Complex disorders usually affect multiple symptom domains measured by several outcomes. The importance of these outcomes is often different among patients. Current approaches integrate multiple outcomes without considering patient preferences at the individual level. In this article, we propose a new composite Desirability of Outcome Ranking (DOOR) that integrates individual level ranking of outcome importance and define a winning probability measuring the overall treatment effect. Stratified randomization can be performed based on the participants’ baseline...

Bone defects caused by trauma or tumor are a significant challenge in clinical practice. Hydrogel-based tissue engineering has been considered an effective strategy. This study successfully formed a series of injectable hydrogels by enzyme-catalyzed crosslinking hyaluronic acid-tyramine (HA-TA) and sodium alginate-tyramine (ALG-TA) under physiological conditions in the presence of both horseradish peroxidase and hydrogen peroxide. The morphology, mechanical properties, swelling properties, and biodegradation properties of hydrogels were investigated. The results showed that the mechanical properties,...

Bone defects caused by trauma or tumor are a significant challenge in clinical practice. Hydrogel-based tissue engineering has been considered an effective strategy. This study successfully formed a series of injectable hydrogels by enzyme-catalyzed crosslinking hyaluronic acid-tyramine (HA-TA) and sodium alginate-tyramine (ALG-TA) under physiological conditions in the presence of both horseradish peroxidase and hydrogen peroxide. The morphology, mechanical properties, swelling properties, and biodegradation properties of hydrogels were investigated. The results showed that the mechanical properties,...

The cement industry is rising rapidly along with the building industry globally. This makes it possible for more competitions that provide customers with preference considerations. The study aimed to contribute to knowledge by exploring consumer preferences for cement brands and factors that influence their selection of cement used for concrete production in Ghana. The study employed a quantitative survey approach. The study comprised of private homeowners (70.7%) and construction/estate companies (29.3%) in four major cities...

Additional file 2: Table S2. Related genes in the disease connection. Table S3. MCODE results for ICM-associated networks, SAP-associated networks, and CHF-associated networks. Table S4. Topological attributes of disease-associated modules (nodes ≥ 4). Table S5. Reconfiguration module matching among ICM-, SAP- and CHF-associated networks. Table S6. Weight results calculated by the entropy method. Table S7. Normalization of disease-related module parameters (nodes ≥ 4). Table S8. K-value of reconstruction module pairs among ICM, SAP and CHF...

Additional file 1. Supplementary figures, materials, and methods.

Additional file 1. Supplementary figures, materials, and methods.

Additional file 2: Fig. S2. Downregulated Rev-erbα expression in ESCs of mice and human with sleep disruption. a (left) Immunofluorescence for Rev-erbα and Vimentin in uterus of mice with normal sleep or sleep disturbance at ZT3. (right) The relative mean gray value of Rev-erbα in Vimentin+ ESCs from mice with normal sleep or sleep disturbance at ZT3. b (left) Immunofluorescence for Rev-erbα and Vimentin in uterus of mice with normal sleep or sleep disturbance at...

Additional file 2. CDC guidelines.

Additional file 3. Receiver operating characteristic curves of diaphragm function indices predicting the frequency of AECOPD

Supplemental material, sj-doc-4-jbm-10.1177_03936155221140421 for Diagnostic and prognostic values of MMP-9 expression in ovarian cancer: A study based on bioinformatics analysis and meta-analysis by Changyu Liu, Ying Shen and Qiyan Tan in The International Journal of Biological Markers

Supplemental Material for Surgical Treatment is Still Recommended for Patients Over 75 Years with IA NSCLC: A Predictive Model Based on Surveillance, Epidemiology and End Results Database by Cancer Control by Yafeng Liu, Wenting Zhang, Jing Wu, Wenyang Wang, Jiawei Zhou, Jianqiang Guo, Qingsen Wang, Xin Zhang, Jun Xie, Yingru Xing, and Dong Hu in Cancer Control

Supplemental material, sj-doc-1-aph-10.1177_10105395221141966 for Ethnic Differences in Social Support for Elderly Individuals in Rural Southern China: A Cross-sectional Survey by Lu Liu, Yixing Yang, Yuan Zhao and Tai Zhang in Asia Pacific Journal of Public Health

Additional file 1: Figure S1. Optical microscope photographs of RLBP and RBC membrane-constructed nanoparticles. The magnification of the picture is 40×. Figure S2. The UV–Vis spectrum of RBCM, LIP-PFP, levobupivacaine, and RLBP. Figure S3. The absorbance UV–Vis spectrum of the levobupivacaine in our study. Figure S4. Calcein-AM and PI co-staining images of the RLBP nanoparticles with or without ultrasound irradiation. Figure S5. Generation of ROS by DCFH staining of DRG cells after being treated with...

Epistatic effects are an important part of the genetic effect of complex traits in livestock. In this study, we used 218 synthetic ewes from the Xinjiang Academy of Agricultural Reclamation in China to identify interacting paired with genome-wide single nucleotide polymorphisms (SNPs) associated with birth weight, weaning weight, and one-yearling weight. We detected 2 and 66 SNP-SNP interactions of sheep birth weight and weaning weight, respectively. No significant epistatic interaction of one-year-old body weight was...

Detailed theoretical calculation and experimental proposal

Supplemental Material for Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review by Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen, and Wei Zhang in International Journal of Immunopathology and Pharmacology

the extra description about devices

Supplemental Material for Pyroptosis in the lung and spleen of patients died from COVID-19 by Xin Tong, Haiqin Ping, Xiaoming Gong, Kai Zhang, Zhaojun Chen, Caiyun Cai, Zhiyan Lu, Rongrong Yang, Shicheng Gao, Yunyun Wang, Xinghuan Wang, Liang Liu and Hengning Ke in European Journal of Inflammation

Additional file 1: Table S1. LC–MS analysis of tryptic-digested peptides of LSSL. Table S2. The full names and abbreviation of species used in the analysis.

Supplement 1

Supplemental material, sj-docx-1-acr-10.1177_02841851221142019 for Aberrant gray matter structure in neurosyphilis without conventional MRI abnormality: a pilot study with voxel and surface-based morphology by Zi-Ning Lu, Sheng-Juan Yao, Yu Cao, Yue Cheng, Xiao-Tian Li, Hong-Shuai Guo and Xiao-Dong Zhang in Acta Radiologica

Research Data for Interventional treatment of keratoacanthoderma: a case report by Dan Mei, Lei Song, Jin-Qi Gao and Jie Wu in Journal of International Medical Research

Supplemental Material for The Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) as a Novel Therapeutic Target in Mantle Cell Lymphoma by Jiao Li, Hui Yu, Xing Wang, Yingying Ye, Wei Fang, Ning Ding, Lan Mi, Lingyan Ping, Xiaogan Wang, Yuqin Song and Jun Zhu in Cancer Control

Supplemental material, sj-docx-1-cre-10.1177_02692155221146085 for Effects of dual-task training on gait and motor ability in patients with Parkinson's disease: A systematic review and meta-analysis by Yi-Hong Du, Jun Ma, Jing-Yun Hu, Lei Zhu, Li-Yan Wang, Ruo-Yu Yang, Lei-Chao Liang, Men Jiang, Ming Cai and Jun Pu in Clinical Rehabilitation