Additional file 1: Fig. S1. Inter-annual variability for air temperature (a), precipitation (b), soil temperature at 20 cm depth (c), and soil moisture (d) from 1900 to 2000 in China. The percentage water-filled pore space (WFPS) is used as an expression of soil moisture. Fig. S2. Spatial patterns of partial correlation coefficients between net ecosystem production (NEP) and (a) air temperature, (b) precipitation, (c) CO2 concentration, and (d) ratio of cropland area from 1900 to...

Prenatal socioeconomic disadvantage (SD) has been linked to DNA methylation (DNAm) in adulthood, but whether such epigenetic alterations are present at birth remains unclear. We carried out an epigenome-wide analysis of the association between several measures of individual- and area-level prenatal SD and DNAm assessed in neonatal cord blood via the Infinium EpicBeadChip among offspring born to mothers of White British (N = 455) and Pakistani (N = 493) origin in the Born in Bradford...

Postmenopausal women with overweight or obesity have an increased risk of developing breast cancer but many of the mechanisms underlying this association remain to be elucidated. MicroRNAs (miRNAs), short non-coding single-stranded RNAs, regulate many physiological processes by controlling post-transcriptional regulation of mRNA. We measured circulating miRNA from 192 overweight/obese postmenopausal women (50–75 years) who were part of a randomized controlled trial, comparing independent and combined effects of a 12-month reduced-calorie weight-loss diet and exercise programme,...

figures of the result of the rest animals and humans

Additional file 1. Supplementary figures [81–83].

Additional file 2. Amendments to the pre-registered protocol.

Supplemental material, sj-pdf-1-imr-10.1177_03000605221129558 for Clostridium subterminale infection in a patient with diffuse large B-cell lymphoma and haemophagocytic syndrome: A case report and literature review by Ying Zhou, Sheng Wang, Xing-bei Weng in Journal of International Medical Research

The supporting material contains data and theoretical derivations that are not given in the manuscript, and it is a supplement to this work.

Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated...

By single-crystal X-ray diffraction (XRD) analysis, five complexes, catena-[(µ-2,2-bis(4-carboxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)-1,3-benzothiazole)-aqua-zinc(II)] (1), catena-[(µ-2,2-bis(4-carboxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)1,3-benzothiazole)-aqua-cadmium(II)] (2), catena-[hepta(µ-2,2-bis(4carboxyphenyl)hexafluoropropane)-diaqua-bis(2-(pyidin-2-yl)-1,3-benzothiazole)-tri-manganes(II)] (3), catena-[(µ-benzene-1,2,4,5-tetracarboxylato)-(2-(pyidin-2-yl)-1,3benzothiazole)copper(II)] (4) and catena-[(µ-3-nitrobenzene-1,2-dicarboxylato)-(2-(pyidin-2-yl)1,3-benzothiazole)-aqua-zinc(II)] (5), were characterized in this research. In these five complexes, H2hfipbb = 2,2-bis(4-carboxyphenyl)hexafluoropropane, H4btec = 1,2,4,5-benzenetetracarboxylic acid, H2NPTA = 3-nitrophthalic acid and bpt = 2-(pyridin-2-yl)benzo[d]thiazole). Complexes 1 and 2 occur in the monoclinic system with space group C2/c, 4 and 5 occur in the monoclinic system with space group P21/c, and 3 occurs in the triclinic system...

Supplemental material, sj-docx-1-mpp-10.1177_23814683231153378 for Translating an Economic Analysis into a Tool for Public Health Resource Allocation in Cancer Survivorship by Zachary Rivers, Joshua A. Roth, Winona Wright, Sun Hee Rim, Lisa C. Richardson, Cheryll C. Thomas, Julie S. Townsend and Scott D. Ramsey in MDM Policy & Practice

Young Prunus persica fruits (YPF) contain substances that are distinct from those found in the mature fruits. Response surface methodology was used to explore the influences of extraction conditions including ultrasonic time (X1), ethanol proportion (X2), liquid-to-solid ratio (X3) and temperature (X4) on UV-absorbing components from YPF. To purify the extract, the adsorption/desorption properties of 280 nm-absorbing components on AB-8 resin were investigated. A total of 11 metabolites (amino acids, glycosylated amino acids and phenolics)...

Pseudorabies (PR) is an acute infectious disease caused by pseudorabies virus (PRV). There are no available drugs due to the emergence of variant of PRV. Dihydromyricetin (DMY) is a flavonoid extracted from Ampelopsis grossedentata (A. grossedentata), which has a variety of pharmacological activities. In this study, we aim to investigate the in vitro anti-PRV activity of DMY extracted from A. grossedentata. MTT assay was used to detect the cytotoxicity and antiviral activity of DMY. The...

