1,033 Works

Does caring for others affect our mental health? Evidence from the COVID-19 pandemic

Chiara Costi, Bruce Hollingsworth, Vincent O'Sullivan & Eugenio Zucchelli
Despite a growing literature about the mental health effects of COVID-19, less is known about the psychological costs of providing informal care during the pandemic. We examined longitudinal data from the UK’s Under-standing Society Survey, including eight COVID surveys, to estimate fixed effects difference-in-differences models combined with matching, to explore the causal effects of COVID-19 among informal carers. While matching accounts for selection on observables into caregiving, multiple period difference-in-differences specifications allow investigation of heterogeneous...

A model-based approach to automated validation and generation of PLC code for manufacturing equipment in regulated environments

Damian McCarthy, Dermot McMorrow, Noel O'Dowd, Conor Mc Carthy & EOIN HINCHY
Validation is a critical stage of the equipment design process as it provides documentary evidence that the equipment is performing as per specification and ensures consistent product quality is maintained at all times. The advent of Industry 4.0 has led to a requirement for reconfigurable manufacturing systems as manufacturers adapt to an increased customer demand for personalised products. As equipment control software becomes increasingly complex to accommodate these equirements, a new approach to equipment validation...

The older person’s experience of autonomy in healthcare decision-making in Ireland: The relationship between law, policy, and practice

John Lombard & Hope Davidson
The law on healthcare decision-making in Ireland is in a period of transition and will be enhanced with the full commencement of the Assisted Decision-Making (Capacity) Act (ADMC Act) 2015. The legislation is intended to empower a person to make decisions relating to their healthcare and personal affairs where they lack or may in the future lack the capacity to make their own decisions. This is especially relevant for the older person in terms of...

The older person’s experience of autonomy in healthcare decision-making in Ireland: The relationship between law, policy, and practice

John Lombard & Hope Davidson
The law on healthcare decision-making in Ireland is in a period of transition and will be enhanced with the full commencement of the Assisted Decision-Making (Capacity) Act (ADMC Act) 2015. The legislation is intended to empower a person to make decisions relating to their healthcare and personal affairs where they lack or may in the future lack the capacity to make their own decisions. This is especially relevant for the older person in terms of...

Magnetically recyclable Schiff-based palladium nanocatalyst [Fe3O4@SiNSB-Pd] and its catalytic applications in Heck reaction

Hamide Hafizi, Md. Lutfor Rahman, Mohd Sani Sarjadi, Mohammed Salim Akhter, MAURICE COLLINS, EMMET O'REILLY, Gavin Walker & Shaheen M. Sarkar
A magnetically separable palladium nanocatalyst has been synthesized through the immobilization of palladium onto 3-aminopropylphenanthroline Schiff based functionalized silica coated superparamagnetic Fe3O4 nanoparticles. The nanocatalyst (Fe3O4@SiNSB-Pd) was fully characterized using several spectroscopic techniques, such as FT-IR, HR-SEM, TEM, XRD, ICP, and XPS. The microscopic image of Fe3O4 showed spherical shape morphology and had an average size of 150 nm. The Pd-nanoparticles exhibited an average size 3.5 ± 0.6 nm. The successful functionalization of Fe3O4@SiNSB-Pd was...

Exosite binding modulates the specificity of the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease

The C5a peptidase from Streptococcus pyogenes (ScpA) is a highly specific enzyme with potential therapeutic value. ScpA is a good model for studying determinants of specificity in the multidomain immunomodulatory enzymes (IMEs), which comprise a large family of bacterial surface proteases. The surface exposed region of ScpA has 5 main domains which includes 3 C-terminal Fn3-like domains (Fn1, Fn2 and Fn3) (Kagawa et al. 2009). Progressive deletion of the Fn3-like domains from the C-ter resulted...

