Spermatogenesis is an important physiological process associated with male infertility. As a kind of post-transcriptional regulation, RNA editings (REs) change the genetic information at the mRNA level. But whether there are REs and what’s the role of REs during the process are still unclear. In this study, we integrated published RNA-Seq datasets and established a landscape of RNA REs during the development of mouse spermatogenesis. Totally, 7530 editing sites occurred in 2012 genes among all...

Background: Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in Shanghai. Methods: We retrospectively analysed 325 cases admitted at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020. Results: 47.4% (154/325) had visited Wuhan within 2 weeks of illness onset. 57.2% occurred in 67 clusters; 40% were situated within 53 family clusters. 83.7% developed fever during the disease course. Median times from...

A dynamic treatment regime (DTR) is a sequence of decision rules that adapt to the time-varying states of an individual. Black-box learning methods have shown great potential in predicting the optimal treatments; however, the resulting DTRs lack interpretability, which is of paramount importance for medical experts to understand and implement. We present a stochastic tree-based reinforcement learning (ST-RL) method for estimating optimal DTRs in a multistage multitreatment setting with data from either randomized trials or...

Additional file 1: Table S1. Search strategy of journal publications on HTA of selected medical devices. Table S2. Search strategy of journal publications on discussing HTA of medical devices. Figure S1. PRISMA flowchart of literature review of journal publications on discussing HTA of medical devices.

Additional file 1: Figure A1. The receiver operating characteristics (ROC) curve of SII for POD. Table A1. Association between SII as continuous variable and POD in different models. Table A2. Association between SII as categories variables used quartiles and POD in different models. Table A3. Association between SII as categories variables with a cut-off value of 650 and POD in different models. Table A4. Univariate logistic regression analyses for POD in the Model PSM.

Additional file 5.

Additional file 5.

Additional file 6.

Additional file 3: Table S2. Top 10 gene interaction pairs identified by JDINAC after adjusting for menopausal status.

more details about the experiment

Additional file 1.

Brominated flame retardants (BFRs) are a group of contaminants of emerging environmental concern. In this study, systematic exploration was carried out to investigate the degradation of tetrabromobisphenol S (TBBPS), a typical emerging BFRs, by thermally activated persulfate (PDS) oxidation. The removal of 5.0 μM TBBPS was 100% after 60 min oxidation treatment under 60°C. Increasing the temperature or initial PDS concentration facilitated the degradation efficiency of TBBPS. The quenching test indicated that TBBPS degradation occurred...

Supplemental material, sj-pdf-4-wso-10.1177_17474930221125993 for Effect of the Shanghai Stroke Service System (4S) on the quality of stroke care and outcomes: A prospective quality improvement project by Jiawen Xu, Yanan Xie, Kun Fang, Xin Wang, Shengdi Chen, Xueyuan Liu, Yuwu Zhao, Yangtai Guan, Dingfang Cai, Gang Li, Jianmin Liu, JianRen Liu, Jianhua Zhuang, Ying Xian, Haipeng Shen, Hao Li, David Z Wang, Bruce CV Campbell, Mark W Parsons, Yi Dong and Qiang Dong in International Journal...

Additional file 1: Fig. S1. Inter-annual variability for air temperature (a), precipitation (b), soil temperature at 20 cm depth (c), and soil moisture (d) from 1900 to 2000 in China. The percentage water-filled pore space (WFPS) is used as an expression of soil moisture. Fig. S2. Spatial patterns of partial correlation coefficients between net ecosystem production (NEP) and (a) air temperature, (b) precipitation, (c) CO2 concentration, and (d) ratio of cropland area from 1900 to...

The rhizome of Rohdea chinensis (Baker) N.Tanaka (RRc) is a famous folk medicine for the treatment of carbuncles and pharyngitis. Steroidal saponins (SSs) were considered to be the most abundant active constituents in RRc. However, to date, the in-depth study of SSs is still lacking. This study was aimed to investigate the SSs profiles of RRc extract by HPLC-ESI-QTOF-MS/MS. Analysis was performed on an Agilent poroshell 120 EC-C18 column (2.1 mm × 100 mm, i.d.,...

Supplementary Material 1

Additional file 2: Table S2. Different pathologists’ pretreatment prediction of pathologic response after neoadjuvant anti-PD-1 treatment according to irHPC.

The rhizome of Rohdea chinensis (Baker) N.Tanaka (RRc) is a famous folk medicine for the treatment of carbuncles and pharyngitis. Steroidal saponins (SSs) were considered to be the most abundant active constituents in RRc. However, to date, the in-depth study of SSs is still lacking. This study was aimed to investigate the SSs profiles of RRc extract by HPLC-ESI-QTOF-MS/MS. Analysis was performed on an Agilent poroshell 120 EC-C18 column (2.1 mm × 100 mm, i.d.,...

Additional file 1: Figure S1. The differential interaction network inferred by JDINAC after adjusting for BMI and menopause status.

Additional file 1: Figure S1. The differential interaction network inferred by JDINAC after adjusting for BMI and menopause status.

Supplemental material, sj-pdf-1-smm-10.1177_09622802221122397 for Penalized Spline-Involved Tree-based (PenSIT) Learning for estimating an optimal dynamic treatment regime using observational data by Kelly A Speth, Michael R Elliott, Juan L Marquez and Lu Wang in Statistical Methods in Medical Research

We identified relapsing fever (RF) Borrelia in 1.45% (145/10426) of the ticks and 1.40% (40/2850) of the wild mammals in a field investigation in China. Three RF Borrelia species, including human-pathogenic Borrelia miyamotoi, Borrelia persica and unclassified Babesia sp. were determined. Main species determined from ticks was B. miyamotoi (44.14%), followed by the unclassified Borrelia sp. (42.76%), and Borrelia theileri (13.10%). In wild mammals, main species found was B. persica (57.50%), followed by the unclassified...

Anaplastic lymphoma kinases (ALK) tyrosine kinase inhibitors (TKIs) are effective and safe targeted therapies used in advanced ALK-positive non-small cell lung cancers (NSCLC). However, ALK-TKIs associated cardiovascular toxicities in patients with ALK-positive NSCLCremain incompletely characterized. We conducted the first meta-analysis to investigate this. To determine the cardiovascular toxicities associated with these agents, we carried out a meta-analysis comparing ALK-TKIs with chemotherapy and a meta-analysis comparing crizotinib with other ALK-TKIs. Statistical analysis was conducted to calculate...

Additional file 2: Table S2. Related genes in the disease connection. Table S3. MCODE results for ICM-associated networks, SAP-associated networks, and CHF-associated networks. Table S4. Topological attributes of disease-associated modules (nodes ≥ 4). Table S5. Reconfiguration module matching among ICM-, SAP- and CHF-associated networks. Table S6. Weight results calculated by the entropy method. Table S7. Normalization of disease-related module parameters (nodes ≥ 4). Table S8. K-value of reconstruction module pairs among ICM, SAP and CHF...

Two novel sesquiterpene derivatives, dendocarbin B (1), bisaborosaol C (2), and nine known compounds (3-11), were isolated from Nigrospora chinensis GGY-3 derived from Ilex cornuta. The structures of new compounds were elucidated using HR-ESI-MS, 1 D and 2 D NMR spectra, X-ray diffraction analysis as well as ECD calculation and comparison. Compound 1 showed moderate antifungal activities against Rhizoctonia solani and Botrytis cinerea. Compounds 5 and 6 exhibited significant inhibitory activity against Phytophthora capsici, Magnaporthe...