The large-enrollment undergraduate organic chemistry laboratories at Michigan State University have been redesigned to incorporate green and sustainable chemistry and evidence-based instructional approaches to laboratory teaching. Students engage in scientific practices such as defining problems, designing and carrying out experiments, analyzing data, and designing solutions during in-person lab sessions. Principles of green and sustainable chemistry are introduced in the case studies, where students investigate a variety of approaches and discuss the relative merits of different...

The large-enrollment undergraduate organic chemistry laboratories at Michigan State University have been redesigned to incorporate green and sustainable chemistry and evidence-based instructional approaches to laboratory teaching. Students engage in scientific practices such as defining problems, designing and carrying out experiments, analyzing data, and designing solutions during in-person lab sessions. Principles of green and sustainable chemistry are introduced in the case studies, where students investigate a variety of approaches and discuss the relative merits of different...

Additional file 1: Table S1. Beta estimates for genome-wide significant SNPs for early/adult life body size in UK Biobank (overall, men, women). Table S2. Summary information on colorectal cancer risk for the SNPs used in the analysis. Table S3. Number of cancer cases by sex and subsite. Table S4. Sample size and power calculations for each phenotype and group in the Mendelian randomization study of early and adult life body size and risk of colorectal...

Additional file 1: Table S1. Beta estimates for genome-wide significant SNPs for early/adult life body size in UK Biobank (overall, men, women). Table S2. Summary information on colorectal cancer risk for the SNPs used in the analysis. Table S3. Number of cancer cases by sex and subsite. Table S4. Sample size and power calculations for each phenotype and group in the Mendelian randomization study of early and adult life body size and risk of colorectal...

Additional file 1: Figure S1. Trend of AMI and stroke incidence to mortality rate ratio in Tianjin, Age ≥ 35. Red line, mortality rate; Blue line, incidence rate; Black solid line, incidence to mortality rate ratio (smoothed).

Additional file 5: Figure S5. Results of GSEA analysis in low-risk and high-risk groups in STAD. A The GSEA findings of the c2 reference gene sets for high-risk groups. B The GSEA findings of the c2 reference gene sets for low-risk groups.

Additional file 1: Supplementary Table 1. Characteristics primary analysis population compared with excluded and ‘COVID-19 without ARI’ populations. Supplementary Table 2. Sensitivity analyses.

Appendix 3. Ethical approval: REC reference 20/LO/0580.

Additional file 3: Supplementary Table 2. Chi-squared test of the timing of chemotherapy drugs between EMM group and LMM group.

Additional file 1. Key informant interview guide

Additional file 34. Review history.

Additional file 1: Supplementary Figure 1 for Figure 2A (SIRT1), 2B (EZH2) and 2C (RUNX3) expression in keloid and normal tissue: this figure is full image of western blots combines with marker. Supplementary Figure 2 for Figure 3A (SIRT1, EZH2 and RUNX3) expression in Human Keloid fibroblast and Human fibroblasts: this figure is full image of western blots combines with marker. Supplementary Figure 3 for Figure 4 (RUNX3 and β-actin) expression after Transfection: this figure...

Additional file 7: Supplementary Fig. 5. A) mRNA expression of splicing factors SF3B1, SRSF1, and SRSF7. B) End-point PCR gel detecting MAZ-1 and MAZ-2 isoforms in AALE cells overexpressing vector, KRAS, or RIT1 variants. C) Differential splicing of MAZ exon V′ in variant alleles compared to respective wild-type alleles.

Additional file 2: Supplementary Fig. 2. A) Number of differentially spliced events vs WT grouped by alternative splicing event type (A3SS = Alternative 3′ splice site; A5SS = Alternative 5′ splice site; MXE = Mutually exclusive exon; RI = Retained intron; SE = Skipped exon). Labeled percentages describe proportion of the group out of all differentially spliced events. B) Overlap of differentially spliced exons either more included (top) or more excluded (bottom) in KRASG12V vs...

Additional file 2. Western blot source data.

Additional file 3. Supplementary Methods.

Additional file 3. Supplementary Methods.