Wheelchair service provision education for healthcare professional students, healthcare personnel and educators across low- to high-resourced settings: a scoping review

Yohali Burrola-Mendez, Sureshkumar Kamalakannan, Paula W. Rushton, Selsabil-A. Bouziane, Ed Giesbrecht, R. Lee Kirby, ROSEMARY GOWRAN, David F. Rusaw, Tomasz Tasiemski, Mary Goldberg, Marco Tofani, Jessica P. Pedersen & Jon Pearlman
Porpose: This review aimed to collate and summarize available research literature about wheelchair service provision education available to healthcare professional students, healthcare personnel and educators across low- to high-resourced settings. Methods: The Joanna Briggs Institute methodological steps for scoping reviews were followed. Included studies were mainly sourced from Medline, Embase, CINAHL, Scopus, Academic Search Complete and ProQuest. Independent title, abstract and full-text screening with defined inclusion and exclusion criteria was performed. All screening and extraction...

Recent progress in biomedical and biotechnological applications of lignin-based spherical nano- and microstructures: a comprehensive review

Martin Stanisz, L. Klapiszewski, MAURICE COLLINS & Teofil Jesionowski
Spherical particles based on materials of natural origin have recently gained increased attention because of their unique properties, including shape, structure, and ability to combine with other materials. Lignin has potential to be applied across multiple sectors, with recent focus on its valorization in high end application routes which favor its renewability, biocompatibility, and non-toxicity. The most promising findings are reported, that spherical lignin particles are a very effective carrier and delivery vehicle for active...

Ethical reasoning in tax practice: Law or is there more?

Elaine Doyle, Jane Frecknall-Hughes & Barbara Summers
Private sector tax practitioners are often accused of unethical behavior in developing contrived tax avoidance arrangements. Such arrangements usually comply with the letter of the law but contravene its underlying (often unstated) ‘spirit’. Prior research comparing the ethical reasoning of private sector tax practitioners, government revenue tax practitioners and a non-tax (control) group in both social and tax contexts found no significant differences between them in a social context. However, where tax dilemmas were concerned,...

Direct deduction of chemical class from NMR spectra

Stefan Kuhn, Carlos Cobas, Agustin Barba, Simon Colreavy-Donnelly & Fabio Caraffini
This paper presents a proof-of-concept method for classifying chemical compounds directly from NMR data without performing structure elucidation. This can help to reduce the time in finding good structure candidates, as in most cases matching must be done by a human engineer, or at the very least a process for matching must be meaningfully interpreted by one. The method identified as suitable for classification is a convolutional neural network (CNN). Other methods, including clustering and...

Feasibility of an audit and feedback intervention to facilitate journal policy change towards greater promotion of transparency and openness in sports science research

Harrison J. Hansford, Aidan G Cashin, Matthew K Bagg, Michael A. Wewege, Michael C Ferraro, Sina Kianersi, Evan Mayo-Wilson, Sean P. Grant, ELAINE TOOMEY, Ian W. Skinner, James H McAuley, Hopin Lee & Matthew D. Jones
Objectives: To evaluate (1) the feasibility of an audit-feedback intervention to facilitate sports science journal policy change, (2) the reliability of the Transparency of Research Underpinning Social Intervention Tiers (TRUST) policy evaluation form, and (3) the extent to which policies of sports science journals support transparent and open research practices. Methods: We conducted a cross-sectional, audit-feedback, feasibility study of transparency and openness standards of the top 38 sports science journals by impact factor. The TRUST...

The Real Deal: A Qualitative Investigation of Authentic Leadership in Irish Primary School Leaders

Recognition of the importance of authentic leadership is growing in popularity amonlead?ership scholars. However, little remains known about how it is valued or received among practicing school leaders. The purpose of this research was to explore the perspectives and experiences of school leaders with reference to authentic leadership in Irish primary school leaders. As this is a scoping study, a qualitative research design was adopted, using semi-structured interviews with school leaders. Core traits of self-awareness,...

The multicomponent diffuse-interface model and its application to water/air interfaces

Eugene Benilov
Fundamental properties of the multicomponent diffuse-interface model (DIM), such as the maximum entropy principle and conservation laws, are used to explore the basic interfacial dynamics and phase transitions in fluids. Flat interfaces with monotonically changing densities of the components are proved to be stable. A liquid layer in contact with oversaturated but stable vapour is shown to either fully evaporate or eternally expand (depending on the initial perturbation), whereas a liquid in contact with saturated...

