Fluorine-doped graphene supported PbO (F-rGO/PbO) composite was prepared through a facile water bath method to study an improvement strategy for its catalytic performance in thermal decomposition of ammonium perchlorate (AP). The characterization results showed that the PbO with the size of 20 ∼ 30 nm are highly dispersed on the surface of F-doped graphene (F-rGO). Compared with other samples, the F-rGO/PbO exhibited superior catalytic performance, as 3 wt% of catalyst added in AP, the peak...

In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, we report that in retinal pigmented epithelial (RPE) cells, LCN2 regulates macroautophagy/autophagy, in addition to maintaining iron homeostasis. LCN2 binds to ATG4B to form an LCN2-ATG4B-LC3-II complex, thereby regulating ATG4B activity and LC3-II lipidation. Thus, increased LCN2 reduced autophagy flux. Moreover, RPE cells from cryba1 KO, as well as sting1 KO...

Cotton (Gossypium hirsutum) is an important economic crop, so it is of great significance to analyze its molecular mechanisms of resistance to Verticillium Wilt. The WRKY gene family encodes transcription factors (TFs) involved in plant resistance to biotic and abiotic stress. Here, we identified 17 group III WRKY genes in cotton based on the cotton genome project. The phylogenetic relationship and evolutionary of WRKY Group III TFs in Arabidopsis thaliana and G. hirsutum showed that...

Blueberries are rich in anthocyanins, which are plant-specific secondary metabolites that are a good source of plant nutrients. Although anthocyanins have been investigated, there is a lack of comprehensive detailed research that includes large numbers of blueberry cultivars, and the anthocyanin compositions of some cultivars are still unknown. Consequently, we determined the anthocyanin compositions of 62 cultivars using ultra-performance liquid chromatography–mass spectrometry (UPLC–MS). In total, we identified 30 anthocyanins derived from five kinds of anthocyanidin....

Sulfate transporters (SULTRs) are responsible for the absorption and transport of sulfate in higher plants. They also play a key role in plant growth, development and abiotic stress responses. However, the SULTR gene family in common bean (Phaseolus vulgaris L.) is still not well studied. In this study, 15 PvSULTRs were identified. Phylogenetic analysis divided the PvSULTR genes into four subgroups. Cis-regulatory element analysis of the promoter sequence of the PvSULTR genes showed that many...

Sulfate transporters (SULTRs) are responsible for the absorption and transport of sulfate in higher plants. They also play a key role in plant growth, development and abiotic stress responses. However, the SULTR gene family in common bean (Phaseolus vulgaris L.) is still not well studied. In this study, 15 PvSULTRs were identified. Phylogenetic analysis divided the PvSULTR genes into four subgroups. Cis-regulatory element analysis of the promoter sequence of the PvSULTR genes showed that many...

Researchers have investigated miR-130b-3p in lung disease pathology, such as lung fibrosis. The present study was performed to elucidate the miR-130b-3p-involved mechanism in acute lung injury (ALI) through delivery by mesenchymal stem cells-derived exosomes (MSCs-Exo). ALI mouse models were induced via intratracheal administration of lipopolysaccharide (LPS) and treated with MSCs-Exo. Lung dry-wet (W/D) ratio, inflammatory factors in the bronchoalveolar lavage fluid, pathological damage and apoptosis in the lung tissues were analyzed. Expression levels of miR-130b-3p...

Model averaging has a rich history dating from its use for combining forecasts from time-series models (Bates and Granger, 1969) and presents a compelling alternative to model selection methods. We propose a frequentist model averaging procedure defined over categorical regression splines (Ma, Racine, and Yang, 2015) that allows for mixed-data predictors, as well as non-nested and heteroskedastic candidate models. We demonstrate the asymptotic optimality of the proposed model averaging estimator, and develop a post-averaging inference...

This study focuses on exploring equity among regions regarding public service delivery. An analytical framework is established to measure the level of public service delivery considering input (resources) and output (results), and an equity analysis is conducted from temporal and spatial perspectives. The results show that there are disparities in the level of public service delivery among regions in China (mainly due to inequality in resources), and within-region inequality has a greater influence on overall...

A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

Additional file 4: Figure S3. Differential microbiota of gastric cancer tissues and non-tumor tissues. A Differential taxa from phylum to genus of Distal T and Distal N. B Differential taxa from phylum to genus of Proximal T and Proximal N.

