNF as a Potential Target for Alleviating Mild COVID-19 Symptoms by Chen-xiong Yang, Shang-zhi Ma, Qian Zhang, Shu-yun Guo, Xiao-di Hu, Yan-ju Liu, Li Wen and Zhong-shi Zhou in Natural Product Communications

Additional file 2 of Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis

Yan Li & Zhenbin Xu
Additional file 2. Methodological Quality of case–control and cross-sectional studies included in the meta-analysis.

Additional file 4 of Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis

Yan Li & Zhenbin Xu
Additional file 4. Summary of the subgroup analyses of the correlation between circulating irisin levels and HOMA-IR.

Supplementary document for Highly Sensitive Terahertz Sensing with 3D-printed Metasurface Empowered by Toroidal Dipole - 6055076.pdf

Wei Yin, zhonglei shen, Yuqing Cui, Huibo Hao, Hao Zhang, Shengnan Li, Feng Gao, Shuting Fan, Liuyang Zhang & xuefeng chen
Supplement 1

Additional file 1 of Association of the gallbladder or biliary diseases with dipeptidyl peptidase 4 inhibitors in patients with type 2 diabetes: a meta-analysis of randomized controlled trials

Meng Yu, Zheng Yang, Chongxin Chen, Yuhuan Lv, Linyu Xiang, Subei Zhao & Rong Li
Additional file 1. Search strategies.

Additional file 3 of Association of the gallbladder or biliary diseases with dipeptidyl peptidase 4 inhibitors in patients with type 2 diabetes: a meta-analysis of randomized controlled trials

Meng Yu, Zheng Yang, Chongxin Chen, Yuhuan Lv, Linyu Xiang, Subei Zhao & Rong Li
Additional file 3. Characteristics of the 75 studies included in the meta-analysis.

Additional file 6 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 6: Fig. S3. DNA methylation profiles of long non-coding RNAs (lncRNAs) and protein-coding genes (PCgenes) in sunflower endosperm from SY1.

Additional file 2 of Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies

Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao & Wei Zhang
Additional file 2: Table S2. Comparison of clinical outcomes between single first-line and repeated first-line treatment subgroups in rituximab cohort

Supplemental Material, CONSORT_a - Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Supplemental Material, CONSORT_a for Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial by Haichun Lai, Wei Huang, Wei Chen and Desheng Wang in Ear, Nose & Throat Journal

Additional file 1 of The effectiveness of case management for cancer patients: an umbrella review

Nina Wang, Jia Chen, Wenjun Chen, Zhengkun Shi, Huaping Yang, Peng Liu, Xiao Wei, Xiangling Dong, Chen Wang, Ling Mao & Xianhong Li
Additional file 1.

Additional file 2 of The effectiveness of case management for cancer patients: an umbrella review

Nina Wang, Jia Chen, Wenjun Chen, Zhengkun Shi, Huaping Yang, Peng Liu, Xiao Wei, Xiangling Dong, Chen Wang, Ling Mao & Xianhong Li
Additional file 2. Searching strategies.

Additional file 8 of Metabolic engineering of Escherichia coli BW25113 for the production of 5-Aminolevulinic Acid based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modification

Changchuan Ye, Yuting Yang, Xi Chen, Lijie Yang, Xia Hua, Mengjie Yang, Xiangfang Zeng & Shiyan Qiao
Additional file 8: Table S2. Primers for Plasmid constructions and Testing.

Additional file 2 of Lrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish

Shanshan Liu, Ting Chen, Binghao Chen, Yijun Liu, Xiaohe Lu & Jiali Li
Additional file 1. Figure S1. Immunohistochemical (IHC) results of LRPAP1 in 3-month-old zebrafish. (A) Negative control. (B) IHC targeting LRPAP1 for wild-type zebrafish. Figure S2. Western blot analysis of LRPAP1 in the eyes of lrpap1 mutants and wild-type zebrafish two months and three months post-fertilization. WT, wild-type; MU, lrpap1 homozygous mutant. Figure S3. Western blot analysis of TGF-β in the eyes of lrpap1 mutants and wild-type zebrafish two months and three months post-fertilization. WT, wild-type;...

Additional file 2 of Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma

Tongyan Liu, Chencheng Han, Panqi Fang, Zhifei Ma, Xiaoxiao Wang, Hao Chen, Siwei Wang, Fanchen Meng, Cheng Wang, Erbao Zhang, Guozhang Dong, Hongyu Zhu, Wenda Yin, Jie Wang, Xianglin Zuo, Mantang Qiu, Jinke Wang, Xu Qian, Hongbing Shen, Lin Xu, Zhibin Hu & Rong Yin
Additional file 2. Supplementary Figures.

Registration Year

  • 2022
    2,863

Resource Types

  • Text
    2,863

Affiliations

  • Sun Yat-sen University
    2,863
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    1,819
  • Shanghai Jiao Tong University
    1,804
  • Fudan University
    1,644
  • Sichuan University
    1,603
  • Zhejiang University
    1,549
  • Capital Medical University
    1,451
  • Chinese Academy of Sciences
    1,364
  • Huazhong University of Science and Technology
    1,341
  • Southern Medical University
    1,188