Human-in-Loop: A Review of Smart Manufacturing Deployments

Mangolika Bhattacharya, Mihai Penica, EOIN O'CONNELL, MARK SOUTHERN & MARTIN HAYES
The recent increase in computational capability has led to an unprecedented increase in the range of new applications where machine learning can be used in real time. Notwithstanding the range of use cases where automation is now feasible, humans are likely to retain a critical role in the operation and certification of manufacturing systems for the foreseeable future. This paper presents a use case review of how human operators affect the performance of cyber–physical systems...

A repeated cross‐sectional analysis of breastfeeding initiation rates in Ireland for two decades and 10 recommended priorities for improvement

Roy K. Philip, Aubree Worobetz, Helen Byrt, Irene Beirne, Raeghnya Zutshi, Tanya Cassidy & COLUM DUNNE
Despite a number of public health and policy‐based initiatives, Ireland's national breastfeeding rates are among the lowest globally. Regionally, the Mid‐West of Ireland has historically had low breastfeeding initiation rates, and parts of its major urban area such as Limerick City suffer the highest levels of economic deprivation in the country. In that context, this repeated cross‐sectional study analysed breastfeeding initiation trends in the Mid‐West of Ireland for two decades, from 2001 to 2020 inclusively....

Improving physiological relevance of cell culture: the possibilities, considerations, and future directions of the ex vivo coculture model

Sophie L. Allen, Bradley T Elliott, BRIAN CARSON & Leigh Breen
In vitro models provide an important platform for the investigation of cellular growth and atrophy to inform, or extend mechanistic insights from, logistically challenging in vivo trials. Although these models allow for the identification of candidate mechanistic pathways, many models involve supraphysiological dosages, nonphysiological conditions, or experimental changes relating to individual proteins or receptors, all of which limit translation to human trials. To overcome these drawbacks, the use of ex vivo human plasma and serum...

Synthesis and evaluation of alginate, gelatin, and hyaluronic acid hybrid hydrogels for tissue engineering applications

Aleksandra Serafin, Mario Culebras & MAURICE COLLINS
Tissue engineering (TE) has been proposed extensively as a potential solution to the worldwide shortages of donor organs needed for transplantation. Over the years, numerous hydrogel formulations have been studied for various TE endeavours, including bone, cardiac or neural TE treatment strategies. Amongst the materials used, organic and biocompatible materials which aim to mimic the natural extracellular matrix of the native tissue have been investigated to create biomimicry regenerative environments. As such, the comparison between...

A Proposed VR Platform for Supporting Blended Learning Post COVID-19

Simon Colreavy-Donnelly, Alan Ryan, Stuart O’Connor, Fabio Caraffini, Stefan Kuhn & Salim Hasshu
The COVID-19 pandemic caused a shift in teaching practice towards blended learning for many higher education institutions. This led to the rapid adoption of certain digital technologies within existing teaching structures as a means to meet student access needs. This paper is an attempt to summarise and extend pre-COVID-19 pedagogical research to leverage digital immersive technologies for blended teaching in the post-pandemic era. This paper forms both a review of these methodologies and a case...

A study of network intrusion detection systems using artificial intelligence/machine learning

Patrick Vanin, THOMAS NEWE, Lubna Luxmi Dhirani, EOIN O'CONNELL, Donna O'Shea, Brian Lee & Muzaffar Rao
The rapid growth of the Internet and communications has resulted in a huge increase in transmitted data. These data are coveted by attackers and they continuously create novel attacks to steal or corrupt these data. The growth of these attacks is an issue for the security of our systems and represents one of the biggest challenges for intrusion detection. An intrusion detection system (IDS) is a tool that helps to detect intrusions by inspecting the...

Design considerations for buckling of composite cylindrical shells on elastic foundations

Mohammad Ansari
Cylindrical shell structures are widely used in aerospace engineering, and buckling considerations often drive their design. However, cylindrical shell structures under compression loading are highly sensitive to imperfections of different nature. Indeed, geometrical, material, loading and boundary imperfections can severely reduce their load-carrying capability. Despite considerable research devoted to geometrical imperfections, relatively little attention has been given to the effects of boundary imperfections on the buckling load of cylindrical shell structures. However, boundary imperfections can...

