Additional file 2. Supplementary Tables.

Additional file 9: Figure S3. Lipid traits – tissue/cell type associations estimated by DESE according to GTEx gene-level and GTEx transcript-level selective expression.

Additional file 26: Figure S10. Comparison of effect sizes for trans-ancestry index variants excluding cholesterol-lowering medication.

By single-crystal X-ray diffraction (XRD) analysis, five complexes, catena-[(µ-2,2-bis(4-carboxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)-1,3-benzothiazole)-aqua-zinc(II)] (1), catena-[(µ-2,2-bis(4-carboxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)1,3-benzothiazole)-aqua-cadmium(II)] (2), catena-[hepta(µ-2,2-bis(4carboxyphenyl)hexafluoropropane)-diaqua-bis(2-(pyidin-2-yl)-1,3-benzothiazole)-tri-manganes(II)] (3), catena-[(µ-benzene-1,2,4,5-tetracarboxylato)-(2-(pyidin-2-yl)-1,3benzothiazole)copper(II)] (4) and catena-[(µ-3-nitrobenzene-1,2-dicarboxylato)-(2-(pyidin-2-yl)1,3-benzothiazole)-aqua-zinc(II)] (5), were characterized in this research. In these five complexes, H2hfipbb = 2,2-bis(4-carboxyphenyl)hexafluoropropane, H4btec = 1,2,4,5-benzenetetracarboxylic acid, H2NPTA = 3-nitrophthalic acid and bpt = 2-(pyridin-2-yl)benzo[d]thiazole). Complexes 1 and 2 occur in the monoclinic system with space group C2/c, 4 and 5 occur in the monoclinic system with space group P21/c, and 3 occurs in the triclinic system...

Additional file 1. A PDF file that includes additional methods and results (Section S1-S3), supplemental figures (Fig. S1-S7) and short tables (Table S1-S2).

Supplemental material, sj-docx-1-tag-10.1177_17562848231165129 for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions by Rirong Chen, Chao Li, Kang Chao, Yizhe Tie, Jieqi Zheng, Huili Guo, Zhirong Zeng, Li Li, Minhu Chen and Shenghong Zhang in Therapeutic Advances in Gastroenterology

Aim: Bullous pemphigoid (BP) is an organ-specific autoimmune bullous disease characterized by autoantibodies that target the cellular adhesion molecules BP180 and BP230. Both immunoglobulin (Ig)G and IgE are involved in the induction of subepidermal blisters. Specifically, IgE autoantibodies are presumed to be responsible for the pruritic and erythematous features of BP. Histologically, eosinophil infiltration is a prominent feature in BP. Eosinophils and IgE are mostly associated with the Th2 immune response. Th2 cytokines, particularly interleukin...

Additional file 1. Supplementary Methods.

Postmenopausal women with overweight or obesity have an increased risk of developing breast cancer but many of the mechanisms underlying this association remain to be elucidated. MicroRNAs (miRNAs), short non-coding single-stranded RNAs, regulate many physiological processes by controlling post-transcriptional regulation of mRNA. We measured circulating miRNA from 192 overweight/obese postmenopausal women (50–75 years) who were part of a randomized controlled trial, comparing independent and combined effects of a 12-month reduced-calorie weight-loss diet and exercise programme,...

Prenatal socioeconomic disadvantage (SD) has been linked to DNA methylation (DNAm) in adulthood, but whether such epigenetic alterations are present at birth remains unclear. We carried out an epigenome-wide analysis of the association between several measures of individual- and area-level prenatal SD and DNAm assessed in neonatal cord blood via the Infinium EpicBeadChip among offspring born to mothers of White British (N = 455) and Pakistani (N = 493) origin in the Born in Bradford...

Additional file 2: Fig. S1. A. Comparison of the file size and loading time between PEFF and SQPD files. B. Comparison of the file size and loading time between FASTA and SET files. Fig. S2. The naming conventions of mature sequencesand small ORF encoded peptides. Fig. S3. The workflow for creating mature sequences for mouse proteins. Fig. S4. The workflow for predicting SEPs derived from circRNA transcripts. Fig. S5. The workflow for generating subsets and...

Additional file 1: Table S1. Diagnostic criteria for viral hepatitis A in Chinese mainland. Table S2. Summary statistics for the annual reported hepatitis A in Chinese mainland in 2005–2018. Table S3. The Global Moran’s I index for the average annual morbidity of hepatitis A in Chinese mainland during 2005–2018. Table S4. The Spearman correlation between the morbidity of hepatitis A, urbanization-related indices and meteorological factors. Table S5. The univariable analyses of the effects of each...