Additional file 1: Table S1-S3. Table S1: Quantitative RT-PCR primer sequences. Table S2: The results of GO TERM_BP enrichment analysis. Table S3: The results of KEGG_PATHWAY enrichment analysis.

Supplemental material, sj-docx-1-anr-10.1177_20530196231167019 for The Sihailongwan Maar Lake, northeastern China as a candidate Global Boundary Stratotype Section and Point for the Anthropocene Series by Yongming Han, An Zhisheng, Dewen Lei, Weijian Zhou, Luyuan Zhang, Xue Zhao, Dongna Yan, Richard Arimoto, Neil L Rose, Sarah L Roberts, Li Li, Yalan Tang, Xingqi Liu, Xuewu Fu, Tobias Schneider, Xiaolin Hou, Jianghu Lan, Liangcheng Tan, Xingxing Liu, Jing Hu, Yunning Cao, Weiguo Liu, Feng Wu, Tianli Wang, Xiaoke...

Supplemental material, sj-docx-2-tct-10.1177_15330338211050775 for Nanoparticle Albumin Bound Paclitaxel in the Third-Line Treatment of Recurrent Small Cell Lung Cancer in Real-World Practice: A Single Center Experience by Yuchao Wang, Li Li and Chunhua Xu in Technology in Cancer Research & Treatment

By single-crystal X-ray diffraction (XRD) analysis, five complexes, catena-[(µ-2,2-bis(4-carboxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)-1,3-benzothiazole)-aqua-zinc(II)] (1), catena-[(µ-2,2-bis(4-carboxyphenyl)hexafluoropropane)-(2-(pyidin-2-yl)1,3-benzothiazole)-aqua-cadmium(II)] (2), catena-[hepta(µ-2,2-bis(4carboxyphenyl)hexafluoropropane)-diaqua-bis(2-(pyidin-2-yl)-1,3-benzothiazole)-tri-manganes(II)] (3), catena-[(µ-benzene-1,2,4,5-tetracarboxylato)-(2-(pyidin-2-yl)-1,3benzothiazole)copper(II)] (4) and catena-[(µ-3-nitrobenzene-1,2-dicarboxylato)-(2-(pyidin-2-yl)1,3-benzothiazole)-aqua-zinc(II)] (5), were characterized in this research. In these five complexes, H2hfipbb = 2,2-bis(4-carboxyphenyl)hexafluoropropane, H4btec = 1,2,4,5-benzenetetracarboxylic acid, H2NPTA = 3-nitrophthalic acid and bpt = 2-(pyridin-2-yl)benzo[d]thiazole). Complexes 1 and 2 occur in the monoclinic system with space group C2/c, 4 and 5 occur in the monoclinic system with space group P21/c, and 3 occurs in the triclinic system...

Additional file 1: Fig. S1. Regional association plot at genome-wide association study (GWAS) genome-wide significant loci. Fig. S2. Principal component analysis (PCA) plot of Han Chinese PE cohort. Fig. S3. FUMA Manhattan plot and QQ plot of genome-wide association study (GWAS) meta-analysis. Fig. S4. The transfection efficiency of cellular experiments for FABP2. Fig. S5. Low-density lipoprotein cholesterol (LDL-C) levels of patients with different genotypes of rs1799883. Fig. S6. Forest plot for the association of total...

In the absence of data from a randomized trial, researchers may aim to use observational data to draw causal inference about the effect of a treatment on a time-to-event outcome. In this context, interest often focuses on the treatment-specific survival curves, that is, the survival curves were the population under study to be assigned to receive the treatment or not. Under certain conditions, including that all confounders of the treatment-outcome relationship are observed, the treatment-specific...

In the absence of data from a randomized trial, researchers may aim to use observational data to draw causal inference about the effect of a treatment on a time-to-event outcome. In this context, interest often focuses on the treatment-specific survival curves, that is, the survival curves were the population under study to be assigned to receive the treatment or not. Under certain conditions, including that all confounders of the treatment-outcome relationship are observed, the treatment-specific...

Additional file 1: Supplementary Methods and Results.