207 Works

Hepatitis B virus middle surface antigen loss promotes clinical variant persistence in mouse models

Junyu Lin, Jing Li, Peilin Xie, Yue Han, Demin Yu, Jia Chen & Xinxin Zhang
Hepatitis B virus (HBV) middle surface antigen (MHBs) mutation or deletion occurs in patients with chronic HBV infection. However, the functional role of MHBs in HBV infection is still an enigma. Here, we reported that 7.33% (11/150) isolates of CHB patients had MHBs start codon mutations compared with 0.00% (0/146) in acute hepatitis B (AHB) patients. Interestingly, MHBs loss accounted for 11.88% (126/1061) isolates from NCBI GenBank, compared with 0.09% (1/1061) and 0.00% (0/1061) for...

Sustainable international engagement using a partner co-hosted teaching model

Brian Gillespie, Paul Doyle, Zy Jiang & Derryl Humble

Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A

Li Wang, Shisong Jing, Han Qu, Kai Wang, Yajing Jin, Ying Ding, Lin Yang, Hangqian Yu, Yan Shi, Qianxue Li & Dacheng Wang
Drug-resistant pathogenic Staphylococcus aureus (S. aureus) has severely threatened human health and arouses widespread concern. Sortase A (SrtA) is an essential virulence factor of S. aureus, which is responsible for the covalent anchoring of a variety of virulence-related proteins to the cell wall. SrtA has always been regarded as an ideal pharmacological target against S. aureus infections. In this research, we have determined that orientin, a natural compound isolated from various medicinal plants, can effectively...

Design and characterization of gambogic acid-loaded mixed micelles system for enhanced oral bioavailability

Zhongcheng Ke, Jianjun Shi, Ziyang Cheng, Xiaoling Cheng, Huan Wang, Meng Wang, Jingjing Wu, Yinyu Sun & Changjiang Li
The aim of this study was to develop a gambogic acid-loaded mixed micelles (GA-M) system, using Kolliphor HS15 and lecithin, for enhancement of oral bioavailability. GA-M was prepared using the thin film hydration method, and particle size and zeta potential indexes were used to determine the optimized formulation was optimized with taking particle size, zeta potential as indexes. The optimal GA-M system had a mean particle size in the nanometer range (87.22 ± 0.68 nm)...

Construction of a membrane yeast two-hybrid library and its application in identification of PsARRO-1-interacting proteins in tree peony

Huiqin Wang, Zheng Wang, Xueyuan Lou & Songlin He
To investigate the molecular mechanism of the ADVENTITIOUS ROOTING RELATED OXYGENASE 1 (ARRO-1) gene in adventitious rooting of tree peony, the PsARRO-1 gene was isolated from Paeonia ostii. Subsequently, a yeast two-hybrid (Y2H) cDNA library using the split-ubiquitin yeast membrane system was constructed, the insert fragments lengths of pPR3-N membrane Y2H library were mainly concentrated between 500 and 3,000 bp, and the library capacity reached 1.3 × 107 CFUs, with an efficiency of recombinant of...

Supplementary document for Significant performance enhancement of UV-Vis self-powered CsPbBr₃ quantum dots photodetectors induced by ligand modification and P3HT embedding - 5987985.pdf

Meng Wang, Dehai Liang, Wen Ma, Qionghua Mo, Zhigang Zang, Qingkai Qian & wensi cai
The experiment and results.

Apurinic/apyrimidinic endonuclease triggered doxorubicin-releasing DNA nanoprism for target therapy

Meng Liang, Na Li, Fei Liu, Nan Zeng, Changyuan Yu & Shuo Li
Drug delivery and triggered release in tumor cells would realize the ultimate goal of precise cancer treatment. An APE1 triggered DNA nanoprism was designed, aiming at the applications of both drug delivery and precise triggered drug release in cancer cell. We demonstrate that the AP-Prism was successfully used as a vehicle based on the intracellular endogenous enzyme APE1 triggered for controlled drug delivery and triggered release. The box like DNA prism was self-assembled by annealing...