Teacher Learning Communities and Leadership: Insights from A DEIS Urban Second-Level School

This article explores the connection between teaching effectiveness and participation in teacher learning communities (TLCs) in the context of a second-level co-educational urban school. In particular, it examines the role of educational leadership in their development and concomitantly toward the enhancement of teaching and learning. Seven teachers contributed to the research across two existing TLCs at the site school. It emerged that relationships and respect amongst the participants are pivotal to their effectiveness. It also...

Enzyme-assisted extraction of anthocyanins and other phenolic compounds from blackcurrant (Ribes nigrum L.) press cake: From processing to bioactivities

Daniel Granato, Marina Fidelis, Marjo Haapakoski, Amanda dos Santos Lima, Janeli Viil, Jarkko Hellström, Reelika Ratsep, Hedi Kaldmae, Uko Bleive, Luciana Azevedo, Varpu Marjomäki, Alexander Zharkovsky & Nora Pap
The effects of commercial enzymes (pectinases, cellulases, beta-1-3-glucanases, and pectin lyases) on the recovery of anthocyanins and polyphenols from blackcurrant press cake were studied considering two solid:solvent ratios (1:10 and 1:4 w/v). β-glucanase enabled the recovery of the highest total phenolic content – 1142 mg/100 g, and the extraction of anthocyanins was similar using all enzymes (~400 mg/100 g). The use of cellulases and pectinases enhanced the extraction of antioxidants (DPPH − 1080 mg/100 g;...

Development and delivery of an allied health team intervention for older adults in the emergency department: A process evaluation

Marica Cassarino, UNA CRONIN, Katie Robinson, Rosie Quinn, Fiona Boland, Marie E. Ward, Rosa McNamara, MARGARET O'CONNOR, Gerard McCarthy, DAMIEN RYAN & Rose Galvin
Background There is encouraging evidence that interdisciplinary teams of Health and Social Care Professionals (HSCPs) can enhance patient care in the Emergency Department (ED), especially for older adults with complex needs. However, no formal process evaluations of implementations of ED-based HSCP interventions are available. The study aimed to evaluate the development and delivery of a HSCP team intervention for older adults in the ED of a large Irish teaching hospital. Methods Using the Medical Research...

Supporting medical students towards future careers in general practice: A quantitative study of Irish medical schools

A.W. Murphy, D. Moran, S.M. Smith, E. Wallace, LIAM GLYNN, K Hanley & M E. Kelly
Aim In Ireland there is a significant, and increasing, shortage of general practitioners. By 2025, this shortfall could be as high as 1,380, from a current workforce of 3,923. We aimed to determine the proportions of EU medical graduates from each of the six Irish medical schools who applied to the national GP Training Program for 2017-21 inclusive. Methods The Spearman rank correlation was used to examine the correlations between the proportions of graduate entrants,...

Atherosclerosis fate in the era of tailored functional foods: Evidence-based guidelines elicited from structure- and ligand-based approaches

Luciana Azevedo, Mateus Sá Magalhães Serafim, Vinícius G.Maltarollo, Andreas Grabrucker & Daniel Granato
Background: Atherosclerosis is the primary cause of cardiovascular diseases (CVDs), contributing to more than 33% of the annual deaths globally. Westernized dietary patterns, a high prevalence (50%) of overweight and obesity, and an increased incidence of glucose intolerance and type-2 diabetes are related to atherosclerosis. However, increased demand for functional foods has boosted the production of different foods to improve people’s life quality and decrease the CVDs’ risk. Nonetheless, functional foods targeting CVDs are scarce...

Registration Year

  • 2023

Resource Types

  • Text


  • University of Limerick
  • University College Dublin
  • Shanghai Jiao Tong University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Sichuan University
  • Zhejiang University
  • Nantong University
  • Huazhong University of Science and Technology
  • Jiangsu Province Hospital
  • Nanjing Medical University