The impact of acute kidney injury (AKI) on the progression of renal function in idiopathic membranous nephropathy (iMN) with nephrotic syndrome (NS) patients have not yet been reported, we sought to investigate the incidence, clinical features and prognosis of AKI in iMN with NS patients and determine clinical predictors for progression from AKI to advanced chronic kidney disease (CKD) stage. We analyzed clinical and pathological data of iMN with NS patients retrospectively collected from Jan...

The principal goal of the present investigation was to enterprise new and effective drug delivery vesicle for the sustained delivery of local anesthetic lidocaine hydrochloride (LDC), using a novel combination of copolymeric hydrogel with tetrahydroxyborate (COP–THB) to improve bioactivity and therapeutic potential. To support this contention, the physical and mechanical properties, rheological characteristics, and component release of candidate formulations were investigated. An optimized formulation of COP–THB containing LDC to an upper maximum concentration of 1.5%...

Nano-titanium dioxide (nano-TiO2) is widely used in many aspects of human life. However, there are still inconsistent conclusions about the effects of nano-TiO2 exposure on autophagy. Therefore, a systematic review and meta-analysis were used to reveal whether nano-TiO2 induces dysregulation of autophagy. The results showed that LC3 II, Beclin-1 protein, and LC3 II/LC3 I protein ratio were significantly increased, but p62 protein was insignificantly changed. Subgroup analyses showed that p62 and Beclin-1 protein were increased...

Preeclampsia (PE) is a disorder that occurs during the pregnancy and could affect the maternal and perinatal mortality as well as morbidity. The aim of our study is to investigate the associations between the hypertension susceptibility genes ITGA9, MOV10 and CACNB2 with PE in Chinese Han population. A case–control study including 178 PE patients and 202 healthy controls was conducted to assess the associations between three loci (ITGA9 rs155524, MOV10 rs2932538 and CACNB2 rs4373814) and...

The large-enrollment undergraduate organic chemistry laboratories at Michigan State University have been redesigned to incorporate green and sustainable chemistry and evidence-based instructional approaches to laboratory teaching. Students engage in scientific practices such as defining problems, designing and carrying out experiments, analyzing data, and designing solutions during in-person lab sessions. Principles of green and sustainable chemistry are introduced in the case studies, where students investigate a variety of approaches and discuss the relative merits of different...

The large-enrollment undergraduate organic chemistry laboratories at Michigan State University have been redesigned to incorporate green and sustainable chemistry and evidence-based instructional approaches to laboratory teaching. Students engage in scientific practices such as defining problems, designing and carrying out experiments, analyzing data, and designing solutions during in-person lab sessions. Principles of green and sustainable chemistry are introduced in the case studies, where students investigate a variety of approaches and discuss the relative merits of different...

Additional file 3: Table S3. Adjusted odds ratios and 95% confidence intervals of the association of metabolic health and general obesity with prehypertension and hypertension by different age periods.

Additional file 2. Amendments to the pre-registered protocol.

Additional file 4. Concentration and forest plots for each individual immune mediator. Concentration plots - Each symbol shows the concentration of the indicated immune mediator in a single sample. Each study is plotted separately. Lines connect samples from the same participant; in some cases participants provided multiple samples in the same phase, in which case multiple symbols within the same phase may be connected. Pale grey symbols are below the lower limit of detection and...

Supplemental material, sj-pdf-1-imr-10.1177_03000605221129558 for Clostridium subterminale infection in a patient with diffuse large B-cell lymphoma and haemophagocytic syndrome: A case report and literature review by Ying Zhou, Sheng Wang, Xing-bei Weng in Journal of International Medical Research

Additional file 1: Table S1. COVID-19 daily reported cases and response policies by local government. Table S2. Variable definitions and parameter values. Table S3. PHMS-Index calculation. Table S4. Intervention simulation corresponding parameters. Table S5. Parameter estimation of actual spillover rate and spillover threshold. Table S6. Rt and PHMS-Index values at different stages. Table S7. Mean, standard deviation, Person correlation coefficient of Rt and PHSM_Index. Table S8. Simulation of different mask wear rates in 4 cities....

Additional file 1: Fig. S1. Correlations between the four V assessments. Fig. S2. Quantile-quantile plots of the GWAS meta-analysis results. Fig. S3. Manhattan plots of the GWAS meta-analysis results. Fig. S4. Quantile-quantile plots of the P value of heterogeneity. Table S2. Sources of summary statistics of breast cancer risk and breast cancer risk factors for calculating genetic correlation. Table S3. Sources of summary statistics of breast cancer risk and breast cancer risk factors for the...