The impact of acute kidney injury (AKI) on the progression of renal function in idiopathic membranous nephropathy (iMN) with nephrotic syndrome (NS) patients have not yet been reported, we sought to investigate the incidence, clinical features and prognosis of AKI in iMN with NS patients and determine clinical predictors for progression from AKI to advanced chronic kidney disease (CKD) stage. We analyzed clinical and pathological data of iMN with NS patients retrospectively collected from Jan...

Special electromagnetic field-treated water (SEW) and far-infrared radiation (FIR) can reduce acute respiratory distress syndrome (ARDS) in rats inflicted by lipopolysaccharides (LPSs). However, little is known about its underlying molecular mechanism. Differentially expressed proteins (DEPs) of SEW and FIR interventions were obtained from a proteomics database. A total of 89 DEPs were identified. Enrichment analysis of DEPs was performed using the Database for Annotation, Visualization, and Integrated Discovery. These DEPs were associated with the responses...

Three new ergosterols, colletosterols A-C (1–3), together with two known analogues 4 and 5, were isolated from the endophytic fungus Colletotrichum magnisporum associated with the leaves of Rauvolfia verticillata by a bioassay-guided fractionation method. The new structures were elucidated on the basis of extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. All the ergosterols were evaluated for their cytotoxic activities against A549 and HeLa cell lines. Compounds 1–3 exhibited notable cytotoxicity with the IC50...

Three new ergosterols, colletosterols A-C (1–3), together with two known analogues 4 and 5, were isolated from the endophytic fungus Colletotrichum magnisporum associated with the leaves of Rauvolfia verticillata by a bioassay-guided fractionation method. The new structures were elucidated on the basis of extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. All the ergosterols were evaluated for their cytotoxic activities against A549 and HeLa cell lines. Compounds 1–3 exhibited notable cytotoxicity with the IC50...

GTP cyclohydrolase II (GCHII) is one of the rate limiting enzymes in riboflavin biosynthesis pathway and is shown to be a potential drug target for most of the pathogens. Previous biochemical and structural studies have identified the active site residues and elucidated the steps involved in the catalytic mechanism of GCHII. However, the last ∼20–25 C-terminal residues of GCHII remains unstructured in all the crystal structures determined to date and their role in the catalytic...

Supplemental material, sj-docx-1-anr-10.1177_20530196231167019 for The Sihailongwan Maar Lake, northeastern China as a candidate Global Boundary Stratotype Section and Point for the Anthropocene Series by Yongming Han, An Zhisheng, Dewen Lei, Weijian Zhou, Luyuan Zhang, Xue Zhao, Dongna Yan, Richard Arimoto, Neil L Rose, Sarah L Roberts, Li Li, Yalan Tang, Xingqi Liu, Xuewu Fu, Tobias Schneider, Xiaolin Hou, Jianghu Lan, Liangcheng Tan, Xingxing Liu, Jing Hu, Yunning Cao, Weiguo Liu, Feng Wu, Tianli Wang, Xiaoke...

Additional file 1: PRISMA checklist.

Additional file 1: Supplementary file 1.

Additional file 4: Supplementary Fig. 3. A) Volcano plot of differentially expressed genes in wild-type MYC overexpressing cells. Blue = downregulated transcripts. Red = upregulated transcripts. Green = transcripts in mSigDB hallmark gene sets MYC targets V1 and V2. B) mRNA expression levels of MYC in vector control cells (grey), cells overexpressing non-MYC alleles (blue), and cells overexpressing MYC alleles (red). C) Same as B) for KRAS. D) Same as B) for EGFR. E) Same...

Additional file 2: Supplementary Fig. 2. A) Number of differentially spliced events vs WT grouped by alternative splicing event type (A3SS = Alternative 3′ splice site; A5SS = Alternative 5′ splice site; MXE = Mutually exclusive exon; RI = Retained intron; SE = Skipped exon). Labeled percentages describe proportion of the group out of all differentially spliced events. B) Overlap of differentially spliced exons either more included (top) or more excluded (bottom) in KRASG12V vs...

Additional file 1. Table S1: All the treatment plans used for the evaluation of the Ray-LEM.

Additional file 1. Supplementary figures and figure legends (Fig. S1-S6).

Additional file 1: PRISMA checklist.