Additional file 1. Original images for western blot.

Supplementary materials

Additional file 1: Table S1. Clinicopathological characteristics of patients with gastric cancer in this study. Table S2. Different microorganisms in Proximal T and Distal T compared to their respective non tumor samples. Table S3. Significant differences in metabolites between Distal T and Distal N. Table S4. Significant differences in metabolites between Proximal T and Proximal N. Table S5. Metabolic pathway enrichment of differential metabolites between Distal T and Distal N. Table S6. Metabolic pathway enrichment...

Fitting methods and supplementary data

CAMKK2 inhibitors have therapeutic effects on cancer, metabolic disorders, diabetes and osteoporosis. However, high-quality CAMKK2 inhibitors are still lacking. Natural product databases were screened for potential inhibitors using bioinformatics strategies such as pharmacophore models, molecular docking, molecular dynamics simulation. Two hit compounds, STOCK1N-53910 and STOCK1N-66485, were got via Lipinski rule, Veber rule, PAINS rule, pharmacophore models and molecular docking. The results of molecular docking showed hit compounds had similar binding patterns to the active control....

Association between neutrophil-to-lymphocyte ratio (NLR) on admission and poor prognosis in patients with acute heart failure (AHF) has been well established. However, the relationship between dynamic changes in NLR and in-hospital mortality in AHF patients has not been studied. Our purpose was to determine if an early change in NLR within the first week after AHF patients was admitted to intensive care unit (ICU) was associated with in-hospital mortality. Data from the medical information mart...

Supplementary Material 1

Supplementary Material 1

This graphic uses cartogram analysis to demonstrate how Covid-19 affects high-speed rail (HSR) and air networks in China. During the first round of the Covid-19 outbreak, intercity transportation networks significantly decreased their service. However, the supply of transport hubs was retained to ensure basic service coverage and efficiency. Conversely, air transportation was affected more than HSR networks. The average number of daily flights declined to 19% of the original traffic, while high-speed trains maintained their...

To explore and expand the application of luffa sponge (LS) fiber, three methods were used to chemically modify the LS fibers. The nanoindentation (NI) results show that the LS fibers exhibit a high elastic modulus (12.4 GPa) and hardness (0.7 GPa). Upon treating the fibers with 5%NaOH-5%H2O2, the NI hardness of the fibers increases by 14.3%. However, when 10%NaOH-20%CH3COOH (method B) is used, the hardness of the cell walls decreases by 28.6%. In this case,...

Whether hemostatic status was correlated with the diverse types of acute kidney injury in cirrhotic patients is unclear. The present study aimed to investigate the relationship between hemostatic markers and the diverse types of acute kidney injury (AKI) in liver cirrhosis. Cirrhotic patients with consecutive treatment at the First Affiliated Hospital of Medicine School, Zhejiang University, were pooled in a cohort. Their demographic and clinical data, biochemistry parameters and hemostatic markers were assessed to identify...

Radioiodine-refractory differentiated thyroid cancer (RAI-rDTC) has frequently been associated with poor prognosis. We conducted a meta-analysis of published randomized controlled trials to evaluate multi-kinase inhibitors’ efficacy and safety profile treatment. A comprehensive search was conducted using PubMed, Embase, Cochrane, and Medline databases. The quality of literature and trial risk of bias was assessed using the Cochrane risk of bias tool, while the results of progression-free survival (PFS), overall survival (OS), and adverse events (AEs) were...

In this work, we have successfully fabricated Sr-doped porous LaFeO3 samples via sol–gel method. The results reveal that Sr2+ cation is effectively doped into LaFeO3 crystal lattice substituting La3+ cation. The visible light catalytic performance of the materials was evaluated by the degradation of 2,4-dichlorophenol (2,4-DCP) and Rhodamine B (RhB). The amount-optimized Sr-doped porous LaFeO3 sample exhibited outstanding visible-light catalytic performance for the degradation of the model pollutants compared to the porous LaFeO3 alone. The...

Richmond agitation-sedation scale (RASS) is a simple and widely used tool for evaluating sedation and agitation in adult ICU patients. Early deep sedation has been shown to be an important independent predictor of death, however, studies on the role of RASS in the prognostic assessment of neurocritical patients are lacking. The purpose of this study was to investigate the relationship between RASS and in-hospital mortality in neurocritical patients, and to develop and validate an effective...