Additional file 1 of Implementing a Canadian shared-care ADHD program in Beijing: Barriers and facilitators to consider prior to start-up

Sayna Bahraini, Alexander R. Maisoneuve, Yirong Liu, André Samson, Qian Ying, Fei Li, Li Yang & Philippe Robaey
Additional file 1:

Enhanced stability of foot-and-mouth disease vaccine antigens with a novel formulation

Jing Li, Rong Zhang, Huiqing Yang & Yanming Wei
The structural instability of inactivated Foot-and-mouth disease virus antigen hinders the development of vaccine industry. The use of an inexpensive, biocompatible formulation to slow down the degradation of antigen would address the problem. Here, phosphate-buffered saline (PBS) was showed to be effective in stabilizing 146S and hence determined as basic solution buffer. Excipients such as trehalose, sucrose, arginine, cysteine, calcium chloride, BSA and ascorbic acid were found to protect 146S from massive structural breakdown. Using...

Increased production of 8-oxo-7,8-dihydroguanine in human urine, a novel biomarker of osteoporosis

Qian Liu, Zhen Liu, Chen-Chen Wang, Xin Gao, Chuan-Bao Li, Meng Wang, Qiang Wang & Jian-Ping Cai
Osteoporosis is a worldwide disease that seriously affects the quality of life and survival rate of the elderly. The detection of bone biomarkers will provide supplementary information on bone mineral density, contributing to the accurate diagnosis of osteoporosis and better health care for prevention. This study aimed to investigate the efficacy of oxidative stress markers—8-oxo-7,8-dihydroguanine (8-oxoGsn) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGsn) in the assessment of osteoporosis. We conducted a cross-sectional study among menopausal women with a mean...

Healthy outcomes of patients with COVID-19 two years after the infection: a prospective cohort study

Dapeng Li, Xuejiao Liao, Zhi Liu, Zhenghua Ma, Jingke Dong, Guoqin Zheng, Mei Zi, Fang Wang, Qing He, Guobao Li, Zheng Zhang & Lei Liu
The long-term effect of coronavirus disease 2019 (COVID-19) has been rarely known. This study aimed to investigate healthy outcomes of COVID-19 survivors up to 2 years after the infection. A total of 155 COVID-19 patients, who were discharged from Shenzhen Third People's Hospital from February 2020 to April 2020, were enrolled and followed up until March 4, 2022. COVID-19 survivors received questionnaires of long COVID symptoms and psychological symptoms, pulmonary function tests, chest computed tomography...

Sub-chronic toxicity of broflanilide on the nervous system of zebrafish (Danio rerio)

Kai Wang, Zhiqiu Qi, Manman Duan, Ru Zhang & Lu He
The new insecticide broflanilide, which possesses high insecticidal activity against agricultural pests, acts on the γ-aminobutyric acid receptor in the insect nervous system. At present, few studies assessed its effect on the nervous system of zebrafish, especially its sub-chronic toxicity on the zebrafish brain. In this study, the sub-chronic toxicity of broflanilide on the zebrafish brain was assessed. After 21 days of exposure at 36.3 μg/L, broflanilide caused oxidative damage to the zebrafish brain, increased...

Additional file 4 of B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma

Yong-Liang Sha, Yun Liu, Jia-Xing Yang, Yang-Yang Wang, Bao-Cheng Gong, Yan Jin, Tong-Yuan Qu, Fan-Tong Xia, Lei Han & Qiang Zhao
Additional file 4: Supplementary Table S4. Primer sequences utilized for real-time PCR in the present study.

Supplementary document for Modeling of ring-core trench-assisted few-mode BDFA for 7-mode signal gain equalization - 6123854.pdf

Dingchen Wang, Li Pei, Jingjing Zheng, Jianshuai wang, Wenxuan Xu, Jing Li & Tigang NIng
Verify the applicability of three-level simulation to BDFA through experiments

Supplementary document for Vari-focal liquid microlens array using electrically responsive fluid actuated by ring array patterned electrode - 6102065.pdf

Miao Xu, Yating Liu, Senhao Li, Jing Li, Lyudi Zhang & Hongbo Lu
Supporting information

Additional file 2 of Implementing a Canadian shared-care ADHD program in Beijing: Barriers and facilitators to consider prior to start-up

Sayna Bahraini, Alexander R. Maisonneuve, Yirong Liu, André Samson, Qian Ying, Fei Li, Li Yang & Philippe Robaey
Additional file 2:

Supplementary document for Femtosecond laser-induced phase transition in VO2 films - 6171202.pdf

Zixin Wang, Xiaowei Ji, Ningning Dong, Chenduan Chen, Zhouyuan Yan, Xun Cao & Jun Wang
Supplemental Document

Additional file 1 of Interactions of CDKAL1 rs7747752 polymorphism and serum levels of L-carnitine and choline are related to increased risk of gestational diabetes mellitus

Hui Wang, Jing Li, Jinnan Liu, Junhong Leng, Weiqin Li, Zhijie Yu, Claudia H. T. Tam, Gang Hu, Ronald C. W. Ma, Zhongze Fang, Ying Wang & Xilin Yang
Additional file 1: Figure S1. Associations between L-carnitine and the risk of gestational diabetes mellitus (GDM) in Chinese women.

Supplementary document for Layer-dependent excitonic valley polarization properties in MoS2-WS2 heterostructures - 6099426.pdf

Shaofei Li, Haihong Zheng, Biao Wu, Junnan Ding, jun He, Liu Zongwen & Yanping Liu
Supplemental Document

Additional file 5 of B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma

Yong-Liang Sha, Yun Liu, Jia-Xing Yang, Yang-Yang Wang, Bao-Cheng Gong, Yan Jin, Tong-Yuan Qu, Fan-Tong Xia, Lei Han & Qiang Zhao
Additional file 5: Fig. S1. MβCD plus anti-GD2 treatment inhibits tumor growth in vivo. A, Schematic of MβCD and anti-GD2 treatments. B, Representative images of xenograft 9464D tumors with different treatments. C, The tumors were removed for weight analysis 21 days after the beginning of treatments. D, Tumor growth curves of subcutaneous 9464D cells with different treatments. Fig. S2. Monitoring of mouse weight during the experiment.

Additional file 4 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 4: Fig. S1. Expressed lncRNAs in two crosses.

Additional file 5 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 5: Fig. S2. Expression levels of lncRNAs and PCgenes in sunflower endosperm.

Additional file 7 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 7: Fig. S4. DNA methylation profiles of protein-coding genes (PCgenes) in sunflower endosperm from SY1.

Treatment-related adverse events of PD-1/PD-L1 inhibitors combined with CTLA-4 inhibitors in clinical trials: a meta-analysis

Ze Mi, Yunshu Zhang, Zhichao Feng, Jiahao Liu, Jianmin Wu, Hongpei Tan, Xiaoqian Ma, Zhenguo Liu & Pengfei Rong
PD-1/PD-L1 inhibitors in combination with CTLA-4 inhibitors are being tested in a number of ongoing clinical trials. As a result, it is critical to fully comprehend the toxicity characteristics of adverse events in combination therapy. This study aims to extensively compare the incidences and ORs of treatment-related adverse events between two combination strategies. The eligible articles were searched from PubMed, EMBASE and Cochrane databases for studies published between 1 January 2010 and 1 May 2021,...

Additional file 1 of The transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0–13 years of age: a longitudinal cohort study

Jiaxin Zhou, Yonghong Zhou, Kaiwei Luo, Qiaohong Liao, Wen Zheng, Hui Gong, Huilin Shi, Shanlu Zhao, Kai Wang, Qi Qiu, Bingbing Dai, Lingshuang Ren, Lili Wang, Lidong Gao, Meng Xu, Nuolan Liu, Wanying Lu, Nan Zheng, Xinhua Chen, Zhiyuan Chen, Juan Yang, Simon Cauchemez & Hongjie Yu
Additional file 1: Fig. S1. Time series and predicting epidemic magnitude of CVA16 activity in Anhua county during 2013-2016 (A) and that in Hunan province during 2009-2018 (B). Fig. S2. Participants’ included time in baseline and follow-up times (A) and the epidemic seasons of CVA16 activity during 2009-2018 in Anhua, Hunan province (B). Fig. S3. Distribution of maternal antibody titre transfer ratio against CVA16 for all pairs of neonate-mother (A) and positive mothers with antibody...

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